November 03, 2002
Hibernation Compound May Work For Stroke and Parkinsons

The compound delta opioid peptide is used in squirrels to induce stroke but it also is made in human nerves in response to stroke and larger doses administered therapeutically may reduce stroke damange and provide protection against other neural disorders:

In an animal model for stroke, delta opioid peptide reduced by as much as 75 percent the damage to the brain’s striatum, the deeper region of the brain and a major target for strokes, according to Dr. Cesario V. Borlongan, neuroscientist.

In fact, evidence suggests that the compound, which puts cells in a temporary state of suspended animation, may help protect brain cells from the ravages of Parkinson’s disease as well.

“When the animals were introduced to an experimental stroke, then injected with delta opioid peptide, we could see a reduction in the damage done by stroke; brain damage is reduced and the neurological deficits associated with stroke are definitely reduced,” Dr. Borlongan said.

This compound may even be useful in slowing the aging process and protecting ogans while waiting to transplant them:

The researcher believes this cell hibernation may have other roles as well, including slowing the aging process. Its potential for helping donated livers, hearts and kidneys remain viable longer until they are transplanted already is being explored by others in clinical trials.

Share |      Randall Parker, 2002 November 03 05:26 PM  Biotech Therapies

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