While decay of myelin due to auto-immune damage is suspected as a cause of multiple sclerosis some UCLA researchers see a much wider role for insufficient myelination as a cause of a large assortment of mental and behavioral disorders.
New evidence points to production of myelin, a fatty insulation coating the brain's internal wiring, as a neural Achilles' heel early in life.
An upcoming application of a novel model of human brain development and degeneration pioneered by a UCLA neuroscientist identifies disruption of myelination as a key neurobiological component behind childhood developmental disorders and addictive behaviors.
Detailed in an article in press with the upcoming annual peer-reviewed publication Adolescent Psychiatry (Hillsdale, N.J.; The Analytic Press Inc.; 2005) the analysis suggests that many factors can disrupt myelination and contribute to or worsen disorders such as autism, attention deficit/hyperactivity disorder and schizophrenia.
Note above that problems with myelination may contribute to addictive behaviors and ADHD.
There's a vicious cycle aspect to this report. Due to insufficient myelination a kid could be more prone to use of addictive drugs. But then the use of the drugs could prevent the myelination process from proceeding. This reminds me of people I know who used a lot of drugs while teenagers who never seem to have grown up since then. Did their drug and alcohol use block their own brain's maturation?
In addition, the analysis suggests that alcohol and other drugs of abuse have toxic effects on the myelination process in some adolescents, contributing to poor treatment outcomes and exacerbating co-existing psychiatric disorders.
Author Dr. George Bartzokis, a professor of neurology at UCLA's David Geffen School of Medicine, concludes that the high incidence of impulsive behaviors that characterize the teen years as well as many psychiatric disorders that occur in the teens and 20s are related to incomplete myelination of inhibitory "stop" brain circuits, while the "go" circuits become fully functional earlier in development. These inhibitory circuits are not on line to quickly interrupt high-risk behaviors that are so prevalent in teens and young adults.
If memory serves the development of the inhibitory circuits does not complete until about age 25. As a consequence of blocked myelin formation are heavy adolescent drug users more prone to impulsive, self-destructive, and violent behaviors even as adults?
There's an aging angle to myelination and demyelination.
"Myelination, a process uniquely elaborated in humans, arguably is the most important and most vulnerable process of brain development as we mature and age," said Bartzokis, who directs the UCLA Memory Disorders and Alzheimer's Disease Clinic and the Clinical Core of the UCLA Alzheimer's Disease Research Center.
"Environmental toxins, genetic predispositions and even diet appear to influence and sometimes disrupt this process," he added. "By shifting our research focus to medications that act on brain metabolism and development, as opposed to brain neurotransmitter chemistry, neuroscientists will likely find a wealth of novel opportunities for addressing the cause of brain disease rather than simply the symptoms."
Myelin is a sheet of lipid, or fat, with very high cholesterol content — the highest of any brain tissue. The high cholesterol content allows myelin to wrap tightly around axons, speeding messages through the brain by insulating these neural "wire" connections.
Bartzokis' analysis of magnetic resonance images and post-mortem tissue data suggests that the production of myelin is a key component of brain development through childhood and well into middle age, when development peaks and deterioration begins (Neurobiology of Aging, January 2004). He also identifies the midlife breakdown of myelin as a key to onset of Alzheimer's disease later in life (Archives of Neurology, March 2003; Neurobiology of Aging, August 2004).
We need rejuvenation therapies that will repair and replace aging myelin sheaths in the brain. Sign me up. I want rejuvenated myelin. Myelin rejuvenation no doubt will be part of the Strategies for Engineered Negligible Senescence (SENS) treatments.
Imagine a future two or three decades hence where parents take their kids in for cell therapies and gene therapies to make their myelin sheaths grow over their inhibitory circuitry more rapidly. Such therapies would reduce adolescent deaths from car accidents and from murder. Plus, the therapies would also reduce adolescent use of destructive drugs.
Adolescent rashness might have been selected for so that males in particular would compete more aggressively for mates. The slow myelination of inhibitory brain circuits might be an obsolete and maladaptive left-over consequence of evolution by natural selection.
|Share |||Randall Parker, 2005 November 25 11:58 AM Brain Development|