May 04, 2004
Odontis Trying To Grow Replacement Teeth In Human Gums

Specially prepared stem cells will be implanted under the gum where a tooth is missing.

Instead of false teeth, a small ball of cells capable of growing into a new tooth will be implanted where the missing one used to be.

The procedure needs only a local anaesthetic and the new tooth should be fully formed within a few months of the cells being implanted.

Professor Paul Sharpe, Head of the Department of Craniofacial Development, King’s College London, is leading the effort to grow replacement teeth inside human gums.

He tells the AAAS Annual Meeting in Seattle* that by understanding the genetic control of the key processes that form teeth in the embryo, the development of a tooth could be recreated in the mouth of an adult patient.

Results obtained from mice populations show that tooth rudiments can be formed from in vitro cultures of non-dental stem cell populations and complete teeth and associated bone can be obtained when these rudiments are transferred to adults.

The goal is to take adult stem cells, treat them in cell culture, and then transfer the treated stem cells into the gum where they will grow a replacement tooth just as happens when humans grow their original adult teeth.

Stem cells, the so-called master cells, would be programmed to develop into teeth and then transplanted into the patient's jaw where the gap is.

It is thought it would then take two months for the tooth to fully develop.

A commercial company, Odontis, has been set up to develop this new approach, which has been studied by Prof Sharpe for the past two years. The next step will take the team to the point where they can form a tooth rudiment consisting of both types of basic cells from stem cells. The method could be ready to test on patients by 2007, he said.

The project has attracted funding from a number of sources.

The project is receiving a total investment of £500,000: £100,000 from NESTA, £300,000 University Translation Award from the Wellcome Trust and £100,000 from a business angel. Kinetique Biomedical Seed Fund has already invested £250,000 in the proof of concept phase.

Professor Sharpe, adds: “A key medical advantage of our technology is that a living tooth can preserve the health of the surrounding tissues much better than artificial prosthesis. Teeth are living, and they are able to respond to a person’s bite. They move, and in doing so they maintain the health of the surrounding gums and teeth.”

It is hard to judge the prospects of this effort for a couple of reeasons. First of all, the original mouse work relied on both adult stem cells and cells extracted from embryos. For humans it sounds like Sharpe's team is trying to use adult stem cells for both of the cell types they think they need. Also, since the research has taken a more commercial turn Sharpe is not revealing which adult stem cell type(s) will be used or all the manipulations that his group will do on those cells in culture before implanting them.

If Sharpe's team succeeds this may well become the effort to coax stem cells into growing replacement body parts which will pass into widespread use. I consider that to be an important turning point from a psychological standpoint because it will show the public at large that the growth of aged and lost body parts is going to become routine. This should lead to much greater government and commercial support for development of techniques to grow replacements for still more types of body parts.

Ultimately we will reach a point where it is possible to grow replacements for all body parts aside from the brain. In situ repair of the brain will become the other major obstacle to the achievement of engineered negligible senescence which is a scientific term for what will be, for all intents and purposes, eternal youthfulness.

By Randall Parker at 2004 May 04 02:02 PM  Biotech Organ Replacement | TrackBack

Comments
Stefan Jones said at May 4, 2004 04:36 PM:

But . . . will Americans have to go overseas, or at least north (or south!) of the border to find a clinic legally able to create these implants?

Randall Parker said at May 4, 2004 04:39 PM:

Stefan, I do not expect so. Why would you expect that? I expect to see this company either open clinics in the US or license the technology to a US company.

Stefan Jones said at May 4, 2004 04:59 PM:

"Why would you expect that?"

It involves the use of stem cells.

The article notes:

"Doctors take stem cells from the patient"

But have we perfected fundamentalist-friendly techniques to turn adult cells into stem cells?

Randall Parker said at May 4, 2004 05:00 PM:

Stefan, adult stem cells are already stem cells. They are already used in some forms of treatment successfully. For many applications there is no need to revert adult stem cells to the embryonic state.

Stefan Jones said at May 5, 2004 11:11 AM:

Turn about is fair play:

Dental pulp used to treat Parkinson's Disease:

http://www.sciencedaily.com/releases/2004/05/040505065427.htm

Judyth said at May 10, 2004 08:45 PM:

Stephan, surely you can see through the use of dead baby cells, which could be your dead relatives for mass market use, is ONLY a front for keeping the abortion business in business, as stem cells, which always are undifferentiated cells that can be coaxed to grow like tissue from similar tissues are far more reliable and safer than dead fetus babies' cells.

Mrs Iris Micks said at May 23, 2004 03:38 AM:

I have been very interested to read all the research taking placing attempting to grow replacement teeth in the gum via stem cells.

I should be very interested to know if volunteers for this research are required, and if so would happily supply all information required as necessary to determine my suitability as a volunteer. My telephone contact is 01895 822141.

Hoping to hear further from you.

Iris Micks

george hanmer said at May 23, 2004 12:39 PM:

I am also very interested in your research and would be more than willing to volunteer to be involved with your work in this field. I am a forty year old male with a few teeth missing It would be a dream come true for peple like my self to be able to grow new teeth. I can also be contacted on. 07941 243153

Sue Workman said at May 25, 2004 04:04 AM:

I am also interested in becoming a volunteer for teeth regrowth, I am 40 years old and lost all my teeth 15 years ago. I just had a new set of dentures made and payed alot for something that I aboslutley hate.

Eileen Brown said at June 2, 2004 07:26 AM:

I am also interested in becoming a volunteer for teeth regrowth, I am 56 years old and lost all my teeth 26 years ago. I also just had a new set of dentures made and paid £500 for private treatment. I hate them - they are obviously false. I have been considering dental implants.

Ben Selden said at June 2, 2004 10:27 AM:

How could an individual like myself become financially invested in such a company. I am a dental student and think the potential for this to explode into a fantastic opportunity will come very quickly.

Regards.

Paul gibson said at June 10, 2004 10:52 AM:

Fantastic idea doctor sharpe.My name is Paul Gibson,i am 35 years of age and in good health.Whislt having a an exciting rugby history it has left me with major teeth problems.I have been referred to manchester dental hospital due to the severity of my case.I would like to put my self forward as a volounteer for teeth re-growth if that is at all possible.
Regards P.G.Gibson

jonathan said at June 24, 2004 05:21 AM:

What are the bans on this practice? Why you have not started yet on human being??
When do you expect will be available for everybody????
Please reply because I need your sensational discovery.
Bye
Jonathan

Paola said at July 3, 2004 02:13 PM:

All'eta' di 43 anni porto gia' una protesi totale dell'arcata superiore mentre l'arcata inferiore è composta da soli 6 denti e tutti con carie avanzata.Vorrei sottopormi alla terapia rigenerativa per far ricrescere i denti .Siete a conoscenza se in Italia cercano volontari per sottoporsi a questa nuova scoperta? Grazie

Mrs K Shah said at July 7, 2004 08:48 AM:

I would be very interested to be a volunteer for teeth regrowth project. I am 51 and in very good health, however I have gum disease and during the past three years, my back teeth (molars) had to be extracted one after the other because they were loose. Losing teeth has been devastating for me because I work in an industry where appearance is important.

I hope you put me in your database for the above - and my best wishes for the research team of Professor Paul Sharpe for this research and any other research - Hope you succeed!!

jonathan said at July 13, 2004 07:13 AM:

Hello I have contacted a dentist who said that your new technique is science fiction and that if we lose the teeth due to bone missing they will never regrow. Please CONFIRM IF IT IS TRUE OR NOT THANK YOU

Rocky Cosme said at July 14, 2004 05:10 AM:

When I was a teen I had some molars taking out making the back ones to move forward. This had cause me to have braces put in two years ago. I just recently had my braces out to undergo surgery for implants, I definitely prefer regrow teeth instead. I wish I could make a choice and try this method if it was available soon.

Aaron D. Smith D.M.D said at July 14, 2004 10:00 PM:

A true turn in the absolute right direction for dentistry! Hats off to you. I too, am very interested in this technology and eventual paradigm shift in dental thinking. There's no dentistry like NO dentistry . . . I would love to practice dentistry where I never have to pick up a drill again in my life . . . . godspeed!
aaroN

Jay Fox said at July 23, 2004 10:55 PM:

Well, I have a couple comments. First, there seem to be a lot of people here who think that Professor Sharpe was actually part of the conversation. He was mentioned in the article posted by Randall Parker, but I think some of you misinterpreted that he was the one mediating this discussion. At best, you could follow the links Randall provided to both Odontis, the company, as well as Professor Sharpe.

As for Jonathan's comment:
"Hello I have contacted a dentist who said that your new technique is science fiction and that if we lose the teeth due to bone missing they will never regrow. Please CONFIRM IF IT IS TRUE OR NOT THANK YOU"

It is not science fiction. It has already been done in rats (or was it mice?). If you really do care about this issue, you can do some research here and at other sites that discuss stem cell research, such as the Longevity Meme or BioMed Central. It shouldn't be too hard to find articles on those sites that cite the actual research studies that proved this is possible in rodents. And if it's possible in rodents, then you can't say that it's impossible in humans, even if it might be harder.

Not that I blame your dentist. I thought this was impossible two months ago. When I saw a prediction that we would be able to grow new teeth with stem cells by the end of the decade, I began to think about it more. But when I thought about it, it sounded too far-fetched to be something we could do in less than 20 years. Science just doesn't move that fast! So imagine my surprise when I found out it has already been done in animal studies! (On a side note, I was even more surprised to find out that Parkinson's disease has been cured in mice using stem cell therapies. I don't know what the success rate was, because I haven't seen the study, but it's surprising nonetheless).

A big theme at this website is that technology is not just advancing fast, it's advancing faster than most of us truly appreciate, and it continues to get faster, faster. The rate of progress in science is increasing exponentially. It's mind boggling to think about how fast technology is advancing. If only the politics could be voted out of the way, we'd be moving even faster!

Anita Hinke said at July 24, 2004 02:47 PM:

Anita Hinke
Preysingstr. 46
81667 München
Tel. 0049/89/4483710

Dear Sir,

i´m sure that I´m the millionst person who offer her volunteer for your experiment. I´ve to decide to make a Implantation which i`dont like to do. i would like to try another way. For the case that all other volunteers are dispappeared you can call me and I will come immeadetly. (Sorry for my Englisch)

Yours faithfully
Anita Hinke

Mark Ross said at July 27, 2004 06:49 PM:

I am also interested in becoming a volunteer, I am 37yrs old and am about to loose my teeth due to gingivitis. I am otherwise a healthy male, who would love a cance to start again and do things right this time, one more thing, any chance of growing more hair?

Grady James Padgett said at July 29, 2004 12:33 AM:

Can't wait...well, I really will very patiently await the availability of "home grown" new teeth.

My very best friend, Siskiyou, a malamute dog, was shot and killed when we lived in Hawaii. Contrary to the sweet touristy images of Hawaii, there are some very violent people living in the rural areas there. When I confronted the person who did this he broke my jaw, broke my nose and knocked out most of my teeth...he's a huge guy way over 2X my size.
Yes, I went to the nearest police, but found out most of them were related (77th cousins or some such), and it was my word against his. Then too I was a mainlander, only recently retired-to Hawaii and he is a "local".

So when we (Siskiyou's "wife, Sacajahwea, and her children, and their children, 3 generations of malamutes all total) moved back to the continental USA I dug-up Siskiyou's bones, cleaned them off and carried them with us...leave no one behind.

My jaw's healed, my nose, well it's sort'a healed, but my heart is permanently broken...Siskiyou saved my life once when we were caught-out in a freak snow storm; "Sis" let me hold-on-to his tail as he guided us the +3 miles we had to trek through Mt. Hood National Forest in the Columbia Gorge, Oregon to get back to the truck. Then there was the 5 Japanese tourists he found. They had been lost in the Columbia Gorge for 2 days/nights when he sniffed them out. And there was the mother and her two young children out for a day hike in the Gorge who got lost (lots of trails but the trail marker signs are great "prizes" for folk who collect such things, so most of the trails are unmarked and if you're not familiar with the area easy to get turned-around or lost in), Sis found them as well.

But this is about new teeth, not way-too-soon-removed from life companion animals. Get'n some teeth will allow my face to smile again, though my heart may never.

The Sane One said at August 4, 2004 07:57 PM:

I have some fears relating to complete regrowth of the teeth: The study I read (in Scientific America) said the final size of the new grown tooth was quite small, I am not sure if there was a reason for it or not, it was not told in the SA. I fear that complete regrowth of teeth will not be possible, at least for those with dead and shriveled nerves, in that I don't know of many studies done on succesful regrowth of nervine and sheath. Perhaps though, a person could have a special surgery done when removing a tooth so that the implanted stem cell touched the nerve to facilitate connection of the pulpine nerve.

As I said, it is highly unlikely that regrowth of the nerve can be induced, especially if the cell transplant is several years after death of said nerve. However, it is possible that regrowth of the nerve will occur, in this case a study should be done on programmed nerve stem cells for direct injection into severed spinal nerves -associated with paralysis- for regrowth of the nerve. Perhaps full paralysis can also be cured quickly!

Shahana said at August 6, 2004 08:04 AM:

Hey Guys..

I have personally spoken to Dr Paul Sharpe & Dr Mary Macdougall (Her team first discovered the potentail of tooth regeneration 20 yrs ago, Univesity of Texas, San Antonio).

Dr Sharpe mentioned he has more than 1000 volunteers at present. We could all just pray & cheer these researchers. I suggest we all send some donation to Dr. Sharpe (even $5 or $10 will help).

King's College London,
Strand
London
WC2R 2LS
England, UK
Email: paul.sharpe@kcl.ac.uk

Like all of you here, I too had tragic problem in England, with 2 of my upper-front teeth when I was 17. I had perfect set of teeth, smile & looks otherwise. Because of the pain & agony, I had to quit law school after a year & then quit medical schools after 3 years.

I have been praying for 12 years for some miracle cure. Please do whatever you could to lead these researcher. Today`s miracle is tommorrows cure/remedy.

There are 5 major japanese research institutes are working towards growing tooth via stem cells. Japanese are hoping to ship tooth-germ to USA by 2007. Forsyth institute/Harvard dental school too. But there are a lot of restriction on stem cell research in USA. Harvard is working with some Brazilian resaerch center.

So there are a lot of hope & just believe in the medical mystery. They are able to clone a human genetically. Therefore, growing tooth should be possible. Sharks replace their teeth every 2 weeks. We replace once .. there must be a something happening within our system to regrow tooth 2nd time. That genetic marker(embryonic stem cells) is so important to identify. I believe Dr Sharpe has identified that marker.

As for the size/shape of the teeth also controlled by genetic signalling. Dr Sharpe is working on that project currently. The reason I know this all is because I have been thing about going into do a research/PhD in this area.

Thanks for reading..

regards

Shahana

Margaret Boyd said at August 7, 2004 04:23 PM:

I have 4 teeth left on my upper gum and two missing on bottom, one my front tooth.I cannot wear my top plate as I constantly feel sick.My problems started when I fell off my bicycle and broke my two front upper teeth at the age of 10. Can you help. I am willing to take part in any experiment.

Yours sincerely

Margaret Boyd

Shahana said at August 7, 2004 06:49 PM:

Does anyone wear partial denture for only two upper-front teeth? If so .. could you let me know how does that work? Does it cause problem speaking? Where does it connect?

Thanks

Shahana

Loretta Lyn Grier said at September 2, 2004 06:54 PM:

I came across this info tonight and got all kinds of excited. I was in an auto accident and as a result of the medication and treatment. I lost all but ten of my teeth, six of them being my front top. I have since then struggled with partials my dentist fits and has made for me and they are horrible...they look good but are awfully uncomfortable and do not work. They leave me with all kinds of sores, I have a mouthful of goop all the time in order to keep them anchored, and I cannot speak too well still. Unfortunately, I have not the finances to pay to have my teeth umplanted into the gums surgically, but have wanted to look into the possibility of having it done. My dentist has come to the conclusion I may be one of the very few he needs to send to a specialist and I am dreading that also. I would be exstatic at the opportunity to be a subject for this procedure, and would welcome the opportunity to see if I could get another set of teeth, especially since the reason I do not have any now is not my fault, and I had beautiful teeth before the accident. Is there any way I can contact someone to find out about this further and see if there is a chance of having this done? It certainly cannot be any more of a disaster than the two sets of partials I have already had made. Where can I go to look into this further? I have spent four visits to the dentist in tears at all I have to go through and this would be a real answer to prayer for me. I live in Charlotte, North Carolina, United States.

shahana said at September 4, 2004 07:01 AM:

Hi Loretta,

Hi. I saw your message on the futurepundit site. I am so sorry about your accident. If you don`t mind .. How old are you now?

The tooth-regrow procedure is still at research stage .. the experiement was successful in other animals like rats, still untested in human. It may take 10-15 years before any success in human. If we are lucky maybe in 5 years.. will see some results. Still remains a mystery if it will work in human or not.

But I suggest you see a few reputable dentist before you decide to do anything .. especially "Implant". You could search on "google" or "yahoo" about cosmetic dentist`s in your area.

Also do some research on "tooth implants". It`s a difficult procedure. The procedure requires first to impant "screw" in your jaw (like the ones we hang paintings). Then leave the screws for 6-9 months to adjust/tighten in your jaw. It could be unpleasent. Lifetime for implants are about 10-15 years.

Implants are OK for 1 or 2 tooth .. but a whole set of 10 or 12 will be tough.

Additionally, if the scientist are able to regrow tooth genetically .. you will have to have good jaw-bone in order to hope for any sucessful regrow.

Alternate thing you could do is remove the remaining ten-teeth & wear a full set of denture .. there will be much less pain & your speech will be better.
My mother-in-law lost all her teeth at age 30 & she is now 60 .. she has been wearing full-dentures ever since.

What matters that you are not in pain & could lead a comfortable life. There are a lot of infection could be caused by multiple-implants.
You have to weigh a lot of issues. I am NOT trying to scare you at all. Just thinking about the most effective or least painful method.

Do see at least 3 dentist for opinion before you decide to do anything further.

Best wishes

Shahana

miraluce said at September 12, 2004 04:03 AM:

Hello
the possibiliy to regrow teeth must be found outside the dentists area.
We have not to waste our finances.
It must become a natural process, by changing our ADN.
It must be a global process involving an inner change.

An alchimist told me that in one ancien tibetan medicine book it is named the herb
that has the power to regrow teeth, difficult to find it now, but we can search
I red that some aborygen people have one similar too for the same purpose.

There are people in the Pacific zone with a third dentition.
In nature it is possible.
It is known that some buddist monks had a new set of teeth.


If you want to try a different way too you can read and patecipate to this search:

http://www.merkabaweb.net/forum/topic.asp?TOPIC_ID=61&FORUM_ID=19&CAT_ID=3&Topic_Title=regeneration

The website is www.merkabaweb.net

all the best
miraluce

Ivana Cassarà said at September 27, 2004 10:02 AM:

I'm a young girl of 14 years. I was born in Sicily and I live there. When I was born I had all my milk theet but when I lose them, around the tenth year, no theet was growing. The rays I have done says that no roots are present. I want to know more about your research, please write back. I want to have the possibility to regrowe my theet.

Best wishes IVANA

miraluce said at October 11, 2004 02:18 AM:

Hello Ivana ,
i wrote above the url of the forum where you can find some suggestions...
It is good to collaborate, to exchange what someone has found.
The search is the search, it is not a discovering.
You can't find the stuff ready.
To want is the fist step but you have to search and to act.

I think that in your case some trauma has caused the inibition of the process .
I suggest you to work in bioenergetic therapyo or
in thr perceptible breathing in order to dissolve the trauma.

http://www.transformationetsouffle.com/t-e-s.pdf

http://www.breathexperience.com

To give the body what it is necessary
you can approch the ayurvedic medicine.
The two things together,

No dentist for that.
wishes


Lisa M said at October 12, 2004 10:11 AM:

Please use me as your test patient. I can not afford implants and I want to be able to bite into a sandwich again someday. I can't even smile anymore at my poor children because I am so embarrassed by my poor smile.

I willfully want to participate, and am desperate for a response, please reply to: mullson@yahoo.com

Thank you.

brenda said at October 15, 2004 11:06 AM:

This is wonderful science...a boon to hunmanity! I would love to be added to your list of volunteers if at all possible and /or mecessary to facilitate this procedure. thanks so much for all you are doing.

Rob Hammerton said at October 26, 2004 06:58 AM:

i can only admire the people behind the technology,

whether it be falling off a bike to a car crash, losing teeth has a vast effect on peoples lives. it can ruin a persons self esteem and confidence, obviously this technology will change lives.


i lost three of my top teeth when attacked late at night. it took 4 months of treatment and best part of £1000 to fix.
although they look very good under the circumstances they still arent the 'the real thing'

Vikram Singh said at October 31, 2004 06:40 PM:


The slightest ray of hope gives humans a reason to struggle for survival. So be positive look after your remaning teeth and gums, don't go into drastic measures of implants as it may permanently reduce your options of using any future medical breakthrough. 'Ayurveda' is beyond doubt the oldest and most researched and successful therepy of its times. It was developed in ancient India and has scriptures on detailed medical procedures (even surgery which was pioneered by Sushuruta ages before it was even thought of by the modern world). But don't be fooled by quaks. If you can get hold of some genuine dental ayurvedic medicine it will help in maintianing what ever you are left with in your mouth. As for getting new teeth by this technique, It won't be possible as the poineers of this medicine have long been dead, the scriptirures are in Sanskrit the vedic books of the Hindu's and there is not that initiative or resources going into research in this field. Moreover earth and plants have evolved over a period of years and many herbal species have become extinct. So good luck to the researchers and till then good dental health try to salvage whatver your have with healthy eating practises.

shahana said at November 8, 2004 08:26 AM:

Please read links below. Other research & development is underway to regrow tooth .. by "calcium phosphate" which is what found mostly in teeth & bone.

http://www.futurepundit.com/archives/001356.html
http://www.ada.org/ada/prod/adaf/paffenbarger/prog_bioactive.asp

penny said at November 9, 2004 01:01 AM:

Hello there! Gee, I see I am not the "only one" doing research on this subject for personal reasons too! I too would like to "volunteer" but think this web-site is not for signing up?? If it is please let m know! I too have many bad teeth, it is like a bad dream one wants to wake from. I hope all of us here are among the first to be healed! please keep me on any list this site may be associated with along with the rest of the good people here. Thank you! :) penowheel@hotmail.com

Take care, & God-speed too!! :)
Peace.

lina said at November 12, 2004 01:03 AM:

Hello Shahana ,
I have crowns on my front two teeth and constantly worry that they may break any day . It has ruined my life . If they break , i don't want to get dental implants as that may spoil my chance of being able to regrow teeth . I will need to look in to partial denture .I read in the posts above that you are in England and doing lot of research on teeth regeneration,do keep us informed . Do you see hope that with in 5 years we may be able to regrow teeth ? Thanx.

shahana said at November 13, 2004 07:48 AM:

Hi Lina ..

According to Dr Paul Sharpe (www.odontis.co.uk) .. with 2-5 years the procedure could be available. One could be hopeful & optimistic. But never absolutely 100% sure. Having said that Surgeon`s has been increasing the bone-density for quite some time. Tooth are also "bones" .. tooth regeneration has been successful in mouse & pigs, these are the two animals biologically similar to human body. When baby tooth falls out from a kids mouth, stem cells has been isolated from that .. those cells was used to grow teeth in the lab. Result was successful. So the function of the mechanics are there. Only thing to figuare out now are the genetical signals to control the size & shape of the teeth.
--------------------------

Your crowns could be fixed with a very good cosmetic dentist. The roots of the front teeth are quite long. The dentist could increase the length of your front teeth but pinching off a little gum. And then redo your crown`s.

Partial dentures are should be second option as you have to take them off at nights; which means the other teeth could shift & move .. & cause problems down the road.

I don`t know the extent of your damage. So I can`t predict what you should do. Consult a few dentist. Don`t just go with your high-street dentist.

Dentists are like "hairdressers" .. some are good & others stinks. Crowns & veneers are part of cosmetic dentistry.
So general dentists usually are not good enough to do those work.

Try to see a reputable cosmetic dentist. For example;
www.londonsmile.co.uk (in UK)
www.advanceddental.com (in USA, my dentist)..

I currently live in CT, USA, since past 3 years. But originally from England. A really bad dentist messed up my front two teeth, so I have veneers on them now. I am sooo angry ..aawwhhh...

By the way, my research for tooth regeneration is out of interest, NOT professional at this stage. I just have medical science background.

Type the keywords; "tooth regeneration" or "regrow tooth baby stem cells" on google.com .. you will find a lot of info.

lina said at November 13, 2004 09:20 PM:

Shahana , thankyou very much for the information . By the way I live in india .Thanks again.

abhiraj said at November 28, 2004 03:17 AM:

HI Friends

Here every one has a story to tell about their dental problems. After reading all the
Comments I decided to post one of mine. But first of all I wish Mr.Dr.PAUL SHARPE all the best.

Right from my childhood I had a missing left incisor tooth, which resulted in having gaps in between my teeth. At the age of 15 I had cavities to 7 of my molar teeth and unfortunately I consulted a Young greedy Dentist with out proper knowledge who went on drilling the other 5 of my healthy teeth as a result I have 12 fillings. Now I am aged 23 and once again had refilling which made my mouth a mess. Fortunately I did not loose any of my teeth but definitely I am missing that great smile and hard food. In fact the missing tooth has ruined my life. I don't even laugh when some one cracks a joke. I just can't express in words what's going in my mind. I even thought of ending my self and which is not a solution. I wish let us be optimistic so that some day people like all of us will have a great smile. And I would like to clarify that the ancient medicine like Ayurveda does not have a solution to re grow human teeth. I am not saying these simply with out any proof, in Mahabharatha Karna who had golden crown that he will donate it to a poor Brahmin which it self tells the story. Ayurveda was much popular at that time and not had a solution. So lets hope the modern medicine and technology will provide a solution to have great smiles. Finally I would like to say to all those great minds behind technology that we Humans need Technology that will bring light in the lives of millions who are suffering from various diseases. What's the use of having luxurious technology? Just think....

Steven said at November 30, 2004 07:40 AM:

4 years ago I was convinced (By a radical lunitic doctor) that my colitis was being caused by parasites in my teeth.

I KNOW THIS IS INSANE BUT I WAS DESPERATE AND FELL FOR IT.

I removed 50% of my healthy teeth in hopes that it would cure my colitis. IT DIDN'T DUH!

Needless to say as a 41 year old man I am desperate to have my beautiful teeth back.

Please ad me to your list.

Thank You.

Steven said at November 30, 2004 07:44 AM:

The first DENTIST that is smart enough to offer this service to customers will make a FORTUNE.

I would pay $10,000 thousand for my teeth back.

No problem.

:-)

Lana said at December 1, 2004 02:40 PM:

Now that California has decided to begin stem cell research, will you be doing studies in CA?

I would like to volunteer for any studies. I have one front tooth that was broken in childhood and replaced with crowns, the root is still alive. I also have one side tooth where the root is dead (the doctor did the dry ice test and it just gets cold), but the tooth is held in place by the surrounding teeth and otherwise looks normal. Would both these teeth get to be regrown?

Thank you so much,
Lana

Constance Gravestock said at December 18, 2004 09:09 PM:

I would be thrilled to be a "guinea pig" for re-growing teeth!

Connie G>

dan said at January 7, 2005 04:12 PM:

I would like to participate in any trials of this procedure as I have lost teeth

Damien said at January 23, 2005 08:33 AM:

Hi, I am a 30 yr old (20 yr) diabetic. I will be losing my teeth in the next few years due to gum disease and due to smoking (in my early years). I live near london and would love to participate in any studies to help move this process further. Best of luck with the project.

shahana said at January 26, 2005 05:28 PM:

Hey Abhiraj..

Please send me an email to: shahanakamal@aol.com
Nothing is worth killing yourself or taking your life.

I understand your pain .. I was only 17 & highly highly ambitious bright at that time my dentist gave me wrong treatment. I too felt like vanishing for the planet .. i had many dreams but remains unsatisfied.

Where are you?

Look forward to hearing from you

much love

Shahana

Aman said at February 9, 2005 01:31 AM:

Hi,
To dear Paul sharpe and the company Odontis,and to all , I would love to be part of this treatment growing tooth through stem cells as I lost my front 4 teeth and now it is fixed by bridge and cap treatement, plz somebody tell me when will this treatment be available in the clinic, Best of luck to all researchers of this project and I hope for early succsess!

Rochelle Hayes said at February 11, 2005 12:32 PM:

Please let me know when you need someone to participate in this project as I lost my upper teeth and would give the world to have them back.

Luis Naranjo said at March 25, 2005 12:30 PM:

I think we are a lot of people waiting for something like this. There´s nothing like a new tooth. I´m scared everytime i have to go for dinner with friends. I would die if my tooth falling while i´m having dinner o simply talking with friends. Please, we need this new technique asap.

Sebastian Reed said at March 29, 2005 09:28 PM:

Hi.

I've been working on tooth regeneration for about 2 years. My body and soul both seem to be benefitting by my working on this project. I'm confident that with a reasonable budget I could grow new teeth in suitable subjects.

The reality is that I have hardly any money, although I'm finally documenting my method, which is happening at www.worldofteeth.com, and in the future I expect to sell my method and my services.

The ORAL HEALTH section of my website details the method I've devised, which is a 5 factor approach to oral health: hygiene, eating, thinking, exercise, and treatment.

There is also a strong emphasis on the philosophy, grounding material for anyone heading towards the high flying technology of stem cells. Reading about the life of a tooth helps to put treatment approaches in their place.

I have specific meditations and theory lessons for tooth regeneration, however, I understand that these meditations may cause problems at other sites in the body (e.g., bone spurs and calcifications) if the user is not healthy.

My meditations are more holistic than tooth germ implantation, yet they are not as powerful either, as I've not yet reached the need to write tooth development meditations.

I expect the gums to harden prior to any tooth sprouting, and if this occurs in my body then I will begin writing tooth development assistance meditations in preparation for teething.

Tooth germs can probably be created in meditation by a skillful application of the meditation processes supported by nutritional support, topical treatment, and so on.

However, my approach is a multifactorial approach combining the various facets of health with specific dietary ad exercise techniques to support cell regeneration and meditation to direct tissue growth.

As such, I encourage anyone wishing to grow new teeth to optimise their general health as a precursor step to growing new teeth as this will improve their chances of a successful outcome.

Since following my method, I've had no need of a dentist, and existing cavities in my teeth are slowly refilling themselves as a result of the practices I follow.

To be honest, this process has taken me very deep inside my life, learning about how I act to cause tooth decay and how to act to cause tooth repair.

Yes, the level of action, not medicine or thought, has been the most powerful for me, especially concepts of self and identity.

Purification of the mind and heart are highly valuable in seeking the complex molecules necessary for tooth regeneration: these organs are powerful organisers.

I wish my material was more organised and edited, but it is what it is. Best wishes to all toothfarmers, personal and professional, including Prof Paul Sharpe, whom I have written to once or twice but am still praying to hear back from.

Sebastian Reed

Sydney Australia

jaima said at May 10, 2005 11:39 PM:

@ shahana,
Why dont you keep your opinions to yourself, instead of touting for punters to go to your website.
A breakthrough has been made and you want to jump onto the pioneers bandwagon, you are no more than a leach shahana !!!!!!!!!.

Sarah said at May 18, 2005 05:54 PM:

@ Jaima,

You sound arrogant, illiterate and annoying.

Shahana, on the other hand is in this message board helping people.
If you read carefully she has"no personal website".

You are nothing but a stupid, immature individual JAIMA!!!!!!!!!!!!!

Tim said at May 22, 2005 04:24 AM:

Im a 28 year old male who lost all of his teeth 4 years ago this affected me seriously i jumped from job to job because i couldnt stand the piss taking all of the time i eventually had a nervous breakdown this made me ill for 18 months then once i was better i returned to work and i realised that i have to do something soo i have spent the last year trying to get help from dentists, i went back to the dentist who took out my teeth and he told me that i cannot wear dentures because of my jaw and that there was no hope so i contacted universaty all over the world trying to get help all of them replying sorry we cannot help you at this stage. I then contacted sheffield hallam dental hospital who said we will give you an appointment to come and see us and eventually they didnt so off i went to sheffield thinking this was it finally getting the help i need but this wasnt the case i found out the dentist who took my teeth out didnt really need to do it and if he had contacted the dental hospital before he had done it they would have been able to help but now they will struggle.

so im back to my life with no teeth and no real future, if there is any chance that the regrowth of teeth happens please consider me

Shahana said at May 22, 2005 04:43 AM:

Dear Tim,

Your four teeth could be replaced by something called "implants". If your jaw doesn`t have enough bone to support, they could surgically increase "artificial bones".

Contact "Cosmetic dentists". Please do a search on yahoo.com or google.com.
Your best bet is to go to London & there are a lot of cosmetic dentists there.
Here is a link for you.

www.londonsmile.co.uk

http://www.londonsmile.co.uk/html/Services_cosmetic_toothreplacement.htm

Please disregard my previous email regarding implant being a difficult procedure ..
In the USA, they have come a long way, and, implants are not so tough anymore.

Good-luck honey..

Shahana

tim said at May 30, 2005 01:43 PM:

sorry you miss understood the dentist removed every tooth i had leaving me with none thats why im looking for some sort of help

shahana said at May 31, 2005 11:39 AM:

Tim,

There is a TV program in USA called extreme-makeover .. they transform unattractive people to extremely attractive. That includes your "dental surgeries" too.

One of the most famous Dentist`s info is here. Please contact, write emails & explain your situation. They might be able to help .. they might fly you to USA & give you free treament.

William M. Dorfman, D.D.S.
2080 Century Park East, Suite 1601
Los Angeles, CA 90067
(310) 277-5678
E-mail: williamdorfmandds@yahoo.com
www.loosveltdds.com

Also look at the list in the website below;
http://abc.go.com/primetime/extrememakeover/extremeteam/89924.html

Try to contact all the D.D.S (Dr of Dental Surgeon`s)..

Best wishes

Jim said at June 7, 2005 07:02 PM:

I'm 39 now and I first got gingivitis about 10 years ago. No teeth lost but I'm concerned about the future as I age. Does anybody know of any online support groups for people with teeth problems? Also, has anyone seen the site about using Cell Therapy for Gum Disease? Thanks!

http://www.medicinenet.com/script/main/art.asp?articlekey=47021

Andrew Price said at June 10, 2005 06:21 PM:

Hey Randall!

Love your blog. You first covered this story over a year ago -- how about doing a follow-up?

Cheers,

Andy

Thom Fleming said at June 28, 2005 01:26 AM:

Shahana,
I have read all the posts and I thank you for offering support to individuals like myself that have lost or damaged teeth. My story is similiar at 38 I went to a extreme makeover dentist in Beverly Hills for a cleaning and routine examine. I walked out 3 appointments later with 10 upper and 10 lower veneers and 2 root canals on perfectly healthy teeth. This was a negligent, malicious and greedy on the dentist's part. I had no idea what was going on in my head the day I agreed...I trusted this guy and he ruined me. I am currently undergoing restorative procedures to regain my natural smile and to get rid of these CHICKLETS! I have been to 5 experts and they are all appalled at what this guy did to me. Do you know if it possible to regrow tooth structure that was shaved away? i have read a few articles but i can not seem to find enough information. Also, do you know if a tooth will be able to be regrown if a root canal has been performed?

God bless everyone sufferring and I hope all your dreams and wishes come true!

Thom
thomfcat@yahoo.com

Shahana said at June 28, 2005 11:52 AM:

Hi Thom...

I am so sorry to hear what has happend to you. You are not alone. Same thing has happend to my front 2-upper teeth. My dentist in England was a very bad, sadistic man.

"Do you know if it possible to regrow tooth structure that was shaved away? i have read a few articles but i can not seem to find enough information. Also, do you know if a tooth will be able to be regrown if a root canal has been performed?"

-- From my readings online I understand that they could regrow teeth even if there are no-teeth left!! However, scientists are still at research stage & nothing is out in the market to regrow teeth!! I just hope it happens within our life-time ..


In America most dentist`s are extremely greedy, commercial. They have learnt a trade & the highest amount of money they could make is by doing "cosmetic dentistry"(veneers,crowns, implants, root-canal etc). So dentist`s here are making suggestions for pretty-much everyone to go through those procedures!! "They don`t want to do what you want them to do .. they want do what they want to do!"

BUT WHY?

Answer: MONEY MONEY MONEY...

Now "Cosmetic Dentistry" means cosmetic or similar to plastic surgery! FOr veneers or crowns preparation - they use this high-speed razor-blades to "CUT" your teeth (what dentists say filing down). First thing they do is cut or narrow each teeth on each-side, they often narrows, shortens, trims to make natural tooth more like a "nail or screw" ...

However, it`s absurd to do that to normal teeth unless an accident happend! It`s a dnagerous procedure! Just if the dentist`s hand moves or fingers slips .. your whole tooth could be destroyed!

Teeth are part of our body, the pain in mouth cause`s all sorts of other illness - such as cardiac arrest or heart disease, lung, kidney infection because of the bacteria in the mouth becomes infected. Additionally, those who has lost teeth knows their smile, their ability to speak clearly becomes difficult. If a tooth is not positioned properly it gives headaches, pain in the jaw & neck.

SOOO please whoever has normal teeth ... please do-not listen to your dentist. Only if you have pain for months or years .. then get opinion. Accept the way you are! The way god has made your smile!

God bless all

Shahana

Aman said at June 28, 2005 01:06 PM:

Hi,
Shahana! I noted that you are so kind to everyone in this discusion.Thats so goood.. I had lost my front 4 teeth 2 yrs back and had treatment of bridge and cap.. but now I feel uncomfortable with that and colour diffrence in teeth.. I want to know that will I be able to have natural teeth by stem cells by removing these fix bridge and cap treatment and one thing more that how these fixed bridged cap teetth can be removed as these are fixed? When will the treatment for growing natural teeth available any hope?..........

Shahana said at June 30, 2005 06:56 AM:

Hi Aman...

1) caps or bridges made of "Porcelain" shouldn`t discolor & should last more minimum 10-15 years.

2) Your bridge & cap shouldn`t discolor and your dentist should have matched your teeth color for bridges/caps.

3) Fixed bridge`s/caps could be removed & redone.

4) Every patient is different - whether stem-cell will work for everyone is a BIG Question??

Finally, Aman I wish I knew the answer. Scientists are still at research stage. Please pray & hope that teeth could be regrown naturally.

regards

Shahana

Elizabeth said at July 1, 2005 09:02 PM:

I am also interested in becoming a volunteer for teeth regrowth, I am 43 years old,a single mom of two teenage children.I lost all my teeth in August 2004. I had a set of dentures made and payed alot for something that I aboslutley hate. I live everyday feeling extremely sad and cry all the time, I feel like a freak. I can not stand the abnormal feeling of not haveing teeth and the feeling of this horrible denture. This would be a dream come true. I look at myself in the mirror and can't help but cry, this took my self-esteem and self-worth with it. I pray to be able to smile again and feel happy, I want teeth that will stay in my head and not in a cup or my pocket. I have been wanting dental implants but can not afford them. I found this website and could not believe it, I was thinking to myself why can't we regrow more teeth, sharks do..I think. Please, I would be grateful to be involved with this project it would ba my dream come true!

Elizabeth said at July 1, 2005 09:10 PM:

I am also interested in becoming a volunteer for teeth regrowth, I am 43 years old,a single mom of two teenage children.I lost all my teeth in August 2004. I had a set of dentures made and payed alot for something that I aboslutley hate. I live everyday feeling extremely sad and cry all the time, I feel like a freak. I can not stand the abnormal feeling of not haveing teeth and the feeling of this horrible denture. This would be a dream come true. I look at myself in the mirror and can't help but cry, this took my self-esteem and self-worth with it. I pray to be able to smile again and feel happy, I want teeth that will stay in my head and not in a cup or my pocket. I have been wanting dental implants but can not afford them. I found this website and could not believe it, I was thinking to myself why can't we regrow more teeth, sharks do..I think. Please, I would be grateful to be involved with this project it would ba my dream come true!

Fred said at July 4, 2005 05:51 PM:

I hope this is available soon, and it is affordable! I hate having fillings, etc. I wonder if it will be available in Canada, and how long Health-Canada (government health agency) would take to approve it if it does come around?

Those in England are lucky that their healthcare covers dental treatment, here we must pay from our pocket, although we can deduct health costs on our income tax return! (Doctors visits, hospital, etc are covered but not dentists)

Julie said at July 5, 2005 05:57 PM:

I heard that it could still be another 10 years before it is available to the public in general. I wonder how much it will cost, and it the research will pan out!

Shuun said at July 5, 2005 09:29 PM:

Shahana, First I would like to thank you for all your hard work in responding to everyone and doing the necessary research. I am interested in this subject because I have chipped a front uper tooth 5 years ago and it has been filled 3 times since. I am afraid there will be nothing left of my tooth after so many fillings because they need to take some of it off every time they refill it. I am wondering if you have heard or read about solutions for chipped tooth? Suppose this research becames sucess for people who are missing teeth. What can be done for those with chipped tooth then?

And I will add that I do believe regrowing teeth will became sucessful some day. It will be a reality some day.

Thanks,

Shuun

shahana said at July 6, 2005 03:34 PM:

Dear Shuun...

Chipped Tooth .. hmm ... best solution is to put "veneers or crown".

Good fillings should stay for 10-15 years. If you had to refill 3 times that means your dentist is not doing the right treatment for you.

I suggest you to get porcelain veneers.

For all my readings I understand .. they will be able to regrow a whole tooth once this procedure becomes available. Which means, there will be a complete 'new tooth' growing to replace your chipped tooth.

I also am praying hard that this procedure becomes a reality. They are able to clone a human, why not a tooth? Right. Also people who has problems with eye-sights are now correcting their vision with 'lasik'(laser treatment) .. God willing teeth could be corrected too.

Best wishes

Shahana

Julie said at July 6, 2005 06:21 PM:

We all pray that it will be available very soon, and that this will be affordable (not just for the rich and famous)
I bet everyone would love to replace teeth that have fillings (bad for the health - although they say it is not!)
This would be great even for people with crowns!

Too bad governments are not investing in this research, as well as a vaccine for cavities! I heard that they have sealants that they can use on teeth now to help (not stop) reduce the chance of cavities. It is a thin plastic layer on the teeth, it would need to be replaced every so often, no harm to the teeth!

I hope the growth does involve growing a fetus at any stage (as that would cause an ethical delima)!!

Dawn said at July 7, 2005 06:27 PM:

Hi. I would be happy and very happy to be a part of any trial that there is to grow teeth. I would travel or do whatever is necessary to have this take place. Has anyone found a dentist or trial on this. I would be the first to volunteer.

Julie said at July 9, 2005 01:57 PM:

Let's see what's going on now as London just had a terrorist attack (where a lot of the research is going on!) I hope this is not a setback!

As for volunteers I heard that they have over 1,000 people ready!

I hope the volunteers they have are a representative sample based on ethnic background, as well as male/female.

I don't know if it will be available on the market within 5 years, as it would take time to train dentists, as well as setup labs to grow the cultures! And yup government regulation and red tape can take years to over come. The cavety vaccine is in its final stage and hopefully should be ready for all. I heard that it would be less than USD$200 but it would be worth it! I'm sure insurance companies would pay for the vaccine as based on the time/value of money they would have to pay out less in the long run due to cavaties. This is a win/win for insurance companies and all of us!!

Aman said at July 12, 2005 11:51 AM:

Thanx Shahana for ur reply... I heard that this treatment wiill be available by 2007. Is it true? I wish this treament would available soon. You are right that scientist can clone whole human then why not teeth! All those researcher on this tooth regrowing should think this also.. Ok guys lets hope and pray for early sucscess and availability of this treatment..

Amina Paterson said at July 12, 2005 03:22 PM:

Aman,

It does not say will be ready by 2007, but they hope to have clinical trials by then.
Do realize that they don't even have the cavaety vaccine out yet. You would want this if you are going to spend money on a new tooth eh?

To add your prayer, ensure that it is affordable, and will the insurance cover it??

Fred said at July 13, 2005 02:42 PM:

I'm not sure if they can really do this. I haven't seen any news releases doing a google search for anything new for 2005. Anyone have any info?

It seems like everyone is keeping very quite, either they are very close, or they are way off! If it is available soon, hopefully it won't be expensive. They can capitalize on economies of scale rather than charging more, thereby everyone wins!

Details anyone?

Thom said at July 13, 2005 11:39 PM:

I haven't seen any press releases regarding this as well. There seem to be several different timelines regarding trials and/or rollout of a product. In a 2004 article, Prof. Sharpe says possibly 2 yrs for clinical trials, a Japanese article talks about shipping a product that is "tooth germ" by 2007. I do not know what that is exactly. Several older articles that are dated Dec of 2000 say 10 -15 yrs, but I believe stem cell research is progressing faster then they anticipated 5 years ago. If anyone has current information, please share it with this site so we can keep each other informed.

Thank you,
Thom

Fred said at July 14, 2005 04:16 PM:

This is the only link I found that seems to be from 2005

http://www.findarticles.com/p/articles/mi_qn4153/is_20050525/ai_n14642374

It seems several groups are researching not just Sharpe, but American, Japaneese, and Luxumberg groups!

Sandra said at July 16, 2005 01:24 PM:

I read some articles saying that it's 5 years away, others say 10, and others say 20 years any clues?
It depends on who is doing the research, etc. and these are from articles in the same year!!!

Thom said at July 16, 2005 03:43 PM:

I have been researching articles by:

Prof. Sharpe(Odontis)
http://www.cnn.com/2004/WORLD/europe/05/03/teeth.replace/
http://www.odontis.co.uk/
http://www.medicaltalk.org/Grow-your-own_to_replace_false_teeth-476054-10-a.html

Pamela Yelick, Ph.D
http://www.freemanlab.org/people/yelick.htm
http://www.abc.net.au/am/stories/s745807.htm
http://www.news.harvard.edu/gazette/2002/11.07/11-teeth.html

Mary MacDougall, Ph.D
http://peddentdx.uthscsa.edu/macdougall.html
http://www.21stcenturydental.com/smith/education/human_teeth.htm

Dr. Tony Smith
http://www.stemnews.com/archives/000475.html

Pamela Gehron Robey, Ph.D and Lawrence Tabak Ph.d
http://www.stemnews.com/archives/000361.html

Dentigenix
http://www.dentigenix.com/Press_Release.html

Forsyth Research Institute(Harvard University and working with University in Brazil)
http://www.news.harvard.edu/gazette/2004/07.22/23-smile.html

Hitachi Medical Corp.(working with 5 Universities in Japan)
http://www.atimes.com/atimes/Japan/EF06Dh02.html
http://www.cleverdot.com/~hwny232/news822.1.html (scroll down to the 5th article)

I think not much is being said, is because these companies are thinking about the commercial value of their technology. So, maybe they are keeping a tight lid on their discoveries to protect their investment. For instance, Hitachi Medical Corp. has 5 universities working on different components of this process to regenerate teeth and they are talking about projected revenue with the launch of their product in 2007. Prof. Paul Sharpe has set-up Odontis and Dentigenix is licensing technology from Forsyth Research Institute to further their project. Currently, $895 million dollars a year are being spent on dental implants. These companies want a piece of that action and that type of competition gets us closer to having our natural teeth back.

Also, US companies and/or universities are partnering with foreign companies/universities, is this because research in foreign countries have less restrictions then the US?

I hope these articles help and if you come across a new article please post it.


Fred said at July 16, 2005 06:13 PM:

Also,

I'm suprised that people are not also taking about a carries vaccine? Prevent them in the first place! I read somewhere that it is in clinical trials any news?

Sandra said at July 17, 2005 04:54 PM:

I hope that it is only a few years away, and that it is affordable! I came across this site as I need to get a crown for a tooth as part of it broke/chipped off on a tooth where i had a filling!

Let pray that it will be ready only a few years away.

From reading some of the articles I read they will be able do this without resorting to creating a human embro, so it won't cause an ethical (and even a reglious) delima. I hope this is true otherwise I will never be able to get rid of that crown! Any info on this part of it??

Fred said at July 20, 2005 02:52 PM:

Thom,

I hope you are right that these companies doing research will result in treatment for all of us soon (replace damaged teeth, teeth that have fillings, teeth with crowns etc).

I just hope it will be available to the general public within the next few years!


I did not find any other discussion boards talking about this when I did a google search. This must be a hot topic!!

Joan Davis said at July 21, 2005 12:29 PM:

Hi

I am very interested in this research and was wondering when it will be widely available as I want to be a guinea pig!

I am 41 and in the later stages or peridonitis and I am expecting to start losing my teeth. I hate the thought of false teeth.

Please reply asap


Thanks

Joan, London

shahana said at July 22, 2005 03:01 PM:

Apparently, there are trials taking place in human .. read the article below..

http://www.chronicle-future.co.uk/subject/person16.htm

Fred said at July 22, 2005 06:37 PM:

Shahana,

I hate to say this but that is a prediction on the future and not a real article. Look at other articles on the site and you will see what I mean. I hope you are able to find news from a more reliable source!

The article talks about injecting some chemical, we know from the on-going research that this will be steam cells not the chemical noted!

Shahana said at July 22, 2005 07:48 PM:

Hi Fred!

A quote from the article;

"In Seed's case, his gum was injected with a protein called BMP-4, which inhibits the gene that makes teeth develop as molars."

My first degree was Biomedical Science & one of my best friend has done her PhD in Gene Therapy/Gene mapping .. So my knowledge is ..

Stem cells research is all about'genes. In another words gene-mapping is stem cells research.
Plus, genes are mostly made of 'protein composition' when you get down to moelcular-structure or chemistry behind it.

Protein(BMP-4) is probably extracted from stem cells, unless of course it is 'lab-created'.

I hope it helps you to understand a little more ...

By the way, all the articles are simply "predictions" so far. However, a lot of research is underway, let`s keep our fingers-crossed!!

God bless everyone..

Shahana

Fred said at July 23, 2005 11:46 AM:

When i did a google search this was the only blog (board) that i found active on this topic!

I hope this research is sucessful, affordable, and available in the next few years! As well as other research related to dental such as study of self filling caveties, a cavety vaccine etc.

sandra said at July 23, 2005 02:13 PM:

It's amazing that they can regrow this without resorting to creating a human embro so I wonder why people are so against it? I was doing a google search on organ donation (when you are gone that is), and many authorative on various ethics say that it is okay if it improves the life of another person (which it would)!

I don't see why some would consider this type of research unethical as it does not involve creating an embro??

Julie said at July 24, 2005 06:30 PM:

Hey this is a 2005 Article!!!!!

June 10, 2005
http://www.sciencedaily.com/upi/index.php?feed=Science&article=UPI-1-20050609-19144700-bc-us-stemcellbank.xml

NIH (United States of America National Institute for Health)
Wants to promote banking of baby teeth and wisdom teeth for future stem cell research

Rhonda said at July 25, 2005 05:59 PM:

This would be so awsome. I as many other would love to be in your test group. As my situation is the same in gerneral as wanting to have there teeth regrown. How ever differs so much from most people as to the reasons they are gone. I am a disabled 48 year old women who for the first time in her life has taken an interest in doing things for myself. this would be one thing I would love to have my beautiful smile back as well as to eat some of the foods I have missed. If you would like the more information please contact me keep up the good work hope to see you all soon. Thank you, Rhonda.

Julie said at July 26, 2005 05:31 PM:

Paul Sharpe is giving a lecture
http://www.oxdent.ac.uk/cgi-bin/enrolments_bs/appstar/D=calendar/V=day/YEAR=2005/MONTH=Sep/DAY=8

Oxford University Sept 8, 2005. Anyone attending these lectures please share exec summaries!

rya said at July 27, 2005 03:17 PM:

unfortunately, the dental industry have bought off the research teams and these will release the results only in 10-20 years from now. we people must raise a protest against dental corporations taking over the research companies and delayng clinical trials in order to maintain their present increasing profits and the enormous numbers of dental practitioners.
MINA.

Thom said at July 27, 2005 05:21 PM:

Rya,

Where did you come by this information? Several companies (Dentigenix, Odontis, Hitachi Medical Corp., etc.)have been set up to benefit from this new procedure and it would mean billions of dollars to the dental industry. I don't beleive all these corporations think this new technology will stop people from buying their products or will this mean the end of any/all dental procedures. But, this will be an additional service available for probably more money then other treatments.

Also, large investments have been made by corporations, universities and private parties, to make this a reality in the very near future. I have researched this technology and I feel it is moving faster then anticipated because these companies are forecasting sales within the next 2-7 years.

I do not doubt what you are saying and there is probably nothing we can do, except support the companies not involved. I will go to another country like Japan, U.K, South Korea, Brazil, China, Sweden or Norway to name a few currently working on this procedure.
Can you please name the companies involved? Thank you.

Mark said at July 27, 2005 08:22 PM:

Is there any news on growing tissue that could be added to teeth(replace missing/worn enamel)?

rya said at July 29, 2005 07:42 AM:

elementary Thom, elementary. no need to go into names . implantology started some more than thirty years ago and only during the last ten years has it become a welcomed option. this happened after the dental industry felt confident enough of the prospective huge profits involved in it for her.
Teeth regrowth has the potential of erasing the dental industry and placing big demands on the dental profession. so it stands to reason that it's going to be science fiction for many, many years unless people do something about it.
RYA

samantha said at July 29, 2005 08:01 AM:

I am interested in volunteering please contact me at 847-980-8644.

Fred said at July 29, 2005 08:08 AM:

Rya,

Technology changes and has exploded in the past few years, actually implants have greatly improved in the past few years due to R&D. Some of the research found in the dental industry is being used in other areas of health. As an example some of the finding of the stem cell research are being used to treat various illnesses ie. ALS, MS etc!

When you talk about dental companies do you mean Crest, Colgate etc. I would think they would love this as it would increase the market for their products ie. toothpaste, toothbrush, mouthwash, floss etc.

rya said at July 29, 2005 11:23 AM:

Fred, I mean those companies based on fabrication of dentures, bridges, crowns, implants and all the materials that go with it( acrilic, titanium, cobalt, ceramics etc...).
Regrowth of teeth is going to replace all this, and the parties involved are going to do all they can and more, so that regrowth of teeth stays science fiction for many, many years, unless people will be on the alert about it and try to prevent deliberate delay in research and clinical trials.
RYA

Thom said at July 29, 2005 03:05 PM:

Rya,

You say its elementary and no need to name names but that doesn't make any sense. How can we be on alert for these deliberate delays if we don't know who you are talking about. Again, who are you referring to? Just give me a name so I can research it.
You said, "Teeth regrowth has the potential of erasing the dental industry and placing big demands on the dental profession".... I think it would be a longtime before this new technology will erase the big companies that make implants materials. Usually, corporations in the technology and research game know they have to keep up with the latest advancements or they will not survive. They tend to invest in companies and/or develop their own technology, so they can profit as well. What about those giant corporations like Crest, Johnson & Johnson, etc. that have alot to gain when the millions of people start taking better care of their NEW natural teeth. You are right about it placing a large demand on the dental professionals...they are going to be so busy they won't have time to count how much money they are making.
There are millions of people around the world that have lost teeth that don't have implants. I know these people will do whatever it takes to have a natural tooth vs. a fake one.

Also, other countries and corporations outside the US are developing this technology and they know whoever develops it first wins! BILLIONS $$$...thats a big incentive and I will go to that country if need be.

Fred, I totally agree with what you are saying about the dental research helping other diseases. I read an article that discussed regeneration of organs and they are supporting regenerative dentistry because if a tooth doesn't take, it's a matter of extraction vs. an organ that requires major surgery and failure could lead to death.

Fred said at July 30, 2005 08:25 AM:

My dental hygenist said that this would be a boom for them (hygenists) as people would want to take extra good care of their new teeth. From she has heard a lot is being spet on research!

Also said sometimes they get people in the dental office who grow a third set of teeth, Wow. I wonder why we don't get more teeth, I wonder how these people are able to get a third set of teeth?

I wonder how much Canada is spending on this research? I know that the United Kingdom, Japan are spending on this any other countries?

Julie said at July 31, 2005 01:48 PM:

As I understand some tests were done on animals (not us humans - at least from what I know) and I was wondering what is the quality of the new tooth? Is it of an equal or greater quality than the new tooth? Just think if tooth regeneration works what impact it would have for general human health - treatments could be found for other illnesses! God willing treatments will be found for these as well.

I know this is not science fiction, but I really wonder if this will be available for us during our life time, as we don't even have a vaccine on the market for dental bateria etc. (Any info on this? I know this is a regrow blog, but this is a related topic).


rya said at August 1, 2005 06:02 AM:

Julie,
I think the quality and looks of the new tooth can be manipulated and as far as I know, tests done on animals (mice, pigs) were successful. As far as us humans are concerned, I am not optimistic about it being available in the near future, not because it's not possible but because it stands in the way of powerful factors.I wish I were wrong about this. Anyway, people living close to the scene of research such as London, San Antonio in Texas, and other places should "keep an eye" on what's going on and report to the world.

Julie said at August 1, 2005 08:29 AM:

Rya,

It's good to see that the research as proven the quality of the teeth can be the same or better!

You say powerful factor such as companies that make dentures etc. Did you know that IBM's main line of business at one time was typewriters? They had to adopt and change in order to remain competitive. Companies like Olivetti etc went under, as they did not keep up with the changes in the market.

I'm sure that the companies you talk about will change otherwise they will not survive!

Could you name some of these companies that are these powerful forces? If it were elementry we would know who they are by now.

Julie said at August 1, 2005 08:35 AM:

Also at one time IBM said the world wide demand for computers would be 5 (five).
Microsoft said at one time 640K is all anyone ought to need!

Both were proven wrong! All companies must adapt and change!

Investors are interested in future earnings of the company. If they produce the same old stuff it shows they are not in growth, and investors will not invest. On the otherhand if they invest in R&D, and put these to action they can increase revenues and thus shareholder wealth. Investors care more about how the firm will do in the future rather than how it has performed in the past!

My question to you is why these 'elementry companies' wouldn't want to increase shareholder value.

rya said at August 1, 2005 10:38 AM:

That's exactly it. Companies must change and adapt, but that takes time, a lot of time, many years. Until then big efforts will be made to delay the new invention from being put into practice. It's no simple matter. If one could regrow teeth , hundreds of technicians fabricating dentures and bridges will become jobless.So will those dealing with supplies of materials for the dentistry services.

Julie said at August 1, 2005 12:26 PM:

But thousands of bioscience professionals will gain employment. I think these technicians will have to re-educate themselfs. In any field people must upgrade their skills this includes techicians, what if you didn't upgrade your skills wouldn't you be out of a job in a few years? Only hundreds of technicians? I think when Ford has their shut-down they lay off far more people. A few hundred people can easily be retrained!

I think companies will re-train their staff to deal with these changes so I don't think these people will be "jobless"

It does not take companies a lot of time to change and adapt. I think companies such as Crest, Johnson & Johnson are larger players then the denture companies! As well as noted by Thom even other researchers are behind this as regrowing a tooth although complex is not as hard as regrowing a kidney etc. So I think there is a lot of backing behind this not only from the dental profession, but from other areas of medicine!

rya, you still have not answered my question!!
Could you please name some of these "elementry companies" by name

Shahana said at August 1, 2005 02:50 PM:

Ref: "elementary comapanies" to delay tooth regeneration!!??

Hi Guys!

There are NOOOOOOOOO elementary companies to stop R & D. Instead there are surge for increase in research, so other bio-tech companies could take advantage! And, scientist`s working in the field wants the treatment available asap ..

Companies listed by 'Thom'(Dentigenix, Odontis, Hitachi Medical Corp., etc.) are established/formed by investors from private & public sectors. Imagine this new companies means more jobs for scientists & technicians.

I think "rya" made a aloof or dogmatic (without proof) comment .. that`s maybe because, she doesn`t have much knowledge about the area.

R&D will continue to benefit the lives of millions. Having said that crowns, bridges & veneers will not be vanished so soon. Tooth regeration may-not work for everyone...

Shahana

Amina Paterson said at August 1, 2005 05:50 PM:

These are articles that are related to this year!

http://www.stemcellnews.com/articles/stem-cells-today-show.htm - June 8, 2005
http://www.stemcellnews.com/articles/stem-cells-teeth.htm ----- May 25, 2005
http://www.stemcellnews.com/articles/stem_cells_growing_teeth.htm - March 9, 2005
http://www.stemcellnews.com/articles/stem_cells_teeth.htm - Feb 20, 2005

Looks like from one of the articles Prof. Sharpe will be conducting trials within the year!

Nanette Mc Clelland said at August 1, 2005 08:16 PM:

HI
PLease think of me as one of your test patients ,i have lost a lot of my teeth and have to wear a plate I have hidden it from people because it feels awful,and it would be great to eat properly again, it realy does affect my state of mind.Can you let me know where i could apply to be a test case. nmclear@hoo.com
thanking you
Nanette

Thom said at August 2, 2005 12:51 AM:

Julie and Shahana,

Thank you for supporting me in the "Elementary Discussion." We still have no names from Rya, thank goodness for that. I was little upset after reading her opinions and I doubt there is much credibilty to her claims.

I truly believe this technology will be available soon to us all and I look forward to discussing new findings with you.

Thank you again.

Fred said at August 2, 2005 05:20 AM:

Nanette,

Please note that we are not doctors nor are we actually involved in the actual clinical trials. We are just like you we would like to know more information about this exciting break through. Read the previous threads, and share your comments etc.

rya said at August 2, 2005 05:29 AM:


Let us put aside differences of opinion and waste no more words on that. Let's only hope and pray that the new and exciting technology will indeed be available soon and that we will all benefit from it. Let's concentrate on the news coming from the research field, if there are any such news.

shahana said at August 2, 2005 06:19 AM:

rya...

Honey you have not done enough research or even read the previous threads. I also don`t feel you understand medical research. These companies mentioned by 'Thom & myself' .. are NO JOKE!

They formed companies to find revolutionary success. The primary test`s were successful on rats & pigs. "Every medicine/drug & treatement that are available in the market to save our life is FIRST tested on rats & pigs" ... The reason is human-body functions matches closest to rats & pigs.

So now that the scientist`s were able to grow NEW teeth by stem cells in rats & pigs.. that means probability of being successful in human is very high.

But, I think the time has come for god to listen to all our prayers too.

Shahana

Cindy said at August 2, 2005 07:26 AM:

I would like to re-grow my new tooth. Where is this treatment available?

Amina Paterson said at August 2, 2005 02:22 PM:

Shahana,

This article says that Prof. Sharpe will start clinical trials within a year!!
http://www.stemcellnews.com/articles/stem-cells-teeth.htm ----- May 25, 2005

Any updated information on this?

Thom said at August 2, 2005 09:48 PM:

Shahana,

Alot of people are asking about signing up for human trials. I haven't been able to find any information...have you?

At the bottom of the Odontis homepage (www.odontis.co.uk) it says this: "The Odontis technology is still in the development stage and it will be some years before it will be ready for clinical use. Please note that we are not seeking volunteers for human trials and cannot enter into any correspondence regarding when or where the treatment may eventually become available."

Thank you.

Shahana said at August 2, 2005 10:07 PM:

Thom,

I called up Dr. Sharpe once last year regarding clinical trials on human. He told me he has more than 1000 voluteer`s already .. So his plate is full.

You could email him or the department .. ask if they are starting clinical trials pretty soon. This is the only way.

I wish I could help you guys more. But, I too am desparate for this treatment .. if it becomes available. Wrong treatment on only two of my upper teeth made my life completely miserable.

"Amina" .. thanks for the info. Let`s keep our fingers crossed.

love

Shahana

Julie said at August 3, 2005 06:21 AM:

Shahana, as you seem to have had contact with Dr. Sharpe maybe you could find out if these clinical trials have started. Can anyone confirm the article that Amina was kind enough to provide with another source (if this is true it may only be a few more years!!)

Also I heard talk about a cavity vaccine, ginavitis vaccine etc. (If this works, down the road the only need for tooth replacement would be due to an accident, or just that you didn't grow a set of teeth). Just think no one would ever be scared to walk into a dental office again. As well such a vaccine would be useful for those who can't afford dental care (not all health plans, or national healthcare plans cover dental care) - as this would keep costs low in the long run. I think the insurance companies would pay for a vaccine as it would reduce the number of claims they have.

Fred said at August 3, 2005 05:46 PM:

Interesting article on Stem Cell Research!

http://www.stemcellnews.com/articles/stem-cells-catholic-grant-adult-cells.htm

The Catholic Church "Australian" is supporting stem cell research on adult stem cells, according to the article they are contributing EUR 60,000.

So I think the "elementry forces" don't really exist at any level. I don't think the other major faiths have anything against adult stem cell research.

Shahana said at August 3, 2005 08:02 PM:

Hi Julie...

I have emailed Dr. Sharpe following your request. Let`s hope they will respond.

Shahana

Dawn said at August 4, 2005 05:17 PM:

Hi. My name is Dawn and Shahana I want to know who to talk to to be a part of any trial I can get in on. Who can I talk to or email? Last year I had an "accident". I was raped and beaten and my Dr's said I would never wake up from the coma that I was in but I did at the begining of this year. Well I woke up and 5 of my front teeth are missing. I want them back. Not implants the real thing. Who can I contact to be a part of this? Please help. My telephone is 817-795-8269. Thanks.

Dawn

Thom said at August 5, 2005 03:55 AM:

Shahana,

I have contacted several of the research development companies and it seems as you've said, they have quite a few test subjects already in place. So, I contacted several third party agencies that will place me with the appropiate treatment facility. I have not paid any fees and I am awaiting responses. These agencies claim to have contacts with research development companies in several countries around the world that specialize in gene therapy, stem cell therapy, fertility and regenerative tissue treatments.

As soon as I get more info, I will pass it on.

Thank you.
Thom

Fred said at August 5, 2005 06:47 PM:

If this works and becomes widely available it will be a step forward for all other types of research. I know of people who are following other (other than dental) stem cell reserach hoping for a cure. From the articles I've read dental stem cells may lead the way for other stem cell research!

Shahana said at August 6, 2005 04:57 AM:

Dawn..

I am soo sorry to hear about your situation.

Unfortunately, the 'real-thing' is still at research stage. It is not available for public in the mareket. It may take 5-10 years before any concrete-result.

Sorry, honey. Consult a few dentist. Implants might be only way for you now.


Shahana

Julie said at August 6, 2005 09:04 AM:

Shahana,

when you say 5-10 years before any concrete results I assuem you mean testing! So this could mean it would take 20 years before it's available to the general public!

Dawn sorry about your situation!

shahana said at August 6, 2005 10:05 AM:

Dear Julie ..

According to studies & articles .. they are predicting possible treatment within the next 5-10 years.

But, first thing is "success rate on human" .. scientists needs to see the test`s results on human .. then the whole process of new treament/medicine or drug is a very lengthy one. It takes years.

But, Japan`s are working on tooth-regeneration too! Japanese are always few steps ahead & hush hush. They don`t give much info to public until the product is ready.

I wish this treatment would be available tommorrow .. but, my tommorrow never comes!

love

Shahana

Thom said at August 7, 2005 01:11 AM:

Julie and Dawn,

I have been researching these treatments extensively and making contacts in the industry regarding treatments. In my opinion, I believe human trials will start within the next 2-5 years. They have had successful animal testing in 3 mammals, which means humans could be next. Several of the articles are already a few years old and stem cell research is advancing faster then expected.

I contacted a company that handles placing individuals looking for organ donors, stem cell therapy, and other alternative medicines. They responded to me with rather quickly and I've attached their email for you to read.

Dear Thom,

Thank you for your inquiry. We are contracted by six major research institutions throughout the world. Two in South East Asia one in South Africa, One in Australia the other two are in Europe! Germany and England.plus we are in contact with many Universities throughout the world. I have looked at our records to see who is dealing with Tooth regeneration we have two institutions that are currently dealing with teeth regeneration. One is more advanced than the other. I have contacted this institution to see what there requirements are regarding your request,

They would like to know which teeth you are looking at replacing plus your age! I gather from your email that you are looking at a full natural regrowth of your teeth.vis stem cell techonogly. This institution has had successful trials using mice. but they still think it will some 12 to 18 months before they have the right formula for human regeneration projects.As you would understand there is a lot of research still to be undertaken to get the end result that everyone requires. Some of the requirements are;

* To understand cell-protein, cell - protein and protein - crystal interactions associated with the creation of hydroxyapatite composite tissues.
* Understand the cell to cell interactions and cell - to - extracellular matrix interactions required for dental tissue formation and biomineralization;
* Understand how interfaces between one mineralized tissue and another (form enamel to dentine to cementum to bone) are formed and how biology mediates their association and the dynamic. but firm anchorage of teeth to the jaw;
* Acquire an understanding of how mineral formation is initiated and shaped to achieve the esthetic, mechanical and scale properties of the original tissue.
* Understand and ultimately control the organization of extracellular matrix by cell surface nano - mechanisms.
* Develop stem cell technologies for tooth and supporting connective tissue regeneration.
* Finally, Be able to recreate functional teeth using biological principles.

Recent experimental advances made in post - natal stem cell research, including isolation and characterization of stem cell derived from human dental pulp, craniofacial bone and other orofacial tissues.Will provide the basis upon which the stem cell technologies needed for human teeth reconstruction and regeneration.

Thom you can see that there is quite a lot of development and research still to do. As for fee's we are not able to set a fee at this time. We will need the number of teeth required, as well as what type of teeth you wish to replace. This institution has indicated that once they feel confident that they have the technology required they will than start a limited human trial with about 12 subjects they have been accepting a limited number of clients for the proposed trial that they hope to start in about 18 months time I believe that this institution is several years ahead of any other institution in the world as far as teeth and cell regeneration work goes. Should you be interested in further developments from this institution or should you wish to add your name to their project list than please contact me for details. Once I have your requirements regarding number and type of teeth required than I should be able to work out a fee structure for you.Thank you again for your inquiry and I hope that this has been of some help to you.

Thom to be listed in our data base we charge a fee of $150.00 U.S. This is a once off fee. Thom for details on how to make payments to us please contact our public relations department. Thank you.

I replied yesterday with the teeth I want replaced and I will forward their response.

Thank you.
Thom


Fred said at August 7, 2005 11:11 AM:

Hi Thom,

Look at this article

http://www.nidcr.nih.gov/Funding/CurrentFundingOpportunities/RecentlyCleared/BuildingATooth.htm

It seems like parts of your letter are from this site. I think .gov refers to american government sites.

Thom said at August 7, 2005 04:24 PM:

Fred,

Parts of the letter..lol. I think the whole letter came from that site. Just goes to show you, besides the dentist that took advantage of me there are individuals and companies out there as well. Read the letter they sent:

Hi Thom,

Thom thank you for your reply. First off I do not think scammed is the right word to describe your case! Conned would be a better word I think! Its the greed factor, It is everywhere these days I'm afraid.

You most certainly had some unnecessary work preformed on your teeth from the sounds of it.Now we are left with quite a lot of work to correct the problem.Thom I have spoken to one of our directors who has contacted our friends at the Asian research institution to see what their views are on the subject and what the overall cost to you would be.

First off they think they can help you get things back in order. As for the fee's this is a bit of a tricky question as I'm sure you will understand with the cost of research being so high I believe that they have spent some 5 Million dollars to date on teeth research alone, they as with most research institutions are all looking at re coving their outgoing costs as soon as possible. Dr Wilson one of our directors has pointed out to them that the cost must be kept to a reasonable level as to be affordable by the average person..

In your case as there is a lot of work to be done he asked them for a commitment as to cost for your case alone as they said they do not know what problems they will encounter along the way, but they have informed us that a fee of $40,000.00 U.S. Would be acceptable. In view of the work required we feel that this is a fair costing of the procedures required. They have also indicated as the first couple of trials will be on a restricted basis with only a limited number of clients will be accepted into the first two trials they think no more the 30 people in total will be accepted and it will be a first come first served basis. We can accept that.

However as Dr Wilson pointed out our clients who we refer will expect results on the positive side and we as a referral center want some guarantee that the procedure will reach a satisfactory con collusion for all involved. He has proposed that Genetic Solutions collect a 50% deposit at time of client registration, And that Genetic Solutions will hold the fee's and we will pay the research institution at the time that the procedure is carried out at that time the client will also have to pay the remaining 50%. If by chance the procedure dose not take place than the deposit will be refunded in full to the client. They have agreed to these terms which I think is a fair deal for all involved as you are protected we also protect our trading name and the institution will have a guarantee from us that they will receive the fee's in due course. They have told us that they are holding the names of nine clients who have already joined their waiting list so that will leave us with 21 places to be filled if there cut off point is 30 clients. Should they decide to reduce the number accept for the trials we will have no control over that side of things that is their choice. However we have requested that all clients be accept on a full confidential bases with no release of client details to anyone at all without written consent of you the client. This they have agreed to.

Thom if you feel that we can be of service to you than please contact me for further details. And please remember you are under no obligation to take up this offer. I trust that this has been of some assistance to you. And please feel free to pass on our details to your support group. Thank you should you require further assistance than please contact me.

There is no way in HELL! I would send $20,000 as a deposit to these guys. As desperate as I am, I will not be conned again. Maybe this company is legit who knows, but I am not going to risk it. I have been told that it would be very difficult to get my deposit back (next to impossible) from a foreign entity.

Fred, thanks again for finding that letter drafted by NIH.

Regards,
Thom


Fred said at August 7, 2005 05:55 PM:

Thom,

The reason I caught it was as I am doing a correspondance course part of the module requires on line discussion. Sometimes if something looks too good, just do a google search on part of the text and Bingo!

I just hope that the legit research that is going on will prove some results. I don't think you should have to pay money to be part of a clinical trial. It goes to show you what type of people are out there. I think that the legit companies that are doing the research can direct you the companies that are handling the test patients if they are still excepting them. Shahana noted that Dr. Sharpe has over 1,000 people on his volunteer list (which I assume is a representative sample, given that London is now a multi-cultural city)

I think the legit trials will not just accept you like that, they will want to see and evaluate (again no money). The reason is the money will be made that the time they can market their services on the open market. By pre-evaluating you they can have a representative sample of people that is considering gender, cultural background, nationality.

I am praying as well that something will be available soon (in the next few years). We just have to be sure that we don't get tricked by such people!

I was just wondering how did you find these clinical trial sites?

By the way the US$20,000 would be $24,344 for me taking into account current exchange rates that is a lot of money!!!

Shahana said at August 7, 2005 07:51 PM:

Thom...

Please DO-NOT take part in this scam! You see in a clinical trials you will be a "ginea-pig" or a "test-sample".
Many legitamate institutions will pay you for taking part in their experiment for your time & the risk involved with it.

As "Fred" pointed out above. Clinical trials are usually done on a large sample .. more than "thousand" human trials.

Whoever, has responded to your search is trying to ripe you off! Not only that, the language of the emails are very poor & unprofessional. By that you should know it`s illegitimate or bogus!!

Thanks for sharing your experience with us though.

Also comments on this discussion Posted by: Sebastian Reed on March 29, 2005 09:28 PM .. Note that guy also has some-website & he is playing with weakness of mind. He is asking for donations from people all the time. You could do a google search on this guy!

Shahana_


Thom said at August 7, 2005 10:06 PM:

Fred and Shahana,

The company is called Genetic Solutions (www.geneticsolutions.org) check them out. I sent another email that I am very interested and ready to sign up...I just want to get an address on this joker. Once, I have all the info on this guy I will post it as a warning to others.

Thanks for looking out for me.

Thom

Fred said at August 8, 2005 05:58 PM:

Thom,

I wouldn't be surprised if they are located in some country that does not have strong legal rules. If you want to be part of a clinical trial your best bet is to contact the companies doing the research, and pray that that they answer you and pick you for your research.

I am sure that they have a lot of people already. I am sure when the clinical trials hit the street we will hear about it!

Fred said at August 8, 2005 06:06 PM:

I just did a whois search on the domain this is what I got

Registrant Name:William Ashford
Registrant Organization:Genetic Solutions
Registrant Street1:111 Lords Place
Registrant City:Orange
Registrant State/Province:NA
Registrant Postal Code:2800
Registrant Country:AU
Registrant Phone:+61.263604886
Registrant Email:geneticsolutions@itxpress.com.au
Admin Name:William Ashford
Admin Organization:Genetic Solutions
Admin Street1:111 Lords Place
Admin City:Orange
Admin State/Province:NA
Admin Postal Code:2800
Admin Country:AU
Admin Phone:+61.263604886
Admin Email:geneticsolutions@itxpress.com.au
Tech Name:Domain Administrator
Tech Organization:HyperMart
Tech Street1:70 Blanchard Road
Tech City:Burlington
Tech State/Province:MA
Tech Postal Code:01803
Tech Country:US
Tech Phone:+1.8772875929
Tech FAX:+1.7819988586
Tech Email:domreg@hypermart.net

Thom said at August 8, 2005 08:00 PM:

Fred,

This guy is crazy! I emailed him pretending my attorney wants to draft an agreement and place the money in an escrow account with established terms and conditions. He said, "NO, that is not how they do it." He went on to explain that they invest the money in low risk investments to collect their fees. I contacted a broker and $20,000 in a low risk account might yield conservatively $500- $700 over 2 years. So, I contacted this guy(James Denning-if thats his real name?) and said, I will pay the interest in advance but I still have to put the deposit in an escrow account. I went on to explain that this gaurantees their fee upfront and I am protected by the escrow account, if delivery of said treatment doesn't happen. I can't wait to see his response. You are absolutely right about sending 20K to Australia is like flushing it down the toliet...I would never see that money again. Shahana commented on his grammar, he is obviously cutting and pasting phrases from articles on the web. My insurance settlement will be saved until I find a reputable organization. I'm finding this rather amusing and educational because it has me on the lookout for these scam artists and there tricks.

Thanks,
Thom

Fred said at August 9, 2005 05:27 AM:

A reputatable firm should have no problem with Escrows. Escrows are commonly used in business for various transactions. Although Australia is an industrailized country, a scam is a scam!

If you really want to take if further Call Willam Ashford at the number listed above. They will really wonder how you got the phone number! Just tell him that you will be "down under" in the next few months and you would like to see them.

Georgia said at August 12, 2005 11:59 AM:

Hi,
I was reading your posts any new information on tooth regrowth? Any theories on when it will be a reality?

wellwisher said at August 14, 2005 08:48 PM:

the human trials have already started..please google Dr. Rene d'souza name at the univ texas houston..this yr in june they extracted molar teeth of 20 patients and tried growing the roots in culture media..some tooth development was noted..i believe scientists will actively start human trials within a year..GL

Thom said at August 15, 2005 12:31 AM:

I have been communicating with Dr. Sharpe's office for sometime. They sent me an email I thought I should share with everyone. If you can donate $10, $100, etc., it would really help.

Dear Mr Fleming

Your correspondence with my colleagues at Odontis and Kings College
London has been forwarded to me so that I can communicate with you
directly.

All the research on producing human biological replacement teeth is
carried out in my university laboratory. The translation and commercial
aspects are supported by the spin-out company Odontis. I understand
that at present private "investment" in Odontis is complicated. However
I wanted to alert you to a new initiative that is about to be launched
in my university research. I have secured money from the university to
refurbish new laboratories to create the worlds first, Centre for
Regenerative Dentistry". The Centre will be purpose built to house my
research in addition to several new scientists I aim to recruit. The
direction of the Centre will be to pursue cutting-edge research in
dental regeneration.
If you are interested in making a donation to support the running of
the Centre and/or provision of the some of the highly specialised
equipment needed then this is very simply to do via a cheque sent to me
and made payable to Kings College London. If required the contributions
of all significant donors will be acknowledged on the plaque we intend
to mount at the Centre reception.

I believe the creation of this Centre marks an important milestone in
dental research that will provide the basis for the new generation of
biological dental treatments.

Many thanks for your interest.

I look forward to hearing from you.

Yours,

Paul Sharpe


Professor Paul Sharpe
Department of Craniofacial Development
Dental Institute
Kings College London
Floor 28 Guy's Hospital
London Bridge
London
SE1 9RT
UK

Fred said at August 15, 2005 12:35 PM:

Hi Thom,

Thanks for sharing that. Notice that Dr. Sharpe asked the donation be made to the university instead of the company, which adds to the integrity of the project. I hope we can get a tax receipts for the donation. I am sure the university is making them accountable for their expenditures (rent,utilities,salaries etc.)

Thom are you by chance related to the famous Dr. Flemming (he discovered penicillin- and yes he was Canadian!)

Also, if you hear from the company "down under" let us know, I want to read something I can laugh at!


If you have the links to the articles by Dr. Rene please post them.

Fred said at August 15, 2005 05:52 PM:

Sorry I mixed Dr. Flemming with Dr. Frederick Grant Banting who discovered insulin. I think Flemming was a Brit!

wellwisher said at August 16, 2005 06:18 PM:


here is the link for the pilot human trial i wrote about earlier...
goes to show that human trials would happen in the recent future!!

http://www.window.state.tx.us/txinnovator/ti0506/

Thom said at August 17, 2005 10:41 PM:

Since, I verified the letter, address and speak with a secreyary from the university these funds will be going into a new regenerative dentistry facility...this could hopefully mean they are getting ready for human testing. I donated $100US but please donate what you can and send a letter each time requesting when human trials are to be expected. GOOD LUCK

Fred said at August 17, 2005 10:55 PM:

Fred,
I am going to post every letter you would not believe the lies and excuses they came up with it is totally laughable and what i said to them is more hilarious.

For everyone unaware what we are talking about I found a comany trying to scam money out of us in Australia
www.geneticsolutions.org

They are crooks harrass them, because they are trying to take advantage of victims.

Thom

Dawn said at August 22, 2005 10:46 AM:

Hi. Sent my donation and my letter. Thanks for the address.

Dawn said at August 22, 2005 10:56 AM:

Hi. Thanks for the address. I sent my donation and letter as soon as you posted the address. Thanks.

Thom said at August 23, 2005 12:11 AM:

Dawn,

You are awesome! I am sure Dr. Sharpe and the university will be pleased that we are trying to make a difference.

Also, I reported these scam artists claiming they could get individuals priority placement in human trials for regrowing teeth after you pay a LARGE deposit. Their site is down as of today, I reported them to the IFCC (International Fraud Consumer Complaint) and they inturn reported them to the FBI. Genetic Solutions is a scam BEWARE if they show their face again. (www.geneticsolutions.org)SCAM SCAM SCAM!!!

Andre Buchard said at August 29, 2005 02:48 PM:

Bonjour,

I was reading your post with interest, do you know when human trials on this tooth growth will start. I read that they have also develop alternate filling which helps tooth as it has dentin (I think dentrix site noted this)

It sound like how you say science fiction, can it be true?

Any information on this?

Dr. C. A. Bellini said at September 6, 2005 09:06 PM:

Hi to All, This is a great board and I am so happy to find it .I have been following DR Paul Sharpe's work for a few yearws now and am so excited that I may actually be able to donate and help out. In 2000 I was arial sprayed with 3 seperate chemicals at my home and developed quite severe ostiomylitis and had abcesses and lost many teeth. I went on to see 8 dentiste in US and Canada all who took great amounts of money and made the problem much, much worse..Till finally one day 2.5 years ago I vowed to never see a dentist again and began researching the regeneration of bone and teeth .
Many Blessings to all of us...and may this great work revolutionize dental procedures.

C. A. Bellini

Junaid Iqbal said at September 14, 2005 09:12 AM:

I found this thread a recent while ago and am very excited, but feel the need for urgency. I keep checking this thread to see if something came out that is available or some major breakthrough which would give greater dental technology now instead of the near future.

What is the latest development with the people who are in touch with the Doctor? What is the latest we can expect in the U.S.? I read a post about an injection to prevent cavities, are there any other latest development that will help individuals now or in the near future 6month - 1year.

Julie said at September 14, 2005 10:50 AM:

Research is being conducted aross the world not just in the US. If any treatment does occur it would only be at most a few years extra for it to be available in these countries.

Fred said at September 20, 2005 01:29 PM:

Laser eye surgery is available, and getting better! It will only be time before you you can re-grow teeth, use alternate fillings, etc.

Just think of the radical change to the dental industry, everyone (dental industry) will need additional continuing education courses for this!

Paul said at September 27, 2005 11:45 AM:

It was fantastic to find this site, it gives me hope for the future, like everyone else i am desperate for the latest info and would willingly undergo any test treatments. We all need to keep our fingers crossed and hope for an early solution!

Ella said at October 9, 2005 10:25 PM:

Shahana,
I realize this is not intended to be a comments page, but I can not refrain from writing to you as your posts contain many clues as to what appears to have been a traumatic experience with a conceited and reckless dentist who disregarded your wishes to fit his own agenda -- and is remarkably similar to one I've suffered recently... even involving, I believe, the same two teeth. For eight months I have been floundering, avoiding the mirror, my friends and hating myself for my stupid misguidedness and trust. I can not escape the feeling that an integral part of me is destroyed: my once quick and open smile replaced by a grimace that is self conscious and strained. I hate and regret what this has done to me and following a few months of near-incessent panic attacks have forced myself to turn numb -- to feel nothing, for fear of what I might do if I were to allow the utter futility and irrevocability of what was done (and can not be replaced) wash over me.
Please don't hesitate to write me at graceblueandgreen@yahoo.com
I suspect hearing from someone whose experience so closely resembles my own might in some way help me not to feel so utterly alone.

Ella.

Shahana said at October 11, 2005 03:53 PM:

Ella...

I couldn`t begin to tell you of the trauma & horror of the problem I have been suffering since 1993. I feel like a fool & a idiot for going to a dentist.

There are people with cancer & AIDs has hope to recover & completely feel healthy one-day. But, we are in a false situation, with limited hope in our lifetime.

Feel free to email me or call me if you want. If I could offer you an inch of help .. I will be grateful.

Email: shanazzaman@yahoo.com

regards

Shahana

Sebastian Reed said at October 13, 2005 11:18 PM:

Dear all,

this post is a reply to a criticism on this message board. It is a shame that someone has criticised me when I do my best to offer a lot of advice to people with dental problems.

I have written a complete system of natural dental care which is available at my website for free and has taken me about 2 years of research and writing to compile and organise. Suggestions and improvements are welcomed.

Shahana is the person that I am referring to. I have had doubters before and this one will not set me back at all. I feel compassion and sympathy for Shahana and I recognise the support that Shahana provides on this board.

Shahana, please contact me personally if you have any questions for me and please do not criticise me as I have only the best intentions to help people and to make the field dentistry pain free.

I urge you, as a matter of fact, to visit www.worldofteeth.com. Although the site is a 'com', not an 'org', there is sufficient material there to heal your dentition completely if you are dedicated (click the oral health tab).

Peace be with you,

Sebastian Reed

Shuun said at October 14, 2005 06:02 PM:

Has anyone attended Dr Sharpe's lucture this past September? If so please share your comments. Thanks.

TYLER said at October 25, 2005 11:14 PM:

I LIVE IN THE U.S.A., I'M 23 YEARS OLD AND HAVE HAD GINGIVITIS MY WHOLE LIFE AND HAVE HAD TO HAD MANY TEETH PULLED OUT OVER THE YEARS. I'M GOING TO NEED MORE TEETH PULLED OUT OVER THE NEXT FEW YEARS IF I CAN'T SLOW DOWN THE DECAY OR KILL THE GINGIVITIS. I WOULD GLADLY VOULENTER MY TIME AND GUMS TO YOUR PROJECT IF IT GOES THROUGH. PLEASE EMAIL IF YOU ARE APROVED.

Randall Burns said at October 26, 2005 05:09 PM:

Does anyone know if any services are helping folks to store removed wisdom teeth? How expensive is it? Is it worth it? I'm about to have the last of mine removed.

Sandy said at November 4, 2005 04:48 AM:

Hi, I have not had most of my teeth since I was only 18 years old. I have wished for more than 20 years to have the feeling of my own teeth. If this ever becomes a reality I would glady be one of your volunteers. If volunteering is not a possibilty please let me know what such an amazing discovery would cost. Also will this be available in Canada too.

shuun said at November 4, 2005 07:25 PM:

Hello all, I recently searched for the latest news in teeth development and foud the following website: http://www.gotoapro.org/

Also check out this article: http://biz.yahoo.com/iw/051025/099103.html

Another ray of hope!

jon said at November 17, 2005 03:45 PM:

If you are looking for test subjects for this procedure... contact me at my email address!

dave dunphy said at December 7, 2005 12:33 PM:

Hello,

How comes this project has been going on for over 3 years and there are no response from the people who have had it done. You would of tought if it was such a success there would be picturwes and comment from those who have had it.
Regards
Dave

Edwin said at December 9, 2005 10:40 PM:

WOW, It's a comforting feeling when you come to find out you're not the only one dealing with a devastating issue. Like most people here I too have been increasingly interested in this topic; my story is very similar. I've read numerous articles and hope, somehow, to get involved. There seems to be a whole lot of information on the subject, as it is, and would just like to know that if I can play even a small role in all of this, even if it's by donation, where might I be able to find the proper information so that I know my donation is going to the right place.

Edwin said at December 9, 2005 10:40 PM:

WOW, It's a comforting feeling when you come to find out you're not the only one dealing with a devastating issue. Like most people here I too have been increasingly interested in this topic; my story is very similar. I've read numerous articles and hope, somehow, to get involved. There seems to be a whole lot of information on the subject, as it is, and would just like to know that if I can play even a small role in all of this, even if it's by donation, where might I be able to find the proper information so that I know my donation is going to the right place.

Paul said at December 19, 2005 11:46 AM:

I do hope that this will come to a reality, and not in too many years. I lost my lower wisdom and next molar and I have never been the same since. It's been like a bereavement, and that's no joke!! I had a dental implant done, but although good, it's not the same. My mouth feels dead at the site of the missing teeth, although I know I was lucky to aford an implant. But despite what people say, it isn't like a real tooth at all. It feels nothing, I can't really describe it, but you just know it is foreign. And yes it is functional and you can chew, but it just feels strange!! Anyway, the associated bone loss and resorption and the change to the feel of my mouth after those teeth were lost has caused me a great deal of stress after losing those teeth. I come from a generation where you aren't meant to lose your teeth so you really look after them. But still I lost two. Imagine, if the regneration could regrow the bone as well..tha would be fantastic!!

Julie said at December 19, 2005 11:53 AM:

I hope it is not too many years before this is available to us and at a reasonable price! And from the articles I have read they can do this with an adult stem cell which can address any ethical issues that maybe faced by this type of research.

Fred said at December 22, 2005 02:36 PM:

Any new news articles on this topic?

Ryan said at December 25, 2005 12:25 PM:

Would they replace lower wisdom teeth also? I know most people want to get rid of them, but I have a large jaw and miss mine after they went. My mouth doesnot feel the same!

Julie said at December 26, 2005 02:18 PM:

Any information how the fake research in south korea will have an impact on overall stem cell research?

This guy was said to be a leading researcher world wide! Thanks for the link Fred

gabe falsetta said at January 8, 2006 04:55 PM:

I too would be willing to volunteer This is a great breakthrough, how can we as a people help to support this...

TINA said at January 27, 2006 03:05 AM:

GOOD SIR,
I HAVE A PROBLEM I NEED A REPLACEMENT OF TEETH

cythian said at January 27, 2006 03:14 AM:

Goodday sir

i need what to been used on my teeth because it just went off i want it to grow back, please tell if there is any solution on it.

Thanks

Drew said at January 27, 2006 12:31 PM:

Commercial aspects are huge. Just wish they'd hurry up, implants are so 1800's. I have one tooth missing.

Thom said at February 13, 2006 11:08 PM:

Shahana and Fred,

Have you come across any new news recently on this subject? It has been awhile since anything significant has been posted online about the progress of the research.

Best regards,
Thom

Paul said at February 15, 2006 09:44 AM:

I am missing three teeth and I als want my lower wisdom teeth back as my mouth feels empty without them. Missing teeth are the curse of mankind. Why in heaven's name we only grow two sets is beyond me. With increasing life expectancy it is madness to expect a second set to last from early teenage years until 70 or 80 years of age. It is amost impossible to do and something is bound to happen to them. Dentures, bridges, implants are not like real teeth. Once teeth are lost the mouth never feels the same again, but with grown replacements with bone support it would be fantasic. Hurry with this therapy as this is what we are desperaely waiting for.

Shuun said at February 16, 2006 01:25 PM:

Hello everyone,

visist this site to read about latest news on teeth regeneration. Exciting news I thought. http://www.healthypages.net/newspage.asp?newsid=4941

shuun said at February 16, 2006 01:46 PM:

I also found this article. I am not sure when it was written but it sounds very recent. I found it interesting. Check it out.

http://www.encinosmiledr.com/future.htm

Thom said at February 25, 2006 12:29 AM:

Both articles look the same Fred is there any significant difference between the two articles? If 3 years is the proposed target date for human trials then we can expect true human application in 5-7 years. Hopefully advancements will be made to accelerate this process. Individuals living with this physical damage are suffering mentally as well. I hope for all our sake a solution is discovered soon.

Thom said at February 25, 2006 12:29 AM:

Both articles look the same Fred is there any significant difference between the two articles? If 3 years is the proposed target date for human trials then we can expect true human application in 5-7 years. Hopefully advancements will be made to accelerate this process. Individuals living with this physical damage are suffering mentally as well. I hope for all our sake a solution is discovered soon.

Thom said at February 25, 2006 12:29 AM:

Both articles look the same Fred is there any significant difference between the two articles? If 3 years is the proposed target date for human trials then we can expect true human application in 5-7 years. Hopefully advancements will be made to accelerate this process. Individuals living with this physical damage are suffering mentally as well. I hope for all our sake a solution is discovered soon.

Thom said at February 25, 2006 12:29 AM:

Both articles look the same Fred is there any significant difference between the two articles? If 3 years is the proposed target date for human trials then we can expect true human application in 5-7 years. Hopefully advancements will be made to accelerate this process. Individuals living with this physical damage are suffering mentally as well. I hope for all our sake a solution is discovered soon.

Thom said at February 25, 2006 12:29 AM:

Both articles look the same Fred is there any significant difference between the two articles? If 3 years is the proposed target date for human trials then we can expect true human application in 5-7 years. Hopefully advancements will be made to accelerate this process. Individuals living with this physical damage are suffering mentally as well. I hope for all our sake a solution is discovered soon.

Thom said at February 25, 2006 12:29 AM:

Both articles look the same Fred is there any significant difference between the two articles? If 3 years is the proposed target date for human trials then we can expect true human application in 5-7 years. Hopefully advancements will be made to accelerate this process. Individuals living with this physical damage are suffering mentally as well. I hope for all our sake a solution is discovered soon.

Fred said at February 27, 2006 09:21 AM:

Thom you must be really excited you posted your message 6 times! Any one have any real info? This was a email interview rather than a phone or in person interview. But all the same it's news!

Thom said at February 27, 2006 01:53 PM:

Sorry about that. I must have hit post button more then once.

Martin said at February 27, 2006 04:48 PM:

Hello, does anyone have ay further information on this topic. Please email me if you do or would like to correspond. I hope that this becomes available soon. Thom has it aout right. The mental and physical price of any tooth loos, anywhere in the mouth is hard for me. I would love to think that this couls be a reality.

jodie said at February 28, 2006 08:23 AM:

I have been studying this field since 1997(now 9 years and its accelerated in last few years tremendously) and it is definitly accelerating and hopefuly will continue to do so.I have been looking at this thread since May 2005 but funnily enough never thought to add my comments until now so I hope these ideas and views are hellpful(espescially re:- organised group prayer;it all helps speed things up on the "physical plane of existence" and I gather angels are "popular" in the USA as well re praying to them;see below).

It's now Im glad to say from an analytical viewpoint now a question more of securing the $ 5.2 million US dollars/$ or 3£million uk pouns needed to fund say 3 year extensive clinical human trial;say with at least 1000(or more)patients he has lined up and which will "satisfy the stringent regulatory and safety requirements of the uk government and regulatory authorities" and which would fund all the laboratory time and staff costs and record keeping and advertising and so on and pay for extra equipment and wages of the extra staff and scientists and dentists and drs they'd need to employ for a large uk wide human clinical trial.

Its a sign of much hope and progress from the emailed Dec 25th 2005(see above link)interview that they have the clinical various types of teeth and in quantity;

("growing ten is as easy as growing 1" he says so he must be fairly confident re the technical requirements re success of his advanced methods which are more developed than e.g. dentegenix or the japanese hitachi medical services corporation's rival efforts or other groups working in this niche specialist stem cell field re teeth regeneration)

technical"problems"of getting teeth to grow exactly and when required(using signalling proteins and growth factors emulating the natural teeth growing processes);

"nailed and identified and are confident it will work in humans as well as mice(or eg dogs)"

but the main problem now is getting the next tranche of funding;some 6 times the original £500,000 NESTA/UK government agency etc grants they got in May 2004;which I hope they get via combination of venture (bio-tech venture capitalists they have lots of thoise in the united states and uk)capitalists and state funding/grants;

maybe some venture capitalists will want to buy shares(ordinary share capital)in odontis (the private side of this effort)private company;in exchange for seed capital to fund the 3 years of human clinical trials.

We could try and pray for it to be accelerated and happen faster.I link with the angels and prayer circles of the seekers trust a charity in addington kent england twice weekly for this(www.theseekerstrust.co or see google or other search engine for their website) and its free service.

One links at set time for just half hour in one's home (anywhere in the world subject to time differences from GMT of course)and they the circle of 6 praying people/seekers trust resident members pray simultaneously("triangulation" its called;triangulated prayer technique) at addington kent at their estate/hq(about 36 acres set in kent countryside).Its a free service and registered charity.See their website(this isn't spam just an extra suggestion).

They are always getting reports of healings that have occurred and I have found since linking for profesor paul t sharpe and odontis and the londo centre for regenerative dentistry things have happened more swiftly.I am praying espescially INTENSELY AT MOMENT TWICE A WEEK WITH THE ANGELS AND THE LINKERS AT ADDINGTON KENT ENGLAND for profesor paul t sharpe to get the $5.2 million US $(about 3 million of our uk £)from either NESTA or other state agencies(he got the initial £500,000 grant from NESTA in May 2004 and said he "hoped to start the clinical human trials in 2006 if all goes well with the remaining animal/mice trials" I saw him live on british television show BBC1 channel in mid-May 2004 and also recorded the interview;this BBC series is set in his hospital called CITY HOSPITAL which features patients from all wards of Guy's Hospital which Kings College is associated with and right next door to in London);

(so if the human clinical trials start in 2006 or 2007 even if delayed due to funding delays;and its now only a question of funding and arranging it to satisfy the "three years of results and clinical trials to satisfy the strict clinical regulatory authorities until it can be offered safely to the general public";then we will probably see Professor Paul T. Sharpe re-interviewed on that BBC tv show they show for about 2 months at a time in the weekdays mornings slot opposite THIS MORNING on UKs ITV channel);

(and eventually we will see on the net and tv and all media worldwide :-actual photographs and tv pics of new human teeth regrown in patients mouths;keep vizualizing this as happening in the future and it surely will!)

OR try any other organised prayer group(s)/ charities(findable on the web re:-via search engines etc)in the USA or whichever country you are in.There are a lot praying for all sorts of things;some better and more powerful in their results than others!(only use those that are free or accept donations though not these commercial "occult" or "spells" websites they seem a little bit dodgy to me as are some things on the web!)

The more people campaigning mundanely by discussing this and asking for it to happen inc letters to say uk govt asking them to fund prof sharpe much more and bigger so he gets the £3millionnhe needs for the trials ;donating to kings college uk directly as thom suggests in above entries on this thread(anyone know any venture capitalists interested in this?);

and praying/actively positively vizualizing for this to happen the more it will come about.

With love and blessings and prayers for all the contributors on this thread;

(I know how much missing teeth hurts physically and mentally espescially if one has problems with prosthetics/false teeth;crowns;bridges;veneers;fillings and the mercury in them if allergic to that or even allergies to titanium screws used in implants etc;and how it can cause gum disease and heart disease due to bacteria entering bloodstream via the mouth and attacking the heart)

JODIE XXX

jodie said at February 28, 2006 08:27 AM:

www.theseekerstrust.org.uk

is the exact website.

They can be contacted by post also.I have been linking for past 3 years with their "Harmony Prayer Circles" for this human teeth regeneration to be speeded up and for Professor Paul T Sharpe to succeed and get all the funding he and Kings College and Odontis needs.

Sue mustard said at February 28, 2006 09:29 PM:

How can I be one of your patients that you do this with?
I live in California, who can I contact here?
I am already missing teeth, and have more infected, which I will loose, and I don't really want to get false teeth.
I would really like to regrow my teeth.
Phone 760 876 4251
Thanks, Sue Mustard

Geoge McBrian said at March 1, 2006 09:08 AM:

Mustard Sue,

Note this is not the site to be a patient (if you read the previous blog entries) this is simply an informational blog that people like your self have posted on.

Please contact the American Dental Association to be a "patient"

jodie said at March 2, 2006 07:06 AM:

There is a site(run mainly by a USA company)(ofices in florida etc)doing patient research including re:- people who have lost teeth;and health problems this causes:-

which my brother(in UK) has joined as panel member to take part in surveys(inc re problems caused by lost teeth;he got pneumonia and heart failure in 2002 and recovered fully but it was due to infection caused by bacteria entering bloodstream due to infected tooth/molar):-

www.thepatientconnections.com

its(like THE SEEKERS TRUST CHARITY IN UK)FREE TO JOIN AND THEY ALSO PAY PEOPLE TO DO THE SURVEYS and are trying to get as many people to join so their research is the best possible re marketing future and currently in development medical treatments(for their client companies who pay them to do this research)

and my theory is ;as they and similar companies do very "patient focused" research and surveys and pass the collated data onto companies(including those who would fund research into teeth regeneration)

it cannot but help to mention teeth loss and problems with standard ordinary dental practice and prosthetics;

so survey companies pass this data on to medical companies and others;

so they get a clearer picture of how much people/patients(ie "patient power/patient empowerment" esp. dental patients) would love to see asap advances in human teeth regeneration;and companies like odontis and centres like london centre for regn.dentistry and usa companies like dentegenix;

get all the funding they need "and more" DUE TO PUBLIC DEMAND.IE THE MORE THIS IS RAISED BY EVERYONE BY WHATEVER METHOD POSSIBLE the more likely it is to be faster provided and dentistry to be truly revolutionised in the 21st century(along with other medicine)

As Professor Sharpe said "fundamentally we are still using much the same methods they originally used in Roman times;and its long overdue for a revolution etc dentistry"

hope this helps;and other ideas anyone?

love jodie

jodie said at March 2, 2006 07:10 AM:

correction:-its a london company the above one
and just has exhibition in florida(and athens greece) in may 2006 not offices in florida usa

Thore said at March 2, 2006 10:10 AM:

Dear Madam,

I am interested in having a new set of real teeth. Where can I make an appointment to visit your office. I am willing to travel to usa if necessary, but no eye scan please at border as I have an eye problem as well.

Martin said at March 2, 2006 10:12 AM:

Here is a recemt story which you ma find interesting. Let me know what you think!!

Martin

http://www.nidcr.nih.gov/AboutNIDCR/Director/Congressional/CongressionalJustficationFY06.htm

jodie said at March 3, 2006 04:58 AM:

Martin thanks for the post re NIDCR:-

this shows the amercians too are comitted to making this a reality and with better funding I think than the UK(unless it transpires otherwise) "a bit" but I still think the uk team is ahead and will probably get there first.It shows how seriously the usa has geared up for this though!they have many universities working in conjunction on the technical problems(foremsot being pam yellick and team at harvard university but michigan university with bruce rutherford and also texas university with mary macdougall) and working in conjunction with colleagues in australia and brazil;as eg are 6 or so at least japanese universities in consortium headed by hitachi medical corporation doing so in similar fashion

re post from "thore"above Martin's(whom I have exchanged few emails with as he is in the uk too thanks martin for the extra data re NIDCR!) I dont have an "office"re "regenerating teeth" just mentioned extra sources of help;

including spiritual healing/prayer and filling in "patient surveys" where one has the opportunity to mention lost teeth and problems with existing prosthetics and otherd ental problems and thereby to "lobby as a private personal individual consumer and dental patient" the medical health industry by mentioning need for/desire to see HUMAN TEETH REGENERATED by various uk and usa and japanese(hitachi medical corporation are working on it too;sub division of HITACHI the large japan based multi- national blue chip company)companies.

I dont have an office offering new human teeth; thore; or Id get it for my brother and Martin and allothers who needed it and make a fortune at same time(not that i need the money or am that interested in financial aspects I just want to see this dental development happen and be availiable to as many people on world a spossible at most affordable price!)

love jodie

Thore said at March 4, 2006 01:58 PM:

Good day Jodie,

I don't think I know you? What part of the UK are you from?

David Alpine said at March 7, 2006 03:37 PM:

Does anyone have any new articles from 2006 on the research, or better yet info from the researchers.

David Alphine said at March 7, 2006 06:23 PM:


I saw a link that some stem cell research maybe fake. Check this out!
http://www.theglobeandmail.com/servlet/story/RTGAM.20051223.wstemc1223/BNStory/specialScienceandHealth/

Lina said at March 8, 2006 06:20 AM:

How do we know the progress Odontis is making since they annonced the possibility of tooth regeneration since 2004 ?

Martin said at March 8, 2006 09:52 AM:

I would love to know also. There are never any updates on the website.

farrah said at March 8, 2006 01:05 PM:

hi. i am very interested to be a volunteer of tooth regeneration.. i live in the philippines. do you think it is possible for us to have that ?

Cindy said at March 8, 2006 06:26 PM:

Hi,

I noticed that this research site is down http://www.dentigenix.com/ does this mean anything?

Martin said at March 9, 2006 11:27 AM:

Here is a fairly up to date link...let me know what you think.

http://www.wellcome.ac.uk/doc_WTX028677.html

Marianne said at March 10, 2006 01:09 AM:

Hi there,

I have been perusing the web for updates to see "when tooth regeneration will be possible, or specifically available to the public. Some sites hint that this technology may be available soon e.g: the Hitachi Corporation hope to ship tooth germ in 2007 and other's (such as the Boston Institute and Odontis) claim this may be available (after clinical trialling) in 10 -15 years time. It all seems rather vague and non-specific. Does any one have any more information. I wonder if Paul Sharpe and Mary Macdougall follow this site (there seems to be alot of active discussion and interest in their product).

Martin said at March 10, 2006 09:51 AM:

Yes, there is an awful lot of interest in the idea of regenerated teeth, and it is no surprise. The loss of teeth is the curse of human existence. The idea that one could restore their dentition and grow a tooth to order is like science fiction, which could hopefully become science fact. It would be an absolutely revolutionary move in health and would benefit millions of people worldwide. The dentak implant market would be killed dead in an instant, as people opted for a real tooth made to order. The fact remains that real teeth are far superior to any artificial device, ever, period!! Dental implants may be acceptable, but they have no feel and do not feel real in the true sense of the word. I contacted Odontis and was told that they are working very hard to make the bio tooth a reality. The only question is when? Certainly, the thought of waiting for aother fifiteen years feels terribly had for me and the others who post (and who do not) on this site.

Rya said at March 10, 2006 06:02 PM:

Hi Martin,
" The dental implant market would be killed dead in an instant..." This sentence which appears in your above message is the key answer to your question of WHEN .
Unfortunately, the huge dental industry of implants, dentures, bridges, crowns, won't let tooth regrowth happen in the near future, as it will make them redundant.

Martin said at March 11, 2006 04:35 AM:

Rya, I can understand your viewpoint, but the march of technology will not be thwarted by the dental industry. It is inevitable that the regenerated tooth will become araelity. Examples of other innovations prove that the market will decide which products and services will dominate in the future, that's the nature of market forces. Once this does become available it will be inevitable that people will most likely want their real teeth back. No amount of bleating by the implat, denture industry will stop this I believe. Of course the key question for us all is when will it become a reality as things appear to have gone quiet over recent months. This leads one to feel that the frenzy around the initial tooth growing experiments were over hyped and there is much still to be done, which may take heaven knows how many years, or that the scientists are working away in the background confidently knowing that this can be done. Of course for many, including myself, the mere thought of this advancement is beyond comprehension, as I wonder how it can ever be possible to grow teeth.

shahana said at March 11, 2006 06:40 AM:

Hi guys..

Just some notes - the researchers are actively performing experiments on tooth regerneration. The results were successful and Dr Sharpe is leading towards "clinical trials in human" ... We must all pray that the clinical trials in human becomes 100% successful. Please know that R & D in medicine/health requires decades of trial & testing. It is NOT like other form of technology like computers, electronics - which could be upgraded immediately & sold to the market. Even minor error in treatment or drugs in human means lethal danger. Refering other forms of treatment like bridges, veneers etc won`t be killed because tooth regeneration is done by gene therapy. Which may NOT work for all candidates. Like Lasik suregery is NOT possible for every client.

Please try to relax & enjoy life with your troubled teeth - Life is too SHORT. I have been suffering since 1993 & now learnt to live with the pain - I look good but I just don`t feel good. Well, such is life!

Best wishes

Shahana

Alfred said at March 11, 2006 08:10 AM:

Also for other dental research such as cavity vaccines etc it could take decades! Note that dentists make a lot of money off people even when you go for an ordinary check-up and cleaning. Why would they want to give up a good thing?

I think they are doing a cost-benefit and it is not economically viable for them to make this available as more money can be made in treatment rather than prevention!

Marsha said at March 11, 2006 12:10 PM:

Yes, but you must remember that stem cells from the pateient will not be the same as testing a new drug in the normal way. They avoid tissue rejection and should come to the market much quicker.

jodie said at March 11, 2006 07:43 PM:

To thore (or is it "thom"?regular poster)I may have misunderstood your post.You are from uk enquiring whether you need an eye scan before admission to USA(due to their stringent security procedures post 9/11?)I'm from south coast UK about 60 miles from london and Professor P T Sharpe.Sorry re any misunderstanding I thought your post was directed to me as it was below mine.

I agree with Shahana that this type of research is slower and must be thoroughly tested;at the very least one has to have 3 years of human clinical trials;in UK at least.

I thought that the main problem now was obtaining sufficient funding from the email interview Professor P T Sharpe gave (25 12 2005) and was linked to in earlier post.But he obtained the original £500,000 "proof of idea" funding from the wellcome trust(who support "bio-teeth")so Im sure he will get the funding.

Even when he does it will be slow progress and have to be exhaustively tested for safety before it is "allowed" to be offered to the general public.

I myself prefer the idea of it being thoroughly tested first;with say 1000 patients of all types and severity of problems and missing/edentulous teeth problems ;and then it can be safely offered to the public.

It may be a minority can not benefit from it (like lasik eye surgery) but Im sure if it works;and its science fact not science fiction;then the majority will benefit.

Re RYA's comments yes a lot of dentists are cynical by the nature of their profession but they will not be able to stop progress;also people are wanting in the entire sten cell industry to see the first body part regrown so they can move with confidence onto other body parts (including hair where they are trying to identify the stem cells to regrow hair re baldness cure ).The recent "fake " results from aone "bent" Korean scientist does not invalidate the 99% of genuine results obtained throughout the rest of the stem cell industry.

Time-lines:- stem cells were first discovered circa 1982 or 1976(not sure will have to check)

Any new technological development(see computers and TV although this is more complex)espescially major medical technology needs decades to mature and be practical reality.It is however decades now since 1976/1982 initial discovery.

It's best to relax and go with the flow as shahana says and be quietly optimistic!

jodie said at March 11, 2006 07:57 PM:

In answer to Alfred's comments re the dental cabity vaccine/vaccine to rpevent caries and combat bacteria:-

on same wellcome trust website Martin refers to on this link:-

http://www.wellcome.ac.uk/doc_wtd004693.html

"more than a mouthful"

it is clear the "real reason" for the long delay(applicable to teeth regen. as well its the sheer complexity of the issues hence decades of research needed and for "SAFETY FIRST" reasons as we are dealiong with human lives here)re these various vaccines research projects is NOt opposition from dentists and the toothpaste industry(who would welcome this as actually people will still need to use both dentists and toothpaste!)

BUT the complex nature of the many "100s" of different bacteria in the mouth;so a "simple" vaccine isnt feasible;a more complex one has to be invented

Martin said at March 12, 2006 01:10 PM:

Yes, I beleive that Jodie is correct, nothing can stop the march of technology. It is best for us to relax and remain optimistic. I know it is hard when such a thing as this seems to be a possibility, and when people are suffering discomfort in their mouths due to missing teeth, dentures, etc. We have to be realistic and hope that this comes true.

Ilona said at March 13, 2006 11:32 AM:

I wonder if any of the researchers ever look at this site? It would be nice if tey would ever consider giving an update for us tooth loss people. :)))

Cindy said at March 15, 2006 11:06 AM:

Hi,

I noticed that this research site is down http://www.dentigenix.com/ does this mean anything?


Did they go under?

marianne said at March 16, 2006 12:56 PM:

I found the definition of tooth germ it is; "A mass of tissue, including the enamel organ and dentinal papilla, that has the potential of developing into a tooth; tooth bud."

Pall said at March 28, 2006 10:58 AM:

Here is somemore information and predictions about the so called 'biotooth' and Paul Sharpe's work. Take a look and scroll down to paage 53 to see information relating to the regeneration of teeth, and when it may become avalable, hopefully soon!

http://www.fco.gov.uk/Files/kfile/UKTIStemCellsReportAugust2005,0.pdf

jodie said at April 1, 2006 02:36 PM:

thanks PALL

that was very very helpful..very helpful post that

and I so far have skimmed thru most of the pdf document..esp page 53 which encouragingly talks of cosmetic applications being first to succeed and be clinically availiable in this sten cell field re medical applications(ie teeth ie smiles;ie appearance/cosmetic) and the fact that a tooth is easier to first do as a body organ replacement... than say a heart and easily accessible...

so the experts have come to same conclusions as we have (the public and posters above)

and say professor paul t sharpe...

re the researchers coming to this thread to read the posts(all are helpful i find these posts some more than others re links)as one poster said...i dont think they have the time and they are well aware of how much this is wanted..so leave them to get on with it and get the funding(a watched kettle never boils...and plants grow themselves whether you watch them or not)

angels have started to heal both michael barrymore(hes coming back to the uk we expect shortly...) and even jodie marsh too ..so angel healing does work...and will work in the long run re teeth regeneration as we have been asking the angels for this for past few years although on physical plane it is expected to be slow progress...

see my brothers' posts at www.michaelbarrymore.net ....

and see www.theseekerstrust.org.uk

for details of angelic healing we referred to earlier...

may have posted the wrong url as www.theseekerstrust.co.uk earlier....

jodie said at April 1, 2006 02:44 PM:

yes the URL for anyone interested is:-

www.theseekerstrust.org.uk

jodie bannister said at April 1, 2006 02:53 PM:

and no my above posts are not "april fool's jokes" as in uk its almost 2nd april 2006 now!

angel healing and triangulation(see seekers trust periodicals for explanation)DOES work sometimes very fast and other times very slow..

and by "synchronicity" as Carl Jung coined the phrase....ie coincidence,....

meaningful or otherwise....

peace love healing and blessings to you all...

Jodie Bannister.

click on my name(in this or other above post) as its URL encoded...hyperlink... and will take you direct to the seekers trust website(or michaelbarrymore.net..... run by our mate Nicky)(where paul posts although be warned some of the posts are semi-serious only...as its a wacky site at times...!)

jodie bannister said at April 4, 2006 06:55 AM:


here is the latest stem cell adcance re growing bladders:-

http://news.bbc.co.uk/1/hi/health/4871540.stm

this is bigger organ than teeth even

proof stem cell therapies not "science fiction"

ian.nuttall said at April 4, 2006 07:49 AM:

hi im 21 years of age and would really like to be a volunteer. coz it could be life changing for me. cheers

Julie Woodchuck said at April 4, 2006 10:12 AM:

This company that used to do research for stem cell teeth is not working
http://www.dentigenix.com/

Can anyone shed some light on it?

Pall said at April 4, 2006 11:49 AM:

You have all probably seen the UK news site about the growing of a human bladder from stem cells. We should all thank God for this wonderful breakthrough which will assist so may with what must be an awful situation to live with. This should also give all of us waiting for tooth regeneration something to be positive about. IT IS COMING!!!! OF THAT YOU CAN BE CONFIDENT

Fred said at April 4, 2006 01:51 PM:

Looking at the bladder research fantastic. I am sure those with such problems are suffering much more than us! Think of terminally ill children at hospitals, or people with cancer. I am sure they are suffering more. We should at least be thankful that our pain is not as bad.

I hope this research will reduce the suffering for everyone not just our teeth. Just think of the impact on healthcare. This will likely reduce the cost (well in the long term at least!) of health care costs both for insurance and national healthcare!


On a side note:
The Royal Canadian has issued the worlds second coloured circulating coin in support of cancer research. The first one was also produced by the mint in support of war vets. http://www.mint.ca/

Julie said at April 4, 2006 05:42 PM:

More links

Everything is just booming," says Pamela Yelick, a researcher at the Forsyth Institute in Boston who is working on growing teeth.
http://online.wsj.com/public/article/SB114409365846715592-hl8NXojaEZjRms91gxg2vL5Wv7c_20060504.html?mod=tff_main_tff_top


(Dentonin) Phase 2 Study Of AC-100 Meets Goal Of Stimulating New Dentin Formation With Favorable Safety Profile In Novel Dental Application
http://www.medicalnewstoday.com/medicalnews.php?newsid=39329

Joan said at April 5, 2006 08:56 AM:

You note that it's comming. I would like to know when it is comming. I know a lot of people who would benefit from this and other treatments!

Pall said at April 5, 2006 10:40 AM:

Joan, I do wish that I could tell you when it will be coming, and I know that we are all waiting for that breakthrough for our teeth. People who have no problems in this area just do not understand the misery and discomfort of missing teeth, but we do as we live with it everyday. I think of the loss of some of my teeth as a before and after situation, cause before it happended I was a different person. I never had the discomfort, sore gums and feeling of gaps I had before, it was all about comfort, but no discomfort, plus of course the way in which it has affected my chewing ability. It is just a very depressing experience, and one that people no longer want to solve with dentures, bridges and even implants. I do believe that the researchers are now undertsnding the importance of this technology and what it can do for us all. We all have to be patient, but time goes slowly when you are waiting for something. I was talking to my own dentist the other day and asked him about this. He said that it will definetly come, and when I sad it sounds impossible he said that they already can make dentin and enamel and understand how to initiate the shape and size and position of a tooth. They are working towards the goal of complete tooth formation now. Hang on and say positive as it is coming, it's just that we don't know exactly when.

Joan said at April 5, 2006 11:35 AM:

Pall,

You are right.

With regards to Fred he has a point on suffering. We should be thankful that our suffering is not has bad as people with cancer and other illnesses. Yes some of us may have a tooth or so missing, but come to think of it we are not suffering as bad as people with kindey problems, bladder problems, etc.


Fred, I got one of the 25cent multi-colour coins in my change that you noted it looks so cool!

Pall said at April 5, 2006 11:53 AM:

Joan you are also so right. I will tell you one thing that this experience has done for me. In no way can I compare how my mouth feels (although I do hate it) to that of having cancer or some other awful illness, but I can now appreciate what other people must be going through. Until I lost some of my teeth I was a bit dissmissive of other people's problems. Now I am calmer and more tolerant of other people's suffering. Now if anyone says that they feel unwell or have some issue or problem I am more attentive and caring. Although I wait with anticipation the day that I can get my teeth back, and hang on to that hope, this experience has made me better as a person in some ways. In every cloud there really is a silver lining.

yann said at April 6, 2006 04:18 AM:

hi i read in a french newpapers the following thiings :

Good-bye, leadings and crowns! The first cutting of a tooth was carried out with success last month in Texas. Announced by the American ministry of Health, the push of this incisor autogreffée stock was done in three weeks.

December 3, Kate Merryl (41 years) underwent, under general anaesthesia, one clonogenic injection of cells stocks to the site of its old sick incisor. Extracted pulp, the cells stocks were cultivated in vitro in the presence of amélogénine (principal protein of enamel). Today, the American specialists are formal: the incisor, well enracinée, is functional.

Even if one knows, since 1998, to cultivate in nutritive medium of the teeth, the exploit is to make them live into twenty and one days.

Most difficult will have been to connect the root to the nervous systems and blood of the bone mandibulaire. Made thing. As for pushes back, it was accelerated by the addition of stimulants of growth, the cytokines, in injection. To have bright teeth at any age thus becomes possible. Of what to find the smile.
http://www.lexpress.fr/info/societe/dossier/2025/dossier.asp?ida=436409

I search more about this and i didn't found. Is it true ? i don't know...

Julie Woodchuck said at April 6, 2006 02:39 PM:

In the USA they don't call it a ministry they call it a department!
http://search.hhs.gov/search?q=Kate+Merryl+&ie=&site=HHS&output=xml_no_dtd&client=HHS&lr=&proxystylesheet=HHS&oe=&Submit.x=20&Submit.y=1

Nothing on Kate Merryl on the US department of health website as noted by the link

yann said at April 7, 2006 02:16 AM:

i know that there's nothing about kate merryl in us department of health website but this article was published in a serious newspaper ans a report was diffused in tv news
...

Kate said at April 7, 2006 09:21 AM:

Hello Yann,

I am interested in volunteering with your organization for the tooth regeneration. Could you provide more information. Do I need to travel to France for this research or Texas?

Thank you / Merci Boucup

yann said at April 7, 2006 10:00 AM:

there's a mistake, i just said that i read and i saw on tv a report about tooth regeneration

Joanne said at April 7, 2006 12:17 PM:

Will we have to travel to the USA for this treatment?

Fred said at April 7, 2006 12:31 PM:

I know everyone is excited, but as the previous post noted she was just sharing some information that is available.

A treatment will come, it maynot be tomorrow but it will come. Until that time we can share the information that we have!!

Regards,

Martin message to you all said at April 8, 2006 04:48 AM:

As Fred is saying we can all get way TOO excited about just when this is going to become available. As Jodie has already stated we must be patient and share information that we have. I know it is very difficult when we are suffering with missing teeth. I know becuase over the pas two or so years my life has been very hard to deal with due to this discomfort. But just think of this! If we had no hope of any future progress in this area then we would have no choice but to suffer. But there is now hope and we need to be postive and build on this. If I hear any more information I will post it immediately. Take care everybody.

yann said at April 8, 2006 02:14 PM:

exactly, i just share informations. i read in a serious french newpapers and saw on tv news that in texas they suceeded to make regrow a tooth while injecting stem cells. But now, i made a lot of search and i didn't find anyelse about that again. i hope that's true...

alan said at April 19, 2006 06:21 AM:

news ???

John Major said at April 22, 2006 09:48 AM:

Alan,

If you have any news please share them with the rest of us!


It will be several years still before the treatment becomes available.
(And No, I'm not the John Major you are thinking of!)

Pall said at April 22, 2006 03:37 PM:

Alan

I do not think that the regeneration of teeth is too far away in real terms, perhaps a couple more years before it is perfected. The Wellcome Trust in the UK is working with Odontis via grants, etc on 'The Biotooth' and they are now at a point where they have to figure out how to ensure that it would grow in the correct position / occulision. I have contacted Kings College in London where Paul Sharpe is undertaking the work on the biotooth, and they say that they are working hard to make it a reality. I know that the time we wait is an agony (it is for me), but that is what keeps us going, the thought that this breakthrough will come to the market soon. The problem is that 'soon' does not mean next week.

Alan said at April 24, 2006 03:19 AM:

Pall,

How do you know that, i made research on the net and found that they can make enamel and dentin and found this http://www.babelfish.altavista.com/babelfish/trurl_pagecontent?lp=fr_en&trurl=http%3a%2f%2fwww.lexpress.fr%2finfo%2fsociete%2fdossier%2f2025%2fdossier.asp%3fida%3d436408. i think they can make grow new tooth but they don't tell us, for them it just a bussiness no more...

jodie bannister said at April 24, 2006 10:17 AM:

Hiya again to you all...

Wow!... quite a few links for me to check out ..as I have been busy studying other mathematics and science and not checked this forum out for a month or so...

I think that the Kate Merryl tooth was repair of an "existing" damaged(pulp wasdiseased and before she would probaly have it extracted as "too far gone/too diseased") incisor by regenerating "in vivo" pulp cells (the existing pulp was clearly damaged /diseased)...

after growing the replacement pulp cells "in vitro"in the laboratory from the patients own donor stem cells....

(ie "in vivo" that is "inside" human patients actual body ;or eg experimental mice as professor PTSharpe started out doing in the 1990's;"in vivo"therapy/treatment as opposed to "in vitro" ie grown in a laboratory outside the living body and transplanted into the body)and replacing some sections(pulp) of that incisor that were missing(ie diseased pulp).It wasnt an actual whole tooth regrown in the patients body but shows they are working towards that end.

It was combination of "in vitro" cells grown outside the body from the patients donor stem cells..and then tranplanted nicely into the damaged site(after the existing damaged pulp removed)and then the "in vivo" therapy part and combined wiht the body's own healing mechanism the damaged incisor was saved and the patient had basically a new tooth.This I can deduce from the article and previous artciles I read re Mary Macdougall and the Univ.Texas and their work re replacing some parts of the teeth that were damaged(this research predates even 2000 when I first heard of it).

So the French newspaper report is quite accurate.She probably recieved treatment from Professor Mary Macdougall at the University of Texas medical site as I first read of her work(she is on the Dentigenix board as is Pamela Yellick and people from also the University of Michigan etc)on BBC teletext and in New Scientist in August 2000(it even got on the end of the english/united kingdom's ITV news that august 2000 bank holiday!)

With regards to the dentigenix website being down there could be any number of reasons.Even if they ran out of funds the technological advances would be taken over by another company and not "lost".I doubt they are bankrupt or in receivership howvere as they were taken over by a huge austrian based massive(in marker size and capitalisation and its on the stockmarket and has been for many decades I think)multi-national company which already makes other teeth regenerative materials "IVOCLAR" or similar name;2 years ago and that is unlikely to be bust as its decades old and huge.They may have technicla difficulties with their website its not uncommon or revamping it/redesigning it.

It is very encouraging Pamela Yellick's comments in the bladder regrown article posted I think by Julie "everything is blooming..."(ie in the field of cell regeneration generally)as scientists are quite conservative and cautious so as to not raise false hope...and for her to say things are blooming is very very encouraging.She is right but everything takes time.

I'm into other research so haven't for some time...googled or searched using other search engines (I used to regularly as did Paul my brother) for these types of links(we just occasionally see some fresh relevant news in new scientist or on bbc news websites the links to which I posted on this site)so thanks to the more regular contributors and vistors to this site for posting these extra links..most encouraging.

Professor Paul T Sharpe is going as fast as he can and I hope by now has attracted the £3 million($usa$ 5.2 million at rough currency exchange rates applicable) for human clinical trials he needs...and solves the remaining technical problems re:-

siting of teeth(espescially if multiple teeth needed to fill larger gaps)ie to avoid "occlusional"problems,(problems re grinding and not fitting together and "bite").

Hello to Martin(Wedge)if he is reading this(please feel free to email me at new email address:- barbara.cox2@ntlworld.com ).

I do think things will steadily improve.

Will now check out the rest of the links provided by you nice people.

Hope my contribution to this site above is helpful!

Love and Healing to you all;

Jodie xxx

jodie bannister said at April 24, 2006 10:28 AM:

This french newspaper report seems dated from 5th January 2005 and refers to a 21 day waiting period to see if the tooth remains healthy and functional.

So its now April 2005 and in absence of any negative news it looks as if it worked!

With regard to one poster(Julie Woodchuck) not finding any more clarifying data at the department of health in USA can anyone try googling or searching the webpages(as I did 2 years ago in 2003)of the University of Texas;they have tons of stuff I saw in 2003 and 2004 :-

re Mary Macdougall's work in this field so the latest news re this successful application is probaby there not at the USA dept of health site(which mainly covers long-term USA GOVERNMENT funding of teeth regeneration I found;as I say i have not regulraly searched those pages for some time!)

I found it more difficult re finding out if any progress made by the Japanese universities:- "5 universities consortium" referred to in much earlier posts(first heard of those in 2003);led by and funded by HITACHI.Anyone found out any fresh news re that project by any chance?

jodie bannister said at April 24, 2006 10:37 AM:

dentigenix has only 11 employees..but was taken over in 2004 by a large bluechip multinational company(google for further data)so it probably is still going.

I wouldnt worry about its website being "down" or "temporarily unavailiable".

There is no news that is has folded for example.

jodie bannister said at April 24, 2006 10:45 AM:

my email address(new one) for anyone to discuss this subject is:-

barbara.cox2@ntlworld.com

yann said at April 25, 2006 03:01 PM:

hi Jodie,
you seem know a lot about this project. Do you mean that Dr Mary Mcdougall is able to make "grow" or "regrow" a natural "crown" (with enamel and dentin) from the root in ejecting stem cell ? if it's possible, good bye ceramic crowns... ?

i read on the web that the firm acologix is able to make dentin and enamel to replace amalgams fillings and this product will be on the market in 3 years

thanks for answer ;-)

John said at April 28, 2006 11:42 AM:

Is anyone working on a method to replace missing enamel as opposed to the entire tooth? I had alot of my enamel drilled off and would like it replaced some day. Is it more likely they will replace the entire tooth first or parts of the tooth?(enamel,dentin)

ALAN said at April 28, 2006 12:24 PM:

HI john,

read this article http://www.acologix.com/news/2006/031006.html and u got the answer... this product will avaible on the market in 3 years if every thing running well...

Ian said at April 30, 2006 08:52 AM:

Yes, but what about complete teeth? Does anybody have any information on this?

jodie bannister said at May 3, 2006 07:12 AM:

see reply to yann sent by email to him

cc to martin too

sorry for the delay

Judi said at May 3, 2006 10:28 AM:

Greetings everyone.

I just had an appointment with the dentist who wants to send me to the periodontist... possible root planing, 3 more teeth extraction, with no guarantee that this will prevent future bone loss.

I also went to a lecture by Bruce Lipton.. www.brucelipton.com, and he was talking about the influences that impact genetic activity.

I'm in California and would so appreciate being kept informed of new research that is being done on bone/gum regeneration

Thanks,
Judi

Ilona said at May 6, 2006 04:52 AM:

The above post alludes to some website about a spiritual way for regenerating the body. Please, this is a serious discussion and announcement board. We do not need those crazy sites.

Thom said at May 8, 2006 10:51 PM:

I agree with Ilona we are looking for scientific discoveries and most of us have our own beliefs that we use to guide us through this experience. The individuals who post these links are doing it to take advantage of our weakened emotional and physical state. We come to this site to find out about new discoveries in STEM CELL RESEARCH ONLY!!! If someone is in need of spiritual guidance they know how to search the web and do not need to find these ridiculous posts on a dental research message board.

mary said at May 10, 2006 03:00 PM:

when ? that's the real question.
i don't understand why they don't invest more in this project. it could change life of millions people...

Martin said at May 11, 2006 01:26 PM:

Mary, you are so right in what you say. Nobody can know the misery of wha missing teeth are doing to millions of people worldwide, both in the developed and underdeveloped world. It can cause malnutrition and certainly does cause pain, discomfort and a never ending misery for those inflicted with it. I and s many others wish for this breakthrough every day. Whether it is one or many lost teeth, it can all affect the physical and psychological health of that person.

mary said at May 11, 2006 03:14 PM:

martin,
there's a lot of speculations around this project and i don't understand why scientifics don't communate more about this subject. Make grow new tooth, is that more difficult that a bladder or an another organ ?
i just hope that japanese tooth regeneration can be real to 2007

jodie bannister said at May 13, 2006 01:55 PM:

We think that either the japanese are keeping very hush hush as they are very secretive re research in general
OR the initial estimates are now defunct and no longer apply

so the 2007 date won't now apply

all dates are estimates and flexible and subject to alteration in our view either slowed down or speeded up

by way our individual plugging of eg the seekers trust was NOT to exploit any persons "weakened state" but merely pointing out alternative therapies for healing which some people use with success as they use "complementary medicine":-

its "complementary" ie "with" conventional medicine and conventional scientific research

not "instead of"

basically we are of the view that all these new areas of science over the last few decades have been "linear" progress

but are due to go "exponential"

as more and more new patents(esp in nanotechnology)are taken out and filed

However there is some delay in new ideas being implemented and entering clinical practice

The teeth regeneration is at least difficult as the bladder regrowing(which took 15 years by the way from first idea to clinical application and is stil ongoing and being retested and improved)

but the blessing is that experimentally if it goes wrong initially(in initial human teeth regrowing experiments eg if the size of the tooth is wrong or some other technical problem occurrs) then the tooth can be removed and then it tried again

and this is far more difficult for internal organs of greater complexity

like the bladder and the heart and liver

where if they go wrong9the new regrown experimental tissues/organs) they are harder to remove and "try again"

But from a recent new scientist leader article we read there is expected EXPONENTIAL GROWTH(rather than slower linear growth mathematically speaking) in all these related fields of research:-

nanotechnology;cognitive science;biotechnology;information technology ;and how they inter-relate:-

SEE:-new scientist magazine BETTER THAN HUMAN SPECIAL REPORT "WHY SETTLE FOR WHAT YOU WERE BORN WITH?"

13TH MAY 2006 ARTICLE AVAILIABLE ALSO ON THEIR NEW SCIENTIST WEBSITE(WE WILL FIND LINK FOR IT AND POST IT)

plus does anyone know a language translator yann durand could use to translate english webpages into french more easily?

jodie bannister said at May 13, 2006 02:09 PM:

exact link to the article may 13th 2006 article re body parts for humans etc

(you may have to subscribe to new scientist to read all the 4522 words on the web but it is widely availiable on news stands or from news agents too)is:-

http://www.newscientist.com/article/mg19025511.500.html

OR GO TO:-

http://www.newscientist.com/home.ns

or just google:-

www.newscientist.com

new scientist(or google "alerts") is excellent method of keeping up with teeth regeneration and other related stem cell research9es) and carried a major AUGUST 2002(AVILIABLE THROUGH BACK ISSUE ARCHIVE ORDER FROM NEW SCIENTIST MAGAZINE DIRECTLY)

august 2002 major article new scientist 8 page ARTICLE RE TEETH REGENERATION COVERING DENTEGENIX;ODONTIS;MARY MACDOUGALL;PAMELA YELLICK;PROF PAUL T SHARPE and predicting availiability in clinical practice:-

by "2010" or circa date

there is no point in getting all stressed up about it not being availiable now as its a long term thing and needs to be tested fully first etc; patient waiting is the order of the day(if in dentalpain get pain relief for it whilst waiting)

links in the article above also mentioned at end of full article:-

www.technology.gov/reports/2002/NBIC/Part1.pdf

www.demos.co.uk/catalogue/betterhumanscollection

www.bioethics.gov/topics/beyond_index.html

and the CURRENT ISSUE OF "NEW SCIENTIST" IS AVAILIABLE IN THE SHOPS(ENGLISH ONES) THIS WEEK PRICE 32-70 PENCE FROM ALL GOOD NEWSAGENTS

AS THE ARTICLE WAS DATED 13TH MAY 2006(IE TODAY SATURDAY 13TH MAY 2006)

AND LIKE SEEKERS TRUST WE ARE NOT PLUGGING NEW SCIENTIST OUT OF A PERSONAL DESIRE OF ANY KIND!

ISSUE NUMBER 2551

jodie bannister said at May 13, 2006 02:27 PM:

we did briefly visit the bruce lipton site as plugged on the above post

but find nothing offensive in any way in its contents

it's merely a different approach(like the seekers trust charity established 1925 and a genuine charity)

so we 2 personally don't find its inclusion on this thread a problem!

new scientist magazine is more helpful re the science of this field and related fields however

and other journals such as the international dental research association journal(s)

(google to locate these various publications for in depth technical data)

professor paul t sharpe sent us a few of his openly published papers in 1998 when we first wrote to him at guy's hosp. after seing new scientist article re his BMP in mice teeth regrowing work in 1998:-

re "bone morphogenetic proteins"(BMPs)

and "signalling proteins"

and its worth reading a few of these detailed papers

to grasp the actually hard complexities and technical problems faced by teeth regeneration researchers;

(since the 1980's when they first considered the idea and tried it in dogs a sthe japanese did too;our dentist told Paul in 2002)

and "why its taking so long"

that is quite apart from the seperate "funding" problems

though as soon as professor paul t sharpe gets his £3 million he will start the aforesaid planned for 2006(may well be delayed) human clinical trials

ie the extra £3 million needed for 3 year human clinical trials

(originally planned from 2006 to 2009 so the treatment would only be availiable from 2010 ;2007 is way way way too soon and unrealistic it may even be later thna 2010 if funding eg delayed)

from wellcome trust or business investors or the ones that funded him in MAY 2004;

(WHICH STARTED THIS THREAD SEE ORIGINAL STORY AT TOP OF COMMENTS RE £500000 MAY 2004 TWO YEAR GRANT TO ODONTIS AND PROF PAUL T SHARPE WHO SHOULD NOT IN ANY WAY BE RUSHED OR HASSLE DIN OUR HUMBLE OPINION AS SCIENTISTS LIKE TO TAKE THEIR TIME)

with the initial £500,000 "PROOF OF CONCEPT" FUNDING;MAY 2004;

(IE TO PROVE IT COULD BE DONE IN MICE FULLY AND THEN PROBABLY IN HUMANS)

(IE FROM 2006 WHEN HE FIRTS PLANNED TO START HUMAN CLINICAL TRIALS IN UK WHICH MAY WELL BE DELAYED UNTIL 2007 OR 2008 FOR ALL WE KNOW!)

by the way when we first wrote to prof. p. t. sharpe in 1998 he didn't reckon the treatment would be availiable until 2020 to 2050

so as he and others are now talking about 2010 to 2020

surely that is an "exponential" increase

in rate of advance

as opposed to a more slower linear rate of progress resulting in 2020 to 2050?

so there is no real cause for complaint vs these scientists!They have speeded up their research since 1998 when we were told 2020 to 2050!

We dont think you realize how slow progress can be but on a scale of centuries or decades

its in fact speeding up all the time

and nearer to exponential "take off" every day!

yours paul and jodie bannister


jodie bannister said at May 13, 2006 02:38 PM:

NEW SCIENTIST IS:-

£2-70 PENCE

SALE PRICE AT NEWSAGENT

WE MIS-TYPED!

AVAILIABLE VIA INTERNET SUBSCRIPTION:-

www.newscientist.com

OR IN ANY UK ENGLISH NEWSAGENT

ITS VERY GOOD RE ARTICLES RE TEETH REGENERATION

AND OTHER RELATED AREAS OF SCIENCE

they predicted by 2010 teeth replacement would be clinically availiable

in an august 2002 issue

which covered 3 different methods by 3 different research teams in uk and usa

and predicted professor paul t. sharpe's was "the most likely to succeed and the soonest"

mary said at May 14, 2006 01:43 PM:

JOdie,
do you mean that Pr Sharpe is already to start humans trials and he "just" need found the 3 millions $ ? do you know if he already tested a human trial?

thanks

Martin said at May 15, 2006 10:35 AM:

Mary, I do not know if Mr Sharpe is yet ready for testing in humans. What I can tell you is that I sent an email to odontis.co.uk and had a reply saying that they are working hard to make the biotooth a reality. If you would like to correspond with me let me have your email and I will contact you.

paul and jodie bannister(and barbara cox too) said at May 19, 2006 09:23 AM:

basically we stopped contacting professor paul t sharpe "directly" in 1998 as he was inundated "then"(and MAY 2004 NEXT MAJPOR PRESS COVERAGE WORLDWIDE0 with worldwide interest and we got the impression that too much time was being taken up by his team and associates at kings college(and valereie joliife of javelin venture capital fund see odontis website) replying to all the deluge of mail(understandable but it consumes time better spent on research)BUT of course we have noted that eg "thom" and "martin" have since emailed prof paul t sharpe and got replies.There is not much they can reply except to say as Martin says they are working very hard to make it a reality.We got the impression that they are waiting for extra £3 million(from an emailed interview done over email dated 24th december 2005 ie last dec 2005 that prof p t sharpe did with someone;I think the link for it exists in above postings as it was posted by someone on this board and then we saw it)(it was done with a usa internet magazine hence the other figure quoted $5,200,000 dollars equivalent)from "wellcome trust"and "NESTA"(ie the 2 organisations who mainly funded the initial "PROOF OF CONCEPT"FUNDING OF £500,000 in May 2004)and "others"(business "angels" or investors)(and other research funding trusts like wellcome)

NESTA= UK GOVT AGENCY9SEE WEB SEARCH VIA GOOGLE OR YAHOO OR OTHER SEARCH ENGINE)

(its a pity someone doesn't email or write to the foundation (charitable which funds science projects and medical developments esp for the third world)bill gates or some other philanthropists/charitable funds to fund this research because we read in New Scientist he has just given $24.6 million to a biotech comapnay to synthesize the main anti malarial drug "artemesis" as he hot on ending malaria as is his wife through the Bill and Malandra Gates Foundation!)

so basically we got the impression from a MAY 2004 TELEVISION INTERVIEW DONE IN THE BBC TV PROGRAMME "CITY HOSPITAL"(IE GUYS HOSPITAL AND KINGS COLLEGE WHERE THEY FILM IT)

WHICH IS ON DAILY WEEKDAYS MONDAY TO FRIDAY BBC TELEVISION ONE UK TV STATION (ITS ON AT THE MOMENT)(SE TV LISTINGS OR RADIO TIMES MAGAZINE)

THAT "HUMAN CLINICAL TRIALS WOULD START AFTER TWO YEARS IE CIRCA MAY 2006 OR THE REGION THEREOF"

"IF THE REMAINING TWO YEARS OF ANIMAL IE MICE TRIALS SUCCEEDED RE GETTING EXACT TEETH TO GROW WHERE THEY WANTED ETC AND OVERCOMING TECHNICAL AND OCCLUSIONAL PROBLEMSIN MICE FIRST BEFORE TESTING ON HUMANS WHICH THEY ALSO NEED TO GET OF COURSE FULL REGULATORY PERMISSION FROM BRITISH AUTHORITIES BEFORE STARTING TOO AS WELL AS THE EXTRA £3 MILLION FUNDING"

however we re-read last week the preamble to this thread(ie the original posting of the may 2004 news by we think randall parker?see above before the 274 plus postings start) which says in fact 2007 as the date so maybe the animal trials last 3 years not two and maybe the human clinical trials which would last at least three years are scheduled to begin 2007 not 2006

the emailed interview he(prof paul t sharpe) did 24th dec 2005 with the usa online magazine said they had made much progress(ie so wellcome are talink re the biotooth in positive terms as martin says)

and had a few technical problems to overcome

and needed £3 million extra funds from eg wellcome trust

(can people reading this who have more time than we do email wellcome trust to ask them /lobby them to provide the extra £3 million as the £500,000 sum they and "NESTA" govt uk agency was INITIAL "proof of concept" funding which was to prove that teeth could be fully regrown in mice ie the most similar mammal to humans etc "first")

(we would but are no longer as PROACTIVE/CAMPAIGNING RE THIS MATTER AS WE HAVE DEVELOPED PATIENCE AND ARE JUST OK WITH LETTING THINGS HAPPEN BUT WE GET THE IMPRESSION SOME OTHERS WOULD LIKE TO HAVE MORE DATA FROM SAY PROF PT SHARPE AND ESP WELLCOME RE THE FUNDING SO IT IS UP TO THESE PEOPLE TO EMAIL POLITIELY WELLCOME AND ENQUIRE AS TO THE FUNDING AND CONTINUED SUPPORT FOR ODONTIS AND PROF PT SHARPE;UNFORTUNATLY we are into heavy mathematical research which is time consuming;plus the linkings with angels of course!;so we didn't keep on writing after 1998 contact direct to prof paul t sharpe but we did email(feb 2003) VALERIE JOLIFFE OF JAVELIN VENTURE CAPITAL FUND WHICH ORGANISES PRIVATE INVESTMENT IN THE CITY FOR ODONTIS and she said cagely;in circa feb 2003 that "finance details were company confidential" but any new developments would as in may 2004 be given to press but even them she complained that every time they did do/were covered by the media although they welcomed the interest from investors they got "zillions" of emails and letters from all over the world ie inundated so when may 2004 announcement came round we didnt feel like adding to the deluge!however martin and thom have emailed the company and got replies since;its better to email them when things are quieter not eg just after a major press announcement/coverage like may 2004 or after the 1998 new scientist article as we get the impression it delays their research and annoys them quite a bit!)

EVEN in the tv interview prof sharpe did with 1 of the 2city hospital2 team he said they kept getting inundated

and "there was no need to write in anf offer to be human patient/volunteer as he had 1000 names already and "

"when we are ready every one will know about it as we willannounce it to the press"

ie much same thing as appears at bottom of the odontis webpages!

so it will happen when all the factors of the equation are in place:-

full funding

regulatory permission

all technical obstacles completed in mice/similar mammal trials they are doing since 2004(this lot funded by £500000)

and the stuff they did 1998 to 2004

and the pre 1998 work going back to the 1980s at least

hope this answers some of your qs mary(and martin and others on this board)

most pro-active thing for people to do would be to:-

email wellcome trust and NESTA to see if future funding will be allocated (ie the £3 million minimum) to odontis and prof paul t sharpe

(you could mention this thread and people are curious but cant seem to get much data at the moment)

email /write to any charitable foundations (like the wellcome trust and billgates foundation there are many of these)

to see if they will fund this type of teeth research

or "have any plans to do so"

we dont have the time to do so as researching ourselves

but if anyone reading this thread does then this is an idea to explore

yours with healing

paul and jodie bannister


paul and jodie bannister(and barbara cox too) said at May 19, 2006 09:25 AM:

any delays to replying to queries = as we are busy re our own research sorry in advance!

Julie Woodfeld said at May 19, 2006 04:03 PM:

It seems the research is being done in the UK, and England will this be available in other countries? When will this be available in the USA?

Martin McBride said at May 20, 2006 03:02 PM:

Were is this treatment available in the USA? I heard the research group in Boston has come a long way.

John Major said at May 21, 2006 08:43 AM:

Martin,

I think the treatment will be offered in the USA first as it is considered the richest country in the world. AFTER the intial few years I can see the treatment expanded to other countries at a lower cost.

Note, DNA and Stem cell research is more complex than making faster computers.

Alfred McBride said at May 23, 2006 07:04 PM:

Will this only be available in the USA? How much will it cost? When will it be available?

paul and jodie bannister(and barbara cox too) said at June 3, 2006 12:55 PM:

new data just found re:-

"BIO-MEMETIC" MATERIALS TO BE USED TO REGROW TEETH

LINK:-

http://seattle.bizjournals.com/seattle/stories/2006/05/22/focus3.html

this is a story from 19th May 2006 so relatively recent development

it refers to a new company being set up to exploit the discovery re ensymes ;this summer; to expolit the application for dental uses(and about other 24 uses)

sounds like a major breakthrough

paul and jodie bannister(and barbara cox too) said at June 3, 2006 01:03 PM:

yes would agree with john major re more difficult than faster computers

so the recent new scientist article we referred to was simplistic re presenting a graph showing exponential growth in computers speeds BUT the computers diagram was used solely as an "example"(re an existing embedded well established technology ie computer chip speeds)analogy to show what exponential growth would look like when theyd cracked the major technical problems...

maybe the above story re BIOMEMETICS is part of that process(the initial cracking of the starting components of the new technologies)

until we reach a "singularity point"

by the way we discovered a print out we did of the december 24th 2005 web article interview(email interview conducted by email across the Atlantic with a usa website)

a usa dental website did with Professor Paul T Sharpe re the $usa 5.2 million funding he will need etc...

and if you want we can (re)post the link here(we will do later in another post)

for anyone who hasn't seen it yet

paul and jodie bannister(and barbara cox too) said at June 3, 2006 01:53 PM:

the 24th december 2005 email interview with:-

professor paul t sharpe

done by JIM RITTER HEALTH REPORTER SUNTIMES (www.suntimes.com)

is in full at this link:-

http://osseonews.blogs.com/osseodaily/2005/12/search_on_for_w.html

on the osseonews.blogs.com

site

which covers dental implants etc

and the time scale referred to by Prof PT Sharpe is "clinical human testing will START WITHIN THE NEXT THREE YEARS "

SO IT ISNT DEFINITLY 2006 THAT THE HUMAN TRIALS WILL START IT COULD BE 2007 2008 so be prepared for any delays

it refers to a dental researcher at the university of illinois we havent heard of before:-

TOM DIEKWISCH

SO

perhaps JOHN MAJOR IS QUITE 100% CORRECT in his post above RE:- the usa BEIN FIRST:-

THE USA RIVALS have seen progress by eg professor paul t sharpe(and others abroad to the usa) and are faster (and wealthier as a nation and a bit less wasteful than the uk is with its funds witness the sheer financial waste in the uk national health service/nhs and the deficits nhs trusts have run up eg)

to fund research than the uk is

eg which is why professor pt sharpe is "still waiting"(inexplicably to me as one would think uk would want to fund this type of research to the maximum!!!)

for the 5.2 million usa dollars referred to in this article

and hence the "immediate usa govt departments enthusiastic in contrast to slower uk authorities"

usa govt.(national institute of health:- an excellent body esp. re:- funding long-term research esp re dental advances)(as amercians care most re their teeth compared to the british!)

and venture capitalist/entrepreneurial funding availiable for the "proposed molecular biomemetics dental applications and other medical applications company referred to in our earlier post today

so it may well be availiable in usa first if uk govt agencies and wellcome trust don't fund prof p.t. sharpe quickly enough

ALSO another web detailed 2 page article we have seen we printed out from:-

OCTOBER 25TH 2005

FROM "THE DECCAN HERALD SCIENCE AND TECHNOLOGY PAGES"

GROWING NEW TEETH IN ADULTS IN THE PATIENTS JAWS

LINK:-

http://www.deccanherald.com/deccanherald/oct252005/snt16364120051023.asp

covers the few remaining technical problems/hurdles to over-come

inc. "problems of the initial stimuli for root development and tooth eruption"

and "how fast do bioengineered teeth grow?" and a few others....SO

it remains to be seen if usa or uk will succeed first but they all use different methods

but usa seems better funded and organised than the uk does

so may well beat the uk to this dental breakthorugh and associated applications thereof

BY WAY TO CLARIFY TO EVERYONE WE ARE NOT BIASED TO THE UK TEAMS:-

BUT WE THOUGHT THAT THEY WERE AHEAD..THEY MAY NOT IN FACT BE..OR EVEN IF THEY ARE..ARE UNDERFUNDED COMPARED TO USA UNIVERSITIES EFFORTS....

sometimes we feel it's a shame the uk isnt 51st state or 52nd state of the usa!!!

Shahana said at June 5, 2006 07:22 PM:

Hi Guys..

My honest opinion about tooth-regeneration is that it is still at research stage & lot of work is to be done before public could benefit from it. We will be lucky if it is available in the next 20 years.

So, please, if you guys have problem, please do seek alternate help, like cosmetic dentistry.

God bless us all,

Shahana

a said at June 7, 2006 10:24 AM:

Australian research breakthrough in growing human organs

Wed Jun 7, 1:41 AM ET

Australian researchers have grown beating heart tissue in the laboratory in a world-first breakthrough that could lead to the creation of entire human organs.

The team of Australian scientists and surgeons said their work aimed to grow organs, including parts of the heart, using patients' own stem cells to avoid the problems of immune system rejection of transplanted organs.

Until now, scientists have only been able to create two-dimensional tissues like skin in the laboratory.

But Wayne Morrison, the lead researcher, said his team had been able to grow three-dimensional tissue that will one day lead to the creation of organs.

"The capacity to create organs has huge ramifications for the thousands of people worldwide whose survival depends on transplants, especially heart patients," he told reporters in Melbourne.

"This tissue engineering breakthrough will bring new hope, confidence, identity and dignity into the future for millions of people of Australia and the world," he said.

Morrison said the work involves using microsurgery to implant a blood vessel in a specially-designed chamber into which stem cells are then inserted and grown into various tissue types.

Researchers from the Bernard O'Brien Institute of Microsurgery at Melbourne's St Vincent hospital and the University of Melbourne's surgery department have used the technique to successfully grow breast tissue, fat, muscles and pancreas tissue that secretes insulin, he said.

Morrison showed reporters a video of beating heart tissue grown by his team.

"The heart cells are actually beating at their own rhythm," he said.

Thom said at June 11, 2006 10:15 PM:

Shahana,

Why do you feel it will be 20 yrs from now for regrowing teeth? I thought you were pretty optimistic in the past, what changed your mind?

Thanks,
Thom

André said at June 12, 2006 04:18 PM:

Thom,

It depends on the funding level that these groups get. Many do not see this as a big issue thus there is not much investment

Pall said at June 13, 2006 10:20 AM:

Andre, I am sorry but you are incorrect when you say that there is little interest in this subkect, and I wonder how you come to this conclusion. Firstly, it is well recognized that in the area of stem cell reseach tooth regeneration is seen as a big thing and a template for future breakthroughs. This is because of the location of tooth as an 'ecternal' organ. Secondly, you should not state that this is mot seen as a big issue. The world over people suffer malnutrition, discomfort and long term problems due to tooth loss. Please do not underestimate the importance of this problem. And twenty years? I do not think so. All the information points to much earlier than that.

shahana said at June 13, 2006 02:35 PM:

Thom...

There hasn`t been any clinical trials in human so far for this research. Without the result of such trial in human (which takes 2-3years to observe the result), our expections are set too high. Then there are genetic factors to consider, eg; the size & shape of the teeth, intra-cellular signalling .. whether it works well for all the sample? It`s still out on the air. Though, there is nothing more I want than this discovery to revolutionize the field of dentistry & make us all feel worth-living.

I don`t believe "money or fund" is the "ONLY" problem behind Dr. Sharpe`s research. If his test results were successful for the majority, then there are a lot of investors, venture capitalists & the university itself could fund the amount quoted. This kind of breakthrough doesn`t wait for money in this day of age.

But, yet again, it is my assumption & research associated with human is a very slow process. So all in all considered, I feel it may be sometime before tooth could be grown via stem cells proliferation.

Though, I believe in Lord & his miracle.

regards,

Shahana

André said at June 14, 2006 07:46 PM:

But you must understand that dentists will make more if cavity vacines and other treatments such as regrowth are not available. If such treatments were not available they will make a lot more. As such they lobby their association

Susan McDermid said at June 17, 2006 11:14 AM:

Shahana, is right this procedure may never be available. And if it is it will be a very long time before it becomes available. I would say between 20-30 years!

Shahana said at June 17, 2006 03:22 PM:

Susan,

As we say in law & order "Innocent until proven guilty". It is the same ethos here in medical discovery too. Until something has been discovered, we can`t predict a certain answer. However, in clinical science "rats & pigs" are two mammals used to experiment all medical treatments & drugs/medicine. Since the results so far was successful in rats, it is more likely to work in human. We have to wait & see if it will be perfect test & positive outcome in human now.

But, I suggest we should be optimistic, NEVER say NEVER. Time-scale 20-30 is more optimal to say than 5-10 years at this stage.

Shahana


Susan McDermid said at June 17, 2006 07:30 PM:

In terms of DNA how close is a rat to a person?

pall said at June 18, 2006 09:42 AM:

I have to disagree with the above posts. I think that you are being way too pessimistic about this. All information coming from the journals in relation to this matter are more positive than this. For example, odontis researchers state that the main challenge is how to get a tooth to grow in the correct position / occlusion. Look at the following for more information.

http://www.wellcome.ac.uk/doc_WTX028677.html

Marianne said at June 20, 2006 03:12 AM:

Hi there,

Yes, I have noticed the posts have been steadily getting more negative. Why can't we post about what postive progress has been made in this field, instead of wondering in the far distant future when this is going to occur?

The facts are, scientists have worked out how to grow teeth sucessfully in rats, (wonderful news!!) they are just working out minor details (a stumbling block). Any updates on their journey would be welcomed.

Regards

Marianne

Martin said at June 20, 2006 10:41 AM:

Marianne

I agree with everything that you have said. We do indeed know that significant strides have been made in this area. Remember that this problem is not an insignificant issue that no body is interested in, that is a silly thing for people to say. Tooth loss and its associated problems such as bone loss, etc are big issues for all of those who are suffering. We should now remain positive that this breakthrough will come. Paul Sharpe has said that tooth regeneration will overcome the issues associated even with implant teeth suc as a a lack of bone. And nothing but mothing feels like a real tooth and nothing can. I can't wait for this development, and I along with others must remain positive.

shahana said at June 21, 2006 02:35 PM:

Guys,

I am really tired of waiting for this discovery to breath-throw. I know it will happen & I really wish that Dr. Sharpe or whomever are working on this project will hurry up with the human trials. You see without that we are betting on horses!

I feel I am in more pain than anyone I know due to one dentist`s mistake. So, yape I too should be more optimistic & hope that we hear good news sooner than later.

Shahana

André said at June 21, 2006 06:34 PM:

Hi Shahana,

I'm sure that they most may try with procedure with other animals (more complex) before testing on humans. I'm sure the various governments will not approve such tests unless the risk factor can be reduced.

Pall said at June 22, 2006 02:36 PM:

Shahana, I know from your previous posts on this board that you are evidently living in a very difficult situation. I know that I too am suffering the heartbreak of missing teeth and it troubles me everyday of my life. I am confident that this will become a reality and hope that it brings you comfort knowing that people are thinking of you too. This message board is a good place to get that support. Take care.

Aman said at June 24, 2006 05:03 PM:

Sahana....

I read ur discussion wid the others.... can u email pf sharpe and ask them ...if this treatment is avialable then for which type of patient ..like if one has bridge and caps treatment alreay or an implant...the Q. is can our previous treatment can be replaced wid this new....I mean can they remove our previous treatment like bridges and implants and then they inject or find stem cells and ........regrow a natural tooth....................

Aman

Aman said at June 25, 2006 04:37 AM:

Aman

I am sure that they are not at the point at which this treatment is yet available. Yet interest in it is growing all the time. Let's hope soon we will all know when our old treatments can be replaced.

Shahana said at June 25, 2006 06:15 AM:

Hi Aman,

According to all the publications, it does state that they will be able to regrow a tooth to it`s perfect "size & order" .. in the place of a missing tooth or broken/damaged tooth & in the place of bridge, caps & veneers.

Best,

Shahana

J. R. Saha said at June 25, 2006 08:37 AM:

Qualquer um tem as ligações aos artigos atuais de maio ou de junho deste ano?

André said at June 27, 2006 07:11 PM:

Este forum deve fornecê-lo com a alguma da informação a mais lastest. Mantenha na mente que não toda a informação da pesquisa está feita a público. Shahana você tem anymore a informação?

This forum should provide you with some of the lastest information. Keep in mind that not all research information is made public. Shahana do you have anymore information?

Pall said at June 30, 2006 02:40 PM:

This is excellent news and just illustrates what Jodie has said on earlier posts. There are a number of initiatives going on and not all discuss it openly until they are ready to announce any breakthrough. Make no mistake, this is just the begining, total tooth regeneration will be next, I am sure.

Thom said at June 30, 2006 03:04 PM:

Shahana,

The information in those links is truly amazing, if what they say they can do is true. I am stunned and do not now what to think about that procedure. What will the stem cell research guys like Dr. Sharpe and all the others think. What do you think about this new process?

Best regards,
Thom

shahana said at June 30, 2006 03:42 PM:

Hi Thom,

I am excited, though only last night I discovered this particular news. If you consider from the stand-point of "Lasik surgery" to reverse the eye-sight for better vision, then ultra-sound also could stimulate the dental regeneration.

The factor we are speaking here is of "neural signalling, the veins, muscles and blood-flow". Dr. Sharpe & other`s involved in stem-cell research also trying to stimulate/signal genetic factors using patients own tissues. So both methods are aiming for same goal.

Now we all are aware of the fact how equipments made of electrical devices (Scans, X-rays, Ultra-sound, Laser) changed human life - both in health & technology. There is something nowadays called Bio-informatics (biology & technology combined) very hot in the health research area. All major pharmaceutical companies are trying to advance using Bio-informatics method.

I currently work in eBusiness & technology. The power of technology is immeasurable. So I am going to hope & pray that this technology is going to become true, real & forever...

I see the rainbow ...

best wishes..

Shahana


Pall said at June 30, 2006 05:13 PM:

Thom and Shahana, this news was on the front page of the papers in London today, that is how important this is. I have seen many negative comments on this board over reecent weeks, but we must always remain positive. The thing is that we have been so conditioned to view medicine in certain terms that the possibility of such things as tooth regeneration seem impossible and a fantasy. As I have said before, this issue IS a big deal for millions suffering. The chance of real live tooth regeneration would be a fantastic move that would improve the lives of almost all people. I would not know what Paul Sharpe would think, but him and the other American researchers are working hard on the stem cell 'biotooth'. The Wellcome trust are funding research in this area and they must be optimistic about this.

Please remember that this is just the start, this new breakthrough cannot regenerate enammel or roots, but that will come. But it can repair damaged roots, etc. Paul Sharpe has already done those things and information from the Welcome Trust notes that the stumbling block is how to get the tooth to grow into correct occlusion.

Praise be that myself and all of us waiting for this may benefit. Dental implants and dentures? Goodbye and good riddance to them.

Thom said at June 30, 2006 08:12 PM:

Pall,

I think this is great news. If you come across any other info forward it on to us. Do you live in London? I live in Los Angeles if you need me to look something up let me know. I would move to Canada tomorrow if this treatment works and I am sure others will be positive that a cure is on its way.

Thank you,
Thom

vic said at July 1, 2006 08:05 AM:

Hi Shahana

I would like to ask you a question...

I have 3 top front teeth missing and now using a partial denture. I take them off at night when i go to sleep,
however, i notice that when i wear them back the next morning... it feels a bit tight, after a while of about 10
minutes, then it seems ok.

Do you know the reason of this? and how can this situation be improved?

Thanks in advance.
vic

shahana said at July 1, 2006 08:22 AM:

Hey Vic...

OK.. You have a very classic case here. Teeth and bones moves and shifts around ... more so when they have room to move, which you might already know. When you take off the partial denture at night on either side of your teeth trying to close inwards. However, your gums are keeping them in place.

I am not sure about your age category & condition of the teeth. Did you consider implants? I believe there has been much advance in implant technology recently.. it takes shorter time (6 weeks to 3 months). Implants are permanent like your own teeth, you don`t have to take them off at night.

But, do see a good dentist. Keep your remaining teeth clean & maintain hygeine. Let me know if I could help further.

Best,

Shahana

vic said at July 1, 2006 09:51 AM:

Shanaha

Thanks for your fast response to my question.... so you mean my condition of feeling tight when i put the partial
on in the morning is a normal case right? Nothing can be done about it? Like what you said...**However, your
gums are keeping them in place. ** since gums keeping them in place...then why teeth and bones still shift ??


FYI : i am 38 years old and had a bridge put in but then after having the bridge for 10 years, i recently felt
uncomfortable and the only thing that could be done was to take the bridge off... i did ask my dentist about
dental implants, however, he says i might most probably need bone grafting (is this wording correct??, i'm not
that sure) and the whole process including the bone thing will take 1.5 years... wow, this is pretty long... and
the cost of implants is expensive.. i am looking forward to the regrowth of natural teeth and hopes this will
be fast...

I recently seem to notice something... while wearing my denture, when i open my mouth up (not widely up,
just slightly), i feel normal. however when i am not wearing the partial and opening my mouth slightly up,
i feel like got pressure in my gums -- where the front teeth is missing and the 2 teeth next to the gap..
i asked my dentist about this.. he says this is the pressure from the upper lips... i thought about it and
thinks he means like cause i have 3 front teeth missing , thus my lips will somewhat be abit flatten when no
denture is in place.. and so when i open my mouth , my upper lips will have to be pulled up a bit, thus
having this feeling... is this correct? Do correct me if i am wrong....

I did experiement by trying to hold my upper lips up a bit while opening my mouth slightly up (of course without
denture in) and it seems like i don't have the pressure feeling thing...


Once again, thanks for your help ...greatly appreciated..

shahana said at July 2, 2006 06:03 AM:

Vic,

When we build a house there needs to be strong foundation to support all the building & the roof above. Tooth is considered to be the supporting foundation for our face & head/neck. Now, the pressure you feel is because lack of teeth has changed the shape of your mouth inside & your tongue is hitting the the upper-jaw/gumline.

As I said before teeth moves (very slightly). Teeth are fragile, it is part of our body which affects other parts. Teeth are used constantly & wearing out. You should talk to elderly people who has lost teeth, you will learn so much.

Yes bone-grafting is correct - when there are not enough supporting bone on your upper or lower jaw, then artificial bone used for bone-grafting. For example if someone has a small nose & wants to have plastic surgery done to make it big - plastic surgeons will bond/add artifial bone.

God bless,

Shahana


Pall said at July 2, 2006 09:14 AM:

Yes, agreed but remember that with tooth regeneration new bone will grow around it, saving worry about bone graft.

vic said at July 2, 2006 09:20 PM:

Hi Shahana and Pall

Thanks for your detailed information..i have a much better understanding now....

Well, so at the meantime, with my partial denture, i guess i just have to accept
the fact that it will be a bit tight in the morning...

Honestly, i am really looking forward to the tooth regeneration as like what Pall
said, new bones will grow about it and no need to worry about the bone graft thing
and the whole period is just about 2 months (from an article i read).

But like in all your previous posts, there seems to be no latest/further news about
this tooth regeneration thing... don't know how long we still got to wait... and not trying
to be pessimistic or what.. but by thinking even if it is out in UK or US, it's still
going to take some years to come into my country

Let's pray and hope we can hear good news soon

Once again, thanks
vic

Shuun said at July 3, 2006 07:38 PM:

Hi everyone, below is a link to a recent article bout a new ultrasound device that might help regrow teeth. It is very positive and gives a timeline of two years for commercial availability. Hope it comes true.

http://www.eurekalert.org/pub_releases/2006-06/uoa-umh062806.php

André said at July 5, 2006 06:56 PM:

Hi Everyone, I just noticed that a new thread has been created as Shunn noted above. I suggest that we move the discussion to the new thread.

http://www.futurepundit.com/archives/003556.html

Best regards,

thom said at July 6, 2006 09:58 PM:

Shahana,

Do you think this new treatment will regrow teeth and what if you have teeth with a veneer?

Thank you,
Thom

shahana said at July 7, 2006 06:23 AM:

Hi Thom,

I am not sure honey, I read some articles and so far it talks about growing tooth structure but not the enamel but there are some articles indicates that they will be able to grow the whole tooth.

We need some more information, I have emails of the professor`s working in this project, I hope to contact them or their offices.

You know I have veneers on my two upper-teeth (the ones my x-dentist ruined) & I also am interested to know.

Best,

Shahana

Julie Woodchuck said at July 7, 2006 08:43 PM:

Hi Everyone,

Are we still posting to this thread or the new one based on the new research noted by Andre?
http://www.futurepundit.com/archives/003556.html

The current thread has been going on for years. I think we should move our discussion to this thread group

thom said at July 8, 2006 03:40 PM:

Julie and Andre,

There is one response in the section you two are talking about. Let's just keep everyone here because we are all looking to regrow missing and/or damaged teeth. Shahana provided the new info about the research the Canadian doctors are working on and hopefully new information on this process will come out.

Best regards,
Thom

Pall said at July 9, 2006 02:36 PM:

I agree with Thom. This board is the best place to stay. All new information can be fed and linked via this website easilly. In many ways I have personaly felt very supported by knowing that I am not the only one who feels the way the do about their situation. I want to thank everybody for their stories which have given me support and hope. I will continue looking regularly and also post anything I find. Jodie, Thom, Shahana and all thank you for sharing your stories and here's to keeping positive that this is coming....

pall said at July 12, 2006 01:54 PM:

Here is a link to a interesting article...

http://www.fightaging.org/archives/000892.php

Jaime said at July 12, 2006 03:08 PM:

Hello from spain. My name is Jaime and I'm 29 years old. I understand those are like me and I'd like to share experience or advicese about it. I think we have to pass through long time 'til this comming already true.
I put my email for whom want to add me and talk. I just say my english could be sometimes not good engouh.
jim_janer@hotmail.com

Randall Parker said at July 12, 2006 05:34 PM:

Actually, I wish you would take the discussion to the newer post. The MovableType commenting software isn't structured for hundreds of comments on a single blog post. I made the new post in part to give you all a more empty thread in which to make new comments.

Patricia said at July 15, 2006 02:57 PM:

Pall,
I agree with you and Thom about staying at this location because no body is at Randall's location. You seem very professional and are providing the most recent information. I have damaged teeth in my mouth and I would love to be able to have them regrown. I have the money to afford this process, if you know of anyone looking for a candidate please let me know.

All the best,
Patricia

Patricia said at July 15, 2006 03:07 PM:

Shahana,

I forgot to mention you earlier about the research and information you are providing...AMAZING!!! Thank you so much for being so helpful. I will continue to research the information you provide. Thank you so much!

All the best,
Patricia

Randall Parker said at July 15, 2006 05:23 PM:

This is the 330th and final comment on this thread. MovableType is not designed for this so I'm turning off commenting. You can the take the conversation to newer post.

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