October 24, 2004
Obesity Being Selected For In Modern Society?

Here is more evidence that Darwinian natural selection has not stopped operating on humanity as a result of medical advances and rising living standards. Lee Ellis of Minot State University in North Dakota and his student Dan Haman have just published a research paper providing evidence that natural selection is currently selecting for fatter people.

This study sought to determine if genetic factors might be contributing to the increases in the proportions of North Americans who are obese and overweight. The body mass index (BMI) for a large sample of two generations of United States and Canadian subjects was correlated with family fertility indicators. Small but highly significant positive correlations were found between the BMIs of family members and their reproduction rates, especially in the case of women. For instance, mothers in the sample (most of whom were born in the 1940s and 50s) who were in the normal or below normal range had an average of 4·3 siblings and 3·2 children, compared with 4·8 siblings and 3·5 children for mothers who were overweight or obese. When combined with evidence from twin and adoption studies indicating that genes make substantial contributions to obesity, this study suggests that recent increases in obesity are partially the result of overweight and obese women having more children than is true for average and underweight women.

Ellis and Haman speculate that medical advances are allowing obese and diabetic women to live longer to have more children. But that does not explain why overweight women would have more children than skinny women.

So what is going on here? There are a number of possibilities.

One possibility is that one or more of the many hormones being released by fat cells are altering the brain to make women (or their spouses) either more eager or able to have children (possibly by causing them to enter puberty at an earlier stage) or more eager to find a mate or to engage in other behavior that increases reproduction. The hormones from fat cells might even be increasing fertility.

The scientific view of fat cells has changed a lot in recent years and fat cells are now seen as exerting many influences on the rest of the body. There are plenty of hormones being released by adipose fat tissue into the bloodstream. (same article here and here and here)

“When we look at fat tissue now, we see it’s not just a passive depot of fat,” says Dr. Rudolph Leibel of Columbia University. “It’s an active manufacturer of signals to other parts of the body.”

The first real inkling that fat is more than just inert blubber was the discovery 10 years ago of the substance leptin. Scientists were amazed to find that this static-looking flesh helps maintain itself by producing a chemical that regulates appetite.

Roughly 25 different signaling compounds — with names like resistin and adiponectin — are now known to be made by fat cells, Leibel estimates, and many more undoubtedly will be found.

Another possibility is that the obesity is a side effect of a higher fat diet that also boosts hormones and thereby makes girls more fertile or eager to have sex or to have children. This is plausible because a higher fat diet in adolescence raises sex hormones and causes other endocrine changes.

Joanne F. Dorgan, Ph.D., of the Fox Chase Cancer Center in Philadelphia, and her colleagues conducted a study ancillary to the Dietary Intervention Study in Children to examine whether diet influences sex hormone levels during adolescence. The study involved 286 girls ages 8 to 10 who were randomly assigned to a low-fat dietary intervention group or to a group receiving usual care (e.g., educational materials available to the public). The researchers measured blood sex hormone levels at the start of the study and 1, 3, 5, and 7 years later.

After 5 years, girls in the intervention group had 29.8% lower estradiol, 30.2% lower non-sex hormone binding globulin-bound estradiol, 20.7% lower estrone, and 28.7% lower estrone sulfate levels during the first half of their menstrual cycles, and 27.2% higher testosterone levels during the second half of their menstrual cycles,compared with girls in the usual care group. After 7 years, girls in the intervention group had half the progesterone levels during the second half of their menstrual cycles as did girls in the usual care group.

All those hormonal differences must be having some effects on the brain and on the reproductive organs.

Another related possibility comes from the fact that the leptin hormone acts early in life to change the brain to lower inhibition from eating and might also lower the inhibition against having sex. This is just speculation on my part of course. But it is at least plausible.

Another possibility is that obesity is negatively correlated with intelligence and that it is lower intelligence that is responsible for the higher fertility. Of course there are quite smart fat people and plenty of dumb skinny people. But it seems likely that smarter people are, again on average, doing a better job than dumber people of consciously choosing foods and restricting foods in order to manage their weight. Well, if that is the case then selection for obesity may be coming as a side-effect of the existing selective pressures that are obviously selecting against higher levels of intelligence. My guess is that this possibility explains part of the difference in fertility between overweight and skinny people. However, the difference in fertility as a function of educational attainment (which is a decent though not perfect proxy for IQ) appears smaller than the difference as a function of weight. So IQ is probably only one contributing factor.

Another possibility is that overweight people have lower expectations about what they can achieve in looking for a mate and therefore they more quickly decide someone they have found is good enough to settle for. Therefore they start having children sooner and have more children than those who hold out for better mates. Skinnier people probably (and again on average) believe they have a wider selection of choices and may be willing to wait longer to hold out for a still better choice. The delay that comes from waiting may cause them to delay reproduction and therefore reduce the number of children that women in particular can hope to have. Some women wait so long that by the time they are ready to try for a kid they are not even able to start a pregnancy.

Update: Are obese people less bright to begin with? Does lower intelligence cause the risk of obesity to increase? Also, does the direction of causation also run in the opposite direction? Does the presence of obesity cause intellectual abilities to decay? Some researchers think obesity appears to interfere with cognitive function.

Elias, a member of the Statistics and Consulting Unit of BU’s Department of Mathematics and Statistics, and his co-investigators at the Framingham Heart Study are the first to show that long-term, early-onset obesity is an independent risk factor to cognitive dysfunction. This knowledge should help inform physician–patient decisions to treat this physical condition.

...

Analyses of these data by the researchers found that the combination of obesity and hypertension showed a statistically significant association with the cognitive functioning of men, but not of women. Among late middle-aged and elderly men, obesity and hypertension were associated with lowered cognitive functioning. Among all men, the effects of obesity and hypertension were found to be cumulative, with cognitive functioning lowered more when both conditions were present than when one or neither was a factor. The researchers speculated that obesity and hypertension may have similar physiological “paths” by which they affect cognitive functioning and that the different distribution of fat on men and women may help to explain the adverse effects of obesity in men compared to women.

Stay skinny for your brain. Stay skinny for your heart. Do it to reduce the odds of getting cancer too.

Share |      Randall Parker, 2004 October 24 05:33 PM  Trends, Human Evolution


Comments
Jody said at October 24, 2004 7:08 PM:

I would slightly alter the cause and effect of your last idea and assert that getting married tends to make you fatter (you stop having to try so hard to look good). The earlier you marry, the longer the period of time you have to bear children (your point which I concur with), and the longer the period of time you have to pack on the pounds.

As a bit of anecdotal evidence, after I got into the relationship with the woman I am marrying in 6 days, I added about 30 pounds and she added about 20 pounds. Before this relationship, I had carefully maintained a weight of 165 lbs for 10 years while remaining a committed bachelor.

Bob McGrew said at October 24, 2004 9:11 PM:

Women who are skinny have a lot more to lose from pregnancy in terms of body image than women who are no longer skinny. Thus it makes sense that they would delay pregnancy at least somewhat, or feel greater inhibitions towards having larger numbers of kids.

Invisible Scientist said at October 25, 2004 5:35 AM:

Maybe rich people are more likely to have a successful relationship, and rich people are
often fatter... But seriously, in many businesses, the successful bosses and managers are often
fat, and their being fat makes them look more authoritative. In business, maybe a fat CEO looks
more serious.

Richard Bellamy said at October 25, 2004 7:53 AM:

Also, the more children you have, the more opportunities you have to not lose the "baby weight" you packed on when you were pregnant.

Anonymous Coward said at October 25, 2004 9:09 AM:

One thing that maybe shouldn't be put aside is that fatter women might be more attractive for a not-only-sex-but-children-also relationship. Just remember all those neolithic fertility idols...

Randall Parker said at October 25, 2004 12:17 PM:

From a natural selection standpoint the key question is whether the obesity (and whatever is causing it) is causing the higher rate of reproduction or the higher rate reproduction is causing the obesity.

Richard Bellamy's point makes the cause and effect flow from reproduction to obesity. The same is true of Jody's point since it is the attraction that leads to marriage and hence to reproduction but that attraction that leads to marriage also leads to obesity.

Anonyomous Coward's point has the obesity causing the reproduction since the fat makes the woman more desirable for reproduction. The same is the case with Bob McGrew's point.

Invisible Scientist, it is my understanding that upper class people are skinnier than lower class people on average.

Lucie Fritz said at October 25, 2004 4:55 PM:

WAY, WAY, too much speculation without any evidence for the possible reasons for these findings to even be seriously considered.

It is going to take awhile for science to tell us all the reasons we have and desire fat, if not culturally, then biologically.

Remember that as a species, we evolved without steadily, readily available supplies of food; many of our predecessors starved to death.
The food supplies we enjoy are relatively recent in our development; and even some of our contemporaries in other parts of the world still
live in the same food-less conditions.


Ryan said at October 26, 2004 8:24 AM:

I don't see this mentioned anywhere, but where the women in question obese before they had kids?

Michael Lewyn said at October 26, 2004 1:13 PM:

Maybe social class is the issue here. Poorer people are fatter. Poorer people have more kids. Thus, over the long haul fatter people will have more kids.

Kate said at October 28, 2004 6:18 AM:

Efficacy rates on female hormone-based contraception diminish as the weight of the woman rises. The pharmaceutical companies are still making the Pill and the Patch for the 180 lb and lower crowd. Perhaps there needs to be a Pill designed for larger women to counterbalance the diminishing efficacy?

I would wholeheartedly suggest this as a viable evolution to current technology.

I was obese before I had my daughter, and while the weight contributed to my ability to get pregnant while on the Pill(due to the diminished efficacy- which is clearly stated on the info packet- no lawsuit for surprise pregnancy, no sirree), it negatively affected my health during my pregnancy. I intend to lose a good bit of weight (at least 40lbs) before I get pregnant again, and I'm already 20 below my prior prepregnancy weight.

GH said at October 28, 2004 8:16 AM:

Just a terminology nitpick:

Natural Selection != Evolution. Unless you think that obese people are a different species, or exhibit greater biological complexity than skinny people.

CB said at October 28, 2004 9:54 AM:

As long as we are wildly speculating, how about the possibility that more active and healthy male and females, many of which may be in better shape, are just not as interested (for non-hormonal reasons) in having kids. Perhaps they are too busy living it up, pursuing their active, fun lifestyles, and working out in the gym!

And guys who bike more and wear tight shorts are less fertile....

GH said at October 28, 2004 10:54 AM:

CB, who is clearly not a parent, thinks that parents are not active ...

Randall Parker said at October 28, 2004 11:16 AM:

GH, Natual selection doesn't have to drive changes all the way to the point of speciation in order for evolution to have taken place.

GH said at October 29, 2004 8:44 AM:

Randall, that's a pretty broad definition for "evolution" then. Any observed variation would be "evolution" and would "prove" the whole evolutionary synthesis. Mighty convenient ...

Randall Parker said at October 29, 2004 11:16 AM:

GH, Evidence of natural selection operating in the short term does not by itself prove Darwin's entire theory on the origin of species.

However, if you feel a strong need to doubt or reject Darwin's complete theory of evolution as the means by which the various species came to exist I can see why you might want to resist acknowledging evidence for selective pressures operating on shorter time scales to bring about smaller changes in allelic frequencies.

GH said at October 29, 2004 12:00 PM:

>However, if you feel a strong need to doubt or reject
>Darwin's complete theory of evolution as the means by
>which the various species came to exist I can see why
>you might want to resist acknowledging evidence for
>selective pressures operating on shorter time scales
>to bring about smaller changes in allelic frequencies.

When did I do that? That is, "resist acknowledging
evidence for selective pressures operating on shorter
time scales to bring about smaller changes in allelic
frequencies." All I said was "Natural Selection !=
Evolution". Observing Natural Selection happen is
not the same as observing Evolution in action.

Randall Parker said at October 29, 2004 12:11 PM:

GH,

I used the word "if" because I couldn't figure out what you meant by "if". I did not set ou to "prove the whole evolutionary synthesis" and so I don't get what point you are trying to make.

Natural selection is a key mechanism by which evolution happens. The other key mechanism is the generation of new variations in DNA sequences (whether by errors in DNA replication and by other means such as viral DNA insertion).

Natural selection causes evolution to happen.

ox said at October 30, 2004 10:44 PM:

Is obesity being selected for in modern society?

Readily available inexpensive energy-dense nutrient-sparse foods combined with diminished energy-requiring activities in an increasingly energy efficient niche for h.sapiens.
Perhaps the environment is changing faster than the species' rate of adaptation. If the species evolved to run most efficiently in an energy constrained environment, will that same species be able to run as efficiently in an energy-rich environment? Invasive species that thrive in energy-dense environments usually disrupt native ecosystems and decrease biodiversity.

Decreased physical activity and decreased mental activity combined with "free" energy/food resources. Any food, any where, any time. Any product, any where, any time. Any drug, any where, any time. Any one, any where, any time.

I think obesity is an example of overcorrection to the current surplus situation. Man used to convert food into energy to power legs to move a body. Now maybe man can convert food into energy to power

Or maybe an invasive species is in your future.

Post a comment
Comments:
Name (not anon or anonymous):
Email Address:
URL:
Remember info?

                       
Go Read More Posts On FuturePundit
Site Traffic Info
The contents of this site are copyright ©