August 29, 2005
Hormone Replacement Therapy Delays Menopausal Skin Changes

Replacement hormomes used from the earliest stage of menopause reduces the development of wrinkles and skin rigidity.

Long-term hormone therapy used earlier in menopause is associated with fewer wrinkles and less skin rigidity in postmenopausal women, Yale School of Medicine researchers report in the August issue of Fertility and Sterility.

"These benefits were seen in women who had consistently used hormone therapy and had been in menopause for at least five years," said Hugh S. Taylor, M.D., associate professor in the Division of Reproductive Endocrinology and Infertility in the Department of Obstetrics, Gynecology & Reproductive Sciences at Yale School of Medicine.

"We don't believe hormone therapy will make wrinkles melt away once they're already there, but the results of our study shows that hormone therapy can prevent them. Hormone therapy makes wrinkles less severe and keeps skin more elastic," Taylor added. Taylor and his co-authors compared 11 women who had not used hormone therapy to nine long-term hormone therapy users. Demographics including age, race, sun exposure, sunscreen use, tobacco use and skin type were similar. The researchers made visual assessments of wrinkle severity at 11 facial locations. A plastic surgeon with no knowledge of which women were using hormone therapy rated the number and severity of wrinkles using a Lemperle scale.

The team also measured skin elasticity using a durometer.

They found that rigidity was significantly decreased in hormone therapy users compared to nonusers at both the cheek (1.1 vs. 2.7) and forehead (20 vs. 29). Average wrinkle scores were lower in hormone users than in non-hormone users (1.5 vs. 2.2) on the Lemperle scale.

Taylor said that what is happening in the skin may be reflective of the functioning of other organs such as the heart and bone, which might also be benefiting from estrogen therapy. The results suggest that hormone therapy keeps the skin looking younger and healthier and may have cosmetic benefits if started early. Hormones seem to keep the skin healthy, but can't reverse present skin damage.

Both male and female hormone replacement therapies for anti-aging might increase cancer risks. But if true that is yet another argument for development of effective anti-cancer treatments. Once the various types of cancer become easily curable we will be able to get the benefits of hormone replacement therapies while avoiding many of the risks.

Share |      Randall Parker, 2005 August 29 02:13 AM  Aging Studies


Comments
Louise Krekic said at April 29, 2010 6:43 PM:

I have a friend who is on HRT since 47 when her ovaries were removed, and her skin is sooo thin you can see all her veins, she is forgetting things at 66 and she has huge amounts of cellulite and spider veins on her hips and legs. She has spider veins on her face too and her facial skin looks like a thin membrane. I had a natural menopause and my skin is really nice and at 62 still thick and healthy looking. I look like an average North American woman at 55. She was trying to talk me into taking HRT in my post-menopause, and Thank God I didnt. My mom, my aunts, great aunts, and all granmas had a natural menopause and they looked younger at their age than many other women. They had young looking legs like balerinas with no veins when they died. Their hair grayed slowly too. They lived healthy, didnt eat in restaurants, didnt smoke, didnt drink and they slept and rested sufficiently. One of the leading scientists in endocrinology said that a woman would be fooling her self if she thinks that artificial estrogen can replace the natural one our body produces, and now they know that ovaries never die. They are active as long as we live and they secrete estrones the hormones that protect woman's health and immunity and allow her to live longer.

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