May 29, 2003
Nanog Stem Cell Gene Enables Pluripotency

Teams led by Austin Smith of the University of Edinburgh in Scotland and by Shinya Yamanaka of the Nara Institute of Science and Technology in Japan have discovered a gene they named nanog which may be capable of turning any cell into an embryonic stem cell.

In one crucial experiment, Smith's team inserted copies of the human nanog gene into mouse embryonic stem cells, and subjected those cells to laboratory conditions that normally force such cells to mature and become one kind of tissue. The human nanog gene prevented that process.

The experiments suggest that as long as the nanog gene is turned on a cell will not differentiate into a specialized adult cell type. What would be interesting to know is whether non-embryonic stem cells also have nanog turned on.

The development of the means to control the expression of genes such as nanog which regulate the type of tissue that cells become will eventually open the door to the ability to grow replacement organs and stem cell therapies to rejuvenate aged stem cell reservoirs. In other words, this latest result is an important step toward the development of the means to reverse the aging process.

So why did they call the gene Nanog? Tir Nan Og is the land of the forever young in Celtic mythology. Tir means Land. Na Nog or Nan Og stands for "Of Youth" or "Of The Young". We in this age are living so close to the time when the breakthroughs that will make Engineered Negligible Senescence possible that we could fairly be said to be living in Tir Tairngire or "Land of Promise". Tir Na Nog is pronounced teer na no-'gue and many of us may live in it some day.

Tir Na Nog is also known as Mag Mell or "plain of joy". It bears some resemblance to Philip Jose Farmer's Riverworld since anyone who dies there reawakes the next day fully restored.

Tir Nan Og is the land to which the Irish faeries know as Tuatha de Danann (Too-ah day Thay-nan, or Tootha day danan) flead when their lands were taken by the Milesians. In Tir Nan Og they spend their days feasting, gaming, love-making and partaking of beautiful music. The faeries can even enjoy the thril of battle, for anyone slain is resurected the following day. It is the paradise that mortals can only dream of.

It is one big party.

No ploughing, no work is needed to make a living in Tir Nan Og: the faerie make love, have feasts, hunt and even play at war with one another--those that die one day are resurrected the next morning to join in the fun again. Occasionally, they grow curious about the humans who live on the other side of the Great Mist, or need to strengthen themselves with a fresh and vigorous human bloodline--and that is when they step out of their dark forests, through the silvery mist to be called into Legend...

Update: New Scientist coverage:

"Nanog seems to be a master gene that makes ESCs grow in the laboratory," says Ian Chambers, one of the team at the Institute for Stem Cell Research (ISCR), Edinburgh, Scotland. "In effect this makes stem cells immortal."

BBC coverage:

Their finding could ultimately enable scientists to transform stem cells from adults into cells that have all the characteristics of those taken from embryos.

Share |      Randall Parker, 2003 May 29 10:34 PM  Biotech Organ Replacement


Comments
Philip Shropshire said at May 30, 2003 5:17 PM:

Uhhh, is that any relation to Gog and Magog, the beginning and the end, or the biblical warnings in the bible mentioned in the book of revelations?

Can't they call it something upbeat and something not prone to misinterpretation like "Happy Fun Nan Cell"...

franco capanna said at June 7, 2003 11:34 AM:

"nanog" cell seems to be the actual proof of what almost all religions called "future immortality" of Humans obtainable "subject to improve soul and spirit power against body will".
I am confident that this is the step were Humans are.

Ancient History said at July 7, 2003 2:18 PM:

I did wonder who was linking through here.

JongWK said at August 12, 2003 7:37 AM:

AH, next thing you know, they'll be posting an article about Homo Sapiens Nobilis ;)

Adamski said at September 4, 2003 6:56 PM:

Why did they link your site and not a gaelic one for the Nanog translation...now people are going to think that Sprethiel is a real language

Randall Parker said at September 4, 2003 8:24 PM:

Scott, I know diddly squat about Gaelic or ancient mythology. I did some google searching and came up with that link. I just wanted to explain to my readers why this Scottish scientist chose to name a gene nanog. The emphasis on my site is on science, technology and the future. If you want to provide some corrective information about Tir Na Nog then go ahead.

Robert Derie said at September 5, 2003 3:05 PM:

I've been wondering about that for a while.

Shiv P shukla said at December 21, 2007 12:15 AM:

is the youngest thing to make 'Nan og'.

Charles E Hardy said at December 27, 2007 9:20 AM:

THIS IS AN OLD ARTICLE FROM MAY 2003. HAVE ANY ADVANCES BEEN MADE IN:

NANOG STEM CELL GENE ENABLES PLURIPOTENCY ?

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