January 06, 2003
Stem Cells, Regenerative Medicine And Rejuvenation

Will it some day be possible to be rejuvenated, to become physically young once again? Yes. Barring an asteroid strike, nanotech goo, robot revolt, or biowar that wipes out the human race the day will come when bodies can be restored to a youthful state. Not only is this day coming but it is coming in this century. Many of us may live to see it. Stem cells topics to cover: - stem cells - embryonic and adult - cloning - what the clone egg does to the nucleus - youthful stem cells outcompete older stem cells - stem cell reseeding as method for rejuvenation and restoration of youthfulness - engineered negligible senescence - The cow experiment is important for a number of reasons. Should you care about stem cell research progress? Yes. Why? Stem cells are great. Stem cell reservoir reseeding will be one of the major rejuvenation therapies for turning back the aging clock so that some day we can become young again. The younger readers may not yet appreciate what a drag it is getting old: poorer eyesight, less endurance, poorer memory, more aches, easier to get kinks in muscles, less ability to bounce back from a night of debauched partying, you name it. As we get older there are more things that we could do when we were younger that we become less able to as we get older.

Current investigations include the evaluation of stem cells to treat incontinence in animal models. In research to date stem cell tissue engineering has been used to restore deficient urethral sphincter muscles in animal models. "These findings are exciting on many levels. First this is the first time that stem cell tissue engineering has been used to restore deficient sphincter muscles. Secondly, it lays the foundation for further investigation into methods of using stem cells to treat stress urinary incontinence," said Michael Chancellor, M.D., Professor of Urology and Gynecology. Chancellor and his colleagues have isolated muscle-derived stem cells (MDSC) from normal rats, transduced them with a reporter gene and injected the stem cells into allogenic denervated proximal urethral sphincters. After two weeks, they prepared urethral muscle strips from normal, denervated and denervated-MDSC injected rats. Fast twitch muscle contractions were recorded after electrical field stimulation. The amplitude of fast twitch muscle contractions decreased in denervated sphincters, and improved in denervated sphincters injected with MDSC by approximately 88 percent. Histological evaluation revealed the formation of new skeletal muscle fiber at the urethral sphincter injection sites.

Share |      Randall Parker, 2003 January 06 11:48 AM  Aging Reversal


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