January 30, 2003
Alteon ALT-711 Anti-Aging Drug
As people age chemical bonds built using glucose molecules connect proteins to each other in ways that are harmful. The resulting compounds are called Advanced Glycosylation End-products or AGEs. This is a bit confusing since AGE the chemical bond sounds like age which is how old something is. As we age we get more AGEs. The neat thing about AGEs is that they are a type of bond that is fairly easily reversible by a whole class of chemical compounds. A company called Alteon has been developing an AGE-breaker drug called ALT-711 for several years. They've had trouble getting funded in part because some in the pharmaceutical industry fear that if ALT-711 gets approved for market it will be very easy for competitors to see that it works and then to rapidly to develop other drugs from the same class of chemicals to compete with it.
A lot of anti-aging enthusiasts have wanted to take ALT-711 for years in hopes that it would generally break AGE bonds throughout the body and by doing so reverse one aspect of aging. While Alteon's low level of funding has slowed its development of ALT-711 it has recently been able to complete a phase IIa trial of ALT-711 with promising results.
Alteon has announced positive results for its developmental agent, ALT-711, from a preliminary analysis of the phase IIa DIAMOND trial in diastolic heart failure. The first 17 patients in the trial, who received ALT-711 for 16 weeks, experienced a statistically significant reduction in left ventricular mass, and the drug had a positive effect on their quality of life.
The results of ALT-711 trials for other medical conditions, importantly including high blood pressure, will be announced in the first half of 2003.
But the real tests of the drug's potential are still to come. Alteon says the results of clinical trials testing ALT-711 in 450 patients with high blood pressure will be available in the first half of this year. Data on another 180 patients with a thickening of the heart's left ventricle will be available at the same time.
Alteon is developing ALT-711 for a wide range of conditions related to aging.
These compounds have an impact on a fundamental pathological process caused by protein-glucose complexes called Advanced Glycosylation End-products (A.G.E.s). The formation and crosslinking of A.G.E.s lead to a loss of flexibility and function in body tissues, organs and vessels and have been shown to be a causative factor in many age-related diseases and diabetic complications. Alteon is initially developing therapies for cardiovascular and kidney diseases in older or diabetic individuals.
The ability to break the AGE bonds may provide many benefits to the aging body. In addition to improving the cardiovascular system it might make skin less wrinkly and possibly it might make kinks in muscles (if there's some medical term for this I'd be curious to know it) less likely to happen. Connective tissue might become more supple and older folks might regain some of the ability to stretch more easily like when they were younger. The awareness that AGE breakers could deliver these kinds of benefits has kept anti-aging enthusiasts as a sort of cheering section for Alteon's progress over the years.
Anti-aging enthusiasts want to see ALT-711 to be approved for just one disorder so that it is available on the market. In the United States once a drug is approved doctors who are willing to do so can prescribe it for off-label uses (i.e. for purposes other than why the US Food and Drug Administration approved it). Alteon will probably not try to get the ALT-711 approved for its broad anti-aging effects. The FDA would be reluctant to approve a drug for that purpose and it would be hard (and rather more expensive) to design a clincal trial that would demonstrate that a drug had broad anti-aging effects. Alteon is smart to pursue ALT-711 approval for a really big market such as high blood pressure treatment. However, once its approved for a single purpose such as for high blood pressure treatment expect to see hard core anti-aging enthusiasts go shopping around for doctors willing to prescribe it for off-label uses.
Even as I write this comment, my printer is spooling off a copy of this post to give to my doctor. He is at the Olive F. Garvey Center for the Improvement of Human Functioning, in Wichita, Kansas USA.
Perhaps you should send a copy of this to Durk Pearson and Sandy Shaw. They wrote the so far "most definitive" book on anti-aging, Life Extension: A Practical Scientific Approach, clear back in 1984.
David N. St. John
Responding to David N. St. John: Do you know of any more recent information about ALT-711 than that in your post of 1/30/03? Dick
"Fairly easily reversible"? I don't know how you come to that conclusion. If it were true, then there would be many AGE-breakers to talk about other than just ALT-711.
There is a whole class of compounds that would also work for the same purpose. As I stated, this is why Alteon has had trouble getting funded. Aubrey de Grey on Alteon and ALT-711:
Actually, advances in the last few years have brought AGE accumulation
closer than telomere shortening to being reversed in vivo. See Vasan
et al, Nature 382:275-278 and postings here discussing Alteon. The
scandalous thing is that Alteon are having real trouble getting ALT-711
through clinical trials, not because of any doubts about its efficacy
but because it (or its suspected active site) is so simple a chemical
that big pharmaceutical companies reckon its patent is not worth much
(i.e. someone could probably rather easily create a similar chemical
that worked the same way but evaded the patent), so they won't put in
the required capital. I have the above from a senior scientist at one
of the several big pharmaceutical firms which have looked at ALT-711,
who was personally involved in his firm's decision not to fund it; he
sees no effective way out for them.
One approach to take in cases such as this is to arrange for contract synthesis of the compound in question, by a chemical synthesis house, for personal use. That is what *we* did, obtaining a personal supply of ALT-711. It was not especially expensive to synthesize. This strategy completely takes the F|D|A out of the loop, because the compound is only consumed by the parties who contract for the synthesis, and not offered for sale to anyone else.
However, this strategy is not for the faint of heart. It requires some sophistication, patience and moderate capital (say 2-15K$ per compound, depending on the complexity of synthesis). But, for those willing to go down that road, the reward is access to such compounds as ALT-711, the new Manganic Porphyrin "super-anti-oxidants," and numerous other useful anti-aging and wellness related compounds.
Specifically, for me, the ALT-711 does produce subjective, positive effects. I wondered, prior to trying it, if it would be completely "silent," in its effects but it was not. It produces a sort of broad based increase in stamina, endurance, and a vague sense of subjective "well-being;" I know, probably all psychosomatic! But really, I suspect that there is some substance to these subjective effects, given the positive performance implications of glycation bond breaking for so many body systems.
Does anyone has the names of such synthesis houses mentioned by Marcus Gitterle in one of the postings here and their contact information? Thanks
what labs can synthisize alt711 @what cost please reply thank you sicerely yours lee.
I can supply the raw material of ALT711. If you want, please send email to me.
THe ALT 711 normally being used by anti - aging doctor. Its real name is called:
CHEMICAL NAME: 4,5 DIMETHYL-3-(2 –OXO – 2 –PHENYLETHYL) – THINZOLIUM
FORMULA WEIGHT: 267.77
Looks great! Thnks. Best of luck in New Year!
I saved this from a forum several years back, can Mike let us know what the
"Chemical Abstracts Service (CAS) registry numbers" are for the chemicals one
would need. You can see from the instructions that you need some special lab
kit. All in all, not a difficult task though, Mike does this look ok?
I am turning 50 next year and I would like to start taking evasive action before
the damage is done....
Regards to all,
For those of you with a chemistry set at home, I thought I would
share the synthetic route I used to prepare a batch of ALT-711:
A flask containing 2.0 grams of 4,5-dimethylthiazole (17.7 mmol),
3.52 grams of 2-bromoacetophenone (17.7 mmol), and 9 mL anhydrous ethanol
was heated under reflux for 2 h under nitrogen with magnetic stirring.
The reaction mixture was cooled to r.t. and filtered.
The cake was washed with ethanol.
The crude yield was 4.46 grams of white crystalline ALT-711
(80.7% of theoretical).
The crude product was purified via recrystallization from 35 mL
ethanol to give 3.68 grams (66.6% theoretical) of pure ALT-711,
Melting point was 207-208 degrees C.
Proton NMR was consistent with the desired structure.
At 50 mgs per dose, this would be enough for almost 75 doses,
or enough for 3 courses of treatment of 20 doses each, with
some left over.
I would only recommend topical use, at this time, at least
until phase III results are available from the clinical trials
in human species. Also, 2-chloroacetophenone could be used to
give the chlorine salt, rather than the bromine salt in
Hi Mike and Reg~ I would like to purchase a batch of the synthesized chemicals of ALT-711. How do I go about this? I am not a chemist but studied biochemistry under Dr. Barry Sears for sometime. AGE breaking is definitely my next step.
You folks are crazy! You're desperate to live longer and better but at the same time are willing to take any chemical concoction recommended by a dude on a web page! You're even willing to knock it out yourself using a home chemistry set! Do any of you have degrees in chemistry? Know anything about quality control? Got any concern about side effects? All drugs have side effects but there's absolutely NO mention of them in the reports provided here.
Ignorance is bliss huh?
J. Boyle~ I don't think knowing what you are doing is crazy. No one said we wouldn't verify the info by the "dude"! I know many people with degrees that are complete idiots, many of us are very well versed in biochemistry but do not have a lab,however know how to verify and analyze. If I had to be a degreed individual I would not have achieved the remarkable results I have. Sure I had to read books i.e. Anti-Aging Zone, which should be taught to every freshmen in nutrition, medicine, etc. My girlfriend is an MD and I can run circles around her with respect to the effects of medicine or nutrition. Even taught her why you could alter eicosanoids within the cell membrane. Not to bad for an MBA, but I guess smart people are smart people regardless of a piece of paper. Thanks for the concern but no thanks!!!
Agreed, Scott. One does not need to have a PhD in chemistry in order to be knowledgeable about alagebrium chloride (ALT-711). While we do not synthesize this ourselves, I and husband, Paul, have been taking it now since mid-2001. Our physical parameters are very good for people in their 50s - *but* I turned 62 early this month and Paul is now 69. See http://morelife.org/personal/health/ **Kitty Antonik Wakfer
I am a student of M.Pharm. Pharmacology from Shree S.K.Patel College of Pharmaceutical Education & Research,Kherva,Mehasana,North Gujarat,India.
I am working on topic related to Advance Glycation End Products (AGEs) Inhibitor.So,I require sample of it.Is it possible to provide me gift sample or anyother means ? Do you know nale of supplier possible from india(no matter from outside india)? Please reply me on my e-mail i.d. firstname.lastname@example.org.Thank you sir.