November 13, 2003
Adult Stem Cell Research Promising For Heart, Lung Disease

A medical conference of the American Heart Association, Scientific Sessions 2003, has produced a number of encouraging reports on the use of bone marrow stem cells to regenerate hearts, blood vessels, and even lungs. A German group used bone marrow stem cells in humans to restore heart muscle function in failing hearts.

ORLANDO, Fla., Nov. 10 – Bone marrow stem cells restored heart muscle that was damaged from a heart attack, providing a new treatment for failing hearts, researchers reported today at the American Heart Association’s Scientific Sessions 2003.

The bone marrow cells came from patients’ own blood and were injected into their ailing hearts. The cells fueled new cell growth, which strengthened the heart’s pumping capacity.

“These results demonstrate for the first time that transplantation of a person’s own stem cells through direct intracoronary injection increased cardiac function, blood flow and metabolism in the damaged zone,” said senior author Bodo E. Strauer, M.D., professor of medicine at Heinrich Heine University in Düsseldorf, Germany.

“If a prospective, randomized, multicenter study confirms these encouraging results, a new therapy for heart attacks could be in reach,” he said.

A Canadian group successfully used endothelial progenitor cells from bone marrow to restore heart function and lower blood pressure in rats.

“This is a novel and exciting approach,” said Duncan Stewart, M.D., professor and director of cardiology at the University of Toronto and head of cardiology at St. Michael’s Hospital.

Pulmonary arterial hypertension (PAH) is abnormally high blood pressure in the arteries between the heart and lungs. It is a progressive disease that can affect the arterioles and capillaries that supply blood to the lungs.

“PAH reduces the heart’s ability to pump blood through the lungs and gradually leads to heart failure. Today, we can achieve some improvement with drugs, but the treatment is palliative and can only delay death,” Stewart said.

Restoring blood flow to the lungs with a stem cell transplant in the pulmonary vessels may hold promise as a new treatment for PAH, Stewart said.

His team used endothelial progenitor cells. Endothelial cells form a thin lining in blood vessels, providing an interface between the vessel and blood. This lining, called the endothelium, regulates a host of basic processes, such as blood clotting and blood pressure.

“Our results show that endothelial progenitor cells from the bone marrow circulate in the bloodstream. We can use them to form new blood vessels or repair damaged ones,” Stewart said.

Stewart and co-investigator Yidan Zhao, M.D., a research associate at the University of Toronto and St. Michael’s Hospital, removed vascular progenitor cells from rats’ bone marrow. The cells were cultured for five days, then injected into the pulmonary circulation of rats with PAH. A second group of rats with PAH received skin fibroblasts (cells), while a third group, which did not have PAH, were used as controls.

Right ventricular systolic blood pressure (the pressure when the heart contracts) was measured 21 days later. The systolic pressure of the untreated, normal rats was 26 millimeters of mercury (mm Hg). Rats with PAH had a systolic pressure of 47 mm Hg. Systolic pressure fell to 32 mm Hg in those treated with endothelial progenitor cells, and it was relatively unchanged (45 mm Hg) in control animals treated with skin fibroblasts.

A Texas Heart Institute group used bone marrow stem cells to restore heart function in humans.

Researchers at the Texas Heart Institute in Houston tested mononuclear bone marrow cell transplant injections in patients with severe ischemic heart failure — the first such study in a severely ill population. There are few treatment options for patients with end-stage ischemic heart failure, according to the study’s lead author Emerson C. Perin, M.D., Ph.D., a clinical assistant professor of medicine at Baylor College of Medicine at the University of Texas Health Science Center in Houston.

Previous laboratory research has shown that mononuclear cells taken from bone marrow then injected into human tissue can promote growth in oxygen-deprived tissue. Mononuclear cells can differentiate into tissue and new blood vessels, and secrete a wide variety of proteins and growth factors, said Perin, who is also director of new cardiovascular interventional technology at the Texas Heart Institute.

Treated patients had better blood flow and could walk longer on treadmill tests than controls. They also reported less chest pain and were able to breathe better.

“To have the sustained ability to exercise at six months is significantly different than the controls. They’re functional and they have their lives back,” Perin said.

In what could turn out to be a useful discovery for purposes extending beyond heart disease treatment a Tufts University group discovered a new kind of stem cell in bone marrow that may be able to differentiate into a wide range of cell types.

ORLANDO, Fla., Nov. 10 – A “universal stem cell clone” found in adult bone marrow regenerated blood vessels and heart muscle, according to research reported at the American Heart Association’s Scientific Sessions 2003.

The cells, called human bone marrow-derived multipotent stem cells (hBMSC), were implanted into animal hearts where they formed multiple cell types.

The hBMSC improved animals’ heart function, said the study’s lead author, Young Sup Yoon, M.D., Ph.D., assistant professor of medicine at Tufts University School of Medicine in Boston.

“This study is exciting because it is the first to show that human bone marrow includes a clonal stem cell population that can differentiate into both vessels and heart muscle. These cells can regenerate the essential tissues of the heart,” Yoon said. This finding comes from animal and laboratory research.

Such stem cells might be used to regenerate damaged hearts for people who have acute and chronic heart failure. They also might help people with hypertension, diabetes or other blood vessel diseases.

The researchers found that these stem cells didn’t belong to any previously known bone marrow-derived stem cell population (such as hematopoietic cells, the source for all types of blood cells or mesenchymal cells that give rise to cell types like bone and cartilage).

These adult bone marrow stem cells have been shown to differentiate into all three so-called “germ layers.” The three germ layers of cells in early human development are the beginnings of the body’s tissues and organs. Differentiation is the term that describes the process in which stem cells change into these specialized cells.

A University of Ottawa group has found that a bone marrow stem cell growth factor helped five heart attack patients.

ORLANDO, Fla., Nov. 11 – A drug that stimulates bone marrow to produce stem cells helped regenerate damaged heart muscle in one of the first studies of its kind, according to a report presented at the American Heart Association’s Scientific Sessions 2003.

The drug, granulocyte colony stimulating factor (G-CSF), treats some forms of cancer. It stimulates bone marrow to produce the different types of blood cells, including white blood cells that can become depleted after disease or chemotherapy.

G-CSF might help repopulate the heart’s muscle cells, which in turn could help repair the damaged heart, said lead author Chris A. Glover, M.D.

“Research has shown that there are cells in the heart that come from bone marrow stem cells. We hypothesized increasing these cells after a heart attack may help the heart regenerate heart muscle cells, and this is supported by our results,” said Glover, assistant professor of medicine at the University of Ottawa and the Ottawa Heart Institute in Ontario.

A larger clinical trial on G-CSF is now planned.

The drug -- granulocyte colony stimulating factor, or G-CSF -- was tested in only five heart-attack patients, says Chris Glover, a researcher at the University of Ottawa and the Ottawa Heart Institute. A clinical trial will begin this spring involving up to 85 to 100 patients.

Tissue-engineered heart valve replacements made from a patient's own tissues were also reported.

ORLANDO, Fla., Nov. 12 – Heart valves engineered from patients’ own tissue may offer a new treatment for valvular heart disease, researchers reported today at the American Heart Association’s Scientific Sessions 2003.

“Using this tissue-engineered valve overcomes many of the problems with mechanical or donor valves because it is a living structure from the patient’s own tissue, and so it does not cause an immunological reaction,” said Pascal M. Dohmen, M.D., head of tissue engineering research and staff surgeon of the department of cardiovascular surgery at Charité Hospital in Berlin, Germany.

The action in heart disease research aimed at developing therapies has obviously shifted toward repair using cell therapies and the use of growth factors to stimulate and guide cells as part of cell therapies. The sheer number of research groups reporting encouraging results at a single conference suggests an even larger number of groups must be working on therapies. It is also worth noting that many of the results mentioned above were done on humans. Heart disease is a major killer. These reports in total suggest that cell therapies to repair hearts are no longer a distant uncertain prospect and successful therapies will not have to wait on advances in poorly funded embryonic stem cell research. The ability to use a patient's own cells to do repair also avoids immune incompatibility problems.

These reports are not a reason for complacency about your diet. If you think that heart disease will be curable by the time you become old enough to have a heart attack then that is not a reason for complacency about diet or exercise. The risk factors for heart disease also cause general aging to happen more quickly. A high level of cholesterol in the blood probably increases total free radical oxidative stress on the body. There is considerable overlap between a diet that is ideal for reducing heart disease risk and cancer risk. General brain aging is going to be accelerated by a high level of oxidative stress. Plaque build-up puts you at risk for a stroke and brain damage. Eat a great diet. Get plenty of exercise. We are decades away from the day when medicine can fully protect us from our vices.

Share |      Randall Parker, 2003 November 13 01:45 PM  Biotech Organ Replacement


Comments
Kerry Rich said at January 5, 2004 12:46 PM:

HI,

My fiance' was born with TGA and underwent the Mustard procedure as an infant. Until just recently, he had not experienced any negative effects as a result of his condition, nor did he require medication of any kind. Last year, he experienced a series of SVT's that lead us to the emergency room. They were able to stabilize his heart rate and released him the same day. This past summer, he was experiencing what he thought to be a chest cold - which was later diagnosed as heart failure. He spent a week at Emory under the care of Dr. Michael Mcconnell and Dr. Wendy Book. We have also visited Dr. Smith at the Cleveland Clinic. Last month, they recommended that he get a pacemaker due to a very low heart rate - his heart rate is getting down into the twenties at night. We have also been told that a heart transplant will be necessary at some point down the road.
He is only thirty years old and other than his heart condition, in perfect health. He is currently taking several different medications, including spirolactone, aldactone, coreg, lisinipril (please excuse my spelling.) and one other medication that I cannot think of off-hand.

Can someone please send me more information regarding stem cell research? We are extremely interested in knowing if this type of treatment would benefit him. Please feel free to contact me anytime.

Kerry Rich
6115 North Point Drive
Flowery Branch GA 30542
770-967-1646 Home
770-289-5493 Cell
770-297-7600 Work
Thank you, I look forward to hearing back from anyone with information that might be helpful to us.


Shannon said at January 20, 2004 8:41 PM:

Hello...

I too am searching for that proverbial needle in a haystack. My Mother is in the hospital as I write, and is being told that there is not much else that can be done for her. She has CAD, CHF, Diabetes, Renal Failure (on Dialysis). I had spoken to a Dr. At the Teaching Hospital in Washington, DC regarding the Stem Cell clinical trial that was being held there. There was some question as to if she would be able to benefit from the therapy, as there was no promise that her stem cells would be of use as she is Anemic. Since then she has been put on Peritoneal Dialysis (nightly) and is closely monitored for signs of Anemia. I am hoping that now she may be able to take part in one of these Clinical trials since being on PD for the past 5 months, and keeping her Anemia in check. I so desperately need for this to happen before it is too late. She is in the end stages of Heart Failure, and had an episode this past month where she went into Respiratory Arrest, and had to be resuscitated. This has sent me on the tedious endeavor of finding every Hospital or Institute that are running these Stem Cell Clinical Trials in 2004. I will drive across the country and personally beg the person in charge of the admitting Criteria, so that I find someone who is willing to let her be a part of a trial. This is her last and only hope at this point, and I am afraid that it will come too late. So if ANYONE is reading this thinks they can help me or point me int he right direction, or put me in touch with someone who can, I would owe you everything that I have & more. Thanks you so very much for reading this, and I am crossing my fingers.

~~Shannon
I can be reached via e mail at Sneeches3@aol.com or via my Cell phone 717-805-6976

mike said at February 28, 2004 2:20 PM:

I am trying, in a quietly desperate way, to find somebody who is actually trying stem cell therapy on humans. At 55 I find myself with COPD and I don't like it. If nobody is working with humans, but will work with lab rats, I can be a lab rat, too. I am versatile and willing.

My own doctor is only too happy to tell me my tests are getting worse. Surely, here in the 21st century, somebody can take a swing at making them better.

Thanks,
Mike

Randall Parker said at February 28, 2004 2:32 PM:

One place to look for clinical trials is this list which has a few clinical trials which mention stem cells in their titles.

You could also try contacting some of the research centers I mention in my post.

Beth Doan said at March 18, 2004 9:20 AM:

Hello:

Although I have no experience in handling heart conditions or diseases, I am currently researching a paper on stem cell research, focused mainly on the stem cell relationship with heart disease. I would appreciate anyone who could give me access to information (statistics, books, articles, etc.) on both the good and the bad of the stem cell research on Heart disease. I could use any type of source, so please feel free to relay stories or book titles dealing with Heart disease. Thank you very much for your time.

Thanks Again,
Beth Doan
beth09_99@yahoo.com

Daniel Holmes said at March 23, 2004 8:08 PM:

Daniel Holmes
514 North Ninth ST..
Goshen , IN 46528

Birthdate 03/02/1956

To whom it may concern:

Hi , I am currently a patient of Dr. Russell P . Valentine . I would like to inquire what clinical trials programs might be available for a CHF patient who is; one right heart cath. test away from completing the evaluation for Heart Transplant . I was originally diagnosed on Aug . 7th 2003 and have survived a enlarged heart as a result of idiopathic cardiomyopathy , leading to cardiopulmonary edema and consequently Congestive Heart Failure . My ejection fraction at the time of diagnosis was 10% and I have improved to a estimated 15%. I am currently on a the standard barrage of meds , coreg, lysinopril , coumadin, Lasix , digoxin , Spirolactone and Q10 . I am out of the hospital doing Ok , therefore I would rank myself as a 2 , however my local cardiologist Dr. Nelson feels strongly that I am more a 1b than a 2 for transplant evaluation. My symptoms are low blood pressure and edema , I have increased my dosages of coreg and lysinopril to 20 and 25 twice a day and am leading a sedentary lifestyle that is contrary to my previous 47 years . This has resulted in my being tired most of the time , when I do recharge my present level of endurance allows me routine exercise for about one hour . My cardiologist in Indy Dr. Valentine has upgraded my NYHA rating from Class 4 to Class 3 ,I have been self employed for 25 years and have been very active . This time of year is becoming very difficult for me as we all have cabin fever . I am experiencing some low level headache and joint pain , otherwise I am in pretty good shape . I have completed all of the tests required except the latest pulmonary test and have not been disqualified in any capacity at this time . I am specifically interested in the clinical trials involving stem cells , I am optimistic that I may be able to restore my own heart . Obviously if I am called for transplant the oppurtunity would be lost for stem cell trials and at my age being relatively young I would very much like to retain my own heart. I hope and pray that you will consider me and will call , I am on SSD and I am available on short notice . I have a solid family structure , I am very optimistic about living and have a positive mental attitude . I am willing and able to participate and have no reservations or emotional barriers , I feel I would be a ideal candidate and want to participate .

DR . VALENTINE , Building HOLMES A NEW HEART .


Sincerely, Dan Holmes

1-574-534-7784 Home Cell phone 1-574-361-7784

C Lee said at April 14, 2004 4:38 AM:

I just last night (4-13-04) at 9pm eastern time on PBS I saw a show on stem cell research that talked about using adult stem cells on HUMANS to correct some cardiac damage. The results they showed were amazing but keep in mind this was TV, I beleve the hospital was in Chicago I cant remember much else. I'm on the net now trying to get more information. I am not a chf pt but am very interested in the condition.

C Lee

Karl said at May 5, 2004 7:13 PM:

I was diagnosed with an idiopathic diolated cardiomyopathy 2 years ago at the age of 40. I was in very good physical condition prior to contracting this disease but I feel that the disease is starting to take its toll. I have an EF of 15-20. Does anyone have any information on whether any work is being done at any lab or hospital along the lines of stem cell regeneration for someone with my condition? I would appreciate any and all information. You can use my home e-mail address kdw3@optonline.net.

audrey sharp said at May 8, 2004 9:54 PM:

Mike I am also looking for info about stem cell research with bone marrow. I understand there is a doctor in Houston Emerson c. Perin, md phd at baylor. I will try ro call him next week and if get any info I will try to reach you.

Sincerely

Audrey

Linda Sumrow said at May 13, 2004 8:04 AM:

Hello Im a 38 year old female with Copd , Emphysema ,and asthma . I would like to see alot more research into Stem Cells for Lung disease . I have been told by Dr the only thiing left is a Lung Transplant and the average lifespan with this is 5 years. I have lots of things on this earth to do and 5 years isnt long enough for me. I want a future and as it is now there are only a few things I can do with a nose hose and a O2 tank .
So please push for more research into Lung diseases and Stem Cell Therapys. Thanks Linda
Sumrow

James W. Bruce said at May 13, 2004 3:50 PM:

Hello: I am 73 years old and have emphysema. My lung fuction is approx. 27% and I appear to be losing my lung function at a fairly slow rate. I get very short of breath even though I am on oxygen. I see a lot of discussion on stem cells for everything except for emphysema. Are there any clinical trials going on for the express purpose of testing one's stem cells to determine if this is a feasible application for the stem cells.


Thank you for any information. James W. Bruce
1-407-892-0568

Robert Crawford said at May 13, 2004 8:43 PM:

I have Idiopathic Pulmonary Fibrosis.....and I am dying.....painfully. My hopes were up when stem cell research began again....but as I sit gasping for air....all that I hear and read does NOT include research for lung regeneration. I know this organ is a little more complicated, but isn't there ANY RESEARCH ANYWHERE LOOKING AT LUNG REGENERATION? I too would be willing to be a lab rat. For some of us there are no other options.

Bob Crawford/Texas

Trudy Teekens said at May 14, 2004 2:38 AM:

I have COPD ( emphysema ) and my lung function is very bad (below 20 %). I am only 48 years old and am on supplemental oxygen 24 hours a day. I desperately seek for a cure or a help to get my lungfunction better than it is. I hope stem cells can help me. Please mail me if you know anything that can help me. PLEASE HELP ME to breath normally.
I live in The Netherlands.

Trudy Teekens / The Netherlands

James W. Bruce said at May 14, 2004 6:53 AM:

Hello. I am a 73 year old male with COPD and emphysema. The doctors I have talked with can only say they can make me breath a little better with different kinds of medicine. I have seen a lot written on stem cells for everything for hearts, bone marrow etc. I have seen nothing on tests being performed for the express purpose of regrowing lungs. I would like to see some clinical trials performed on treating the lungs with the stem cells. There are many in the USA with this disease and millions around the world. If there is a clinical trial going on or about to start I would like to be appraised of this. Thank you in advance.

James W. Bruce
1-407-892-0568

Geneva Stewart said at May 14, 2004 11:15 AM:

I an 63 years old with COPD/emphysema. I too would like to see stem cells for the lungs. If stem cells go to where they are needed why not the lungs too. I am very much willing to be a rat. There has got to be a cure for this. Also doctors need to emphazise with their patients that smoke; to quit now and explain in detail, show pictures etc, not wait until its too late to tell them or explain the horrids of it.

James L. Henderson said at May 14, 2004 1:45 PM:

I am 72 y.o. male on O2 at night at 2 lpm. When stressed during the day I use some oxygen. Please keep me advised of any stem cell or similar test that will help the lungs work better.
Thanks, Jim Henderson.

Gloria Sanchez said at May 15, 2004 6:37 PM:

I would like to be directed to stem cell research. Put me down as a lab rat too. I have severe copd.Also have mild cor pulmonare. lnfact there is a world wide membership of"Efforts group" at www.emphysema.net Im sure alot of my friends would love to be included in the clinical trials for the lungs and stem cells. glori62950@aol.com

Amanda Henderson said at May 16, 2004 7:36 PM:

I have just recently heard of all the advance in the stem cell research, and my mind is blown away at all of the endless possibilites that stem cells offer. This is going to change everything as we know it in the medical world. I am 20 years old and I am so excited to know that I will be alive when they can finally say we have found a cure for some of the most horrible diseases that no one should have to go through.

Tony Hamel said at May 17, 2004 1:31 PM:

I had a single lung transplant at the age of 51 in Dallas, Texas. My transplant was on Feb 10th, 2001 at St Paul Medical Center. I had some difficulty and my lung funciton at present is 33% up to 38%. I would gladly be a subject for stem cell for my native lung and I believe if I can get that "dead" lung to functioning at some level it would extend my life. My lung function before transplant was 9% so the native lung does not have hardly any measurable function. My docs say there are air sounds in the native lung but very little.
If you do decide to need subjects for research with stem cells, I will be more than willing to be one of those. I still have much to do in my life.
Tony Hamel

Danny said at June 2, 2004 9:15 AM:

We need to start doing clinical trials soon! I am only 25 and have 40% lung capacity but don't need O2 yet. I have not really even started my life and was diagnosed at 21 with COPD. Studies need to start!

Manpreet Singh said at June 19, 2004 9:51 PM:

Dear Sir,

My father has COPD and his lung function is only 30%. He has to be on oxygen for atleast 16-18 hours every day. Is there any stem cell treatment which can help him.

Which are the institutions who are doing research / treatment in this field. Could you spell out a few names for us.

Rgds

Manpreet Singh

Dale Peek said at July 1, 2004 5:47 PM:

Hello, I'm a 52 year old male with severe COPD or emphazema with only 30% lung function. I exercise consistently, which helps but it's getting worse. What is the outlook for lung replacements through stem cells. Is there hope coming soon? Please respond.

James Evans said at July 11, 2004 10:59 AM:

I am a 59 year old man with severe emphazema -----with aprox. 25 to 30 percent lung function. I am
full of life and want to do so much more. I would like to be in a study involving stem cell research
for the lungs or any other program that will help me improve my and my family's life.
If you know of any research projects involving stem cell research would please advise me.

Sue Dick said at July 20, 2004 9:09 PM:

Hello, My father is suffering from severe COPD/Emphysema. Like many of you with this condition, he takes several medications and breathing treatments as well as using oxygen. Have any of you found any information on treatment for this disease using stem cells? I found only 1 article about St. Michaels in Toronto using this treatment on rats...has anyone started doing this on humans? I keep coming up with dead ends and he is running out of time...I would appreciate any advice/information you would be willing to share.

Recpectfully,

Sue Dick
Email: garyandsuedick@yahoo.com

Joanna Olson said at July 28, 2004 7:11 PM:

Would like to have a positive purpose before I succumb to COPD by volunteering for stem cell research. 60 year old female. Looking at the comments prior to this one, I see a wide age range and level of lung function.

NORMAN DESPAUX said at August 1, 2004 6:09 PM:

I AM A 67 YEAR OLD MALE WITH SEVERE HEART DISEASE, HAD SEVERAL HEART ATTACKS, BY PASS SURGERY TWICE , I NOW HAVE A BYVENTRICULAR DEFIBULATOR, OTHER THAN MY HEART PROBLEM I HAVE TYPE TWO DIBETES CONTROLED WITH MEDICATIONS OTHER THAN BEING OVERWEIGHT I AM IN GOOD SHAPE, GO TO THE GYM EVERY DAY AND TRY TO EXERCISE TO KEEP SOME MUSEL TONE, WENT THROUGH THE HEART TRANSPLANT EVAUATION AT UAB, AGE WEIGHT AND DIBETES KEPT ME FROM BEING EXCEPTED, I HAVE A 20%EJECTION FACTOR, WAS TOLD I HAD ENOUGH HEART FOR THEM , THE DR'S TO WORK WITH, I FAILED TO STATE I HAVE CHF, I WOULD BE A VERY GOOD EXPERMENTAL PATIENT, CAN TAKE CARE OF MY SELF AND CAN TRAVEL, THIS STEM CELL RESERCH SEAMS TO HAVE BEEN DEVELOPED FOR ME.IF THERE IS THE SLIGHTEST CHANCE FOR ME TO GET IN STEM CELL RESEARCH PLEASE LET ME KNOW, I AM A FIGHTER AND HAVE THE WILL TO LIVE. CALL ME @ 850 682 4335. MY EMAIL IS NDESPAUX@CYOU.COM////I DIDN'T LIST ALL THE MED'S I TAKE CAUSE IT WOULD TAKE ANOTHER PAGE.ANY PERSON OR DR. WHO WOULD LIKE TO TALK TO ME PLEASE CALL, ANY BODY WHO CAN GIVE ME SOME INFO, WHERE TO GO OR CALL FOR INFO. ON STEM CELL PLEASE DO SO, THANKS FOR TAKING TIME TO READ THIS, NORMAN DESPAUX @ PO BOX 442 CRESTVIEW FL.

RON said at August 3, 2004 8:54 PM:

I WOULD LIKE TO KNOW ALSO OF CLINICAL TRIALS BEING DONE ON COPD PATIENTS USING STEM CELLS.

RON said at August 3, 2004 8:55 PM:

I WOULD LIKE TO KNOW ALSO OF CLINICAL TRIALS BEING DONE ON COPD PATIENTS USING STEM CELLS.

Rosetta said at August 16, 2004 4:01 PM:

Any info on stem cell testing copd / I am on O2 24/7 i am 61 have been coping for a long 10 years, read thousands of pages and stem cells seem like the only thing that might work after hearing of the successes in other areas. Any info please. also if anyone knows anything about the retinoic acid testing please let me know.

Jessica said at August 26, 2004 6:56 PM:

I am a 34 year old female with severe coronary artery disease. I have had 2 heart attacks and bypass surgery. My injection fraction is 24 %. The doctors say this is all i will have. I am now considered disabled and my activities are limited.. i am looking for a stem cell study. can anyone help?

Lorie Wichman said at September 6, 2004 7:47 AM:

My Husband has only 30% of his heart working.He is 48 years old.Unfortnatly in 1996 he was diagnosed to have had a anxiety attack when indeed it was a major heart attack.Aug.24 2004 he had a heart attack and found this out.They put stents in to open his arteries and have said that there is nothing more they can do.he would not be a canidate for open heart surgery because his heart is to weak and damaged.Please some one help us..A Stem cell (bone marrow mononuclear cell)would be a gift for us.Please someone give us our lives back...We have 9 children between us...Where can we seek help and Where can this be done? I know the story of 16 yr old Dimitri Bonnville of Michigan.Texas Heart Institute is doing things but how do I find information out?What can be done?
Help...

Charlene Kutterer said at September 7, 2004 9:36 PM:

I was diagnosed with congestive heart failure about two and a half years ago. I am on coreg, enalpril. I was on three different cholestrol lowering drugs because my cholestrol was high. they all caused me to have terrible leg cramps and muscle weakness for months at a time. I stopped taking the last cholestrol lowering drug the 2oth of July. I'm in real trouble and can hardly walk. My doctor thinks my heart medicine may be doing the same thing to me,causing the muscle weakness and cramps. this is one of the side effects of both the medicines I am still on. I would like to know where I could go to get some stem cell treatment. Even a stem cell study to be part of would be worth a try. If anyone has any information please contact me!

Charlene Kutterer said at September 7, 2004 9:36 PM:

I was diagnosed with congestive heart failure about two and a half years ago. I am on coreg, enalpril. I was on three different cholestrol lowering drugs because my cholestrol was high. they all caused me to have terrible leg cramps and muscle weakness for months at a time. I stopped taking the last cholestrol lowering drug the 2oth of July. I'm in real trouble and can hardly walk. My doctor thinks my heart medicine may be doing the same thing to me,causing the muscle weakness and cramps. this is one of the side effects of both the medicines I am still on. I would like to know where I could go to get some stem cell treatment. Even a stem cell study to be part of would be worth a try. If anyone has any information please contact me!

Charlene Kutterer said at September 7, 2004 9:36 PM:

I was diagnosed with congestive heart failure about two and a half years ago. I am on coreg, enalpril. I was on three different cholestrol lowering drugs because my cholestrol was high. they all caused me to have terrible leg cramps and muscle weakness for months at a time. I stopped taking the last cholestrol lowering drug the 2oth of July. I'm in real trouble and can hardly walk. My doctor thinks my heart medicine may be doing the same thing to me,causing the muscle weakness and cramps. this is one of the side effects of both the medicines I am still on. I would like to know where I could go to get some stem cell treatment. Even a stem cell study to be part of would be worth a try. If anyone has any information please contact me!

Beth Miller said at September 8, 2004 5:19 PM:

My father recently was given 6 months to live due to pulmonary fibrosis caused by the chemotherapy drug, cytoxan. His cancer is in remission, and he was healthy before all of this happened--non-smoker, walked 2 miles/day. We can see him getting worse daily--is there anything in stem cell research that could help him--soon?

John Shaw said at September 13, 2004 2:39 AM:

In regards to Stem Cell research on the lungs. My son was born at 29 weeks into my wifes pregnancy. He was 2lbs. 6 oz. He was on a respirator for the first 6 weeks of his life.
He had a collapsed lung after 8 days and had a tube inserted into his lung to inflate it.
He was then on pure oxygen for the next 2 years. We moved to Arizona for the warm dry climate, which the doctors told us it would probably help him. It did help him greatly.
He has grown to be a normal "Looking" young man of 16. Unfortunately we had to return to Massachusetts, where he was born, due to an illness in my family. His lung function is between 43% and 50% after some exertion. When just relaxing, his blood oxygen level can be up around 90%. If he walks around for 5 - 10 minutes, his oxygen levels drop down to around 50 - 60%. He was originally diagnosed with BPD (Broncho Pulmonary Dysplasia) at birth. Then somewhere around 10 years of age it became COPD... He has been under the impression that he could get a Lung Transplant and live a fairly normal life. Our Pulmonologist didn't tell us that half the Transplant Patients die within the first 5 years and don't normally exceed 10 years. Is there any Stem Cell research going on anywhere in the world for the lungs. My wife and I are both from the UK and still retain citizenship there. Is anyone doing research there?

rob miller said at October 4, 2004 3:36 PM:

i am a 69 yr old male and i am currently suffering from impotence!i would like to know if there is any stem cell reserch for my problem.

Stephen A Nick said at October 7, 2004 6:57 PM:

I have emphysema am 73yrs old and am looking for anything or anyone that can help me, will try anything go anywhere to get aid. Thanks. Stephen A Nick

Jenny Soltow said at November 21, 2004 5:38 PM:

HEllo, I have a five year old son that was diagnosised with a malformed aortic valve, it is classified as bicuspid, but he really has about 2 7/8 th leaflets. He currently has a mild aortic insufficiency. Other than that he is perfectly health and normal. I am looking for any information on tissue generated valve growth. Although at this time he requires nothing but observation and antibotics before dental work, I would love to be ahead of the game. I am also a registered echocardiographer (I actually discovered his problem by error!)Any info would be greatly appreciated.

Jenny

deborah cooper said at November 24, 2004 11:33 PM:

I am also a patient with chd, copd, emphezima, and astha. I'm currently waiting for a defibulator to be approved by my insurance company. My ejection fraction is about 25% and they suspect I have chf. I tire easy and have muscle aches all the time. I would like to be up to date on stem cell research and would be willing to be used in any studies as I believe my disease is worstening.
debbie

Michael Morrison said at November 25, 2004 5:54 PM:

I have sclerodrma and it has affected my lungs. I would like to know if there are any stem cell research going on to help me.704-392-8162

Jim Buffington said at December 20, 2004 5:12 PM:

I am 64 years old and have emphysema. My lung function is getting very low. I am interested in stem cell research for the lungs. Please send me any news that you can.
Thanks,
Jim

Patricia Chronister said at December 26, 2004 10:44 PM:

I am 75 and have bronchiectasis. Use oxygen 24/7 for two years now. Do pulmonary exercise class twice a week and able to walk treadmill for 45 min. at 1.7mph with 2 liter oxygen flow. Like others on this web site, I'm eagerly awaiting news of stem cell research for which I might qualify in a clinical trial. All current trials that I find exclude patients on supplemental oxygen.

Jan Van Zandt said at December 29, 2004 5:38 PM:

Two years ago at age 58 I was diagnosed with congestive heart failure. I am taking metropolol, lisinopril and lasix.
I am a divorced self-employed artist and am without insurance coverage. My insurance cancelled after the first round of tests and now I can't afford insurance because of my pre-existing condition. I am losing the quality of my life because of the physical restrictions of this disease. I am looking for a stem cell clinical study or an angioplasty study. If you know of a study or a doctor who can help me, please let me know.

Larry Johns said at December 30, 2004 6:24 PM:

I was diagnosed with CFH, Dec. 12, 2003 I am an adult male ( birthdate-01-31-1950 ). I am told that I have an ejection rate of 20 percent. My arteries are not blocked and my colesterol is in the low 160 range. I have always led a physical lifestyle until now. I have never had any illeness until this. I would like information on becomig a test case or any kind of experimental study subject. I have applied for SSD but have not been accepted yet. I do not have insurance and am not wealthy, but am more than willing to be a test subject if it will help others. Please get in touch with me on this matter. Thank You, Larry Johns ( lajohns1@netzero.net ) P.O.Box 26 Chapman Ne. 68827 Phone# 308-986-2872

Ray Holcomb said at January 3, 2005 6:50 PM:

I am a 59 year old male diagnosed w/COPD in February of 2003. Currently I am on 3.5 liters of oxygen while active and 1 liter at night through my CPAP machine. I have been to Mayo (where I was diagnosed) and gone though all the test for a possible lung reduction. After completion of the tests I was told that my left lung is attached to my chest wall due to the triple bypass procedure done in 2000, and that the right lung is involved in all three sections, therefore this procedure is not available to me.

Then they put me through all the testing for a possible lung transplant. After these test were done they informed me that my lungs were not bad enough for a transplant and that by the time they were I would be too old for one. This along with the fact that they found some osteoporosis makes me ineligible for a lung transplant.

I tried for a second opinion at the University of Minnesota in Minneapolis and received the same results.

I would be very interested in getting ANY information on stem cell research on lungs.

I too would be willing to be a reseach candidate.

Sandi Sandilla said at February 7, 2005 1:55 PM:

I would be very much interested in clinical trials of stem cell research. Seems that is the only hope most of us have that have the big E. I have had a bilateral lvr in 1999, but not any help. I'm 55 now and feel really good, if only I wasn't sob all the time. Sob doing everything, showering, cooking, dishes, forget vacuming. I don't think I'm getting worse but not any better either. Stem cell research sounds very promising.
I would be very interested in any info on lung stem cell research.

Justin Rubino said at February 16, 2005 10:10 PM:

My Dad is currently suffering from Idiopathic Pulmonary Fibrosis. Due to a poor heart condition he is unable to qualify for a lung transplant. Unfortunately it is in the end stage. We are running out of options. If anyone knows of any stem cell programs or clinical trials please contact me.

Justin Rubino
jnbino@hotmail.com
757-636-6572

Cathy Grant said at February 22, 2005 5:43 PM:

Metis, female, 48 yrs, severe COPD (11% lung function) diag. 2001, prognosis was 18 mon. Inquired at 2 lung transplant facilites Vancouver B.C 2001 and Edmonton, AB 2002, I opt'd out of both. I am involved in a COPD group thru our hosp. I asked my Dr's about stem cell when I was first diag. and they basiscally said I wouldn't live long enough. I am still here 4 yrs later and would like to know of any stemcell clinical trials that I may qualify for. Currently on oxygen 24/7
2 ltrs except for when exercising then i increase to 3 ltrs. Symbicort, Combivent.

Norm Boger said at March 5, 2005 7:01 PM:

I am a 59 year man with Emphysema COPD and Lung Cancer in my right lung At this time my Cancer is in Remission.Would love to no if Stem Cell can work for some one like me.

SHARON K. said at March 14, 2005 6:40 PM:

i also have emphasema, and copd i ask my doctors all the time about any new research but nothing has come up i think people think that i brought this dasease on myself from smoking ,but if i would have known all this 40yrs, ago i wouldnt have lit that first one im not afraid to die but like everyone else i guess i would be a lab rat to just to be able to breathe again even if its just for one day.im 56 yrs. old and have 6 children and lots of grandchildren, whom i love very much.so if any thing is new out there please let me know. thank you

tammy lynn henderson said at April 5, 2005 7:32 PM:

HELLO EVERYONE MY NAME IS TAMMY LYNN HENDERSON I TOO HAVE HEART FAILURE AT AGE 35 . I HAD A MASSIVE HEART ATTACK AT AGE
31 AND A DOUBLE BYPASS. A YEAR LATOR I HAD ANOTHER OPEN HEART OPPERATION FOR MITRAL VALVE REPAIR.WE BELIEVE I AHD THE HEART ATTACK BECAUSE OF PREVIOUS RADIATIONS THERAPY FOR HODGKINS DISEASE AT AGE 20. I ALSO HAD PREVIOUS REDUX USE WHICH
MAY HAVE CONTRIBUTED.I HAVE TWO CHILDREN AND A HUSBAND OF 15 YEARS. I AM DESPERATE TO TRY ADULT STEMCELL TO REPAIR MY HEART. ANYONE THAT KNOW OF A CURRENT TRIAL USING HUMANS PLEASE CONTACT ME. MY OXYGEN LEVEL VO2 IS 12 AND MY ENJECTION
FRACTION IS BETWEEN 18-30.I REALLY WOULD LOVE TO AVOID A HEART TRANSPLANT AT ALL COSTS. I NEED TO STAY ALIVE TO TAKE CARE OF MY FAMILY. IT IS NOT THERE FAULT AND WHY SHOULD THEY SUFFER WITHOUT A MOTHER? thank you tammy henderson

Madeline F. Matz said at April 30, 2005 5:08 AM:

I too, am interested in any clinical trials of stem cell research concerning pulmonary function. I too, have COPD/Bronchitis. I am 69 years old in otherwise excellent health. This diagnosis has knocked me for a loop, and I'm ready to be a guinea pig to stem cell researchers. I live in Washington, DC.

don lyons said at May 15, 2005 4:26 PM:

I am a canadate for stem heart treatment per my doctor is there a facility on the west coast other than scripps doing this research not on a double blind but actually looking for a patient who needs the therapy desperately contact me by e mail asap

Lynne said at May 18, 2005 3:46 AM:

I am 48 years old and have been diagnosed with Bronchiectasis for 8 years now and would like to know if I would qualify for clinical trials into stem cell research for this condition.

Stephanie said at May 20, 2005 9:34 AM:

I am a 25 yr old female diagnosed with Idiopathic Constrictive Bronchiolitis Obliterans. I developed the disease almost 5 years ago and my current pulmonologist thinks I developed it by contracting a virus from an animal at a pet store that I worked at. My lung function is currently at 33% and prednisone has failed to help me in anyway. I've been searching for over 2 years for some kind of stem cell research involving lung dieases. My disease is unfortunately rare and not much research has been done on it so I doubt that there will be any studies on it. But I can't help but hope that some day that there will be research done on my disease. If anyone knows anything about possible pulmonary stem cell research that has no restrictions on what type of disease please let me know. Thanks!

Stephanie said at May 20, 2005 9:34 AM:

I am a 25 yr old female diagnosed with Idiopathic Constrictive Bronchiolitis Obliterans. I developed the disease almost 5 years ago and my current pulmonologist thinks I developed it by contracting a virus from an animal at a pet store that I worked at. My lung function is currently at 33% and prednisone has failed to help me in anyway. I've been searching for over 2 years for some kind of stem cell research involving lung dieases. My disease is unfortunately rare and not much research has been done on it so I doubt that there will be any studies on it. But I can't help but hope that some day that there will be research done on my disease. If anyone knows anything about possible pulmonary stem cell research that has no restrictions on what type of disease please let me know. Thanks!

Lynn Evans said at May 24, 2005 4:41 PM:

Hello good people,

Thank you all for posting, and may God bless each of you.

My Mom is 62 years old and has emphyzema/COPD. I have been giving her an herbal treatment developed by Wei Lab. It's supposed to improve damaged lung tissue. We've been doing the dosage for a couple of weeks. Along with all the medicine and the 24/7 O2, I pray her condition improves.

I would also like to know about any developments in stem cell research. It seems like such a promising medical breakthrough in so many areas. I don't understand why it is a political issue for politicians to argue about.

Best to all of you.

Samantha Storey said at May 29, 2005 3:30 PM:

Hello, my sister is currently waiting for a heart and lung transplant as she suffers with restrictive cardiomyapothy and pulmonary hypertension. She has been waiting on the transplant list for 15 months now, she has just turned 16 years old and hasn't even really started her life yet. She currently takes a whole host of tablets daily and has a hickman line in place which delivers epoprostonol to help with her lung pressures 24 hours a day. She is very postitive that she will get her transplant and has a long list of things she would like to do, which at the moment are not possible. Even if she receives a tranplant, this would not last for the rest of her life and me and my family hope that the research being done on stem cells will benefit her in the future. There are so many people who could benefit from the things that are being discovered, both young and old. Hopefully the research will enable people who have life threatening conditions to have the opportunity to live a longer, better quality life.

Best wishes to you all.

melissa said at June 16, 2005 12:28 PM:

hello my mon has very bad copd and has been in the hospital for the past 5 months , if anyone knows anything about any type of stem cell research for the lungs please contact me. we are willing to try just about anything to get her better

Raven said at June 19, 2005 11:03 PM:

I was diagnosed with COPD about 3 years ago. I got it from secondhand smoke from the chain smokers who use to live below my apartment. I have done A LOT of research on COPD and stem cell research. Most researchers are working on heart disease, diabetes and spinal cord injuries. I have found only TWO researchers who are doing major research on lung regeneration and/or stem cells of the lungs. One in the U.S., on the contaminated (w/rat feeder cells) embryotic stem cell lines that George Bush said could get federal funding and one in the U.K. who has had a lung transplant herself. The one in the U.S. is Dr. Stephen Rennard, M.D., Larson Professor of Pulmonary Medicine at the University of Nebraska Medical Center (who, by the way, was turned down for National Institutes of Health funding -- your tax dollars and mine). He is doing work on emphysema using the stem cells approved by Bush and getting private funding (and some problems from one of the regents at the college). The website is http://www.unmc.edu/stemcell/index.htm. I believe that his research is just getting started (on ***rats*** NOT humans) after a 2-3 year delay. As you can see, all of the obstacles that he is going through are causing MASSIVE DELAYS for people like us. WRITE THE CONGRESS AND THE MEDIA constantly if you want this to change. The other researcher, in the U.K., is Dr. Julia Polak from the Imperial College Tissue Engineering and Regenerative Medicine Centre (http://www1.imperial.ac.uk/medicine/about/divisions/is/tissue/). She had a lung transplant in 1995, so she has a vested interest! I'm sure that someone in South Korea is working on our health issues, since they get SOLID support (financial and otherwise) from their government. The lack of support and the controversy associated with embryotic stem (ES) cell research has stalled ***ALL*** stem cell research in the United States. People have been purposely confused about STEM CELL RESEARCH as a whole. That confusion and controversy is drying up private funding and the research can't get public funding unless limited, contaminated stem cell lines are used. That is why the research is limited to heart disease (#1 killer), diabetes (strong lobby group) and spinal cord injuries (#1? disability). If you want a cure or any improvement of your condition, don't bother to look to the United States for at least 20-30 years. There maybe other researchers, but I have not found much and I work for a medical university.

Michelle said at July 14, 2005 5:07 PM:

Hi! I'm a 32 yr. old homeschooling navywife and mom. I have 3 kids, 17, 12, and 5. My husband of 13 years is in the navy! I pray that everyone who has posted will somehow be comforted by God's Love. I too have lung disease. I have rheumatoid lung and arthritis. The arthritis part isn't worth mentioning because I really haven't had any serious joint pain, or joint damage in 4 years. The problem is the lungs. I am one of the 25% of people with rheumatoid arthritis with this disease presenting in the the internal organs, in my case, it chose my lungs. I am currently, as of about June of this year on Oxygen (2 lpms at rest, and 5 to 6 with exercise) 24/7. My lung capacity is about 40 to 45 percent. The disease doesn't seem to be progressing in my lungs or joints anymore. I seem to be in remission, but there is extensive lung damage causing restriction, brochiechstasis, asthma, and mild to moderate pulmonary hypertension. I have just begun pulmonary rehab and hope to regain some ability to do some of the activities I enjoy! I too hope to see more strides in ADULT Stemcell research. I am very encouraged at what I am reading and seeing in this research! Even if I'm not around to see it, I pray that others will benefit. I want to be able at minimum to finish raising my children and be able to see my 25th anniversary with my beautiful husband ( which is about 12 years from now!) My prognosis is up in the air. My doctors say that I can hang around anywhere from 10 to 20 years from now provided I take care of myself. But I am a firm believer in My Lord Jesus Christ. God is the only one who has our days numbered before we are born. I am at peace with going to be with the Lord at any age. God, not the disease is in control. I know I can trust my husband to raise our children well without me with our Lord's help. My kids will survive and grow from losing me because I trust that they will have so much to gain from God whether I am here or not. My prayers are with all of you and for the success of Adult Stemcell research! If anyone is interested in contacting me for some moral support with lung disease, my e-mail address is chelle@ourgrantfamily.net. God Bless!

Raven said at August 1, 2005 5:39 PM:

For those who do not wish to avail themselves of treatments or cures that use embryotic stem (ES) cells, please feel free *NOT* to but I will avail myself of a treatment or cure that will restore my life. Please don't stand in MY way causing me UNNECESSARY SUFFERING for YOUR beliefs. If a treatment or a cure is discovered using ES cell research BEFORE a treatment or a cure is discovered using adult stem cell research, please feel free NOT to take the treatment or cure! I'm not punishing you for your beliefs, please don't punish me for mine.

John said at August 5, 2005 9:10 PM:

I am 60 years old and have copd and chf. I have not been given a timetable by my cardiologist but am being treated for chf. It seems to me to be a complete shame that Doctors and Universities across this country have conducted successful stem cell research on chf patients with injections of adult stem cells but feel no need or desire to help the chf people in most desperate need. Bush, as most everyone is aware is a long way from being Born Again, and in many peoples opinion is a butcher. Hopefully I am a God fearing or favoring Christian and what I see on the internet for CHF for the most part makes me sick. I can not understand how this country can spend billions of dollars on medical care for illegal immigrants{ Wal Mart and Tyson Foods workers} but can not fund stem cell intervention for chf and copd patients. I would like to start an NPO to do research on CHF since so few people understand it or it's entire causation and do programs to match and recruit heart and lung donors as well as to develop a program such as "Make a Wish for CHF patients before they are to far advanced to enjoy it.

Raven said at September 20, 2005 7:46 PM:

For those who would like to keep up-to-date on the latest research, I have found a site that lists reports from various news agencies regarding stem cell research. The site is http://www.stemcellresearchfoundation.org/. It is updated weekly. This web site is a good place to visit regularly. It instills hope! They just recently reported about an advance made at the Imperial College London. This is the organization run by Dr. Julia Polak, who I mentioned in my first post. She works with a variety of stem cells (embryotic, umbilical cord blood stem cells & adult) but the advance was made with embryotic stem (ES) cells. After further tests, the researchers plan to use their findings to treat problems such as acute respiratory distress syndrome (ARDS), but I don't know how far down the road that will be. Once again, it shows what can be accomplished with support from the government. I will be putting aside money, so that I can get my treatment or cure when it comes, hopefully in time to save my life. It's too bad that the treatments/cures will be found OUTSIDE of the United States of America. It's also too bad that others will no longer be looking for treatments and cures in what was once the medical mecca of the world.

Jim Risdal said at September 23, 2005 1:09 PM:

I am 59 years old and have COPD. What are the qualifications for a lung transplant? At 59, am I too old? I have about 30% function of my lungs. What determines you as a candidate? What are the problems and what is the life expectancy of a transplant recipiant? Do you regain most or all of your capacity after a transplant?

S. Horton said at October 24, 2005 8:45 PM:

I would like to know more informaton about heart valve research. I know the Texas Heart Institute is working on this, how would I get information on recent studies. I currently reside in Texas and would like to talk to someone who knows of a doctor currently working with (stem cell) heart valves.


Thank You

S. Horton

S. Horton said at October 24, 2005 8:45 PM:

I would like to know more informaton about heart valve research. I know the Texas Heart Institute is working on this, how would I get information on recent studies. I currently reside in Texas and would like to talk to someone who knows of a doctor currently working with (stem cell) heart valves.


Thank You

S. Horton

sandra said at November 21, 2005 10:51 AM:

my husband has been diagnosed with congestive heart failure . He looks like a walking strong man of normal health. His doctor says.(Dr. Mark Goldfard St.Thomas Hospital) that there is no hope. He had a massive heart attack when he was 42..He is now 63 and has had 2 open heart surgerys and aortic aneuyrism (3aneuyrisms) and a stunt running from one leg vein to th other one due to a blood clot during the aneuyrism surgery. The doctor says 25% OF HEART MUSCLE IS ALL THAT MY HUSBAND HAS TO WORK WITH NOW.The doctor has an opinion of smokers also.....He has basically told us that there is no hope for my husband due to the damage done to his heart from the heart attack years ago and progresive damage done during these years from the 2 bypass surgerys closing up and a vavle that has 2% out of a 4% damage.He says no stunts no more bypasses. no nothing....just wants to treat him with medicines other then trying to cure.He says no hope .My husband has tried to lay the cigarettes down and has come from 3 to 4 packs a day to 3 to 4 cigarettes a day.He has changed his diet (good) and exercises but can not do much because of the lack of heart muscle and is also type 2 diabetic....These doctors just treat something when it gets a name and a medicine is put on the market for that disease. Why cant there be a cure..say..stem cell recovery in the works for our loved ones...Help..I have been married for 40 years ..I love my husband...Its a sorry case when we come this far and due to not knowing so much in the 80's about what affect a heart attack can do in terms of damaging a heart muscle....and taking a heart to 25% function....can destroy our future.....Why can we fly a rocket into space and spend money on such stupid research when we need to be spending it on heart recovery..GOD put us on earth ......please someone out there save my husband ..dont let these uneducated doctors that are not up to date or dont want to be up to date on cures get away with controlling us by simply treating a condition...........If stem cell can help my husband and I can get the word out .....I am all for it..I truly love GOD and I believe HE is my bypass to life for my husband...I trust GOD to get this in the right brain of someone that will help..and I pray in JESUS'S name for every single person on this site and all your family members that GOD"S eyes be upon you and you get HIS help........I'm standing in for my husband asking for many more years for him and our family......anybody out there got news for us??????? nashville tennessee 615 650-3206....I'd post my home phone number ..but I have no home right now..we cant live there because we have to stay near the emergency room of St. Thomas ..as I write ..we have just been sent home after my husband was admitted for flash edemia (fluid buildup)and he released 2 gallons of fluid..... They gave him lasix..he couldnt breathe and was really in pain......Theres got to be someone that GOD put on this earth to help with this current heart damaged world. I'm not saying my husbands doctor isnt a good one..I saying that he has gone as far in his knowledge as a heart doctor as he can because it seems he doesnt know any more or hasnt been presented with day to day discoveries......time is running out for lifes that can keep going.......help.........

LungHelp said at November 26, 2005 2:42 PM:

Anyone knows info on stemcell/bonemarrow research for lungs?

Ronald L. Shankland said at January 10, 2006 2:05 PM:

To Whom Concerned: Jan 10, 2006
I am trying to find a trial medical Clinic doing stem cell research on the human lungs.
Please let me know if one is available out there anyplace in the world. Thank you.
Ronald L. Shankland; email: ronald.l.shankland@prodigy.net; phone number 941-923-0968

Larry McC said at January 20, 2006 6:58 PM:

I too have copd and would like to find out more info on lung regeneration with stem cell treatment. read the above posted inquiries,would like to see replies from readers/researchers to posted questions. what site do i go to?
thanks
larry

charlotte potts said at February 4, 2006 1:15 AM:

my boyfriend has suddenly been suffering with fluid buildup around the lungs and this time two months later they say its around the heart. about 6 months ago he was tragicly shot and it tore up parts of his stomach and his lungs. they have done all types of tests on him but cant seem to find or just not telling us the cause. im new to computers so my email may not go through but i would like to speak to someone who may can give me some advice. im in garrison tx.

marcia m said at March 28, 2006 7:52 PM:

I have COPD too... recently read that the NIH trials of retinoic acid (ATRA) treatment of emphysema has not proved to regrow new lung alveoli.

I found this site looking for anything new that might regenerate lung tissue, have read the posts, where exactly can one go for information regarding trying stem cell transplants?

Are they being done in Europe or Asia to treat lung disease? Thanks for the help, I'm 48 y/o w/young children and I'm not ready to die.

Thanks.

GENE NOON said at April 4, 2006 9:11 AM:

MY MOTHER IS SUFFERING FROM COPD. SHE HAD A LUNG VOLUME REDUCTION APPROX. SEVEN YEARS AGO. THE LUNG VOLUME REDUCTION WAS A SUCCESS AND HAS ADDED YEARS TO MY MOTHERS LIFE. HOWEVER, HER CONDITION NOW SEEMS TO BE WORSENING. SHE CURRENTLY HAS A 30% lung capacity. We are looking for information on stem cell research trial. we are willing to do what ever takes. If anyone knows of a stem cell research trial, please contact me at my web address or at my home [570] 842-8840. Thank you for your time.

Loretta A. Cox said at April 19, 2006 6:44 PM:

I am COPD and have bronc. Asma. I would like to get on your experimental surgery list. I am 70 years old and my lungs are quite bad. I am using 3 liters of oxygen presently. If there is any way you could help me out please do so, it would be deeply appreciated.

william l. richmond said at May 15, 2006 2:47 PM:

I have copd and congestive heart failure. I am 78. I wonder why with all the reserch being done with stem cells on heart and lungs,why arn;t tests being done in every state in the U.S.A

Markia S. said at July 27, 2006 10:10 PM:

I was diagnosed with severe emphysema when I was 32 years old. I am now 47 my lung function is 18%. Recently my Thoracic surgeon informed me that I do not have any lung tissue remaining so LVRS is not an option. After evaluation for lung transplant a few months ago I was told I must gain 15 lbs. in order to qualify for a double lung transplant. I had lost weight due to severe emphysema and my needing more calories to breathe then what I was able to consume. At the suggestion of my transplant doctors I now have a PEG tube and I have gained about 8 lbs. with the help of the PEG tube feedings in addition to eating several small meals everyday. Considering the fact that many patients die while waiting for lung transplant the odds are not good that I am going to survive and receive a lung transplant. Even so, I am keeping my hope and struggling to survive hoping to beat the odds. My children are still young and need me.

It is my hope stem cell treatment will be offered to those of us who are reaching out. I will travel to most any country - any time for stem cell treatment to save my life. Thank you

d.delarosa said at July 31, 2006 3:28 PM:

Hello! My mom has very bad copd and has been on a ventilator since October 2005. At her young age of 91, she has such a will to live. Does anyone know anything about stem cell research for the lungs. We remain optomistic. Please help. Thank you.

suzanne said at August 1, 2006 1:39 PM:

I am 33 yeaars old an would like to know more about stem cell and gene therapy for people with pah. Any one with more info please respond.

s.haider said at August 6, 2006 10:15 AM:

I am looking for stem cell therapy for my child of two years as he was born with chronic renal failure and suffers with cysts on one of his kidneys and the other is dilated.The doctors have said he will need a transplant in the very near future But I really believe that stem cell therapy could help my son if someone is willing to take him on.Please can anyone direct to a centre who would be willing to take him on.I am willing to go anywhere in the world to make my son better, this is a plea from one desperate mother.
S.Haider

Royce Britt said at August 25, 2006 5:55 PM:

I have severe emphysema and I am looking for stem cell repair. Does anyone know of a facility anywhere in the World that is performing lung tissue stem cell repair?

I have heard that a facility in India and one in Thailand are performing adult stem cell heart repair. These facilities send the patient's blood to Israel where the stem cells are developed and put back in the patient's blood. The blood is sent back to India or Thailand and re-injested into the patient. The entire procedure takes about a week. I have read comments from patients that have had great results with this procedure.

My question is: "Does anyone have an e-mail or telephone contact with the facilities in India, Thailand, or Israel where these procedures are being performed?"

If anyone has any information, please contact me by e-mail (roycebritt@yahoo.com) or telephone 703-435-8756.

william l. richmond said at August 28, 2006 8:22 PM:

I think every one who has COPD AND OR CHF and their kinfolk should write their congressman to shw how big a problem this is and how people suffer with it

William L. Richmond said at August 28, 2006 8:29 PM:

I think every one who has C.O.P.D. AND OR C.H.F. and their kinfolk should write their congressman to show how big a problem this is and how people suffer with it

suman hamal said at August 28, 2006 11:48 PM:

hey i am from Nepal and i need u guys who are living in USA .actually my momis heart patitent and doctor has prefer futher treament in USA so i need recombodation letter or mail from USA doctor so plz in need help so plz will u guys help my mom to go further tretment

Diane Murphy said at January 28, 2007 10:20 AM:

My sister is in the ICU of a major cancer research hospital but they are giving her little hope in that they say her lung cancer has traveled to her brain and possibly other parts of her body. She is currently breathing from a tube and hooked up to a ventilator. Most likely she will die. I want to believe that stem cell research may help but I don't know who to contact. Can anyone give me information? My sister is only 51 years old.

Jeanette said at February 6, 2007 6:25 PM:

My 65 year old father has CHF .He went from a 65 year old man looking at the rest of his life to a man hoping for today to turn into tomorrow. He walks two feet and he's out of breath. Also my 55 year old father-in-law has COPD with emphysema he quit smoking last year but he has to be on oxygen 24 hour's. I don't know where to turn. Stem cell repair sounds like our only hope if anyone can give me some advice I would really be greatfully. Thanks for reading.

Sandra Ghent said at February 26, 2007 5:22 PM:

I am interested in stem cell for lungs. I am 56 years old and lung disease which is getting worse. The doctors tell me eventually I will be on oxygen and medications all the time. I would appreciate it very much if some one could lead me in the righ direction for more information on stem cells.

I also have another request regarding the stem cell information. My Grandson is 3 years old and he has hydrocephalis. At 2 weeks old he had bacterial menengitis and about a month after he had a stroke. He is now on 3 medications for seziures, has a shunt and has severe brain damage. I would also appreciate any information for our family on the stem cell research for brain damage

Thank you, Sandra Ghent

Terri said at March 23, 2007 10:13 PM:

What kind of web sit is this? There are only questions, no answers. I have a similar story. My 58 year-old-dad, who got addicted to cigarettes when working for the United States government who handed out free cigarettes to their workers. He then developed COPD. He is an amazing person. I am not ready to lose him. He has been on oxygen full-time for two years. Stem cell therapy seems to be the only hope. If you know of any treatment please contact me ASAP. He is currently in the hospital with pnemonia again. He does get around. He is an incredibly strong man. He has an extreme will to live. It is heart breaking to watch somebody die this way. When he started smoking, we didn't have the information we have today. If you smoke today, you are either incredibly weak, selfish, and/or stupid. If you help in any way to produce cigarettes, you are the same! I do not blame my dad for his disease, I blame the cigarette companies who knew exactly what they were doing and the United States government at the time who allowed it. If you can provide help, please contact me at meyerbt@yahoo.com

Jack Parker said at April 18, 2007 7:19 PM:

I read about a man named Nassim that had stem cells taken from has hip(bone marrow) and then injected in the pulmonary vein. He was on oxygen 24/7 and two months later was only on oxygen when he slept, and getting better every day. Why don't we that have emphysema have this treatment available to us?
I'm willing to be a lab rat for this procedure. I think Nassim's treatment was done in Florida by a Dr. Vena or maybe it was Dr. Vera. If you have any more info for me I can be contaced via email. Thank you.

Carole Sherwood said at April 28, 2007 10:54 PM:

Jack Parker wrote about Nassim having stem cell taken from his hip and injected in the pulmonary vein.I would like more information on this. Please email me. I have copd 61 years old

Gloria Moll said at May 4, 2007 7:37 AM:

I am a 63 year-old female with COPD, emphazima and asthma. Been in the hospital many times in the last couple of years. Last time in ICU on a respirator for a week. I would be willing to be a lab rat. Please send me any information.

Thank you

Carolw S. said at May 10, 2007 4:37 PM:

Where do we find answers to our questions. I have copd please email me would like to know about stem cell in the US. I know they are doing it in the UK
cjsj@goeaston.net

whidden said at June 5, 2007 6:45 AM:

I am a 67 year old man with copd and emphyzema. I am interested in clinical trials in stem cell in or out of US please email me.

Romina MR Manceda said at August 1, 2007 5:03 AM:

Hello,

I am a 28 year-old female living in Madrid. I had Non-Hodgkings Lymphoma in 1999 and got into complete remission. Two years later I had Leukemia (AML) and therefore, later that year I had an allogenic Bone Marrow Transplant. It´s been 5 years and 8 months since the transplant and I am ok, but I´ve developed bronchiolitis obliterans in my lungs and now I may need a lung transplant. I am very interested in finding out if there is any clinical trial or study that I could be part of regarding stem cells and lungs.

I would greatly appreciate if there is any information anyone can give me about doctors or research groups in any country that I could contact and find out more about these studies.

Thank you Very Much.
My e-mail is romina_mr@hotmail.com

Trapal Narula said at August 9, 2007 9:48 AM:

I would like to enquire about stem cell therapy in Thailand to treat pulmonary fibrosis. We are desperate for some kind of alternative therapy such as stem cell treatment that can help her condition.

My Mother-in-law is suffering from SLE for many years which has brought on her condition of Pulmonary fibrosis. Currently, she has been in and out of the ICU for the last 3 months - starting from ARDS (Acute Respiratory Dysfunction Syndrome), she has since recovered and shifted to the ward in Bumrungrad International Hospital in Bangkok, but she has always been on the respirator/ventilator and recently had a relapse which has taken her back to ICU - this time the doctors were concerned that she may never be off the ventilator.

If anyone has any information on where we can get stem cell therapy to reverse the conditions of her lungs, we are desparate for information. I have read the story of Nassim posted by Jack Parker at April 18, 2007 07:19 PM: - does any one have information where he got treatment?

Please help!! Call me at my mobile to give us more information on where we can get such treatment here in Thailand or abroad.

My contact details are as below –

Trapal Narula
Mobile - +66891293395

Any help that you can give us would be greatly appreciated.

Yours Sincerely

Trapal Narula

Shaleen Kacker said at September 2, 2007 10:09 PM:

High dosage of n-acetylcysteine is proven to reduce the inflammation and deficiency of glutathione.It is available online as a health supplement.Yoga especially Pranayam will help.

There are some clinics that have started stem cell treatment of Auto immune disorders(in the US).I will keep you posted.

fc said at October 3, 2007 11:37 AM:

IS there any information re advanced research for pulmonary hypertension. I have a client who opted out of the lung transplant. She is in her mid thirties and is interested in participating in stem research.

TS said at October 29, 2007 7:17 PM:

I am a 41 year old woman with a genetic disease called alpha 1 antitrypsin deficiency.
Basically what it is is 2 defective chromosomes (1 from each parent), and it interferes with the production of "healthy" enzymes that's produced & excreted by the liver. These enzymes are essential for keeping the lungs healthy.
With AATD, the enzymes are deformed and are unable to leave the liver. The build up in the liver ultimately can cause cirhorris. And the lack of AAT (major protector) in the blood leaves the lungs unprotected -- which causes emphysema.
I have emphysema. So far, my liver is functioning normally. But my lungs have taken a beating.
I have a 42 year old brother who is also deficient -- we are pretty much identical in regards to this disease.
I receive weekly infusions of AAT to slow the progression of the disease.
I am ALWAYS looking for alternative treatments. I've always believed that Stem Cell Therapy will be the miracle that will either cure or treat most diseases.
At this point, I don't see a cure for AATD ... not unless you can alter a person's DNA(?)
But a treatment for emphysema would be WONDERFUL.
I'm too young to feel like a 90 year old.

Christine Ball said at December 14, 2007 5:29 PM:

I was looking up stem cells and COPD and came across some neat work by Cellmedicine a stem cell clinic..they treat people with their own stem cells and apparentlyh had some success in heart failure and COPD, they have a site on www.cellmedicine.com and a channel on youtube if you search "cellmedicine" on www.youtube.com

Annette said at February 26, 2008 1:14 AM:

Copd and stem cell, I found this webpage, check it out.http://www.stemcellpioneers.com/showthread.php?t=734

gary rakes said at March 19, 2008 9:06 AM:

dear sirs ,

i am 62 years old and have end stage heart failure. i am going to emory in atlanta to se if i qualify for a vad. is ther some other alternative for me? is stem cell therapy possible for me? is there a clinical test that i may participate in. i need some help. please contact me. sincerely, gary rakes 8779 skitts mtn. rd. clermont, ga. 30527

Tony Sternola said at April 28, 2008 1:08 AM:

From Tony

My brother, a brilliant and giving 73 year old man, has COPD and about 5 years to live. In his instance the reasons against stem cell implantation are rediculous and hypocritical. I'm not interested in locating a "study" in which he'd have a one-in-three chance of actually receiving what might be beneficial treatment. I'm interested in finding him an institution or a physician somewhere in the world who's actually treating COPD sufferers with stem cell implantation - and damn the risks. He's got very little to lose. Please. Please, does anyone know of any actual stem cell treatement for COPD going on anywhere on the planet? Let me know. You could be saving the life of a very fine man.

Tony Sternola said at April 28, 2008 1:11 AM:

Tony says

In the above post I neglected to place my email address, which is alonra@aol.com. My cell phone is 425-210-9534

Mary Gordon said at June 13, 2008 2:23 AM:

I am 58y old with c.o.p.d. Like everyone else, would be grateful for any info on stem cell therapy going on in the UK. Thank you. My email is Mary.e.Gordon@ntlworld.com. If anyone would like a penpal with the same illness, please get in touch. Thank you, Mary.

Suzanne Frew-Harris said at July 23, 2008 2:38 AM:

My name is Suzanne Frew-Harris and I have COPD and asthema. I find the only way to be able to function is to take prednizone in low doses so that I can walk and take care of business. If not, I could barely breath. The meds have piled on the fat onto my body and as time passes, I am getting bigger and because of my poor lungs, I cannot exercise very well without getting out of breath. I suppose I'm looking for a miracle, but I am very much interested in research trials for re-growing your own lung cells. If I had good lungs again I could excercise and lose weight and have a normal and very active life again. That's all I would need to turn it all over again and get back in good health. Please let me know if there is some clinical trial going on that I can participate in to clone my lungs (the good parts) and live life again. Thank you! I can be reached at (707) 961-1055 at home and (707) 964-5691 at work my cell is (707) 972-6907 Please contact me if you have any information.

linda said at December 7, 2008 11:24 PM:

My name is Linda Kirkpatrick and I am dying of emphysema just like many of the writters above me. I too am willing to try stem cell treatment and would like to be part of a clinical trial involving stem cells. Without steriods, I would not be able to make it thru the day. I hate taking them because of all the side effects. Each day seems to be more of a struggle. Please don't give up on the research. There are so many of us needing help. I would like to hear from anyone who has gone thru any trials with stem cells or either the bronchical stints and how you felt afterward. I can be reached at kirkpatrickranch@aol.com
Thank You,
Linda Kirkpatrick

Christine Adams said at December 28, 2008 9:45 AM:

Please email any information on stem cell research for COPD

Christine Adams said at December 28, 2008 9:49 AM:

Please send any information on stem cell research for COPD to adamsccadams@ewol.com

Jeannine in NH said at January 14, 2009 2:04 PM:

Please come and join us at copdliving.com and stemcellpioneers.com

The founders of both sites have COPD and have had stem cell treatment.

Charles T Hosey said at March 2, 2009 1:26 PM:

Hi i too have emphysema i was 51 when diagnosed i been on 02 four year ,and got about 15 per
cent or less lung function and still going down hill send me any info on stem cell
i will a rat if needed don't have anything to louse but may have lot gain

THANK YOU
CHARLES HOSEY

robert w taylor said at June 2, 2009 5:13 PM:

hi my name is robert w taylor and i have been diagnosed with severe pulmonary hypertension.the doctors have informed me that there is no cure.i am now on oxygen 24 hours i am severly short of breath and i have severe chest pain any time i try to do any activity. does anyone know of any clinical trial that i could participate in or any clinic or hospital that would take my case for a reasonable fee. i am 69 years old and am in good health other then the hypertension.

robert w taylor said at June 5, 2009 2:54 PM:

hi my name is robert taylor i have been diagnosed with pulmonary hypertension as you know this is a fatal desease. i am interested in participating in clinical trials for stem cell research it seems that that is the only hope that i have. i have done quite a bit of research on stemcell clinics and i understand that to have any type of surgery it has to be peformed out side of the united states. i read an article about a individual in macon georgia that had this same desease and was treated with adult stemcell therapy,and it proved to be very successful.if anyone has any information about how to contact the clinic that performs this operation i would greatly appreciate it

kanti said at June 15, 2009 10:54 PM:

Hi My name is Kanti, I'm diagnosed with pulmonary fibrosis and as you know there is no cure for this diseases.I do want to partcipat in clinical trial for stem cell research.Can you please help me to participate in this kind of research and who to contact I will really appreciate. I do need help please. Thank You.

Faye said at October 12, 2009 7:09 PM:

Please contact me at aussiesheila2006@yahoo.com or faye@adultstemcellfoundation.org for more information about products we have available that will rejuvenate and grow your own stem cells and enhance your immune system. I am an Honorary member of the Adult Stem Cell Foundation in Australia.My sister is taking the products for 6 months in anticipation of a lung stem cell transplant...she has pulmonary fibrosis in both lungs.

Laurie said at October 13, 2009 7:40 PM:

I am 50 years old and all I know is that no.1- I can't spell or punctuate and no.2- I have sever Pulmonary Arterial Hypertension. The presure in my lungs is 110, my heart is enlarged, I need a lung transplant and I have 2 years to live if I'am lucky. I do have dumb luck so maybe I'll make it to 3. I can't do anything physical and I'am sick all the time from all the medication that they give me. I don't want to live like this but I don't want to die either. I want to be a stem cell rat or even a guinie pig. If there is anybody our there that is as board and frustrated as I am. Or has any info on stem cell research or my condition that could help me. Please e-mail me at lauriemontoyaf@aol.com, Thanks and I wish all of you out there the best of luck

Kenneth A Dietich said at May 17, 2010 9:41 PM:

I AM 62 YEARS OLD AND WOULD LIKE TO BE USED AS A TESTER IN STEM CELL CURES FOR COPD. DO NOT SMOKE HAVEN'T IN YEARS. I DID SMOKE ONCE BUT MOSTLY I THINK IT CAME FROM BEING AROUND ASPESTIS. wOULD LIKE SOME KIND OF HELP WITH THIS THANKS KENNETH

cj said at August 5, 2010 11:58 AM:

I was just seen by a lung transplant doctor at a well know hospital. He told me that stem cell will not help copd.

Randy said at January 5, 2011 8:30 PM:

Someone should ask the billionaires like Bill Gates (Microsoft), Warren Buffet (Berkshire Hathaway)and Mark Zuckerman (Facebook) who say they are going to donate their fortunes to charities to remember stem cell research in their wills--perhaps even make some early contributions---How about them funding an annual Noble Prize-like award targeting stem cell research/cures?

Claudia said at March 28, 2016 8:03 PM:

(MUST READ: HOW I GOT CURED FROM COPD)
My name is Claudia Kosa I thought i should share this here as someone may need this information; I was diagnosed of COPD in February 2015, my doctor told me it has no permanent cure, i was given inhaler to help relax my airway and other medications to ease the situation, this continued till a friend of mine Anna Burke told me about Dr Ejiro from South Africa who cured her father of COPD and Glaucoma. I contacted this herbal doctor via his email and bought the herbal medicine from him, i received it within 6 days and applied it as prescribed and was totally cured within 19 days of usage. my life is back again! Contact this herbal doctor via his email ejiroherbalcure@gmail.com or call/whatsapp +27617403481

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