July 02, 2006
Ultrasound Regrows Damaged Teeth

University of Alberta scientists have developed a wearable microminiature ultrasound generator that causes damaged teeth to generate more tooth material.

Hockey players, rejoice! A team of University of Alberta researchers has created technology to regrow teeth--the first time scientists have been able to reform human dental tissue.

Using low-intensity pulsed ultrasound (LIPUS), Dr. Tarak El-Bialy from the Faculty of Medicine and Dentistry and Dr. Jie Chen and Dr. Ying Tsui from the Faculty of Engineering have created a miniaturized system-on-a-chip that offers a non-invasive and novel way to stimulate jaw growth and dental tissue healing.

"It's very exciting because we have shown the results and actually have something you can touch and feel that will impact the health of people in Canada and throughout the world," said Chen, who works out of the Department of Electrical and Computer Engineering and the National Institute for Nanotechnology.

The wireless design of the ultrasound transducer means the miniscule device will be able to fit comfortably inside a patient's mouth while packed in biocompatible materials. The unit will be easily mounted on an orthodontic or "braces" bracket or even a plastic removable crown. The team also designed an energy sensor that will ensure the LIPUS power is reaching the target area of the teeth roots within the bone. TEC Edmonton, the U of A's exclusive tech transfer service provider, filed the first patent recently in the U.S. Currently, the research team is finishing the system-on-a-chip and hopes to complete the miniaturized device by next year.

"If the root is broken, it can now be fixed," said El-Bialy. "And because we can regrow the teeth root, a patient could have his own tooth rather than foreign objects in his mouth."

The device is aimed at those experiencing dental root resorption, a common effect of mechanical or chemical injury to dental tissue caused by diseases and endocrine disturbances. Mechanical injury from wearing orthodontic braces causes progressive root resorption, limiting the duration that braces can be worn. This new device will work to counteract the destructive resorptive process while allowing for the continued wearing of corrective braces. With approximately five million people in North America presently wearing orthodontic braces, the market size for the device would be 1.4 million users.

This would allow more rapid realignment of teeth for those undergoing orthodontic therapy.

El-Bialy had previously demonstrated this effect using a larger ultrasound generator. He teamed up with other faculty and developed a wearable device so that the benefit could be had more easily. His previous research showed that the ultrasound also helped cause damaged bones to repair.

El-Bialy has shown in earlier research that ultrasound waves, the high frequency sound waves normally used for diagnostic imaging, help bones heal and tooth material grow.

"I was using ultrasound to stimulate bone formation after lower-jaw lengthening in rabbits," El-Bialy said in an interview Tuesday.

To his surprise, not only did he help heal the rabbits' jaws after the surgery, but their teeth started to grow as well.

He foresees the day when people with broken bones will wear ultrasound emittters wrapped into the bandages.

This approach by itself probably can't solve the problem of growing replacements for entirely missing teeth. However, ultrasound might help stimulate tooth building cells once scientists develop techniques for creating suitable cells. Still, additional problems must be solved to get tooth building cells to produce the particular tooth shape desired.

Share |      Randall Parker, 2006 July 02 07:22 PM  Biotech Teeth And Gums


Comments
Jaime said at July 6, 2006 1:55 AM:

Hi from spain. I'm 29 years and had from born 2 missing teeth called in spain "agenesia de los incisivos laterales". That is some common less teeth growing, for me very very very very uncofortable, as I always wanted to have a nice and complete teeth.
About ultrasounds technic, can this way recover wasted pieces?
Sorry about my english. Thanks

dr somdatt said at July 13, 2006 2:28 AM:

i have gone through the article published last week regarding regrowing lost teeth.i had few teeth missing. i am 81 yr old.can i be benifited with this method.i am willing to come to canada if u ask. i m not dibetic and hypertensive. kindly send me the full detail of (lipus} da wonder formula to regrow teeth.

Pall said at July 21, 2006 5:57 PM:

Well if we have to come to a new board to post..let me be the first to say, keep posting any information here

Shuun said at July 22, 2006 10:49 AM:

Hello everyone, as you know, president Push has signed a bill denying federal funding for stem cell research in the U.S. Many of you might be wondering how will it impact the progress we have been following all these years. It seems that we are in luck in the area of dental research since adult stem cells can be used to further tooth regeneration experiments. Check out the article posted on the site below. It sounds like adult stem cells alone could be sufficent for tooth regeneration. Also don't forget that there are many researchers who are not pound by this restriction.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12619122&dopt=Abstract

Pall said at July 22, 2006 1:37 PM:

Of course the controversy around stem cells continues, especially with the right wing of the United States. I am not going to get into a discussion about George Bush, but what I will say is that the sight of Michael J Fox shaking with Parkinson's Disease is enough to convince me that stem cell research must be allowed to continue and expand. Wjether it's teeth or some other much more dreadful chronic illness, we are all suffering in some way. Is that how the human conditon must be, to suffer so.

Patricia said at July 22, 2006 7:07 PM:

Shuun,

The page you gave me to look at says that tooth regeneration might be available in a couple of decades. That is not what I am looking for, do you know who is doing research that has more recent results?


All the best,
Patricia

Bob Badour said at July 22, 2006 8:25 PM:

Shahana or anyone else who wants to,

I am a friend of Randall's, and I have a web-server with gobs of free space and bandwidth. If someone can register a suitable domain name, I would be happy to host a user forum where you can continue your discussion. I have experience setting up forums using Simple Machines Forum software.

It would be possible to provide your discussion with better structure than just a sequential list of comments. For instance, you could have one board for sharing personal stories and other boards for following developments of promising technologies. However you want to structure the discussion forum.

If someone is interested in setting up and moderating such a forum, email me at bbadour@pei.sympatico.ca

Pall said at July 23, 2006 6:13 PM:

Remember that there are numerous stories on the net about how long it may take to perfect tooth regeneration. Most do not think it is 20 years away. As I have said before we must remain positive. There really is not much else to say. I and others look regularly and will post any new news straight away.

Shuun said at July 25, 2006 7:16 PM:

I am sorry for the confusion, the article I referred to is in fact older dating back to 2003. The point I was trying to make is that the author citing scientific research, stressed that without doubt adult stem cells will lead to complete regeneration of teeth. I chose to ignore the two decade estimate since we all know a lot has happened since this article was published. I personally think this will be a reality withing 2-3 years.

Pall said at July 26, 2006 4:04 AM:

Shuun, thank you for that positive posting. I know that sometimes we can all get carried away hoping so much and then almost beleiving anything. But I do agree with you that I really do beleive that this will come much quicker than we realise.

I was looking at the offer of a new board which maybe could be set up as aproper forum on this topic. it sounds interesting, and I wonder how we might proceed with this.

Patricia said at July 26, 2006 4:13 PM:

Does anyone know how to reach Shahana, Thom, Fred, etc. They seemed to have the most recent information and we need to have them on this site. Please email the individuals looking for this site. The research the guys are doing at the Canada company looks like it may help some of us.

Pall said at July 26, 2006 8:19 PM:

Patricia, as you may know I have be in touch with Odontis, who are associated with Paul Sharpe's work and they have said that they are working very hard to make the biotooth a reality. I do not think that there is any more up to date information than this at this time. It is worth you having a look at the funding being put in place by the welcome trust here in the United Kingdom. The address is

http://www.wellcome.ac.uk/doc_WTX028677.html

Bob Badour said at July 27, 2006 5:04 PM:

Pall,

If someone wants to take me up on my offer to host a forum, the first step would be to think up and register a suitable domain name at a domain name registrar like GoDaddy or Joker. As an example, Randall registered futurepundit.com as the domain name for his blog.

There are other free forum hosting sites where you would not have to register a domain, but you would still have to think up a name for the forum.

Then, it's just a matter of creating the account on the server, installing the forum software and configuring the software to your liking. I can help with (or do) all of that. If you have any questions, feel free to email me at mailto:bbadour@pei.sympatico.ca

Email is the best way to reach me because I do not follow this thread. Randall mentioned the thread in passing, and I thought it would be nice to offer you all a more suitable permanent home.

shahana said at August 2, 2006 6:49 PM:

Hi Bob,

Thanks for your offer. Now are you trying to say that Randell is going to discontine this site?

I think all these people in this forum will benefit from a permanent discussion board & I would like to help building a permanent site. It`s a console, a relief just to know that researchers are trying hard to find cure for this dreadful problem. Also to offer share similar stories makes another feel that they are not alone. If someone didn`t suffer from dental issue`s they will never realise the pain.

If Randell is taking this site off then there needs to be a different site. But, if he keeps this forum alive, I think this is fine for now.

Thanks,

Shahana

Randall Parker said at August 2, 2006 7:15 PM:

I have no plans to discontinue this site and the thought has not crossed my mind.

jodie bannister said at August 2, 2006 7:22 PM:

Just visiting briefly to add that we also saw the encouraging(ie another method to add amd to explore)"ultrasound" story /article in the new scientist a few weeks ago-and also read that due to PRESIDENT BUSH'S ill-thought out veto:-

(which eg other more visionary Republicans incs Arnold Schwarzenegger Californian State governor do NOT share-he has himself authorised california to research stem cells "at state level"ie not dependent on "federal national government funding" as states have their own laws and funding independent of the federal government)

there may be an influx to and emigration to(a brain drain) the united kingdom of usa scientists who feel they have not got proper funding or support from the usa federal govt so that may well help progress as the uk DOES fund or tries to fund stem cell research

re the time limits/schedules before these various strands of different research bear fruition(and recall our earlier/last post(s) re that seattle company we mentioned-not dentegenix a whole new one with whole new line of research)

we don't know if its 2 years or 20 years or somewhere in between "for sure"

but our hunch is probably sooner rather than later

and that full data re progress isnt released due to commercial reasons and patents pending or confirmed etc(understandable)

one tends to see developments when one least expects it(the may 2004 announcement by prof sharpe and odontis took us by surprise)(for example)

it is interesting that new developments /new strands /new methods are appearing

jodie bannister said at August 2, 2006 7:24 PM:

thanks for the reassuring confirmation Randall-as eg we sometimes do not visit for a long while-so would be concerned if it suddenly vanished!we were going to post the ultrasound article but thought you all would probably see it anyway

jodie bannister said at August 2, 2006 7:40 PM:

seems from extra reading of the main body of the article(which goes more into depth than the new scientist briefer article did we saw a few weeks ago)ABOVE -STARTING THE NEW THREAD:-

it could well be combined with the "scaffolding regrowing teeth idea"(that harvard university and pamela yellick developing-and mary macdougall of texas university usa) so it would be combined with a scaffold "specified to correct size"-which could solve the occlusion and size problem so it would grow to FILL THE EXACT SIZE REQUIRED-AND LOCATION REQUIRED-

IE designed scaffold of a tooth(possibly using dental stem cell therapy as well) and the ultra-sound emitting nano-circuit at the bottom regrowing the root-or some sort of combination of the 2 technologies-

probably they will explore this with other companies and at dental conferences

we saw briefly on the net reports of another dental conference in Feb 2006(it seems to depend on which serach engine one uses and how far one goes into the pages-digging deeper usually produces a story /lead one has not seen before-as they all throw up different stories)

which various leading researchers attended;they do share some data at international conferences but others they keep secret for commercial reasons

we bet they end up combining various methods to overcome any such problems-but it may be that will also delay progress and this is why we have not heard much from odontis and others

ie they are perfecting the methods to overcome the remaining hurdles-its not just re funding problems that delay progress-all the money in the world won't overcome a technical difficulty it has to be solved by trial and error first experimentally so patience is required

we also feel start of human clinical trials may well be delayed in the uk but we dont see the rush though we are aware people in dental pain want progress as quick as possible-my brother like shahan says has gotten used to the situation so is happy to wait although he is not in pain unlike others reporting their stories on this thread/past thread

jodie bannister said at August 2, 2006 7:57 PM:

see our post on 3rd June 20069last posy until 3rd august/2nd august 2006 so we have been away for 2 months!)

RE SEATTLE BIO- MEMETICS COMPANY (new one not the old dentigenix one whose website went down)

bio memetics the article says(see june 3rd 06 post for link)(previous thread)is whole new method of replacing lost organs and the company wanst to look at about 20 diferent clincial applications inc dental ones re new teeth-the scientist said he was so excited he couldnt sleep at night and they dont say stuff like that unless they really are very excited -normally scientists are cautious -

this with the ultra sound devlopments means several strands of research which may coalesce and join at some stage and combine methods

and means several different approaches to the problems not just stem cell therapy/treatment(which itself has several different methods from in vivo to in vitro methods and some use scaffolding and others do not)

will copy and paste the link in next post so anyone who didnt see it can revisit

jodie bannister said at August 2, 2006 8:02 PM:

HERE IS THE LINK-DONT UNDERESTIMATE THIS COMPANY BUT WE WILL ALSO NEED TO GOOGLE AND USE OTHER SEARCH ENGINES TO UNCOVER MORE RE THIS SEATTLE COMPANY:-

http://seattle.bizjournals.com/seattle/stories/2006/05/22/focus3.html

OR ANYONE WHO WANTS TO CAN CHECK THE COMPANY OUT BY UTILISING VARIOUS SEARCH ENGINES(INC SCIENTIFIC SPECIALIST ONES WE ARE AWARE EXIST AND TRY VARYING THE WORDS YOU USE IN THE SEARCH THAT YIELDS RESULTS LIKE WE DID TO GET THIS DATA RE THE SEATTLE COMPANY)

PLUS OUR NEW EMAIL ADDRESS=

paul.bannister.173@ntlworld.com

or use:-

c.89@virgin.net

or use:- c.85@virgin.net

or

laxhatman@yahoo.co.uk

Martin said at August 3, 2006 3:21 AM:

Jodie, I have bee trying to email you but me emails keep beng returned....can you get in touch, hope u r well.

Martin said at August 3, 2006 3:29 AM:

I do find reading this site very helpful. I am so tired of living without my two lower back teeth, it just depresses me everyday. I hope that this solution comes in the near future.

jodie bannister said at August 4, 2006 2:39 AM:

see the new email addresses provided above re discussing any developments re the new dentistry

barbara.cox2@ntlworld.com is now defunct and was used temporarily

so emails sent there would bounce back to sender(s)-sorry!

Mike Colen said at August 5, 2006 6:57 AM:

Hi all,
I've been gathering informations about growing new teeth also. Honestly I don't think it's gonna available in the near future. As far as I understand, the experiments Paul Sharpe did on mice have to use both adult and embryonic stem cells. If this is the case, it's not practical to do it on human now because, first of all I don't think human embryonic stem cells are easy to get. Even if they are, there will be body rejection problems because the embryonic cells are not taken from your own body. If my understanding is wrong, please point it out. Thanks.


Mike

emf said at August 6, 2006 4:12 AM:

I just found this thread, after googling stem cell dentistry, and, from there odontis. I read an article on this 2 years ago. That article said that the technique should be commercially available in 2 years. This is the reason I googled on the subject now, to find out how much closer they are. But I see that now, after the 2 years have passed, they are again talking about 2 years - or more... Well, it seems it is going to happen, but we really do not know when...

Mike Colen said at August 6, 2006 7:24 PM:

Ok, maybe I was wrong in the previous post. I just found a very recent news with title: Dental Stem Cells Have Been Characterized For Tooth Tissue Engineering. The news data is Jul/01/2006. And here is the link:
http://www.medicalnewstoday.com/medicalnews.php?newsid=46198
I'm not sure how closely it's related to growing new teeth. But it sounds like they are making progress in it.

BTW, the previous thread was very active. But this one seems dying out. I guess you guys are getting frustrated.

Mike

Marianne said at August 7, 2006 5:21 AM:

Hi,

Has anyone heard any news on how the "Hitachi Medical Corporation" are progressing? An article written last year stated they were hoping to ship tooth germ to the USA by next year!! (wouldn't that be nice! - but unlikely it seems, based on proposed timeframes being outlived already with all the other researchers/companies). So depressing - hopes some major breakthrough happens soon...I'm too young to lose my teeth!

Regards

Marianne

Pall said at August 7, 2006 11:16 AM:

Mike, I certainly would not say that this thread is 'dying out' at all. In fact this thread has been started due to the degree of posts on the earlier thread. However, because there is not much news available then people are not going to kepp posting about the same thing. We do not know how many people actually visit this site as there is no counter, but many do not post unless they have news.

Shuun Shacni said at August 8, 2006 11:46 AM:

Hello, lets stay positive people. I am begining to see a lot of negativity, which is not needed right now. We need to stay positive. As for Mike and Marianne, I would say reread your articles again. I read all of the mentioned articles and if I remember it correctally, Odontis said they hoped to start human trials in 2 years which would have been by 2006. We do not know know whether that has happened yet and if it did, they would not publish it untill the human trials are over and a success is made. Aslo keep in mind that human trials can take a while. Also keep in mind that there is a very good chance of success when they combine adult and embroyanic stem cells since the rejection risks are lowered by combining it with the adult cells and the body thinks its own cells.

As for Hitachi, I believe the article said they hopped to ship commercial packages by 2007.

Please stay positive, nothing has been done without positive thinking. I think next two years will be interesting to see. Keep searching and hope for the best!

Pall said at August 8, 2006 2:07 PM:

Shuun thank you for that posting. I do so agree that the negative posting does not help. It is true that although positive thinking canot bring a breakthrough any quicker, it can make that wait a more positive experience. I know that everyday I get down with the discomfort and 'feel' of my mouth, but I live with it and try to think positive. I know that we are living in very exciting times, where the possibilities in so many areas are clear to see. Remember, that even ten years ago such thoughts of tooth regeneration were a fantasy. We are now moving to a reality!! Odontis would not have posted their website if they had no intention of making tooth regrowth a reality at some point. As I have said, a dedicated site to this subject would be good, if we could just get it off the ground. As I have said so many times before, knowing that other people are in this situation keeps me feeling better. I do look forawrd to a time when I can once again get the lower two molar teeth that I have lost back. I am unable to chew properly on the one lower side and live with the discomfort everyday. It does not help that I never should have bee in this situation and that it was through no fault of mu own, and that does not help. But whatever the reason for tooth loss is, some peple just cope with it as there are so few options open to them. But I really do beleive that such 'coping' will be a thing of the past....just stay positive.

Pall said at August 8, 2006 2:40 PM:

Shuun thank you for that posting. I do so agree that the negative posting does not help. It is true that although positive thinking canot bring a breakthrough any quicker, it can make that wait a more positive experience. I know that everyday I get down with the discomfort and 'feel' of my mouth, but I live with it and try to think positive. I know that we are living in very exciting times, where the possibilities in so many areas are clear to see. Remember, that even ten years ago such thoughts of tooth regeneration were a fantasy. We are now moving to a reality!! Odontis would not have posted their website if they had no intention of making tooth regrowth a reality at some point. As I have said, a dedicated site to this subject would be good, if we could just get it off the ground. As I have said so many times before, knowing that other people are in this situation keeps me feeling better. I do look forawrd to a time when I can once again get the lower two molar teeth that I have lost back. I am unable to chew properly on the one lower side and live with the discomfort everyday. It does not help that I never should have bee in this situation and that it was through no fault of mu own, and that does not help. But whatever the reason for tooth loss is, some peple just cope with it as there are so few options open to them. But I really do beleive that such 'coping' will be a thing of the past....just stay positive.

Julie Woodchuck said at August 20, 2006 9:18 AM:

I really don't think that this will be available for at least the next 20 years. I'm sure at that time it will not be widely available for at least another 10 years. So we are looking at 30 years before the average person can benefit from this.

We don't even have the cavity vaccine, which research has been done on. If you look at the information on this such a treatment should have already been released.

Fred said at August 20, 2006 5:06 PM:

I agree with Julie, I think that it will take at least another 20 years before this is available.

milo said at August 22, 2006 6:15 AM:

we cannot say when it will be availabe,the only thing we can do is waiting

milo said at August 22, 2006 6:17 AM:

Why paul sharpe's society doesn't give to the general public more information about at which stage the research are?

Pall said at August 22, 2006 11:20 AM:

The bottom line is that nobody can predict exactly when this will become available. It is crazy saying we will have to wait 30 years, there is no evidence of this.

yushan said at August 23, 2006 1:23 AM:

Hi, I have got a question. Is it necessary to be made up in a device of "pea size" ? I highly doubt it.

If it really can help to regrowing tooth, I don't care even it as big as a cellphone. 20 mins a day, shoudn't be a big problem. I mean why don't just focus on how to minimize the ultrasonic tranducer or the piezoelectronic device, then using wire to connect to the generator. No doubt "Nano technologies" is the way to go, but don't see any reason to stick on the Nano. and even it comes to reality, just like some people have mentioned above, most people can not afford it.

And Ultrasonic is not some sophisticated technologies. If they can share the"frequency", "power", and some usage tips, I believe that most people here can do it by yourself.

Brooke said at September 1, 2006 9:39 AM:

Why don't you all just get the titanium dental implants that are available right now?

Pall said at September 2, 2006 4:51 AM:

Well, Brooke. That is an absolutely sort sighted and very misunderstood question. The fact is that although titanium implants may be acceptable as the best treament that is currently available, in no way can they compare to any real tooth. I know because I have one. As dental researchers themselves have commented 'implants are like living with a woodeen leg'. Yes they are indeed functional but there still remain limitatins with them. These include initial bone loss and the fat that any crown sits over the gumline ad not emerging from it as a real tooth would. There is sometimes gum irritation and of course implants are not able to respond to the person's bite, but reman rigid in the jaw. Although implants are the best that is currently avaiable they ae not the holy grail, but real teeth are.

Here are some referemces for you to visit if you feel the need:

http://main.uab.edu/show.asp?durki=91310

www.odontis.co.uk

mike said at September 7, 2006 8:43 PM:

Why you have not started yet on human being??
When do you expect will be available for everybody????
Please reply because I need your sensational discovery.
Bye

Brooke said at September 10, 2006 3:38 PM:

When do you think this will truly be available to the American dental patients?? Will there be ANY concern of having someone else's teeth implanted other than your own? I worry about them getting mixed up somehow and then being exposed to someone elses body fluids...is this a concern?

Jaime said at September 14, 2006 11:32 AM:

I'm thinking in put implants coz I'm getting realize this gonna take too much time. I hate it them a lot but I can't live like this anymore. I listen comments from mate's job doing jokes about my teeth and I get into depress when nobody understand it. Maybe is why I'm living in a small island and has no enough sensibility. I'd like to ask to someone about autotransplanting for make it as fast as possible.
Anyone know a place to advice me? Thanks.

Brooke said at September 15, 2006 11:08 AM:

I have a question about the ultrasound...will it be able to regrow a tooth that has a crown on it that HAS NOT been root canaled? Will it work on those teeth that have been ground down? Thanks. Also does anyone know if the titanium implants are safe? Can they cause diseases?

Pall said at September 16, 2006 12:24 PM:

Jamie, this post has gone a little quiet as of late, which is to be expected as there is no new news at this time. However, I know how difficult this can all be when a person is suffering with missing teeth. Sadly no one yet knows when tooth regeneration will come. Some say it is ten years away, I don not think this is the case, but of course I just do not know. Try not to get too depressed about it. We are living with times where a breakthrough like this that will help millions is just around the corner. We can't yet see it, but it is coming. Have faith.

Julie Woodchuck said at September 26, 2006 7:10 PM:

From the threads I've been reading I think it maybe 10-20 years before treatment is available.! Research is a long way off.

Maritza said at September 28, 2006 11:05 AM:

Hi everyone, My name is Maritza and I am 28 years old I recently got crowns on my two front teeth, no no root canal was done my teeth were perfectly healthy, I had my braces taken off last year in November I wore them for 16 months and was done with my treatment, after wearing my retainer for a few weeks my two front teeth started to slightly move apart not to much. I went back to my ortho Dr. and he suggested I get veneers, I thought that was easy. But I had to wait because my Husband was getting ready to leave to Korea for a year (military). When he returned for his midtour last month in August I went in a day before to consult my dentist He said I would need crowns on them because my bottom teeth would either pop the veneers off or break them. So the next day I showed up and he got started it took 3 hours this is because my teeth were healthy. I have been diagnos with Post Traumatic Stress and Depression due to this I feel something died and am in mourning over this. I can't eat the same way and on top of that I trie to kiss my babies and I can't feel it, its like my upper lip has gone numb. I went to see my Ortho Dr. and told him I got crowns and he was alarmed he didn't understand why, he even said that he should of told me of Dental Bonding, he said he was so sorry I also developed a bacterial infection, I am in counseling with a wonderful person to help me get through this even though I feel its a weird reason to be in counseling but I need it. I also asked my Ortho Dr. about regrowing human teeth and he said he had heard of it but that was still a couple years away I also called the Dental Department in the University of Alberta in Canada and spoke to an assitant and she told me the same thing 2 more years I pray everyday to give me the strength and patience. I believe I feel bad because I had healthy teeth I didn't lose them to a root canal or a accident that is why I am having a hard time dealing with this but we all have to remain hopeful. I tell my Dr. to please please educate everyone who is coming in for cosmetic purposes but yet he doesn't understand why I feel like this, don't get me wrong the crowns look beautiful but I would give anything for my own teeth. I have also read that the price of this would be about what we pay for a crown even if its a little more I believe it would be worth it. I emailed Dr. Tarek El-Bialy so is one of the Dr.s working on the Lipus but I have not received any information I asked him the same thing that Brooke (above) asked. It's amazing how something like this has affected every aspect of my life. But lets pray for the Dr.s that are working on this and that nothing derails their progress.

Pall said at September 29, 2006 2:12 PM:

Maritza, please do not feel silly to be feeling about wha happended to you. I and many others really do understand how hard it is to lose your own teeth in this way. I have agued for a long time on this thread that nothing can ever feel like your real teeth. I know that it can be so hard and make you depressed too. It's like if you have gaps in your mouth where you should have teeth. That is so hard to bear and it makes a person suffer everyday. No false tooth or implant ca replace that. I know because it happened to me. But please keep holding onto that faith that things will improve via this research that is happening. I also beleive that that it will not be 10 or 20 years. If you want to write to me then place your emal and I will do that. All the best to you.

Shahana said at September 29, 2006 6:53 PM:

Dear Maritza,

My heartfelt sympathy for you. I have gone throught the trauma you are experiencing now 13 years back, when I was 17. It changed my life. People who sees my old picture, can`t recognise me now. It changed the way I look. Truth is I was very beyond beautiful, some used to describe me as stanning and still good looking but I look like a differnt person. Looks are secondary to me, I just want to feel good. I will do anything to feel normal again.

Prayer is a form of healing and god listens to prayers, which leads to miracle cure. Please everyone pray every night before you go to bed. I have to redo one veneer out of two next week. Because one vaneer shape is not adjusting to my jaw & shape of the mouth. It is hurting my jaw, neck, head and back. Please wish me luck that I survive!

Thanks,

Shahana

Maritza said at September 29, 2006 10:12 PM:

Thank you, so much Pall and Shahana for your words. It's true, Prayer heals and with Prayer Miracles do happen. The military Doctors put me on anti-depressents and I tried one for a day and I hated the yawning affect because I have TMJ that's why I also had braces, so I decided not to take them I don't need them. I have lost 6lbs in almost two months so now I weigh 92lbs. I have the full load of house and yard duty because my husband still has alittle more than 3 months to go in Korea. My dad sent my mom to be with me for two weeks and it has helped and I have decided to pack up and leave Utah and go home to my parents in Calif, were I can have some support with my family and for my kids I don't want them to see me depressed all the time. My counselor has adviced me to seek Legal advice and take action against the Dental Office. But yeah I do pray all the time I don't sleep alot I have nightmares but I'm praying for the Dr.s to be illuminated. I even pray for my dentist so he is more cautious and careful how he explains procedures to people. I'm the one who payed the price not him and he got paid. But everyone here will be in my prayers. Shahana I will pray for you that everything works out. God bless you all. Pray for my family and me for a smooth and safe move, I have never done this before without my husband. Good Nite Everyone

Maritza said at October 1, 2006 1:08 PM:

This is the latest article I could find.. http://www.gateway.ualberta.ca/view.php?aid=6276

Jaime said at October 2, 2006 3:30 PM:

I understand you Martiza. I haven't lost my teeth like Pall but have this trouble is so depressing...
People that haven't that kind of problem can't understand what is be going throughout this. I don't share any smile with everyone, make me be the spare day-time in my room, just praying this to improve faster and wasting my unsocial time here.
At job is just be in such a hell. I just avoid everyone who wants to speak (no matter whom), and I'm always trying to decide what to speak about, but I'm listening in my made question and escape again.
Then I understand you much but because I'm passing through it... This is really hard and I really pray to any improvement and/or to know news about it.

Sorry about my english coz I'm from spain. Best wishes to everyone here.

Ren said at October 6, 2006 9:27 AM:

Hi guys,

Hope you are all well, and positive about getting new real teeth soon.
I am definitely looking forward to that.
I have one challenging question for you:

What can we do today in order to get these new real teeth very soon?

..any idea welcome !!!

Take care

Ren

Pall said at October 6, 2006 12:58 PM:

Ren, if I knew the answer to that question I would be there straight away LOL

Ren said at October 7, 2006 1:51 PM:

Sorry, I meant, what can we do today, that could accelerate the whole process.
Campaigning, getting some money for some of these companies,
boycotting politic parties that would not support this kind of research, gather a list of thousands of names of people
that are desperate to get new real teeth, letting people know how bad can be dental implants..

I guess, it is a case of better communication, politic parties don t realize how important that is.
By sending them lists of hundreds of thousand of names of people that are desperate for new real teeth, they would probably give more funding... It would be great if funding for regenerative dentistry could be part of some of the parties programm for the elections... etc

It is all about marketing, the more people will know about how good it can be, the quicker things will go forward.
There are thousands of things that we could do to help. And I am sure, you guys, have plenty of ideas that could help massively.

Why aids research get so much funding every year? For lots of reason, but one is marketing... we hear about aids every day..

Maybe the first step for us could be to identify, what are the things that are slowing down the proccess at the moment.
Any ideas?
examples: limited scientific knowledge about genetics? the politics (Bush??) lack of funding? lack of investors?
lack of human resources...

Maybe we could form a group, and through this group, get in contact with all the different companies dealing with regenerative dentistry, and get some information about their progress. We could offer them, lists of potential investors.. Maybe we could be in contact, with newspaper or any kind of media, to make articles about the massive needs in regenerative dentistry.. Marketing is everything

these are just a few ideas..

But I would love to hear yours ideas!! lol

we probably won t make the scientific findings that will allow us to get new real teeth, but there are probably loads other things we could do that would help

have a nice evening
take care to all of you
R

Ren said at October 8, 2006 9:57 AM:

Hi all,

What are the names of the companies, that are working on regenerative dentistry?
I have heard about Odontis, but is there any other companies in the world that are working on that too?
thank you
R

andy said at October 9, 2006 10:41 AM:

hi iv read all these posts from this thread and the old 1 in last 2 days and its quite amazingi had no idea they could do any thing like this.
the thing is i started serching because i was thinking of paying 4 grand and buying a totaly new set of teethbecause im 22 and my teeth are REALY small my back teeth are that small my gums almost go totaly over them plus iv always got toothach *me own fault* got dentist on wednesday for a filling 100 pound gone again >.hi iv read all these posts from this thread and the old 1 in last 2 days and its quite amazingi had no idea they could do any thing like this.
the thing is i started serching because i was thinking of paying 4 grand and buying a totaly new set of teethbecause im 22 and my teeth are REALY small my back teeth are that small my gums almost go totaly over them plus iv always got toothach *me own fault* got dentist on wednesday for a filling 100 pound gone again >. any ways i was gona buy new teeth because mine are small and new 1s would make me look a lot better but i got a full set off teeth and there nothing much wrong with them apart from loads of fillings and there small so if i get a new set off teeth even tho they luck better would i regret it because of loosing the feeling of my own teeth and when we can grow are own teeth will it cost more then it would to get the fake teeth put in ?

andy

andy said at October 9, 2006 10:46 AM:

hi iv read all these posts from this thread and the old 1 in last 2 days and its quite amazing i had no idea they could do any thing like this.
the thing is i started serching because i was thinking of paying 4 grand and buying a totaly new set of teeth because im 22 and my teeth are REALY small my back teeth are that small my gums almost go totaly over them plus iv always got toothach *me own fault* got dentist on wednesday for a filling 100 pound gone again . any ways i was gona buy new teeth because mine are small and new 1s would make me look a lot better but i got a full set off teeth and there nothing much wrong with them apart from loads of fillings and there small so if i get a new set off teeth even tho they luck better would i regret it because of loosing the feeling of my own teeth and when we can grow are own teeth will it cost more then it would to get the fake teeth put in ?.
plus if i do decide the get a fake set of teeth *what ever the implants called* does that meen they wouldnt be able to grow my own teeth because they would be gone ?

soz about post before this some reson it messed up

andy

Martin said at October 9, 2006 2:10 PM:

I have been reading these posts recently with much interest. I have missing teeth and it wrecks my life everyday. I sometimes feel very depressed by it all, but I know that I have to carry on despite how I feel. I wonder if tooth regrowth would get me out of this situation. But it all seems so far fetched and like a dream? Could it ever really happen, or am I just pinning hopes on the impossible. Until anyone is in this situation, they can never know what it does to a person. False teeth are not the same, but what other choice is there? If this became available I woudl go anywhere and pay any price to get my missing teeth back.

lt said at October 11, 2006 9:36 AM:

Hi Everyone,

Has anyone heard latest news from any of the companies above? Please keep us posted on what you receive.

Thanks--Lt

lt said at October 11, 2006 3:15 PM:

Update to everyone here...

About the Ultrasound teeth regrowth from the Canadian scientists. I have obtained the latest with answers to some of yours above:

1. They cannot regrow tooth from scratch (From Nothing)
2. The trial seemed to work and they have tested on dental patients, not just animals like rodents or rabbitts( You know, these animals growth their teeth like mad...an inche per month...so if they have tested on these animal model, pretty much not too good.). This is a good news.
3. Currently, the research has been done to regrow existing teeth which have shorten roots ONLY.
4. It has not been done on abutment teeth that have previously prepared for bridge to anchor.
5. They are researching to create anamel...and also with the ones that have abutment teeth prepared for bridges.

They only filed provisional patent...not really an application yet.

Hope this helps.

Maritza said at October 11, 2006 8:19 PM:

Lt
Does this mean this won't work on people who have gotten crowns but not had a root canal done?
If you know the answer please let me know..Maritza

lt said at October 12, 2006 12:39 PM:

Maritza:

For the moment, they have not done any research on patients that had crowns with or without root canal done or even patients with bridges. So far, it has been tested to work on patients with shorten roots only.

As for Odontist, any latest development from their research they will post on www.odontis.co.uk. But they said do not expect much in the way of newsflow in the near future. Furthermore, they said their technology is still some way from being ready to enter the clinic and they are not currently seeking volunteers.

That's all I got.

David said at October 14, 2006 1:26 PM:

Anyone interested in doing a PhD in regenerative dentistry???
There are loads of PhDs being offered, please have a look:

http://www.dentistry.bham.ac.uk/ecourse/phd/welcome.asp

let me know your thoughts about that.
thanks
D

David said at October 14, 2006 1:32 PM:

UNIVERSITY OF BIRMINGHAM

PHD STUDENTSHIP IN STEM CELL BIOLOGY
SCHOOL OF DENTISTRY
Applications are invited for a PhD studentship with the Pulp Biology and Regeneration research team, starting in October 2006. This post is fully funded (living expenses and tuition fees) for UK/EU students only.

Dental Regeneration and Stem Cells

Dental disease affects many in the population impacting on healthcare resources and quality of life. Significant advances in our understanding of the biology of the dental tissues now set the scene for biologically-based regenerative therapies to be realistic alternatives to traditional “drill and fill” approaches to management of dental disease and provides the opportunity to harness stem cells in development of novel therapies.

Our research group has been very active in the tissue regeneration field identifying the involvement of extracellular matrix sequestered pools of growth factors, especially members of the TGF-b family, in cell signalling during dental regenerative processes. The postnatal stem/progenitor cells involved in dental regenerative processes are at the cutting-edge of research in this field currently, because of the exciting opportunities for translational research exploiting their use in novel therapies.

These stem/progenitor cells comprise a heterogeneous population of cells, which may arise in the pulp as a consequence of embryonic development of the tissue as well as possibly being systemically derived from the vasculature. These different derivations of the stem/progenitor cells in pulp may have important consequences in terms of the nature of the tissue formed during regeneration and a spectrum of such tissues arise in teeth after regeneration ranging from that with a bone-like appearance to matrix indistinguishable from physiological dentine.

Thus, the tooth provides a valuable broader model of tissue regeneration in general. The aim of this PhD project will be to improve our understanding of the influence of stem/progenitor cell nature and derivation on the outcomes of postnatal dental regeneration.

The project will provide sound research training in various aspects of cell and molecular biology and would suit someone keen to be involved in translational research with exciting therapeutic potential. Cells from a variety of derivations will be studied allowing experience to be gained in cell culture and cell immuno-selection techniques. The fate of these cells, after stimulation with appropriate signalling molecules, will be investigated using microscopical, gene expression and biochemical analytical approaches. Our research group collaborates with a range of centres internationally and the project may provide scope to participate within these collaborations.

The successful applicant will join a very active and successful research team based at the University of Birmingham, an institution where research of national and international importance is a priority. A multi-disciplinary approach is adopted for all projects, combining the talents of our scientific and clinical teams.

Applicant Background: This position will suit an individual who wishes to work in the cell and molecular biology areas with a strong translational focus to their research. A background in an appropriate area of Biosciences would be an advantage, but is not essential, as appropriate training will be provided. Applicants from dental/medical fields would also be considered.

Funding: The studentship provides a maintenance stipend and tuition fees at the UK/EU rate and is thus only suitable for UK and European residents. Applicants for this position should have, or expect to achieve, a 2:1 or 1st Class Honours Degree (or equivalent) in an appropriate discipline.

Contact Details: Should you wish to discuss this project any further, please contact Professor Tony Smith by email at the above address or by telephone (0121-237-2882). We will endeavour to be in touch with you as soon as possible. Applications should be submitted as soon as possible.

To apply: Further particulars and an application form are available from Ms Jan Poller (j.b.poller@bham.ac.uk; 0121-237-2926). The studentship provides a maintenance stipend and tuition fees at the home/EU rate and is thus, only suitable for UK and European residents. Applications (to be returned to Ms J Poller as soon as possible) should include a completed application form, a CV, names of two referees and a brief statement indicating why you wish to pursue a PhD on this topic. Web link:- www.dentistry.bham.ac.uk/research

alias G. said at October 15, 2006 12:37 AM:

Hi I think it is wonderful that you might be able to regrow teeth so soon. Although I am still young my tooth enamel has somehow been damaged, and is now painful and slightly discoloured. The sensitivity began two or three years ago and allow I've taken measures to slow it down such as using sensodyne and using a flouride mouth wash the wearing away of my enamel has rapidly speeded up in the past nine months. I don't drink or smoke, and it is distraughting for this to happen for a young girl. This sounds selfish, and unimportant but it's very true. You said you might start human tests as soon as 2007. When would they be complete, or when may the product go to market if it was successful? I've heard that regrowing the enamel is more difficult, and that they haven't quite finished figureing out the process? If your enamel was wearing away but your teeth weren't fully decaying yet or missing wouldn't it make more sense to repair the enamel instead of replacing the tooth, I just don't want to have to wait longer for an enamel repairing technology to come out if my teeth could be regrown. I am very interested in any of your further research and would possibly not mind being a test volunteer if you need one. number 1-604-736-6008 Canada

David said at October 15, 2006 4:37 PM:

Hi,

I wanted to ask you for some advices.
I have an implant instead of my top right incisive. I am so incomfortable with it, I am actually thinking of having it taken off, as I believe it affects my overall health.
Do you think removing that implant would be a wise thing to do?
What could I put on the hole instead of the implant in order for the food not to go into the hole?
thank you for your help
David

lt said at October 15, 2006 7:11 PM:

Hi David,

I don't have the answer for you, but please visit the following website to search through responses to all of your question with regard to your implant. I heard that in the long run, dental implant is not good for the health since the area where the abutment meets the crown will havest the bacteria and built up to the top where hygienist could not access to clean. Since there was no long-term studies done on this, I do not know how true this is. However, from the logical view, I think it is an ideal location to gather bacteria because it has water, air and food.

I recently lost a baby tooth and I was debating whether I should do an implant but at the end, I opted for a bridge.

http://osseonews.blogs.com/osseodaily/2005/12/search_on_for_w.html#comments

Martin said at October 16, 2006 1:16 PM:

David, I can relate to your post so much. I have an implant at second lower molar area. I have this implant not because of my own neglect but because of my dentists. I have no choice but to either leave the gap or fill it with an implant. I hate it so much. I can always feel that it is there and the gap behind it, it traps food at the gum line area due to the previous bone loss, and it all makes me so angry and sad. But of course I now understand the limitations of implants, and I now no longer accept it when people say that implants are great. They may be for some people, but not all. And let us be clear about this, they are not like real teeth at all, beacuse they are not real teeth. They are a titanium post driven into the jaw, with an abutment crown placed on top. There is no emerging gumline, and all I get is a false feeling and agitation on a daily basis. So I really do understand how you feel. As to whether you could remove it at this time, well what is the point?. There is nothing you can really replace it with. My advice is the same as that I give to myself. Wait and hope for this technology to come available, then look at having it removed. I will without hesitation. Some people say that it will be difficult to get it out, but I don't care what risk there is, I am not prepared to live like this until I die. Then once it is out I will hopefully regrow my own teeth properly as it is meant to be. Sometimes I feel I am going to go crazy with how I feel everyday, ans I a certainly neither neurotic or psychologically ill. I am pefectly sane thank you very much. But I do know what is right for me, and how my mouth now feels is not it. David, you like me have to wait. That's the hardest part, but you ca do it with support. Thanks so much for this board, so at least I can vent my sadness at how I feel.

lt said at October 16, 2006 1:55 PM:

Hi Martin,

I am sorry to hear about your story. Why did you not go with a bridge before? I would be more carefull about "trapping foods at the gum line are due to the previous bone lost" I read that they build up bateria under the abutment as well. Visit the website I posted to David a bove and you will get more into others' stories.

I hope the regenerative dentistry is coming out soon.

lt said at October 16, 2006 3:27 PM:

David,

Below is the implant removal message I found:

Implants are simply titanium or titanium alloy screws with a very special surface that allows bone to grow into the roughened surface to increase bone to metal contact.

Osseointegration is considered when approximately 40%-50% of the implant surface area have intimate contact with the bone. This is achieved depending on the surface characteristics within 6 months or as early as 3 months.

The implant never becomes a part of your body, it simply exists in an environment where the bone does not react to the metal, unless gum disease and periodontal disease affect the integrity of the bone. There are no nerves that attach to it, there are no arteries or blood vessels that attach to it. Therefore, once the implant is removed, the bone will repair the empty void or space, just as if you had a tooth removed.

Removing an osseo-integrated implant requires a trephine bur, which is used to cut the bone around the implant and the implant is removed. Depending on the size of the implant and what vital structures exist around the implant (ie other teeth, nerves, vessels) it may be a simple or difficult task.

Another option is to treat the implant like an impacted tooth and remove bone using a surgical bur around the implant. This technique is more destructive around the implant and will require more bone removal than a trephine bur. Metal shavings from metal to metal contact can cause incorporation of titanium into tissues which can result as tattooing.

So to answer the questions, it depends on your own clinical situation. Find a reputable clinician who has experience with dental implants and seek a consultation.

Ratan said at October 17, 2006 11:07 PM:

I have a query. My wife had a dental extraction of an upper first molar at the age of 22. She is now 26 and has been advised to fill the gap with a bridge or implant in order to prevent tooth movement. However, she has not exhibited any tooh movement in the last 4 years. I'am not sure whether it is necessary to replace a missing tooth. Is there someone who has had an experience of tooh movment as a result of an extraction of a posterior tooth? Please let me know.

Paul Daloo-Ford said at October 18, 2006 6:40 PM:

Any new articles on when the treatment will be available?

Ben said at October 22, 2006 1:32 PM:

Hi Ratan,

It seems that your dentist is pushing for business..
Tooth movement wont be an issue at all.
But your wife will probably start to get issues if she put a bridge (will damage the teeth next to the bridge), or an implant (implant are not comfortable and often create headaches and all sorts of pbs after a while, as they are changing the balance of the jaw, as they are never of exactly the same size/shape than the original tooth..).

You will find that most dentists push people to have implants, bridges, etc.. in the same way than most banks will push you to get new loans or insurances, haidressers to get your hair cut more often.. etc

It is their job, and unfortunately that is all they know. The fact that is the right thing to do for your wife or not in the long term, is not really their priority..

Good luck
Take care
B

Ben said at October 22, 2006 1:46 PM:

Has anybody read this article?


http://seattle.bizjournals.com/seattle/stories/2006/05/22/focus3.html


It is good to see that Odontis is not the only company dealing with regenerative dentistry.
A bit of competition is always good to get things done quicker.
B

shahana said at October 22, 2006 4:06 PM:

Ratan,

I agree with Ben ... Don`t make your wife suffer for reast of her life. Don`t make her do anything.

My mom is almost 70 years old Indian woman & has never been to a dentist.
I think that was the best decision she has made.

Shahana

raul said at October 23, 2006 8:09 AM:

hi, someone knows about hitachi project ???

Ben said at October 23, 2006 12:28 PM:

Hi Shahana,

I am glad to hear about your mom having never been to the dentist. You are right, it was a very wise decision to make.
It is a fact that implants, bridges, and all these things are being "sold" based on lies. You can read on loads of dentists website that implants "feel like real tooth".. and all sort of great lies about them..
Unfortunately, they hide the truth, as at the end of the day, they are very bad for your health in the long term.
I feel there is a big need to let people know, about all the troubles you can get into by getting implants, bridges...etc..
Take care
Ben

Ben said at October 23, 2006 12:30 PM:

Hi raul,

I remember an article about hitachi saying they were planning to get regenerative dentistry going by 2007, but that was an article written a few years ago.

To my knowledge there are 3 companies working on regrowing teeth:
- odontis (uk)
- hitachi (japan)
- and this new company linked with the university of washington.


Shahana, am I missing anything here?

Take care
Ben

Ratan said at October 24, 2006 2:37 AM:

Hi Shahana and Ben,
Thnks for your advice. I'am seriously disturbed by the farce that is being enacted by modern dentusts under the guise of interventionist dentistry. We have decided not to go for a bridge or an implant. However, is this entire concept of "tooth drifting" that is bandied to justify dental bridges an elaborate farce or does it actually happen in most young patients who do have an extraction of a posterior tooth? Most dentists that I have spoken to are of the unanimous opinion that an extracted tooth should be replaced to prevent tooth movement. However, the comments on this website are definitely to the contrary. I'm really finding it extremely difficult to take a decision owing to the overwhelming opinion among dentists to replace the missing tooth. Are there serious complication relted to bridges apart from the fact that they need to be replaced every 5 - 10 years and a probable root canal in the long run. Would it be prudent to risk teeth drifting rather than the complications associated with a dental bridge. Plese do let me know.

lt said at October 24, 2006 10:00 AM:

Hi Ratan,

I have three chewing teeth missing 15 years ago and I am doing fine (neither bridge nor implants). Still, I did not put in any bridges or implant.

Now, I would say that if you miss one of the front teeth, it is fine to opt for a bridge rather than an implant. Implants sounded great from the beginning but in the long run, this will complicate the health issues.

These days, they are offering all porcelain (LAVA brand from www.3m.com) bridge to replace missing teeth. If I had a missing front tooth, I will personally pick a bridge over implants (cuz of the future health related issues and bacteria gathered around the abutment gaps). As long as the dentist fits and bonds the bridge well, and what you have to do is good home oral cleanings (flossing after every meal, brushing and mouth-washing after every meal, every once in awhile, rinse your mouth with salt water) and regular dental check up to spot any issues with your bridges. Having a bridge requires extra care to your oral health, but why not...at the end, you are doing good deeds to yourself.

Matin said at October 24, 2006 2:48 PM:

Jodie, I have been trying to email you for a while but the emails are returned? Do u have a new email address? Martin

Ratan said at October 24, 2006 7:14 PM:

Dear friends,
It's been heartening to receive the advice that each one of you has rendered. We have decided not to go for a bridge or an implant at this point of time. Instead, my wife shall be going to my family dentist once a year for a checkup to determine any tooth movement. The day she is diagnosed as having any form of tooth movement, we shall go for the bridge. I have spoken to my dentist about this and he has accepted that this is perhaps the least invasive and most conservative way of dealing with the situation.

Once again, I wish to thank each one of you for your advice. Do keep this forum alive as this is an immense repository of information. I have been avidly following up the discussions on this forum and shall continue to do so.

Ben said at October 25, 2006 1:58 AM:

You are welcome Ratan.
I hope this forum will stay alive for a long time, at least until we are in a position where we are being offered to regrow our own teeth! I am looking forward for that time, where we will be able to share the joy to have new real teeth.
Until then, I think we need to tell people the truth about the danger of implants, bridges and all kind of traumatic dentistry..

Take care
Ben

ron said at October 28, 2006 6:42 AM:

Hi,

I wanted to ask you some advices. My english is not perfect, as I am french. But I will try to explain the best I can, and hopefully we will understand each other.

I have a cap instead of one of my superior incisive.
This cap is far too thick compared to the other teeth, and is causing lots of problems with the balance of my jaw and all sorts of consequences.
The dentist who installed it told me he couldnt get it thiner, because of the way it is fitted.

Questions:
1- What is the best way for me to get a cap that match the thickness of my original incisive, so I can close my mouth properly?
2- Is there some kind of machine that would take pictures of my existing incisive and build the exact same shape?
3- Is the LAVA brand from www.3m.com presented earlier by It, the best method available, in terms of matching shape and size?
4- What material should I go for? ceramic or porcelain?

Thank you for your help
Ron

Pall said at October 28, 2006 9:57 AM:

Ron

This is not a board for general dentistry questions, but rather about tooth regeneration. Try the following denistry board for this type of question instead.

http://members5.boardhost.com/CosmeticDental/index.html?1135799303

lt said at October 29, 2006 8:25 AM:

Posters on that board seemed to dislike everything else but dental implants. When you are on that board, you do not have the freedom to have or share ideas about the negative impacts on dental implants...they only want to hear the positive issues. These guys urge anyone to have dental implants...

Ron said at November 1, 2006 8:25 PM:

Thank you for your comment It.
To be honest, I don t think there is any positive thing to say about dental implant.. except from the fact that it is such a profitable business..
Dentist pushing for people to have dental implants should be forced to experiment them personaly by having a few ones, so at least they know what they are talking about..
R

Ratan said at November 2, 2006 7:14 PM:

Hi Ron,
It seems that you have had a bad experience with dental implants. Could you throw some light on what went wrong?

l said at November 2, 2006 11:24 PM:

Ratan,

Did you read my message earlier? People on the board of http://member.... are all about implants. Are they trying to talk you into how great implants are?

I do not like the idea of preparing for a bridge either, but for me, it is not too invasive (surgically anyway). I had a baby tooth (#10) fell off a month ago, in the front, my dentist suggested an implant but I opted the 3 unit zirconium bridge. Anytime when there is dental work done on a tooth, there is a risk that root canal will soon followed. There is a bit of luck and hope that the dentist will do a good job shaving the abutment teeth. Once the bridge is on, keep your good oral hygien (flossing, using waterpik, brushing, rinsing with non-alcohol mouthwash and seeing your dentist 3-4 times/year. I went to the cosmetic dentist, Dr. Lori Kemmet (google her). Her husband has a 3 unit bridge lasted for 30 years, the dental assistant at her office has two three unit bridges on both sides of the front for more than 13 years. I wonder why they do not go for implant is it is so good and they are in the dental profession anyway?

If you do not want to shave down the teeth for bridge or do not want an implant, maybe you should try partial denture for now until you are comfortable with any of the treatment later on?

Whatever you decide, I hope it will work out for you.

Ratan said at November 3, 2006 12:36 AM:

Hi,
Thanks for the information. As I had stated earlier, we have decided on a "wait and watch" approach. We have decided that my wife shall undergo a dental examination every year to check for any tooth movement and the day we are informed of any form of movement, we shall opt for the bridge. We are definitely against implants. I suppose this is the most prudent thing to do at this stage. By the way, you are right about the other forum. The people over there are some of the biggest supporters of implants.

Ian said at November 4, 2006 3:51 AM:

I do hope that this board does not become a forum for discussing the pros and cons of dental implants. I have one and yes I absolutely agree that they are not the best in any way. I also think that the people who advoate for them maybe have non themselves. At the end of the day, the implant market exists because they are probably the best that we have right now. But NO they are not perfect and I do not like my molar implant at all. But I have no choice but to put up with it, as there is no other choice. Would I get rid of it if I had an alternative?, yes I would without hesitation. I sometimes do wonder though whether stem cell teeth will come anytime soon. I think mabe that we could be waiting decades and not years, if they come at all. When you are living with missing teeth it is s hard. The thought of waiting for ever with no guarantee that they will ever become a reality is the hardest thing to bear.

Michael said at November 5, 2006 5:16 AM:

Does anyone know what is going on with this?

It's a patent application from Japan:

***

Method of regenerating tooth germ and a regenerated tooth germ

Abstract

An object of the present invention is to provide a method for regenerating tooth germ, and more specifically, to provide a method for regenerating tooth germ that enables the treatment of patients who have lost teeth or have had teeth damaged by dental diseases such as pyorrhea alveolaris or dental caries. The present invention provides a method for regenerating tooth germ by culturing tooth germ cells while giving mechanical stimulus to the cells, and a regenerated tooth germ.

***
Is this the Hitachi project?

lt said at November 5, 2006 4:17 PM:

I read through the patent, it is very promising. I wonder if and how it will actually work.

I think this is the Hitachi project.

I do hope this this is not turning into that pros and cons forum. I will reserve my 2 missing molars for regenerative dentistry. i cannot go through implants.

Ben said at November 6, 2006 6:22 AM:

Hi Michael,

Thank you so much for that link!
I am so happy to read that patent. It is likely that it is the Hitachi project.
I have the feeling Hitachi will be the first to offer regenerative dentistry.

I have one question, will the tooth that is regenerated be exactly the same shape and size than the one missing??

I would think yes, as it seems it will be based on our own DNA, but I am not sure.

Thanks for letting me know
B


Ben said at November 6, 2006 8:31 AM:

Hi again,

I have found this very interesting link:

http://lib.bioinfo.pl/auth:Honda,MJ


Ben

Michael said at November 6, 2006 7:36 PM:

Thanks for the articles. It looks like the Honda team is experimenting with scaffolding. I think this is the approach Yelick and Forsythe Institute researchers are taking and different than the work of Sharpe. I have to admit, I don't particularly understand how the scaffold would be clinically applied - is it the size of a full-grown tooth like a steel-frame for a building or is microscopic to facilitate the formation of a tooth bud?

ben said at November 8, 2006 4:38 AM:

Hi Michael,


I am not sure about what tp think about the scaffolding either.


Here is an other interesting link, this time about Paul Sharpe research.

http://lib.bioinfo.pl/index.php?field=PubMed&query=paul+sharpe

It seems to me, that what is slowing down the process, is the need to understand how to control the shape
and size of the teeth. Once this is fully understood, I believe things will start very
quickly.

B

Martin said at November 8, 2006 2:40 PM:

B, do u think that we are this close to regeneraive teeth coming to reality. I do hope so, I am so tired of living my life like this.

Julie Woodchuck said at November 9, 2006 6:55 PM:

I know this is not about teeth, but even even better breakthrough


I saw something on the BBC International Channel about blind mice getting their sights back, it looks promising. I just hope they didn't have their tails cut off by the farmer's wife.

Here is a link to an article that talks about it http://www.bbc.co.uk/radio4/science/leadingedge.shtml


Such research could mean we are getting closer!

Marianne said at November 12, 2006 1:41 AM:

Has anyone heard how the Hitachi corporation is progressing? Evidently they were advertising tooth germ would be ready for export to USA next year (2007).

lt said at November 24, 2006 2:23 PM:

Hi Everyone,

Have you guys heard anything more about the latest in regenerative dentistry?

Maritza said at November 24, 2006 2:43 PM:

Hi Marianne,
Where did you see that the tooth germ would be ready for export to the US in 2007?
thank you for any info.


This part is for Ratan I would ask a ortho dentist to make your wife a retainer to maintain her teeth were they are, she could probably just wear it at night to sleep.

It's true this forum is wonderful this is the only place that I feel that people actually know what is going on with the feelings of others going through the same thing its painful but we can almost see the light at the end of the tunnel and it is very promising, and I pray faithfully for the Doctors to remain on track and that nothing derails their progress, I believe this is going to be awesome if I don't get to get this done some day my children will have the opportunity to have this to their advantage and I still feel that's a blessing in its self. Thank you for keeping this forum open and for letting us vent our frustations on things that have happened to us no matter how different they are they still have one thing in common.
Maritza

MIKE said at November 25, 2006 11:05 PM:

Here is a link to an article (Hitachi project) Histological and immunohistochemical studies of tissue engineered

MIKE

MIKE said at November 25, 2006 11:12 PM:

Here is a link to an article (Hitachi project) http://cat.inist.fr/?aModele=afficheN&cpsidt=17071883

MIKE

Pal said at November 26, 2006 4:30 PM:

I absolutely agree with Maritza, I am s glad to have this site to visit on a regular basis. Other people and their stories keep me going.

Paul Bannister said at November 27, 2006 4:10 PM:

dear all-have not visited for a while nor has Jodie:-

sent this email to Professor Timokor at Helsinki University in Finland(probable colleague of Professor /Dr Irma Theslaff who is very well known in field of dental research)

(she was in original 2002 New scientist article I have mentioned in this thread or other one)

mentioned in the link above ;this one :-

http://www.yet2.com/app/list/techpak?id=36800&sid=90&abc=0&page=tpoverview

as follows:-

Dear Professor Timokor

http://www.yet2.com/app/list/techpak?id=36800&sid=90&abc=0&page=tpoverview

from paul bannister researcher into teeth regeneration and contributor(with Jodie Bannister) to www.futurepundit.com website thread(s) re teeth regeneration

( re :- e.g:-

www.odontis.com

and re hitachi's work(dr minora ueda and dr honda et al)

are you a colleague of Dr Irma Theslaff's by any chance?

please see link posted very recently above for "techpak"

and could you briefly summarize what stage you have with Professor Zakhartchenko(Russian Federation)

reached re teeth regeneration and do you have any plans to start any human clinical trials in Finland or Russis in the next 5 or 10 years?

subject to funding requirements being met?

I last heard "Odontis" and Professor Paul T Sharpe/Kings College/Guy's Hospital

were seeking(email interview in december 2005 published in a USA journal)funding for human clinical trials

(I am very patient and realistic about the time scales involved in this field and am just making very preliminary enquiries to you as to the potential future developments in your and Professor Zakhartchencko's work)

and are you at the stage of seeking private and or public sector funding for your work?

Would be very interested to know if not company confidential or commercially sensitive-

have been following eg Professor Paul T Sharpe's work since 1998;

and that of Dentegenix; Harvard University(Pamela Yellick) and many others

including Hitachi joint project with about 5 or 6 Japanese Universities and Prof Minora Ueda's work and Dr Honda's:-

all different types of appraoch from scaffolding to eg Professor PTSharpe's signalling approach

(inc his latest papers:-

http://lib.bioinfo.pl/pmid:15721158 amongst others)

It would be nice -if feasible- for say a Professor like you or someone similar-

to contribute to the www.futurepundit.com website threads

although some of the contributors do get a bit emotional- understandable as some are in pain and have found eg bridges and implants painful or unsuitable-Im neutral and very patient re waiting for developments in this emerging field myself.

I have not seen your work until today with the above link from the futurepundit.com website

and wasnt aware of the company you have set up at all until today

though was aware of :-

http://seattle.bizjournals.com/seattle/stories/2006/05/22/focus3.html

the bio-memetics start up company run with the University of Washington State/Seattle

run by Dr /Director of Research Mehmet Sarakiya

I dont know how you feel about enquiries by members of the Public(here in the UK!)

to yourself but any helpful or explanatory data would be useful.

My own feeling is that various methods to teeth regeneration will come to fruition eventually after some delays-

and the more the Public support this-understand the technical difficulties and delays-

and maybe lobby Politicians worldwide to fund this type of research(esp as president Bush has been defeated in the mid term elections and lost control of the Senate and Congree and can no longer easily block or delay stem cell research)

the better.

I see there have been several patents filed by several companies in this field so that is a good sign too.

Hope you are well and your Russian colleague and any data you can give me would be very much appreciated

Yours sincerely

Paul Bannister.

Hopefully this may possibly yield more data?

Obtained his email address form the link above re TECHPAK- a very interesting development and a new company run jointly by this Finnish Professor and a Russuan Federation Professor Zakhartchenko-works at moscow University and haven't heard of him before)

Paul Bannister said at November 27, 2006 4:25 PM:

error corrected-

its "Professor Timo K Korpela"

though I got the Russian collegaue correct!

cannot harm to make polite enquiry as I and others have done to say Odontis in the past

and professor Paul T Sharpe and his backers at Javelin Ventures venture capital company(Valerie Jolliffe-see odontis website)

will be interested to see how this new company does in the future and the bio-menetics one in Seattle I and others posted the link for previously

Have not visited this thread for ages so nice to catch up on all the news-keep posting as developments are occurring 2all the time" although one must be very patient!

Professor Minora Ueda(will post link later if I can find it!-its on another PC I have which needs repairing as it crashed!)has also done new work re:-

removing wrinkles through use of skin stem cells-and has set up extra company to exploit this commercially-

which techniques he is also commercially developing as well as his teeth regeneration work although he complains that that is harder toget funding for unfortunately

tip to find extra data:- use "google alerts" service at www.google.com

and use words like "teeth regeneration"

and "dental stem cells"

in your google alerts

and google serahc all the web to send one daily "comprehensive" updates and links to click on

thats how I found about the extra work on wrinkles removal and skin restoration Profesor Minora Ueda is "also working on"

he is very keen to get commercial applications for both wrinkles treatments and teeth regeneration

anyone got any more news?yours Paul

Paul Bannister said at November 27, 2006 4:31 PM:


Dear All:-

appears to be joint Finnish-Russian major Biotechnology collaboration-

the paste below is from the NON CIS collaborator webpage:-

// People / Non-CIS Collaborator Language: ENG RUS
Search | Portals navigator


Tech-DB portal
About Portal PRA TA S&T Needs ISTC Projects Institutions People Guidelines
to friend to print


PRA, TA Participants by Name
PRA, TA Participants by Location
PRA, TA Participants by Affiliation
Non–CIS Collaborators
Reference Data
Display all items


Contact Information for non-CIS Collaborators


Name: KORPELA Timo K.

Organization: Finnish-Russian Joint Biotechnology Laboratory, University of Turku, Finland, JBL

Position: Professor, Director of JBL

Main activities of the company / institute: (i) Fundament and applied research, (ii) Technology transfer in biotechnology, (iii) Protection of intellectual property rights

E-mail address: timokor@utu.fi

Tel. number: +358-2-3338066, +358-49-764470 (mobile)

Fax number: +358-2-3338080 (public)

Mailing address: University of Turku, Joint Biotechnology Laboratory, BioCity 6a, Fin–20520 Turcu, Finland

Technology areas, which interest you: Biotechnology



// People / Non-CIS Collaborator Language: ENG RUS
Search | Portals navigator



Tech-DB portal
About Portal PRA TA S&T Needs ISTC Projects Institutions People Guidelines
to friend to print


PRA, TA Participants by Name
PRA, TA Participants by Location
PRA, TA Participants by Affiliation
Non–CIS Collaborators
Reference Data
Display all items


Contact Information for non-CIS Collaborators


Name: KORPELA Timo K.

Organization: Finnish-Russian Joint Biotechnology Laboratory, University of Turku, Finland, JBL

Position: Professor, Director of JBL

Main activities of the company / institute: (i) Fundament and applied research, (ii) Technology transfer in biotechnology, (iii) Protection of intellectual property rights

E-mail address: timokor@utu.fi

Tel. number: +358-2-3338066, +358-49-764470 (mobile)

Fax number: +358-2-3338080 (public)

Mailing address: University of Turku, Joint Biotechnology Laboratory, BioCity 6a, Fin–20520 Turcu, Finland

Technology areas, which interest you: Biotechnology




© ISTC 1993-2006
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Questions or comments? Please fill the feedback form

hope this is useful to you all;

yours paul bannister


Paul Bannister said at November 27, 2006 4:37 PM:

DEAR ALL-THIS IS SAMPLE OF VALUBALE DATA AND HELPFUL INFORMATIVE LINKS ONE CAN OBTAIN VIA THE EXCELLENT GOOGLES ALERT SERVICE-ONE CAN TYPE VARIANTS AND SEVERAL DIFFERNET PHRASES AND GET VARIETY OF LINKS TO WEBPAGES-AND THERE ARE ALSO SPECIALIST SCIENTIFIC SEARCH ENGINES AVAILIABLE TOO-YOURS, PAUL:-

Google News Alert for: stem cells in dentistry

Dr. Jane Aubin appointed new Scientific Director of CIHR's ...
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Dental Industry Investing: The Future Looks Bright
Seeking Alpha - New York,NY,USA
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Craniofacial Tissue Engineering by Stem Cells
Journal of Dental Research (subscription) - UK
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All Headline News - USA
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Google Blogs Alert for: stem cells in dentistry

‘Master stem cell’ find sparks hope for regrown he...
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The Longevity Meme -- live healthily - fight aging - extend your life
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Health News & Medical News from Medical News Today
Biochemists at Oregon State University have developed a new method to identify the "DNA-binding transcription factors" that help steer stem cells into ...

ADA.org: Banking Baby, Wisdom Teeth For Stem Cells
The stem cells have the potential to save injured teeth and grow jawbone. ... the public's health and promoted the art and science of dentistry since 1859. ...

Guardian Unlimited | Science | Grow-your-own to replace false teeth
Paul Sharpe, a specialist in the field of regenerative dentistry at the Dental ... Doctors take stem cells from the patient. These are unique in their ...

Farewell, Tooth Fairy
Dr. Christopher Nosrat of the University of the Michigan School of Dentistry has experimented with adult tooth stem cells as a treatment for Parkinson’s ...

Search results matching tags 'Stem cells' and 'Dentistry'
Cells with characteristics of adult stem cells have been
Google Web Alert for: stem cells in dentistry

The Longevity Meme -- live healthily - fight aging - extend your life
The near future of dentistry, as for many other fields of medicine, ... Mesenchymal stem cells are the offspring of mesenchymal cells following asymmetrical ...

Health News & Medical News from Medical News Today
Biochemists at Oregon State University have developed a new method to identify the "DNA-binding transcription factors" that help steer stem cells into ...

ADA.org: Banking Baby, Wisdom Teeth For Stem Cells
The stem cells have the potential to save injured teeth and grow jawbone. ... the public's health and promoted the art and science of dentistry since 1859. ...

Guardian Unlimited | Science | Grow-your-own to replace false teeth
Paul Sharpe, a specialist in the field of regenerative dentistry at the Dental ... Doctors take stem cells from the patient. These are unique in their ...

Farewell, Tooth Fairy
Dr. Christopher Nosrat of the University of the Michigan School of Dentistry has experimented with adult tooth stem cells as a treatment for Parkinson’s ...

Search results matching tags 'Stem cells' and 'Dentistry'
Cells with characteristics of adult stem cells have been

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... Paul and Sheila Wellstone Muscular Dystrophy Center · Stem Cell Institute ... School of Dentistry · School of Nursing. Centers and Partnerships ...

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... bone marrow stem cells (BMSC) to regenerate lost periodontal attachment. ... UBC Faculty of Dentistry 2199 Wesbrook Mall, Vancouver, BC Canada V6T 1Z3 ...

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Paul Bannister said at November 27, 2006 4:44 PM:

JDR UAB Recruitment
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J Dent Res 85(11):966-979, 2006
© 2006 International and American Associations for Dental Research
REVIEW
CRITICAL REVIEWS IN ORAL BIOLOGY & MEDICINE
Craniofacial Tissue Engineering by Stem Cells
J.J. Mao1,*, W.V. Giannobile2, J.A. Helms3, S.J. Hollister4, P.H. Krebsbach5, M.T. Longaker3, and S. Shi6

1 Columbia University College of Dental Medicine and Biomedical Engineering, 630 W. 168 St. - PH7 CDM, New York, NY 10032, USA;
2 Michigan Center for Oral Health Research, University of Michigan Clinical Research Center, 24 Frank Lloyd Wright Drive, Lobby M, Box 422, Ann Arbor, MI 48106;
3 Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, Palo Alto, CA 94305;
4 Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109;
5 Department of Biological and Materials Science, University of Michigan, 1011 N. University, Ann Arbor, MI 48109; and
6 National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30, Room 134, 30 Convent Dr. MSC 4320, Bethesda, MD 20892

* corresponding author, jmao@columbia.edu

Craniofacial tissue engineering promises the regeneration or de novo formation of dental, oral, and craniofacial structures lost to congenital anomalies, trauma, and diseases. Virtually all craniofacial structures are derivatives of mesenchymal cells. Mesenchymal stem cells are the offspring of mesenchymal cells following asymmetrical division, and reside in various craniofacial structures in the adult. Cells with characteristics of adult stem cells have been isolated from the dental pulp, the deciduous tooth, and the periodontium. Several craniofacial structures—such as the mandibular condyle, calvarial bone, cranial suture, and subcutaneous adipose tissue—have been engineered from mesenchymal stem cells, growth factor, and/or gene therapy approaches. As a departure from the reliance of current clinical practice on durable materials such as amalgam, composites, and metallic alloys, biological therapies utilize mesenchymal stem cells, delivered or internally recruited, to generate craniofacial structures in temporary scaffolding biomaterials. Craniofacial tissue engineering is likely to be realized in the foreseeable future, and represents an opportunity that dentistry cannot afford to miss.

KEY WORDS: stem cells • tissue engineering • biomaterials • wound healing • regenerative medicine


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Paul Bannister and associates said at November 27, 2006 8:34 PM:

This I also today (via excellent GOOGLE ALERT SERVICE-highly recommended to people using this Forum)saw in COSMOS MAGAZINE and mentions the work of the FINNISH dental researcher in this field IRMA THESLOFF-(her name is actually mis-spelt in this pasted article)-who I mentioned above and is probably colleague of the Finnish researcher co-working with the Russian Professor-

more work is also needed in perfecting the "wnt" signalling pathway(see other data I will post later on)which is one of the protein signalling pathways which if turned on or turned off by evolution determines how mammals bodies grow(see other data in wikipedia and on the web re recent better understanding of the "wnt" wingnut protein signalling pathways used by the mammalian body and also birds and other species)

by the way for all those silly ignorant anti Jodie Marsh people stalking us(ie looking on google for our posts re this serious subject) as a chaos magicik group interested in this scientific subject-all those freaks and losers out there tuning in(god knows why but they have oodles of time to waste the tossers) this one is especially for you!and we can use any alias including "Jodie bannister" we damn well want to-espescially if it confuses your rather limited neanderthal ignornant poor low bandwith minds!:-

yours from "paul" "catlover" "ashwani" "reg" and especially "Barbara Cox"-we would never give our real names on any site!(thats a message to the time wasting stalkers with nil better to do with their lives!)

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News | Ancient worlds | Health & Medical | Innovation & Technology
News
Teeth regrown for the first time
Monday, 27 November 2006
by Hamish Clarke
Cosmos Online
Teeth regrown for the first time
Humans may one day be able to re-grow lost teeth after scientists stimulated a dormant tooth-growing pathway in mice.
Image: iStockphoto

SYDNEY: For the first time researchers have been able to induce the growth of replacement teeth in mammals. Unlike other vertebrates, mammals normally lose the ability after they replace their milk teeth in infancy.

"Our results may have implications for organ regeneration and bioengineering of teeth and the understanding of the genetic basis of the evolution of teeth," the authors said in a paper published in the U.S. journal Proceedings of the National Academy of Sciences.

The research was conducted at the University of Helsinki, Finland, as well as in Berlin and Kyoto, using mouse tissue.

Most vertebrates - famously including sharks - have continuous tooth generation, meaning that lost teeth are replaced with new teeth as needed. Somewhere in their evolution mammals, including humans, lost this capacity, with the sole dental replacement being permanent teeth for milk teeth.

"Intriguingly, a trend in mammalian evolution has been a reduction of number and renewal of teeth, concomitant with the evolution of progressively more complex...teeth," the researchers said.

Irma Sesloff, from the University of Helsinki, and fellow researchers stimulated a molecular trigger, called the Wnt pathway, in tooth buds extracted from mouse embryos.

Tooth buds from mice with the activated Wnt pathway gave rise to dozens of teeth with normal tooth enamel, developing roots and the usual dentin interior. The new teeth were observed to bud off from previously developed teeth, which is how tooth renewal proceeds in other vertebrates.

However the teeth weren't quite like normal mouse molars in every respect. Typically mouse molars have several points, or cusps, but the teeth from the experimental mice were simple and cone-shaped.

The authors concluded complex teeth may have been a trade-off with the ability to grow new ones at will. "These results may implicate Wnt signaling in tooth renewal, a capacity that was all but lost when mammals evolved progressively more complicated tooth shapes," they said.

The findings may also provide a greater understanding of cancer of the teeth. There were parallels between the teeth grown in mice with hyperactive Wnt signalling and odontomas, which are tumor-like malformations consisting of multiple small teeth - sometimes over 100.

The demonstration that tooth renewal can be restored in modern day mice given the right conditions is reminiscent of the 2003 finding that chicken still posess genes from their dinosaur days - now silenced -involved in tooth generation.

More importantly, it means that the potential for continuous tooth generation may also have been retained in humans. The ability to harness this latent power will depend on the progress of future research in the area. If tooth regeneration becomes viable, it will be good news for boxers, the elderly and other people whose teeth have gone walkabout.
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leon said at November 28, 2006 1:56 PM:

Hi All,

Have to say this is the most informative message board I have been on regarding regenerative dentistry. Just thought that I would add my thoughts on Odontis. I too read with great interest and optimism the reports a couple of years ago which talked about their exploits in re-growing mice, and the £500k of funding they had received. Their research is indeed very promising, but I think the papers did get very carried away. If you read the article in new scientist you would have noticed that there were major challenges, such as the availability of ethical stem cells (i.e. adult stem cells). They also were a long way from understanding how to control tooth size and shape, which is fundemental if the teeth are to be of any use. They only thing that they realy proved was that you could grow teeth in and adult mouth, and be combining ESC with bone marrow stems cells that you could produce a tooth bud. This is all very very promising.

I think there are a few people who have got over optimistic, i.e. saying clinical trials would be in two years. Paul Sharpe was quite clear that he was looking to begin human trials within 5 years (back in 2004), and might expect to have a working treatment in 10. There is still much to understand about tooth development so I suspect it might be longer than 10.

Althouh there has not been much press I am still very positive about their progress because of a number of things I have read:

1)http://osseonews.blogs.com/osseodaily/2005/12/index.html - Paul Sharpe said he was looking for $5.2m of funding to begin human trials within 3 years, which would bring him within his orginal target. This would indicate he has made excellent progress since his press of 2 years ago

2)Looking at the Odontis annual accounts it says that the "Company has just come to the end of its two year research grant, and had successfully acheived all the milestones it agreed with the Wellcome trust. The company is now looking for further funding with the view of progressing the technology to clinical trials"

3)A look at the shareholder list shows a gentlemen by the name of John Moulton. He invested over £100k in 2004, and is a very experienced and successful venture capitalist, who runs Alchemy Partners. This was a personal investment so he must have seen something that he liked (Alchemy does not fund start ups).

4) Odontis recently filed for a patent jointly with intercytex, looking at using tooth buds for ridge augmentation/bone regeneration. This obiviously stresses the point above that they cannot fully control tooth formation at the moment, however it shows great progress because they must be close to producing acceptable buds from stem cells.

In addition to the above, you have the news from Canada, which is very positive. Although you cannot regrow missing teeth, this technology may help save diseased teeth that would previously be lost. It should also be cheap, and has been approved by the FDA.

I think you should all stay optimistic and positive, there is a lot more research going on in this area than ever before, so there is a good chance that full tooth regeneration may oneday be a possibility.

Martin said at November 28, 2006 5:01 PM:

Here is a further interesting link which may be useful to put the whole thing into context. I reman confident that this technology is coming, and thank you to Jodie and Paul for their new post, and Leon for his realisic one. Here is a new link of interest...

http://www.associatedcontent.com/article/50043/is_it_possible_to_regrow_human_teeth.html

barbara cox and jodie bannister said at December 4, 2006 10:41 AM:

Hi Martin and thanks to Leon for the most helpful informative post in a long time-

have you got any other links for us to look at the data in more detail ie to the odontis accounts?that would be very helpful indeed Leon if you can manage that at all-we did see at one time some limited accounts by ODONTIS but they were not very detailed at "that stage" -it seems things have moved onsomewaht which is positive sign!

reply to martin(wedge)-re bouncing emails that you kindly sent to us-we had a lot of problems with various web harassers and troublemakers due to our support for various people-unrelated to this forum yet they located our various contirubutions to "make fun of people who suffered lost teeth or who had dental problems etc" and take the piss out of this research-ie they are very sick mentally ill people on the whole-some are like that on the Web-so thats why we kept changing the email address-they are stupid timewasting troublemakers

to confuse them or mislead them(and wind them right up back!)

if you want to ask us a specific question do it via the forum-as we wont be giving out specific email addresses in future as not safe.Hope you are not in too much pain now Martin

Yours "paul cox/paul creasey/paul bannister/Jodie Bannister/jodie cox/jodie creasey/Barbara Cox/Barbara Creasey/ashwani kumar/ashwani cox/reginald stokes/reginald creasey -whatever and any alias used to protect our true identities"!!!

jodie bannister and barbara cox and other aliases! said at December 5, 2006 8:33 AM:

INTERCYTEX-

the company Leon mentioned-

we just checked out their website and they have also being awarded a £1.85 million grant or contract to develop:-

"innovative hair regeneration technique"

as well as working with ODONTIS (see leon's post above which we found ultra helpful)

yours barbara and jodie

Steve said at December 12, 2006 4:06 AM:

This is my first comment on this post, but have been regulary checking for any further developments.

The following link makes for some interesting reading, if this page has been posted before, i apologise.

http://faculty.dbcc.edu/tulsian/interestingReading/biology/Test_tube_teeth.pdf

Marianne said at December 14, 2006 3:40 AM:

Hi,

Loads of fantastic articles. Any progress made in trials yet by odontis or hints of the Hitachi Corporation starting trials of tooth germ top anyone's knowledge??????

Ron said at December 15, 2006 8:29 AM:

Hi Steve,

Thank you for the link!
That is probably the most exciting link I have seen so far.
It is good to see that all these teams that are working on regenerative dentistry,
are cooperating and sharing findings.

Tim said at December 16, 2006 7:31 PM:

Thought you guys might be interested in this:

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1600-0722.2006.00385.x

European Journal of Oral Sciences
Volume 114 Issue 4 Page 310 - August 2006
doi:10.1111/j.1600-0722.2006.00385.x
Volume 114 Issue 4


Cell proliferation in teeth reconstructed from dispersed cells of embryonic tooth germs in a three-dimensional scaffold
Shinji Iwatsuki1,2, Masaki J. Honda1, Hidemitsu Harada3, Minoru Ueda1,2
Iwatsuki S, Honda MJ, Harada H, Ueda M. Cell proliferation in teeth reconstructed from dispersed cells of embryonic tooth germs in a three-dimensional scaffold. Eur J Oral Sci 2006; 114: 310–317. © 2006 The Authors. Journal compilation© 2006 Eur J Oral Sci

Tissue engineering can now reproduce tooth from postnatal tooth cells. However, crown formation is not accurately reconstituted, even when the complex structure of the enamel dentin is reproduced. Here, we showed that a tissue-engineered (TE) tooth, exhibiting morphogenesis according to regular crown-cusp pattern formation, was produced by embryonic tooth germ cells in a three-dimensional scaffold. Heterogeneous cells dissociated from embryonic day 14 (E14) mice tooth germs were seeded on a scaffold and implanted under a kidney capsule in adult mice. The developmental process of the implants was examined for up to 14 d. At 5 d, the cells had formed initial tooth germ, followed by enamel-covered dentin tissue formed symmetrically. To study the developmental process, we examined the growth pattern using 5-bromo-2'-deoxyuridine (BrdU)-labeling analysis. The initial cell-proliferation patterns of the TE teeth were similar to that at the cap and early bell stages in natural teeth. This was particularly true in the cervical loop, which showed a similar distribution pattern of BrdU-positive cells in TE- and natural teeth. These results suggested that even when embryonic tooth germs are dissociated, the single cells can reconstitute tooth, and that enamel organ morphogenesis proceeds as in natural teeth.

Carra said at December 17, 2006 12:41 AM:

Hello to All, I have not checked in here for quite some time....It is great to see that there is movement globally as it will take a great force to materalize the regeneration of bone and teth as this is the most dense part of our bodies. The problem with the teeth conforming may have a simple solution. As in Kirlian energy when any missing part of a growing organism in lost for whaterver reason, the frequency or energy of that part remains. If they could active that energy memory the teeth may remember what shape and size it was, when it had form.
I found Professor Sharpe's Odontis site in 2003, after many years of very unsuccessful and damaging dental work following a chemical spraying accident in California. I decided that traditional dentists would not work on me ever again. It seemed im possible for any of the 8 that I saw to actually do exaxtly what my mouth needed. so since I found that there will be stem cell regeration I will wait. This is the only hope for the future of golbal health. I have practiced Homeopathy for over 30 years and one of the basic tennents is that each tooth is connected to an organ, gland or system of the body and when that tooth is not healthy what it is connected to is also not healthy. True health is almost impossible without dental health. So if any of the researchers are reading I send all the positive creative loving support that I can muster, I know and have known for a very long time that this day would come and it will solve many of the worlds health problems that are not even known to be connected to the teeth.

paul b and barbara cox said at December 18, 2006 12:05 PM:

Thanks for the very helpful link Steve re the article in Scientific American-as we missed that particular edition.We get the magazine on and off here in the UK.

Didn't know Conan Young and Professor Paul T Sharpe(the joint authors of the article)were friends/linked.

One of the most helpful links so far!Bodes well for the future.Thanks again and if you see any in-depth articles like that- "anyone" who reads this forum-please post them in this excellent informative much appreciated forum.

yours Paul -and Barbara(who I have e-mailed this article to)

lt said at December 18, 2006 11:13 PM:

Seemed like the problem they are trying to figure out right now is to control the size and shape of the teeth. I am wondering why don't they start testing the implant of tooth germs onto human and work with cosmetic dentist to shave the implanted tooth germ after growth to have veneers done on those. This way, many people could be benefited from their research. Still, they can continue to work on their second phase which is to controll the size and shape.

These days, people are putting titanium implants and crowns after the implant buds are secured. I would implant the real tooth germs and have dentist veneered them if the size is too big. Let's say that it the tooth germ grows too big, you can just extract it...this is even better than the titanium implants.

Please let me know your thoughts...I am wondering why they are not doing this.


Paul said at December 20, 2006 11:51 AM:

its not just the size and shape that are a problem but also root formation, so changing the shape or using vaneers would not work as they would not have a secure foundation.

lt said at December 22, 2006 8:12 AM:

Hi Paul,

Thank you for your responses. I see it now.

Happy Holidays everyone,

l

Ben said at December 24, 2006 5:27 AM:

Merry christmas everyone!!!

paul b and others said at December 24, 2006 4:08 PM:

HERE IS NEWS RE PROGRESS REGARDING ROOTS GROWN- re the problems still needing to be solved re root formation mentioned in posts above

more progree from Songtau Shi whom we have been following since 1993-his progress re root formation could be used by other researchers still having problems re this aspect of teeth regeneration-yours paul b.and others

Public release date: 20-Dec-2006
[ Print Article | E-mail Article | Close Window ]

Contact: Jon Weiner
jon.weiner@usc.edu
323-442-2830
University of Southern California

USC-led researchers use stem cells to regenerate parts of teeth
Los Angeles, CA., Dec.20, 2006-A multi-national research team headed by USC School of Dentistry researcher Songtao Shi, DDS, PhD, has successfully regenerated tooth root and supporting periodontal ligaments to restore tooth function in an animal model. The breakthrough holds significant promise for clinical application in human patients.

The study appears December 20 in the inaugural issue of PLoS ONE.

Utilizing stem cells harvested from the extracted wisdom teeth of 18- to 20-year olds, Shi and colleagues have created sufficient root and ligament structure to support a crown restoration in their animal model. The resulting tooth restoration closely resembled the original tooth in function and strength.

The technique relies on stem cells harvested from the root apical papilla, which is responsible for the development of a tooth's root and periodontal ligament. Previous studies conducted by Shi and collaborator Stan Gronthos at the National Institutes of Health had utilized dental pulp stem cells. Shi found the new technique to be superior.

"The apical papilla provides better stem cells for root structure regeneration. With this technique, the strength of the tooth restoration is not quite as strong as the original tooth, but we believe it is sufficient to withstand normal wear and tear," says Shi.

He hopes to move the technique to clinical trials within the next several years, a potential boon for dental patients who are not appropriate candidates for dental implant therapy or would prefer living tissue derived from their own teeth.

"Implant patients must have sufficient bone in the jaw to support the implant. For those who don't, this therapy would be a great alternative," says Shi.

According to Shi, the not-so-distant future may be one in which not only wisdom teeth, but those baby teeth once left to the tooth fairy for a pittance, will become valuable therapeutic tools.

"We will be able to provide not only this technique, but other new therapies utilizing a patient's own stem cells harvested from their preserved teeth. This is a very exciting discovery and one that I hope to see in wide-spread clinical use in the near future," says Shi.


###
Funding for this study came from the National Natural Science Foundation of China, the Beijing Major Scientific Program grant and the National Institute of Dental and Craniofacial Research.

Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine. Wataru Sonoyama, Yi Liu, Dianji Fang, Takayoshi Yamaza, Byoung-Moo Seo, Chunmei Zhang, Liu He, Stan Gronthos, Cun-Yu Wang, Songlin Wang, Songtao Shi. PLoS ONE, 10.1371/journal.pone.0000079, Dec. 20, 2006.

--------------------------------------------------------------------------------
[ Print Article | E-mail Article | Close Window ]

paul bannister and barbara cox and other aliases! said at December 24, 2006 4:12 PM:

the above brealthroughs/progress seems designed intially to help implants-but could be adapted for use "with" methods of whole teeth regeneration-used by other researchers

if other researchers utilise this research in combination with their methods-

seems promising anyway-

and he speaks of "human clinicla trials within the next few years"!Great!

p bannister and barbara cox and other aliases! said at December 24, 2006 4:18 PM:

http://abblogger.com/dentistry/

dont know if this link will work-try google if not-

re "dental stem cell bank in CANADA"-

first I have heard of this sort of thing

p bannister and barbara cox and other aliases! said at December 24, 2006 4:19 PM:

http://abblogger.com/dentistry/

dont know if this link will work-try google if not-

re "dental stem cell bank in CANADA"-

first I have heard of this sort of thing

paul bannister and barbara cox and other aliases! said at December 24, 2006 4:22 PM:

link does not take you straight there-so have pasted the info re BIOEDEN:-

Dentistry Info Site
BioEDEN Tooth Stem Cell Banking Service Now Available in Canada
BioEDEN Tooth Stem Cell Banking Service Now Available in Canada
BioEDEN -- the first fully operational processing laboratory and storage bank for primary tooth stem cells in the world--is now able to offer their services to Canada (PRWeb Oct 26, 2006) Post Comment:Trackback URL: http://www.prweb.com/chachingpr.php/TWFnbi1aZXRhLUNvdXAtU2luZy1NYWduLVplcm8=


Dentistry Sites
Canadian Dental Association

Tags: Dentistry, Cosmetic Dentistry, Dental Schools

Posted in
BioEDEN Tooth Stem Cell Banking Service Now Available in Canada
BioEDEN -- the first fully operational processing laboratory and storage bank for primary tooth stem cells in the world--is now able to offer their services to Canada (PRWeb Oct 26, 2006) Post Comment:Trackback URL: http://www.prweb.com/chachingpr.php/TWFnbi1aZXRhLUNvdXAtU2luZy1NYWduLVplcm8=


Dentistry Sites
Canadian Dental Association

11:02 PM - 12/10/2006 - post comment

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jodie bannister and barbara cox and other aliases! said at December 24, 2006 4:25 PM:

2006-12-24


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BioEDEN Tooth Stem Cell Banking Service Now Available in Canada

Download this press release as an Adobe PDF document.


BioEDEN -- the first fully operational processing laboratory and storage bank for primary tooth stem cells in the world--is now able to offer their services to Canada

Austin, TX (PRWEB) October 26, 2006 -- With world health care moving toward personalized medicine where treatment is customized for each individual, the use of stem cells found in children's primary teeth is a significant step forward. These cells are a viable, ethical, and morally non-controversial alternative to the possibilities offered by embryonic stem cells. At the forefront of this new technology, BioEDEN is the first tooth cell bank in the world to offer cellular isolation and storage services for these valuable tooth cells.

According to President Jeff Johnson, "Public interest in primary tooth stem cells is growing not only locally, but globally. As a private laboratory registered with the FDA, we maintain high standards required for FDA oversight. After a recent FDA review, we are now approved to accept teeth from our neighbors in Canada.

"A primary consideration in the use of tooth cell storage is the cost. At less than 1/3 the cost of cord blood storage, banking a child's primary tooth stem cells not only provides a guaranteed matching donor for life, it is simple and painless for both the child and parent, and it preserves the cells before natural damage occurs. There are only twelve teeth that contain these promising cells, and cell viability – determined by when a tooth is expelled -- reduces the longer a loose tooth remains in the mouth. A tooth collected shortly after it becomes loose is most viable, and is critical that we receive a tooth quickly after it falls out."

BioEDEN isolates and stores tooth cells, and returns them to the original donor if they are ever needed. Unlike cord blood banking, which is public, BioEDEN's customers are only given their own cells. This autologous banking system eliminates worry about communicable diseases, tissue rejection, or immunosuppressive therapy, and will contribute to successful therapies where it is imperative that the source of the stem cells be compatible with the recipient. BioEDEN also leads the industry in offering a complete guarantee.

For more information regarding this pioneer service, visit www.bioeden.com.

###

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CONTACT INFORMATION

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Shahana said at December 26, 2006 12:45 PM:

http://www.eurekalert.org/pub_releases/2006-12/uosc-uru121906.php
http://www.plosone.org/article/fetchArticle.action?articleURI=info:doi/10.1371/journal.pone.0000079

Above links with respect to some recent development - tooth regeneration via stem cells.

You guys might find it useful.

Shahana

Martin said at January 1, 2007 6:09 AM:

Happy New Year to all who post on this board. Particularly, Barbara & Paul who continue to so supportive in this area of endeavour. Let us hope that 2007 brings a significant breakthrough in tooth regeneration. For all of those suffering still, continue to be strong and stay positive. This board is unique and continues to offer a means of strength for us all. Martin.

lt said at January 4, 2007 11:01 AM:

Did anyone see the headlines on CNN news today about teeth regrowth in pigs?

Brooke said at January 4, 2007 3:38 PM:

I didn't see CNN...did it sound promising? How long realistically until humans can have teeth regrown?

Brooke said at January 5, 2007 6:13 PM:

Shahana...are you the one who mentioned that your mom has never been to a dentist? Has she ever had a toothache or lost a tooth on her own or anything? That is very interesting, especially if all of her teeth are in perfect shape. Are cavities really real?

Also does anyone know if root canals are safe to have??

Shahana said at January 8, 2007 7:42 PM:

Brooke,

Yes, my mother like many other men/women from Indian-subcontinent never went to a dentist, though my mom has been living in England for the past 20 years. She is close to 70 years old, she lost some of her teeth. But, majority still intact. However, there has never been any kind of major pain for which she needed to see the dentist!

I know a lot of Indians died at age 80 or 90 with all whole set of teeth. The saga with dentistry is one of major complexity! A lot of dentists are highly commercial .. they care about what they want to do to make money than what you actually need.

Root canals are often a necessity and with the right dentist .. it is safe.

Thanks,

Shahana said at January 10, 2007 6:08 AM:

Check this out. This is very funny. Another tooth regeration discussion board.

http://www.freerepublic.com/focus/f-news/1761157/posts

Shuun said at January 14, 2007 9:57 PM:

The news getts better and better everyday. Every time I do a search I seem to stumble upon yet another successful research. Of course all of these are still in early stages, however, it gives me great hopes for the future. You can check out the full article at this link. http://www.medicalnewstoday.com/medicalnews.php?newsid=59616

Pall said at January 20, 2007 6:12 AM:

Shun, that is a great link. As we can see things really are moving forward more now. I would like to know how Paul Sharpe's research is progressing too. No updates on the website at Odontis for years now....

paul bannister and barbara cox and other aliases! said at January 25, 2007 11:11 AM:

LOVE THE LAUGHING PIG WITH NEW HUMAN TEETH shahana from free republic other teeth forum

have sent it onto Barbara(she actually exists as well as being an alias too!) and others we know -brilliant picture!made us really luagh!

Kimmy said at February 11, 2007 3:31 PM:

Hey Guys

This is my first time here. I wanted to know when this Stem Cell Procedure will become available throughout the world? I am from the Caribbean and started developing a teeth deficiency problem with my molars from age 12 or so up until now. Sometimes it is really embarassing since it penetrates loss of self-esteem or as some people know you find yourself speaking so only those front teeth will show and no one sees in the back. The horrible thing about it is that everytime I got a cavity I got the tooth removed. This teeth regrow phase is like a miracle to us all. Please get on with that 1st Human experimenting and let me know when I can get my Stem Cells implanted here in the Caribbean.

Pall said at February 17, 2007 5:16 AM:

Edward, thak you for that wonderful post. As I have said on this board so many times few people who are not suffering with dental problems like this can ever know the physical and emotional pain that tooth loss causes. Similarly to you my own tooth loss was caused by the poor DDS that I trusted as a health professional. That surgeon almost ruined my life but we must saty positive with whatever life throes at us. Tooth regeneration will come, we just have to wait.

Alex said at February 19, 2007 12:49 PM:

Japanese scientists grow teeth from single cells
WASHINGTON (Reuters) - Japanese researchers said on Sunday they had grown normal-looking teeth from single cells in lab dishes, and transplanted them into mice.

They used primitive cells, not quite as early as stem cells, and injected them into a framework of collagen, the material that holds the body together.

After growing them, they found their structures had matured into the components that make teeth, including dentin, enamel, dental pulp, blood vessels, and periodontal ligaments.

They were "arranged appropriately when compared with a natural tooth," the researchers reported in the journal Nature Methods.
Reuters Pictures
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The teeth grew and developed normally when transplanted into a mouse, said Takashi Tsuji of the Tokyo University of Science in Chiba, Japan and colleagues.

They said their method was the first to show an entire organ could be replaced using just a few cells.

"To restore the partial loss of organ function, stem cell transplantation therapies have been developed," they wrote.

"The ultimate goal of regenerative therapy, however, is to develop fully functioning bioengineered organs that can replace lost or damaged organs after disease, injury or aging."

The researchers went after the "organ germ" -- the early cells made using partially differentiated cells known as epithelial and mesenchymal cells. In this case the cells were taken from what is known as the tooth germ, the little bud that appears before an animal grows a tooth.

"Our reconstituted tooth germ generates a complete and entirely bioengineered tooth," they wrote.

"This study thus provides the first evidence of a successful reconstitution of an entire organ via the transplantation of bioengineered material," they added.

"Our present findings should also encourage the future development of organ replacement by regenerative therapy."

Framejunky said at February 22, 2007 6:48 AM:

Two days ago their was an item on the France television about the teeth in mice thing.
They concluded that it will take up to twenty years before they put this thing on the human market.

Stan said at February 25, 2007 8:33 PM:

Hello,

Great info guys. Missing a few myself, and when I saw the U of A article, peaked my interest and rejoiced. But as of yet, not a reality that can be taken advantage of.Who knows, hopefully in the near future. Thanks again guys, all the best,

Stan.

BJP, PhD. said at March 4, 2007 1:37 PM:

It seems that most who post on this board have fogotten, in their hopes for cures to their dental problems, that it has been dentistry that has by and large caused or exacerbated those problems and caused or excerbated many other non-dental health problems. So what is the rationale that further 'help' from the invasive medical professions will be beneficial, ultimately? The track record is absymal.

The common thread is that everyone seems to want someone else to fix their problem, and quickly, damn the (largely unforeseen) consequences to other bodily systems. Let's not forget the "blessing" (NOT) bestowed on mankind by the mercury fillings we all got as kids in the 50's through to the 80's. They knew mercury is toxic a century ago!

There are ways both to avoid and to cure all physical problems without invasive treatments. However, the price is out of the range of most Western, and lately Eastern, mentalities, mainly because laziness, instant gratification and ignorance seem to be the main/preferred attributes of the current lifestyles. I know this truth that the body can and will fix itself from the personal experience of curing a herniated neck disc, without the surgery that was scheduled and without the 50% risk of ending up even worse off, risk that is statiscally proven attendant with such neck discotomy surgeries. My neuro-surgeon is flabergasted. It took 5 months of nearly daily effort, but I can move my 58 y.o. neck now better than at age 25.

I am going to make tooth regeneration a personal research project and will report my results to this board. I have some that were removed, outright; some that had rootcanals, two that are loose, and two yet that have mercury fillings. Step One is going to be getting rid of those old mercury fillings ( that's an obvious starting point...get rid of resident toxic foriegn element in my mouth) I noticed that I have ringing in my ears but that it is louder in the ear closest to the two teeth containing mercury fillings.

good luck,
BJP

Kim said at March 10, 2007 6:24 AM:

Does anyone know if there has been any improvement in the regeneration of new teeth? I know Dr. Shi from USC has been able to generate roots, but this was derived from wisdom teeth. What sources are there for people who no longer have wisdom teeth? It looks like Dr. Sharpe has been unable to find a replacement for embryonic epithelial cells for tooth regeneration, and the only replacement for mesenchyme cells that has been identified so far is bone marrow cells, which isn't ideal for commercial use. Also, these teeth don't develop roots. Is teeth regeneration going to happen. There has been a lot of discussion that this is a possibility, but outside of animal models, I haven't seen any evidence in humans. When Dr. Sharpe initially started odontis, he said that he would be ready in 2-3 years (2007) for human clinical trials. Now he is saying it is going to be about 3 more years in an article in technology review. Also, it looks like a lot of companies are not continuing their research (dentigenix, hitachi). Can anyone provide any information that shows we are moving forward and that tooth regeneration will happen in the near future and is not just a theoretical idea that only works in animal models.

Max said at March 12, 2007 1:26 AM:

Hello everybody,

I'm new, I'm Max.
Take look year, It's a few month ago old.

http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1469-7580.2006.00622.x

Heather said at March 17, 2007 7:35 AM:

It looks like it will be a long time before teeth regeneration will be available. The authors are from king's college, where Paul Sharpe is doing his teeth regeneration work.


Dent Update. 2007 Jan-Feb;34(1):20-2, 25-6, 29. Links
Tooth development: 2. Regenerating teeth in the laboratory.Onyekwelu O, Seppala M, Zoupa M, Cobourne MT.
Department of Orthodontics and Craniofacial Development, Floor 22, Guy's Hospital, GKT Dental Institute, King's College London, UK.

Tooth loss can occur for a number of reasons and a variety of prosthetic tooth replacement solutions are available to the dental practitioner. This article discusses current approaches in the use of tissue engineering to replace teeth or repair dental tissues. These strategies will depend upon the manipulation of stem cells in the laboratory and, whilst much progress has recently been made, it is likely that successful human tooth regeneration is still some years ahead.

Pall said at March 19, 2007 3:20 PM:

This is NOT what Paul Sharpe has said at all. Please do not mislead people with this information as this board is a great assistance to many who ae hoping for this breakthrough to happen. Here is a link to information about Paul Sharpe's current position. Please read this and keep your hopes alive.

Regards, Pall

http://www.cloningresources.com/Research/Advances_in_growing_new_teeth.asp

Leon said at March 25, 2007 2:00 PM:

Hi there everyone,

There may be some cause for hope with Odontis. I have had recently looked at their annual fillings and they increased their nominal share capital by 20,000 'A' shares in Jan 2007. One of the reasons you might do this is if you were looking to obtain further equity investment in the company.

Coincidently I also found this on google :-

The Gibson IndexTissue engineers at Odontis to get £1.35m from Wellcome Trust. Odontis’ team, technology and patents are designed to make it a world leader in bringing ...
gibsonindex.if5.com/default.aspx - 22k - Cached - Similar pages

A word of warning - I am not sure how reliable the source is given that the £1.35m mentioned does not come up on any other site. You would expect there to be articles all over the news given the size of the funding.

Take care everyone, and keep up the good work.

Leon

Alex said at April 4, 2007 11:47 AM:

Engineers Building Drug Filled Tooth

NEW YORK (AP) -- Instead of settling for the bling of gold, a more practical person seeking a false tooth might eventually be able to get one that can deliver drugs.
Researchers in Europe and Israel, funded by the European Union, are working on a tiny drug-dispensing system called IntelliDrug that goes into a person's mouth - with the ultimate goal of getting the parts small enough to fit into a replacement tooth placed in the back like a molar. The device can release a specific amount of medicine at certain intervals, ensuring that the patient gets the proper dosage at the right time.

[FuturePundit deleted most of this post because it violated copyright]

Mark said at April 6, 2007 4:13 AM:

Hello,

Am interesting read indeed.

Things may seem impossible - humans would never reach the moon, instant international communication would never happen. Given time pretty much anything is possible. Keeping praying.

I, along with everyone here, look forward to the opportunities that await is the future in dental regeneration.

Liu said at April 7, 2007 9:25 AM:

Do you have some news?

Heather said at April 16, 2007 6:02 PM:

No new news. If it works out, commercially available tooth regeneraton is very far away (at least 10+ years). Paul Sharpe's work is still in mice and he has a number of barriers to overcome before he can start in humans (develop roots, find a replacement for embryonic epithelial cells, etc). It will be about 4 years, if not longer before trials can be started in humans.

paula said at April 19, 2007 9:27 AM:

Where do you have these news? Maybe it will be earlier than we expect, they can make discovery tomorrow, don't be pessimistic...i hope so, everybody hope so...i think if he(paul sharpe) was not sure of his "deal" it would not have investors...

be hopeful

Sohiab Rehman said at April 20, 2007 8:12 AM:

Gone today, tooth tommorow!

Pall said at April 22, 2007 4:37 AM:

I would think that the launch of this commercially is going to be about five years or so. The progress that has bee made so far is very good and we should reman positive but also realistic. Here is another post I have found recently....

http://www.newscientist.com/channel/sex/stem-cells/mg19325925.100-no-more-gaps-with-homegrown-teeth.html

Regards, Pall (who is hoping so much for this solution to his own dental woes)

paula said at April 30, 2007 8:10 AM:

I'm Desperate...

Theresa murphy said at May 6, 2007 2:06 PM:

I had a canal root treatment on a bottome left molar toothe which was then recommended by dentist to be crowned . Because it was lying slant the crown did not fit as the gap between the lowere and bottomw teeth was too wide. I had the crown removed due to infection. i have a small amount of enamel left on the outside of the toothe and often wonder cound it possibbly be regrown from this enamel? i follow avidly the new research especially the ultrasound emitter from canada and the stem cell research in Brazil which may have stem cells from adults used to regrow crowns within a year. i am keeping my hopes up. I have had a terrible time from dentists .

Lila said at May 8, 2007 10:31 AM:

Hello everybody!
Its a lil stopped this year the discussion.
I lost one tooth behind a lot of mistakes.Also lost part of my gum
For first should not put product for cavity without isolation.And it continous...I will describe later
Its not easy to here youre boyfriend asking why your gum is diferent in this point darker
Also i dont about you guys but i felt so much pain after the implant
Dentists dont say that imediatly after you eat if you dont brush bad sensation of taste in the mont in the implant zone
its not so confortable an implant plus is horrible to use floss on it
i think exist an implant that youre gum doesnt look a lil bit darker
I hope this scientist... they going to lead implants for some from 18 century!
Its not possible is too agressive.Psicologicaly is horrible someone putting mecanical parts inside of you with tools and squeeze
I dont like implants i dont think theyre functional at all
Must have something better.We are in 2007!

Pall said at May 13, 2007 5:01 AM:

Lila and Paula, we all sympathise with each other about this. I also agree that dental implants are not the same as a natural tooth. We are all desperate for this cure to come. I still say that we have to hang on amd get our support here. Things can go a little quiet but many do check back regularly. Kepp hanging on!!! Pall

Jaime said at May 14, 2007 3:46 PM:

I'm agree with Lila. It's 2007 and has passed about 5 or 6 years from the begining of the investigation. And I hate the implants. I need a normal teeth as I never had. I can't express myself easily, just by writting. At the moment I'm working in a job only 4 hours coz this is too annoying and I feel really uncofortable. I'm always turning my face when someones' trying to talk me, and I make them feel serious coz I don't want to laugh revolving the conversation with serious attitudes. I'm really good with that... :( it's horrible and I'm wondering how long I can stand like this. I will get ill :(
I need money for a too expensive treated (about 10,000 euros) and my earnings are around 1000 euros or less per month. What can I do?

paula said at May 18, 2007 7:11 AM:

No news?

it would be so cool if it was now available or if there was already tests in humans...hope it'll arrive soon only God knows...


Be hopeful,

Shuun said at May 21, 2007 12:27 PM:

http://www.blackwell-synergy.com/doi/pdf/10.1111/j.1469-7580.2006.00622.x

Some of you might be interested in reading the above link. One of the authors is Dr. Sharpe himself. The article explains the difficulties ahead to grow new teeth. It is through and provides good understanding; however, it is in abstract form and it might not be as clear as we would like it to be. I have read another article by Dr. Sharpe and his coleage a while ago, which was written for the lay person and which was very detailed. That article also explained the difficulties ahead and all the problems they have already overcame. It seems to me that Dr. Sharpe knows axactly what he is doing, and it gives me hope because the authors, as knowlegable as they are, were very confindent that all of the problems they are facing will be solved and bio-engineered teeth will be a reality within the not so distance future. I cannot remember the link to the other article, but I will search for it and post it if I find it again. The aricle was extremely lengthy and it explained how teeth grow from begining to end. They also said that they were able to solve one of their biggest hurtles, which was controling the size of the tooth. One thing they were not able to grow was the root which grows last. I am convident that the future of bio-engineered teeth is near. I can almost smell it!

Lila said at May 23, 2007 7:49 AM:

I felt so much pain after the implant
My family didnt believe me
Now a days i dont feel pain but one month later i felt
I dont remenber how many times i cryed thinking that is not my tooth anymore
like my dentist said what god makes is better so implant is not the same
I had to watch the list of pantients and horrible problems they had
i had to smile for a photograph whitout a real smile just because is the result
i used to be a girl with a big smile but i want to hide it with my hand all the time
i wish a dentist could read this to see so many good things this research can bring
is dificult for a dentist believe because i have beautiful tooths exeption for implant
I was so beautiful im still but...with something missing
how can i forget surgeries no diagnoses...so much sadness
im alive and stronger to fight for a better world in my area for people...
but i didnt had courage to say to my husband that i have implant
he saw something diferent he dont know what it is
i want to keep in secret because is painful and he cannot think about treatments at dentist he get scared has no canal or implant
i dont want poor you...
i dont know my dentist use pictures of pacients for everybody who whent to the clinic to see how good he is
they dont have respect
you have to listen only your boyfriend will know because get close
please stop to kill us with words!!!!
wheres the humanism?

Alex001 said at May 30, 2007 3:06 AM:

When I was 18 I had my 1st molar from the top extracted. I had a maryland bridge which broke 2 times. My dentist said that the only solution left was a 3-tooth bridge. The metal thing from the maryland bridge didn't break and it was there holding my 2 teeth so they couldn't move. I was fine, no problems.

Now I'm 24 and two weeks ago I decided to have the 3-tooth bridge. I regret it every second from the moment I did that. I can't help thinking that I destroyed two teeth. I didn't have a problem. Why did I do it? I'm very depressed. I cry every day. I can't find meaning in anything I do. I just want my teeth back.

poppy said at June 3, 2007 9:41 AM:

i send a mail to odontis company and they answered me that they were just updating their website (www.odontis.co.uk) but it's not the case, there is no news i don't understand.

Alex said at June 3, 2007 6:21 PM:

The Odontis technology is still in the development stage and it will be some years before it will be ready for clinical use. Please note that we are not seeking volunteers for human trials and cannot enter into any correspondence regarding when or where the treatment may eventually become available.

Ben said at June 13, 2007 5:04 AM:

Hi all!

Hope you are well.
Here is a link i found:

http://www.cloningresources.com/Research/Advances_in_growing_new_teeth.asp

Dr Sharpe seems to be planning human trials in the next 4 years.

regards

Ben

Martin said at June 13, 2007 2:21 PM:

I was feeling a little low today for some reason about my missing teeth. I was thinking..does everybody feel this way or is it just me. I sometimes can't remember what it was like before I lost them. of course I still have many, but I do miss the lost ones and the reasons why it happened, which was due to negligence of dentist and not myself. The I read this last post from Ben and felt better....it's really all we have this hope that one day this will become a reality. Heaven knows this situation bligts my life, and so many others everyday.....:((

Jaime said at June 14, 2007 5:08 PM:

Hi Martin and everyone,
I feel down every day coz my teeth. I can't give any argue, sounds stupid say I have a "little" trouble with wide gaps, then I put a bitter face coz's too ungly for me to smile. Everyone's thinking I don't like the job or my mates in it and that's a big problem, when I need the money to pay the too much expensive operation I'd pray to do (10,000 €).
I will make my own homepage with pictures telling all the troubles I got with a bad teeth from teen. Everyone here have the same problem, and may contribute in whatever way explaining how much painfull get during the day with this "poor" affection of the image of oneself (to unkown people), in the street or public jobs. It hurts a little by little the selfworth we need to be as much people. I know there's more poeple with really worse troubles (having arm or legs less) but express oneself naturaly is really important. I look ashame all the time I speek and I try to avoid it everyday but I can't...
It's really frustrating and I think sometines I should have my right to ask for economic help.

Pall said at June 25, 2007 5:25 PM:

The Odontis website is now updated and looking very promising, There is more information than ever before. Yes we may still have to wait a few more years but this is now very promising. Thank heavens for Paul Sharpe and his team.

www.odontis.co.uk

Pall said at June 25, 2007 5:27 PM:

The Odontis website is now updated and looking very promising, There is more information than ever before. Yes we may still have to wait a few more years but this is now very promising. Thank heavens for Paul Sharpe and his team.

www.odontis.co.uk

Marianne Menzies said at June 26, 2007 2:23 AM:

Yay!! Thank you for that Pall. I had given up looking on the that website, because it never changed. That does look promising.

Regards


Marianne

Alex said at July 5, 2007 1:05 AM:

I guess Paul need good web designer. Good web designer will keep our hope high!!

Jaime said at July 10, 2007 12:46 PM:

I'm not really sure what's speaking about this page http://www3.interscience.wiley.com/cgi-bin/abstract/109792447/ABSTRACT?CRETRY=1&SRETRY=0
Can someone tell me wether is the same as Paul Sharpe is investigating?

mary said at August 5, 2007 3:18 PM:

hi

I have a similar story to the woman named Maritza who posted some months ago. I had veneers on my tooth at a very young age without being warned of the danger of this procedure (I did not even know they had to remove teeth to put the veneer on) and now, in my late twenties I have to replace those veneers by crowns... so I will have 2 crowns on my top central incisors. This is totally depressing knowing that I will have to replace those crowns many times, that they are even less attractive then my original teeth were, and I am not talking about the cost, the fact that I can not eat apples-carots and the hot-cold sensitivity I now have on those teeth.
I am really looking forward to this possibility of having new teeth. Sometimes I dream about it because those problems with my teeth even if they are only minor health problems have caused me major psychological distress. I too am seeing a therapist for that. I am just totally angry at that dentist who did that to me. I dont understand how dentists can be so careless. And people tend to see that really as a minor problem ("who doesn't where denture at age 70? that does not kill them") but loosing teeth (especially when it was NOT because of an illness or an accident but because of deliberate malpractice by a dentist) is really hard to accept. I dont think those bioingeneer teeth will be available for the next 10-20 years but sometimes when I am really depressed over all this it is the only thought that helps me going.

p bannister and barbara cox and team said at August 9, 2007 3:28 PM:

Yes the odontis website has been revamped and contains far more detail than ever before.

They could do with more funds though and this type of data will we hope attract more venture capital espescially as the product becomes nearer to the market.We like the fact that it is realistic in content and style-you cannot hurry projects like this and they need to be properly tested before being availiable-if they were not people would complain re "that" and not the fact it took "x" number of years to be fully introduced.

Thank you for Pall for updatinmg all of this and we chanced upkinthe revamped new improved odontis website by chance via Paul Sharpe's entries in Wikipedia-where there is an entry re "stem cell therapies and tissue engineering".

We always thought it would be more likely to become a reality in the second decade but there has been measurable factual progress in the first decade of the 21st century compared to the state of play/progress say in 1998 when we first happened upon Professor Sharpe's(and others )work and say compared to the work done in the 1960's initially by that female uk dentist and scientist whose name we dont have to hand.

Does anyone know what happened to "dentegenix"? -we thought it had been taken over by austrian-swiss dental implant company -we will google and serach for data on that company too to update us.

Harvard University and other usa universities have also made progress in this field and also the Japanese but we still feel that the uk teams are the leaders.

We hope you are all well the readers of this thread.

p bannister and barbara cox and team said at August 9, 2007 3:36 PM:

yes it had been taken over(in 2004 we think or 2005) by this swiss-austrian giant blue chip type firm "ivoclar-vivadent" but we dont know if it has its own website still...which went down prompting qs from the thread members re:-"whats happened to the website and the company"

so this with odontis and many other companies worldwide is the present state of play..and for eg that seattle company involved with biomemtics and "dental applications therof"-we have not been following it as closely as before but its all progressing..these things do take time though in order to be done properly and people would complain if they were not done properly so patience is required and fortitude and faith:-

" Dentigenix Inc. is a wholly-owned subsidiary of Ivoclar-Vivadent, Inc. the world’s leading manufacturer of quality dental products."


Dentigenix Inc.
Focus:

Discovery and development of therapies to regenerate dental tissue

Company Profile:

Dentigenix Inc. is a wholly-owned subsidiary of Ivoclar-Vivadent, Inc. the world’s leading manufacturer of quality dental products.

Management:

Erick Rabins, COO, President
Bruce Rutherford, Dr., CSO
Jeanette Ennis, Dr., Intellectual Property Manager

Scientific Advisory Board:

Rutherford, PhD
Bruce J. Baum, PhD
William Giannobile
Paul Krebsbach, PhD
David Mooney, PhD
David H. Pashley, PhD
Tony Smith, Ph.D.
Malcolm Snead, Ph.D.
Phil Stashenko, Ph.D.
Irma Thesleff

Address:

454 North 34th Street
Seattle, WA 98103
USA
Phone: +1-206-547-4790
Fax: +1-206-547-4789

Website:

http://www.dentigenix.com

Technology:

The company develops a family of dental tissue engineering products to treat and repair progressive destruction of tooth structure. The object is the preservation, repair or regrowth of natural dental tissue. Basically, the company has three programmes, the whole tooth regeneration programme intends to grow new permanent natural teeth as alternatives for conventional prosthetic devices such as dentures and dental implants, secondly, the company is developing two products, DTX.21 and DTX.DR-1 to induce dentin regeneration over vital pulp exposures (potential alternatives for up to 50% of root canal treatments), and thirdly, developing DTX.41 to improve the natural remineralisation process of teeth.


last update 2007.08.10 © regenerationnet | disclaimer

p bannister and barbara cox and team said at August 9, 2007 3:44 PM:

Irma Thesleff

she is on the board of dentigenix-

she is at univesity of helsinki finland and expert on teeth morphogenesis etc

we first saw her mentioned in the new scientist article we saw in august 2002

which can be obtained via google or other SE search

both the boards of odontis and dentigenix are very qualified

but we'd like to see more financial backing by venture capitalists and blue chips of odontis...but as paul sharpe said "if the product is too far from the market they are averse slightly to backing it "...

though he has had good funding(and more we hope... more power to his elbow!)(ifonly the uk govt would spend more in this field though they have increased science funding..in last ten years....but at same time have closed down science labs in uk universities which we find baffling and contradictory!)

ie as nowadays there is hot money globally in hedge funds chasing short term returns...mind you with the present credit crunch we are seeing(possibly entering a kondratieff winter or similar?...who really knows?) we see a lot of these hedge funds "now" in trouble ..they'd do better to invest in odontis we think!...but the pursuit of the short term gain rules at this part of the cycle...tho of cours ehtere is tons of money being put into long term research and development as well(television as eg took a few decades to fully take off to use a simplistic analogy)

p bannister and barbara cox and team said at August 9, 2007 3:55 PM:

LASTLY we saw this piece about bmp-7...the dentigenix firm is called Ivoclar Vivadent-Dentigenix as it was merged/taken over-there is no independent website for this firm as far as currently aware-though there may be data on say the main ivoclar parent company website for anyone interested

"Dr. Bruce Rutherford, a former U-M
Dentistry professor who now serves as chief scientific officer of
private tissue engineering firm Ivoclar Vivadent-Dentigenix, was a
co-author, as well."

TOPIC NAME : Use of BMP-7 in tooth reconstruction
http://www.sciencedaily.com/releases/2005/02/050205103557.htm
Source:
University Of Michigan

Date:
2005-02-12
Print this page
Email to friend

Gene Therapy Promising For Growing Tooth-supporting Bone

ANN ARBOR, Mich. -- A University of Michigan research team has found
that introducing a growth factor protein into a mouth wound using gene
therapy helped generate bone around dental implants, according to a new
paper in the February issue of the journal Molecular Therapy.

Gene targeting model to evaluate dental implant osseointegration. (A)
Dental implant osteotomy defect model for gene delivery. bWell-typeQ
osteotomy defects were created that measured 1 mm in depth and 2 mm
coronally (left). The titanium dental implant was press fit into
position (middle), followed by the delivery of the 2.6% collagen matrix
containing either Ad/BMP-7 or Ad/Luc (right). (Graphic courtesy of
University Of Michigan)


In a patient with a sizeable mouth wound, replacing a tooth takes more
than simply implanting a new one---the patient also needs the bone
structure to anchor the new tooth in place. Such reconstructive surgery
today involves either taking a bone graft from the patient's chin or
jaw, which leaves a second wound needing to heal, or using donated bone
from a tissue bank, which yields unpredictable results.

William Giannobile, professor of periodontics, prevention and
geriatrics, led a team at the U-M School of Dentistry that delivered the
gene encoding for bone morphogenetic protein-7 (BMP-7) to large bone
defects in rats in an attempt to turn on the body's own bone growth
mechanisms. The study showed that animals that got the BMP-7 treatment
produced nearly 50 percent more supporting bone around dental implants
than those receiving the conventional treatment.

"This study represents a proof-of-concept investigation. We are
encouraged about the promise of this treatment," said Giannobile, also
an associate professor of biomedical engineering and director of the
Michigan Center for Oral Health Research.

More work will need to be done before the approach can be tested in
humans, Giannobile added. He said he optimistically would like to see
initial trials begin in humans in four to seven years.

BMP-7 is part of a family of proteins that regulates cartilage and bone
formation. Recent studies have shown that BMPs are present in tooth
development and periodontal repair.

This study mixed BMP-7 genes with an inactivated virus in a gel-like
carrier and injected it into wounds. Giannobile said using a virus, with
the harmful effects turned off, harnesses the virus' ability to enter
into cells and use their genetic machinery.

Once inside the cell, the viruses help BMP-7 genes get where they need
to be in the host's cells to boost bone production. Gene expression
producing BMP-7 proteins peaked after a week. Giannobile said that was
ideal because the team did not want to make any permanent genetic
changes. The gene acted quickly to get bone growth started, then
disappeared within about 28 days.

Giannobile said a next step in this process could include looking for
non-viral approaches to delivering gene therapy to the defect site.
Alternatively, scientists could conduct the gene therapy outside the
body using a tissue biopsy and then transplant the genetically-modified
cells back into the patient, but this would require two surgical
procedures instead of one.

The Molecular Therapy paper is titled "BMP Gene Delivery for Alveolar
Bone Engineering at Dental Implant Defects," and the work was supported
by the National Institutes of Health and National Institute of Dental
and Craniofacial Research.

Giannobile is part of a cross-campus program called Tissue Engineering
at Michigan, funded in part by the National Institute for Dental and
Craniofacial Research. TEAM aims to provide an interdisciplinary,
research-intensive environment for those pursuing careers in the oral
sciences, with a focus in the area of restoration of oral-craniofacial
tissues.

Co-authors on the paper include Courtney A. Dunn, adjunct clinical
lecturer in orthodontics; Qiming Jin, research associate in
periodontics, prevention and geriatrics; Mario Taba Jr., research fellow
in periodontics, prevention and geriatrics; Renny T. Franceschi,
associate dean for research and professor of periodontics, prevention
and geriatrics, all at the U-M School of Dentistry. Francesci also is a
professor of biological chemistry. R. Bruce Rutherford, a former U-M
Dentistry professor who now serves as chief scientific officer of
private tissue engineering firm Ivoclar Vivadent-Dentigenix, was a
co-author, as well.

###

For her work on this project, Dunn was recently selected to receive the
2005 Milo Hellman Research Essay Award from the American Association of
Orthodontists. This award is given for the most outstanding resident and
/ or doctorate research done in orthodontics. Dunn performed her
research with mentorship from Giannobile.

More about Giannobile:
http://ipumich.temppublish.com/public/experts/ExpDisplay.php?ExpID=286

Tissue Engineering at Michigan:
http://www.dent.umich.edu/team/overview.html

The journal Molecular Therapy:
http://authors.elsevier.com/JournalDetail.html?PubID=622922&Precis=DESC

Editor's Note: The original news release can be found here.
------------------------------------------------------------------------

This story has been adapted from a news release issued by University Of
Michigan.

Can't find it? Try searching ScienceDaily or the entire web with:
Search
Web sciencedaily.com




Martin said at August 12, 2007 6:02 AM:

Paul and Barbara I have been trying to email you but they are returned. So glad that you are still there and giving information. A message for Mary too. Mary I and many other people DO understand how the psychological stress of this situation can make you feel ill. I had the same thing happen to me and it almost made me feel that I was not able to go on. I have come to terms with my own surgeon's malpractice and damage that this person did to me. If I saw them I think I would feel like running them over and killing them, that is how angry they made me feel. They almost wrecked my life, as I looked after my dental health so well, and I lost two molars because of them, and the trust I placed in them. But now I understand that I must go on and wait until this regeneration becomes available. As you also say this is the hope that I keep in my mind. Mary, please keep holding on to that faith, it will get you through this. And as for dental implant, please do not get me started on that, they are not like your own teeth no mattter what people may say.

Thanks for this board and I will always keep looking periodically.

Martin

Martin said at November 6, 2007 2:13 PM:

Sounds very interesting Alex. I note that this board has gone a little quiet of late. Perhaps it's because Odontis have said that their product 'to market' is a few years off yet. That is, I hope, a source of encouragement and not disappointment. We now know that research is going well, and there is a real possibility that tooth regeneration is coming....and not too far away either!!

Dana said at November 9, 2007 6:40 AM:

I just hope this technology comes soon and that it is not just a ploy for them to get fundings.

martin said at November 10, 2007 10:53 AM:

Dana, I would agree with your comment. But I would not imagine that Pal Sharpe and his team would be loking for funding that was not done with a real possibility of success. Keep hoping...it is coming!!

Dana said at November 19, 2007 3:13 PM:

Martin I hope you are right. I would love for the idea of regrowing teeth but I spoke to my dentist and an ondodontist about it. They both said that maybe in monkies but not in humans.

Dana said at November 19, 2007 3:19 PM:

oops sorry about that I meant to say Endodontists.

Martin said at November 19, 2007 3:47 PM:

Dana

I think that you should look at the website www.odontis.co.uk and have a look at what Paul Sharpe is doing. You have to understand that general dentists are not involved in the research that is happeneing, and are probably being negative. Do not listen to that information. They cannot possibly know what is going on in the research of Paul Sharpe.

Dana said at November 19, 2007 9:36 PM:

Yes Martin but the website does not indicate the dates of entry. How long has it been there, no way to ask questions about updates. I also would like you to read the following from Wikipedia.org regarding stem cell research. They also do not provide any dates. It makes feel positive yet worried what if it is not true.

Missing teeth
In 2004, scientists at King's College London discovered a way to cultivate a complete tooth in mice[11] and were able to grow them stand-alone in the laboratory. Researchers are confident that this technology can be used to grow live teeth in human patients.

In theory, stem cells taken from the patient could be coaxed in the lab into turning into a tooth bud which, when implanted in the gums, will give rise to a new tooth, which would be expected to take two months to grow.[12] It will fuse with the jawbone and release chemicals that encourage nerves and blood vessels to connect with it. The process is similar to what happens when humans grow their original adult teeth.

It's estimated that it may take until 2009 before the technology is widely available to the general public, but the genetic research scientist behind the technique, Professor Paul Sharpe of King's College, estimates the method could be ready to test on patients by 2007.[13] His startup company, Odontis, fully expects to offer tooth replacement therapy by the end of the decade.

In 2005, Cryopraxis a stem cell bank in Brazil, collected baby tooth stem cells and harvested different types of differentiated cell types including neurons. This technology may one day make baby tooth a good source of stem cells.

In the next three years, Paul Sharpe hopes to identify more-accessible stem cells that may be able to form not only teeth, but also--and more importantly--roots.[14]

Zero said at November 22, 2007 8:27 AM:

Ok So news about the Ultra sound growing teeth thing has been out since last year 2006, and it's now Thankgiving day 2007. I was just wondering if those reseaher have made any progess in making this ultra sound device a reality. do they even have a website like the Odontis?

Dana said at November 22, 2007 5:53 PM:

Zero
The ultrasound is does not grow tooth (enamel) but it repairs roots so if your tooth is knoked out you are out of luck. This is only for people who have damaged their teeth as a result of braces so instead of giving a root canal which is what they usually do, ultrasound is used to correct that.

Martin said at November 23, 2007 2:31 PM:

Dana

I know that it is hard to wait...I'm waiting myself and every day it is hard. The Odontis website was updated in the last two months. It is possible to email them, but at this time they are just getting on with developing the product. We must accept that we have to wait, at least a few more years. But surely that is better than no hope at all?. Just imagine if NO research was happening and the possibility of tooth regneration was impossible. But Odontis are NOT saying that. There would be no way that someone like Paul Sharpe would be atempting, if they did not think there was a possibility. Try to think about the level of understanding that people like Paul Sharpe have in this area..evidently very knowledgable.

Until tooth regeneration comes we can all support each other on websites such as this. If you want to write to me, just use my email anytime.


Dana said at November 23, 2007 5:31 PM:

Martin,

Thank you for the encouraging words. Fear is the biggest thief of time and every day I worry that they’ll come out and say that the efforts failed (tooth regeneration). You can imagine how worried I am. Most of the articles I have found and read (believe me I’ve read too many of them) seem to indicate that the human trials will begin in 2007 and that by 2009 the procedure will be available. By the way on November 20th there was the news about stem cells. That also gave me more hope and I pray to God that this will happen soon and the people who suffer with dental problems will no longer suffer.

Another said at November 28, 2007 7:05 AM:

I just wanted to share my experience, I recently discovered that lots of the food products actually contain sugar. So when you buy milk, bread or even packed vegetables, check the "nutrition facts". I avoid any products that contain even 1 g sugar, and that helps me a lot, I dont feel such pain like before in my teeth.

P Smith said at December 18, 2007 1:58 PM:

Wow! I know now I am not imagining things - this is what I was told when I explained to many dentists my teeth felt very uncomfortable and it was agony. Mentally I was not 100% and it was known, I guess it was discrimination. I just got my mercury fillings replaced today and even a miniscule bit more filling can make all the difference but it is still agony because well, its a long story but my teeth are not the same as they used to be when I was younger and people called me "flash" because of my nice white teeth and I tell you I miss them very much, this is the miracle I have waited longer than 20 years for in the mean time doubting myself actually because I was told I was imagining things. I still waited patiently and will do & pay whatever it takes to regrow my teeth in to their proper size. I hear it will be a long shot, I was told not to wait and I suppose it is because dentists will loose money, but does the amount of people suffering equal to the few dentists? NO! the ratio is about 100:4 (patients to dentists) the scales of justice eh!! How dare anyone stand in the way of something that will put people out of this agony!!! Don't let it happen!!!! I find all this reading on this blog is a lot so if anyone wants to make my life easier and email me at Pegasus_302@hotmail.com anything/support would be welcome and I will do my best to return the help.

Martijn said at December 19, 2007 7:19 PM:

Odontis has raised 2 million for investment, that will never be enough!
Maybe, cause I know a lot of people are longing for this, it's a idea
to raise money, for them. If everybody pays a dollar worldwide, 2 million is easy to raise, and the 10 years to wait could be sliced to 5.

Just idea, know somebody to start it up!

Dana said at December 21, 2007 7:06 PM:

If you check their website this is what it says:

Can I invest?

Because of legal and regulatory constraints, we can only accept investments from professional investors.

http://www.odontis.co.uk/faq.php

Isabel said at December 26, 2007 9:39 PM:

"In 2004, British scientists cultivated a complete tooth in mice and grew them stand-alone in the lab. Researchers theorize that stem cells could be coaxed in the lab to turn into tooth buds which, when implanted in the gums, would grow into a new tooth in a process similar to the way humans grow their original teeth.

King College’s Paul Sharpe predicts this technology will be developed and could become available to the general public by 2009.

Tooth replacement is just another area of expected miracles to come during the biotech revolution, 2010-2020."

This article was published by The Singularity will some one please confirm if it is true?

Dave said at December 28, 2007 1:11 PM:

i don't mean to break any hope but seeing as how they are barely beginning to estimate clinical trials, in order to classify this procedure even avaliable to the general public, get acceptance from the government, manage and distribute their service, prepare dentists for this procedure, then begin the works of the actual procedure, I wouldn't bring my hopes up for another 10 to 20. It's a lengthy process that, sadly, many are publishing just to bring up false hope. Best thing as of now to do is to amend our worries of asthetics and focus on whats really important, the fact that we are still healthy is one of them.

After reading these articles for over a couple of years and seeing little to no progress i have not given up hope but i have taken this procedure of regenerating teeth in another point of view, as a miracle alternative. As of now, I am not waiting for it as a solution to my problems but will gladly accept it if it becomes available, all that i am saying is that we shouldn't bring our hopes that high, for the future of this procedure doesn't seem too bright.

Pall said at December 31, 2007 2:21 PM:

Dave

I accept that there will be no overnight cure for tooth replacement therapy. However, most people know that the wait is going to be around another seven to ten years before it becomes available. What is certain is that this technology will come to fruition, it's just a matter of when. Technology is moving at a massive rate now, esp with the genome prject bought to fruition. People should of course live their lives in the meantime. Also, physical health is intertwined with emotional and overall well being. There should be no underestimation of the way in which tooth loss affects both physical and emotioanl health. It depends on one's perception of health.

Dave said at January 2, 2008 7:02 PM:

Just out of curiosity, does anyone have any idea how much each tooth regeneration could cost?? I'm curious


In my opinion such tecnique would require the germination of the toot then the actual implant.
I say around 10,000 per tooth

Dana said at January 4, 2008 7:29 PM:

Dave
This will give you an idea how much it will cost

http://edition.cnn.com/2004/WORLD/europe/05/03/teeth.replace/

Eugene P. Foitek said at January 6, 2008 12:48 PM:

I've scanned the the above comments fairly quickly and didn't see anything that represents my concern. Here it is. First, I'm 68 years old and my last physical in early December revealed that I was in fairly good health but I had a dental concern that I wanted to correct. My 8 lower front teeth were wearing quite-a-bit and not in the best alignment. Otherwise, due to good dental care the past 50 years, my teeth were in pretty good shape. So, to avoid a future partial, I asked my dentist of 20 years if I could do something about my concern and he said if I have two outside teeth of the 8 removed and the remaining 6 spaced and realigned he could crown them for me. So, I went to an orthodontist who corrected my daughter's teeth about 20 years ago. To make a long story short, five days after the spacers, bands, brackets, etc. were installed, within a matter of three hours I developed vertical double vision which my eye doctor the next day diagnosed as RIGHT 4TH CRANIAL NERVE PALSY and ordred an MRI. You guessed it, The MRI was overcome by the braces so now I have a CAT scan scheduled for 9 January 2008. Typically, from the questions I was asked, I guess my condition can be caused by head trauma, diabetes or high blood pressure. None of those conditions exist.

Now. I've lived long enough to know that many times a person causes his or her own problems and the place to start to correct that problem is to review what you last done just prior to the problem presenting itself. In this case I had 20/20 single vision and then the double vision occurs.

I would like to know if anyone has ever heard of my condition being caused by the installation of braces. It's the nearest thing to head trauma that can I come up with. Of course, the CAT scan may bring up a whole new ballgame.

If anyone, professional or otherwise, has any experience or thoughts on this condition, please let me know at FoitekE719@AOL.COM. I would like to get back to where I was two weeks ago and go back to work even if it means removing the braces and ending up with a couple of spaces that can't be seen anyway.

Gene Foitek





Dave said at January 24, 2008 12:18 PM:

Does anyone have up to date info on teeth regeneration I would really appreciate it.

Thanks

Aaron said at January 26, 2008 7:20 PM:

Yeah i would like to know if anyone has up to date info on this as well, I got hit in the mouth with a baseball about 6 years ago, and I was never able to afford to go to the dentist but now i have full benifits and I would really like to know when this of if this is coming out, I am getting married in the fall and would really like to be able to smile in the pictures

Thanks

gfd said at February 11, 2008 2:19 PM:

Darn it I wish this were out soon. They said they would hit the test market by 2007. It is now 2008! I'm sure the company is inundated with requests by email because tooth loss is a worldwide problem. I've got a porcelin crown molar that I would love to extract for a real one. On top of that I want the awful mercury amalgams to become obsolete, which is what I believe is what is causing long-term toxic effects in people. On top of that losing one tooth is a nightmare of misalignment, bone loss and further surgery. Once you lose one tooth all your money goes towards keeping the rest in balance, which means you pay forever basically. All this is due to our refined diets and high fat intake because let's face it, our pets experience fewer caries because their diets are streamlined. The whole world wants this natural alternative to the heavy metals, dead teeth and demineralization that occurs in people's mouths around the globe. I wish there were an American equivalent company working full time on a stem cell tooth procedure and was open to donations. They'd get my dollar.

paul said at February 19, 2008 12:03 PM:

Absolutely, well said gfd. I too hope and wait for this to come everyday. Because of my oral surgeon's incompetence I lost two back lower molars three years ago. I have one implant which I live with because I have no choice, but my mouth feels all misalligned and it causes me much distress. I only hope that this comes soon. It is what keeps me going. people do not understand unless it happens to them, just what losing teeth does to a person. I used to think it was all in my mind, and I was worrying over nothing. But there is nothing wrong with me, I just want my teeth back. Having an implant is not the same, as my mouth feels strange in the area where the implant is. It is not the same. Regards to all who wat for this breeakthrough, my thoughts are with us all.

Paul

Jaime said at March 7, 2008 5:00 AM:

I am fully depressive... and the worse is that nobody understand my position. I have 4 bigs gaps in my in front of teeth and I am still a young good looking guy. I am wasting all my life because I have an "stupid" consideration of my aesthetic teeth . I've got much worrying at job, leaving the job because the bad feelings of my strange/reserved attitude. And that means not long term job then not facilities at the bank.
Probably I can overtake it for a day, but the next time I can't bear the same as before, and I get depress again.
Always I deiced to be alone and my family and friends get worrying on me. And that make me feel more bad
What I could do................................................................................................
...............................................................................................................
...............................................................................................................
...............................................................................................................
...............................................................................................................
...............................................................................................................!!

ouivalerie@yahoo.com said at March 9, 2008 10:25 AM:

you sound just like my daughter....wasting all her life on worrying about her teeth. It's good to work on this problem....not waste time. Here you are working on it. I'm glad about that. Diana went off a cliff, running from the police chasing her with dogs to go back to a mental institution, where they were mishandling the hell out of her case. Diama has young and dumb problems just like most people. If you don't let your parents correct you, it's very easy to make all the same mistakes they did because they never got a chance to watch you and share correction and their own experience so...that's the way it works. It's good to have the sense to be embarassed, but not good to not do something to shake off the guilt. LIke right your wrongs. Apologize to people and see if they will forgive you. Being alone is good...sometimes, but not for everyone and not if you are alone and acting like someone else is there when they are not. That doesn't count with meditation or communicating with things beyond. That can be real but they don't seem to hang around unless it's really important and nobody else will help or be with you. Such as a tiny child and mom is watching tv, or on the phone, and there's nobody else in the house. Then...they have angels...
We are meant for working together, and if you have a looks issue, it could be your chosen destiny. For example it would be good if nobody wanted to kiss you and give you germs you could never ever handle. Germs make people lose a lot of teeth and you can get them from kissing or poor oral hygiene. Good bacteria in the mouth has to be considered just like acidolphilus in the intestines. My front teeth are crumbling apart from bloody gums I got from eating too much dried fruit. Same problem, I have to get some cosmetic dentistry, then dentures. I want to work on a 3rd set of teeth with everyone else though. That's my hope. My sister had one vampire tooth (pointed) grown in her upper jaw under the lip. and it took her years to get it removed. She had a stupid smile hiding it all the time. After a number of years she focused on the problem and got it fixed. But it took focus and not losing time on other things, and asking for help all along the way. ouivalerie@yahoo.com and you may want to call my daughter and see if she wants to get on this site with everyone, she hates computers but I think she should be a part of this group. Diana (208) 412-6289 Call on the weekends or after 7pm California time only, because of cell phone minutes too expensive.

Jaime said at March 11, 2008 5:09 PM:

Hi to everyone.
With this message I would like to explaining about my own experience, having big 4 gaps on my front teeth.
I am 31 years old Spanish living in Menorca island. So my English is not my mother-tongue.

I have lateral incisor agenesia -no lateral incisor was generated, then they are missing in my mouth. Until 15 years old I conserved a "good" aesthetic teeth. Having for a long time my 4 first (milk) dentition (two lateral incisor and two canine tooth, both sides) the rest is 2nd -uncompleted- dentition.
My both lateral milk incisor fell cause the canines eruption, growing on lateral incisors position, and kept my milk canines teeth. Then I had 4 canines (upper teeth) until 23-24 (or after) years old.
I felt really really uncomfortable and weird with 4 canines long time. So it caused many troubles in my social communications, until having not much social abilities. Losing the sensibility of words, being sometimes like little incoherent.
Now I am on teeth treatment. The dentist performed a complicated orthodontics with piercing little implants that make a big traction on canines to move them into its right position. I was before than this on a similar treatment but it was appalling me long time, because the indescribable and awful palatine bar. So I decided to go to Barcelona. Now my treatment is -comparing with last one- just amazing, and I having good expectations of achievement.

Meanwhile I am suffering everyday (since 24 years old), and it causes to me an unconsciously type of physiological reactions, and a big anxiety. I try to be aware of this reactions but it is impossible to take control of them while I am speaking, or walking on the street. They situation made me become a very good observer and expert of what they can say to me anytime.. Can you figure out when I am working? I suffer much... Now results that I have a bad job and a bad incoming and just praying to get a better job -yes, I can say the teeth is the cause of lot of painful and a wide bad quality of life.
Then the next step in improve my quality of live is observing myself, paying more attention to my reactions and "disclose it".
I think it could be a good experience in share this reactions making aware of them when each one is alone in the room or house or any space to feel better.
Thru my too long experience I notice I salivate much, maybe because my "obsession" -with irony- focusing and mind my front teeth more than usual.
Another reaction is that quickly I feel like hungry. I realized is when I feel comfortable. That means I have to keep my mouth eating and having food, and is when the education helps me to "feel" (better) during little short time. Because it is usual that speak while eating is wrong and they can say: please, shut down and eat now. That is a kind of what I would like to listen because I suffer.
Therefore I do many strategics ways unconsciously to don't show my front teeth clearly, such as getting strange attitudes of communication and a long big ETC.I know much people is in the same situation and condition. Don't you agree that the commutations is too important to reach a good feeling to make people know how I really feel.

I appeal to the feelings and ask everyone to expose they experience. Trying to be aware of the deficiency and bad quality of life this makes feel like.
I feel very tired today, so I will leave this message like uncompleted, with hope someone would like to explain more about oneself. Good night.

Paul said at March 12, 2008 12:13 AM:

hi everyone

i have been looking at the possibilites of tooth regeneration and replacement since i fell foul of malpractice in 2004. In short the dentist carried out unnessary works to my teeth as i was covered by insurance.

having scoured the internet endlessly for hours at a times there is an abdundance of conflicting information and even on this thread to be fair, therefore can i ask for someone to advise me as to the current projected timescales before this is a reality?

all help is appreciated

regards

paul

ISABEL said at March 13, 2008 4:18 PM:


HAVING A BOTTOM MOLAR TOOTH EXTRACTED AND REPLACED WITH AN PORCELIN IMPLANT. HOW LIKELY WILL I HAVE MISALIGNMENT AND BONE LOSS IN THE FUTURE?

Muslim said at March 15, 2008 1:55 AM:

I think teeth regenration using stem cells is still in the embryonic stage although there's signficant advancements established already. I think it needs sometime to mature a bit. In my opinion, they would find a way with regenrating cells to fix partial teeth damages before they can develop a full too from grass. Ableit, this will happen 1 day.

Jaime said at March 16, 2008 9:05 AM:

I feel hopeless...

Muslim said at March 16, 2008 10:40 PM:

Jaime dont give up. There's good progress so far. There are huge work being doine in that area. Japanese are trying days and nights to be the 1st to achieve this.

HENRY said at March 21, 2008 4:50 AM:

when it will be able ????

Josh said at March 24, 2008 11:19 PM:

I have been talking to a friend of mine who works in the dental industry. Now take this with a grain of salt so to speak but he has heard and is trying to get more information on this but 3M is going to start FDA trials very shorty on their biotooth product. It does sound interesting because it will use your own born and blood to make the tooth crown material so there should be no bio compatibility problem nor any toxic material put in your mouth. He said it is about 1 to 2 years away if the trials with the FDA goes well. If I find out more information I will post it.

Muslim said at March 25, 2008 5:11 AM:

If I knew, I would've told you. Be patient and wait, you know never it might be tomorrow.

Dana said at March 25, 2008 7:37 PM:

I just want to remind you guys that even though it is very hard, one must remember that there are people who are facing life threatning illnesses. Please stay positive(I know it's hard) It is a lucrative market so you can imagine everyone is trying to be THE ONE maybe not publicly but believe me they want this to happen more than we do.

martin said at March 27, 2008 12:10 PM:

Dana

Thank you so much for that post. I was feeling very low today and your words did lift me. Certainly it is hard having your mouth feel and look the way it does. The imbalance and feel of my jaw and tooth loss gets me down. It eats away at your soul and self esteem. Then there is the panic thinking..'will I be this way forever?'. I do feel confident that this will come, although as you say the waiting is hard. But at least we have hope.

Martin

Dana said at March 28, 2008 9:50 PM:

Martin,

I'm so glad to hear that. You know hope is one thing you can't loose. Trust me when I say this, Japan, UK and the US are trying very hard. Each country is trying to be THE INVENTER. Can you Imagine how much they have to gain? Just keep in mind that teeth are fixable and that it is just a matter of time. Martin check out this page and see the guy with no limbs. After watching that, search you soul and see what you come up with. In case the page doesn't display that video search for Nick Vujicic. Remember it's not how you look but it's how you feel. I wish you all the best.

http://abcnews.go.com/Health/story?id=4531209&page=1

Muslim said at March 30, 2008 5:53 AM:

I second you Martin. There are millions being spent in this field. There are successful stories already on mice remember. Odontis which is a company doing research in this area was setup in 2002 and has been doing lots of papers and studies in this field. So there's no worry and be optimistic. You need to get me a gift as soon as this comes available :) :)

Rosie said at April 1, 2008 3:42 AM:

Is this now available in the UK? and approximately what are the costs? does it cover chipped theeth aswell.

Cute Guy said at April 6, 2008 10:49 AM:

Any update on this device? Is it working? How much enamel can it regenerate in mm?

Cute Guy said at April 7, 2008 5:00 AM:

Can someone come and give us some hope?

Jaime said at April 17, 2008 4:36 AM:

for me the life is worse day by day...

henry said at April 18, 2008 12:08 PM:

hi Josh , where did u find informations about the 3M project ????

alex said at April 24, 2008 7:52 AM:

hi, what do we have really ??? only words ; promises ?? when this biotooth will be real ????? scientist can clone human beens but not teeth ????

yan said at April 25, 2008 6:00 AM:

hi, they work about this project since 1999 - 2000 . We're now in 2008 ....

Alex said at April 28, 2008 10:14 AM:

They need another 15 to 20 years.

Alex said at April 28, 2008 10:33 PM:

Forget Dr. Sharp no progress for 6 years.
Take a look this
http://www.sciencedaily.com/releases/2008/04/080405095752.htm

David said at April 29, 2008 2:45 AM:

Hi everyone, this is David from Spain.
It's been great to find this place. It's disappointing to be hours and hours browsing the internet while it seems you will never find any clear information about teeth regeneration. Thank you for all your posts. I have been doing my own research and I will post anything I find interesting and new.

Regards,

David

David said at April 29, 2008 5:22 AM:

Good news today,

This advance can be for sure be used in teeth regeneration, specially interesting for people who has gone through root-canal therapy. I just mean this is a little piece of the problem that has been solved. As far as I know scientists are totally sure teeth regeneration will be possible in a near future, they just need to solve some partial problems to solve the hole thing.

http://www.sciencedaily.com/releases/2008/03/080306190902.htm

For those like me who want to know WHEN teeth regeneration will be possible, I have found the emails of some of the scientist who are carrying out investigation in this field. I have tried to contact some of them but only got reply from Professor Van Thomson from the NYU College of Dentistry. He was very polite, in his opinion teeth regeneration is still at least ten years from now, but I have read comments from other scientist and I they have shorter predictions. A lot of improvements are being made and each group can (should) benefit from the other group's work. Obviously a lot of work remain unknown becasuse of economic interests. Some partial regeneration (dentin, enamel)can be possible earlier than the total recovery from zero.

Regards,

David.

Martijn said at May 11, 2008 9:47 AM:

The next time you get a cavity, you might get tooth regeneration instead of fillings.

Materials scientists are beginning to develop a solutions of chemicals which can actually rebuild decayed teeth. Enamel and dentin, the natural materials that make teeth the strongest pieces of your body, would replace gold or ceramic fillings.

Enamel and dentin are strong, long-lasting, and can repair themselves. But they are also very complex.

But with the help of a calcium-containing solution of ions, scientists have been able to rebuild dentin and remineralize some parts of the teeth. Still, the complicated process is still years away from being used in your local dentist's office.

Shuun said at May 25, 2008 3:22 PM:

Martin, what is the source of this information? Where can I go to read more of this? It is an exciting news.

Martin said at June 1, 2008 4:48 AM:

I don't know where I found the above, but here they say something like the same:
http://www.wired.com/medtech/health/news/2008/04/tooth_regeneration

David said at June 3, 2008 2:33 AM:

Hi all,

I browse the internet daily looking for new information. I will post any important news I find.

From my point of view Paul Sharpe's group is the leading one and the one who has taken the better possible approach: try to reproduce the natural way in wich teeth are developed in the embryo. I have been reading some of his scientific articles and my conclussion is they are doing good progress, for example understanding how to control the shape of the tooth they are creating. However they are know facing the critical point of the investigation, I reproduce here this little paragrah, part of one of his articles of May 2007.

"Whether teeth derived from
autologous cells, such as DPSCs and SHED, which can be
deposited in cell banks, can be produced remains to be
established. Immune responses to the cells used are
unknown but these have to be understood before any
clinical trials can be performed."

They are close to do a huge advance, if the suceed in this, I'm sure we will have a clear perspective of when it can be possible and available for everyone. I have also read a press article in 2007 in wich he said that he expected to start clinical trials in 3 or 4 years. Odontis webpage reads that they don't expect to get it before 7-10 years. I guess they don't want to make a second mistake (they were supposed to have it already or at least be doing trials) so maybe they are being cuatios with the estimation.


Do you agree with my opinion? Does anyone have some direct information from Paul's Sharpe group? What about the Japanese and the US teams?

Regards,

David.

Allen said at June 3, 2008 4:53 AM:

Hi everyone,this is Allen from China
I just want to know weather the LIPUS device that can regrow teeth is avaible now,many people need it very much,if you who know the newest information about the device,please tell us,thank you very much.May God bless you all!

Isabel said at June 4, 2008 10:15 PM:

GREAT PROGRESS ANNOUNCED IN THIS ARTICLE. I POSTED THE LINK AND ARTICLE ON THE BOARD. PEOPLE PLEASE READ ....... PERHAPS NOW, HAVING THE ABILITY TO GROW THE CONNECTIVE NERVES THAT ATTACHES THE TOOTH TO THE BONE (PERIDONTAL LIGAMENTS) WE COULD NOW ATTACH REAL TEETH (TEETH ARE AN ORGAN CALLED PRIMORDIA) IN PLACE OF TOXIC PORCELAIN IMPLANTS IN THE JAW. TEETH THAT HAVE BEEN DONATED FROM DECEASED INDIVIDUALS. PEOPLE WHAT DO YOU THINK? PLEASE COMMENT BACK...........BEST REGARDS, ISABEL.

http://www.eurekalert.org/pub_releases/2008-06/nofs-stb060408.php


Public release date: 4-Jun-2008
[ Print Article | E-mail Article | Close Window ]


Contact: Agnes Berendsen
a.berendsen@vumc.nl
31-204-448-663
Netherlands Organization for Scientific Research

SAVING TEETH BY USING PERIODONTAL LIGAMENT REGENERATION
Teeth may fall out as a result of inflammation and subsequent destruction of the tissues supporting the teeth. Dutch researcher Agnes Berendsen has investigated a possible solution to this problem. At the Academic Centre for Dentistry Amsterdam (ACTA), she has studied the regeneration of the periodontal ligament by use of tissue engineering. The 3D in vitro model she has developed appears to be promising for regenerating periodontal ligament and may also prove valuable for restoring tendons and ligaments elsewhere in the body.

The periodontal ligament forms a flexible connection between the tooth root and the surrounding jaw bone. Trauma or inflammation can cause destruction of the periodontal ligament. Berendsen chose tissue engineering to tackle this problem. Research in tissue engineering uses cells placed in a 3D model, after which signals are applied to activate the cells. Berendsen developed a new 3D model in which cells isolated from periodontal ligament were implanted in a collagen network suspended between an artificial root and artificial bone. She wanted to see if viable periodontal ligament could be generated in this way.

The composition of the collagen network in which the cells are located has a considerable influence on the contractile properties of the cells. Contraction of the cells creates internal tension in the network which keeps the cells active. The network must be well attached to the surrounding solid surfaces to prevent its detachment. Berendsen managed to attach the network to these artificial root and bone surfaces present in the model by creating an enzyme-mediated mineral deposition on the surfaces. By subsequently applying loading to the tooth root (mimicking the process of chewing) in the 3D model, she was able to deform the mineral-anchored network containing the cells. The subsequent response of the cells was dependent on the magnitude of the loading.

Follow-up research will investigate whether the cell-culture results can be translated to an animal model to obtain more accurate insights concerning the potential use of this method in humans.


###


David said at June 5, 2008 1:04 AM:

Thank you Isabel for these great news. It gives hope to confirm that much investigation is in progress, so a lot of efforts can be added to find definitive solutions as soon as possible. I don't like to think that we must rely on the work of just some groups.

Regards,

David.

Isabel said at June 8, 2008 11:48 AM:

David what do you think of using real teath from deceased people?

David said at June 9, 2008 2:33 AM:

Dear Isabel,

I'm not a scientist, but personally I don't like the idea of wearing other people's teeth. It's not your own tooth so probably our inmune system will react against it. I think the great thing in regeneration is that you recover "your own" teeth made with your own genetics, this would make me feel I have recover them and feel them totally natural, I'd rather choose an implant than wear other's teeth. I don't know if there are situations in which this could be the only possibility.

Regards.

Martin said at June 9, 2008 1:50 PM:

I have an implant ans although it is ok, it feels rigid in the jaw where my molar was. I have posted on here over the last few years or so. My tooth loss at the back of my lower jaw was not even my fault, but I was very distressed by what happened to me. In many ways my mouth does not feel 'right' now so I live in the hope that this will come. Let's hope so eh? I would go and get this implant out whatever it took, to get my own teeth back. An implant in my opinion is no substitute for the real thing.

Isabel said at June 9, 2008 10:21 PM:

Dear David, if you had an implant you would only know the desperation Martin and I feel. Though any comment is better than no comment. So thanx. And Martin I also have an implant where my molar tooth belongs I will keep you in prayer and I hope you do the same.

David said at June 10, 2008 3:17 AM:

Dear Martin and Isabel, I'm very sorry if any of my comments disturbed you. I suffer the lack of several teeth (agenesia) and I will start soon a long process (2 years) first with an orthodontics and then several implants. I know that nothing is the same as your real teeth. I met people that is happy with the their implants but actually I don't know how actually it feels, for me is the only solution, but I see from your comments that it feels rigid and different. I'm sorry but I'm sure it is just a temporal solution and in a few years we all will enjoy new natural teeth. I thank god for science.

Everyday I search the internet, I will post any important information I find.

(I'm spanish so forgive me if my english isn't good)

Regards,

David.

Debrah said at June 18, 2008 10:32 PM:

Can someone tell me of any doctors that do autogenous teeth "transplants"?

Alex said at June 20, 2008 2:57 AM:

Yes, Dr. Sharp but waiting line is 10 years long.

David said at June 24, 2008 2:35 AM:

Dear Debrah, if you visit the odontis webpage and then the faq section, you will read:

http://www.odontis.co.uk/faq.php

When will the technology be available to the public?

We are making good progress but we do not expect the technology to be available to the general public for at least another seven to ten years.


This estimation was recently confirmed in an article I found in the internet by one of the responsibles of the company. They are now in the critical stage of generating a tooth from autologous cells from humans (I read this in one of the last articles of Doctor Sharp). I have asked them to update the information in their webpage and they answered they will try to do it, although they can't reveal details because of economical reasons (patents...)

Regards,

David.

Laura said at June 27, 2008 10:27 PM:

Dear David,

How old is the odontis website? 10 years old? That would mean the technology should be ready right about now. listed in the article below should be a means or a starting point to resolving patent issues.


US office upholds embryonic stem cell patents
Wisconsin Alumni Research Foundation receives certificates; ruling ends long-fought challenge
By KATHLEEN GALLAGHER
kgallagher@journalsentinel.com
Posted: June 26, 2008
The Wisconsin foundation that holds several key embryonic stem cell patents said Thursday that it has received certificates signaling the end of a long-fought challenge to the patents.

Recent Coverage
3/11/08: Group wins patent fight
7/2/08: Scientists join patent protest

Advertisement


Buy a link hereThe Wisconsin Alumni Research Foundation, known as WARF, received the so-called re-examination certificates from the U.S. Patent and Trademark Office this week, WARF spokeswoman Janet Kelly said. The certificates confirm the patent office’s ruling in March to strike down a challenge to the patents that started in October 2006.

The ruling, which cannot be appealed, makes the foundation a critical part of many companies’ plans when they are going to market with an embryonic stem cell-based product in the United States.

The patents broadly cover the preparation of embryonic stem cells, which are the basic material from which virtually all organs, cells and other body tissues are formed. WARF could receive royalty payments if therapies are developed from the research.

“It secures the WARF intellectual property and secures WARF’s place as a must-visit stop for people interested in stem cell technology,” said Tom Still, president of the Wisconsin Technology Council. The annual market for all embryonic stem cell-based products might be as large as $10 billion by 2016, the council has estimated.

While embryonic stem cell-based therapeutic products might still be on the horizon, the ruling also comes as a swell of embryonic stem cell-based products for researchers are hitting the market.

“In the last year, and especially in the last six months, there’s an explosion of research products in the market and an explosion of interest (in WARF’s stem cell licenses) from companies that are not licensed to produce research products,” said Andy DeTienne, WARF’s licensing manager for stem cells.

More than 20 companies have negotiated 30 commercial embryonic stem cell licenses from WARF, DeTienne said.

They are big, global companies such as Invitrogen Corp. of Carlsbad, Calif., and BD Biosciences, part of Becton, Dickinson & Co., based in Franklin Lakes, N.J., and Vancouver, British Columbia.

They are also smaller companies such as BioTime Inc., an Emeryville, Calif., company whose Embryome Sciences subsidiary is developing a collection of tools to help researchers identify, scale-up and purify many of the cell types that emerge from human embryonic stem cells.

James Thomson, the University of Wisconsin-Madison researcher who did the work behind the patents, has two companies based in Madison: Cellular Dynamics International and Stem Cell Products Inc.

WARF has licensed its stem cell patents to more than 900 academic institutions, Kelly said.

The European Union has refused to grant similar WARF patents. WARF has appealed that decision.


Laura


David said at July 5, 2008 2:30 AM:

Dear Laura, I know some years ago Sharp's group promised they would have it by say 2009. Obviously they were too optimistic. But that doesn´t mean they are not excelent researchers and they are one of the world leading group by today. Today we all know much more about stem cells and the problems we still have to face in order to use it and get the expected results. I believe form what I have read from other researchers that 10 years from now it's pretty realistic.

I'm also very interested in tooth repair (not only in the total regeneration of a tooth). If you all read about this you will notice that great advances have already been done to regenerate jaw bone and the periodontic ligaments but much less regarding pure dentin regeneration. These days is running at Toronto the the 86th General Session of the International Association for Dental Research. I really recommend their webpage where you can read the abstracts of all the works that will be presented, that's enough to understand what's going on in each field (if you want the full article you have to pay). http://www.dentalresearch.org/i4a/pages/index.cfm?pageid=3533 Go to this section to see the articles http://iadr.confex.com/iadr/2008Toronto/techprogram/index.html

I had already found an article what is without no doubt a great advance for dentin regeneration. It is also referred today at the sciencedaily webpage:

http://www.sciencedaily.com/releases/2008/07/080704130806.htm

Regards,

David.

Clint said at July 10, 2008 1:03 PM:

What the hell is going on with the status of LIPUS? I can't find anything about it and the team won't respond to any of my e-mails.

Patti said at July 21, 2008 3:34 PM:

I came up with an idea after reading about the Ultrasound for stimulating new growth of teeth. It's taking them a long time because they are trying to make the device tiny enough to 'wear' in your mouth constantly. The first one designed had to be held in place for 15 minutes once a day. We would all LOVE to have something like that to use right now! Who would mind taking 15 minutes once a day if there was even a small amount of improvement? Well I've kept on reading and there is a new toothbrush called 'Ultreo' (very expensive, $169) but it cleans your teeth with Ultrasound. Does anybody else on this board think maybe it might help us to use it? I can afford one in August and am going to give it a try. It can't make my teeth any worse and I'm so embarrased and ashamed of the way they look now. People who notice a person has bad teeth look at you like you are a dirty person and it makes me depressed. Anyway maybe this Ultreo toothbrush will help. I can't wait another 10 years for the research to be done, I want to do something now. Oh and don't get the other types of pulsating electric toothbrushes, they don't have the Ultrasound in them.

David said at July 24, 2008 10:36 AM:

Hi all,

Clint, I tried to find something about LIPUS but I couldn't find anything. It seems it is not as good as it seemed to be. Other way we should have heard something new by now. I'll keep on searching.

Patti, I don't know what's exactly your problem but if you are talking about regeneration I don't believe a simple commercial brusher will do it. If you look at their webpage http://www.ultreo.com/web/home/learn-about-ultreo/Default.aspx?AspxAutoDetectCookieSupport=1 they just talk about "clean" but nothing else, I mean that this is just a new way to get cleaner teeth but don't expect anything else.

Regards,

David.

Jaime said at July 28, 2008 9:37 AM:

Hello David,
I am from Spain. Where are you living presently?
I am from Menorca, Spain.

juan said at August 16, 2008 3:32 PM:

hi, some news ???
if they able to grow up new teeth on mice why they don't try on human....
i hear talk about this project since 10 years ....
why odontis, hitachi and others,why they don't communicate about their searchs....
all this is business , they don't care about us , our pain ....

Tony said at August 16, 2008 5:06 PM:

To the comment above, If that is true..then they are bastards! There is no shame in saying the truth. Afterall they do use taxpayer dollars. I also am tired of waiting. Odontis isn't that based at Kings College in London? College and taxpayer dollors go hand in hand. Anyway on a better, brighter and Im sure more honest note; today California Institutue for Regenerative Medicine has honored Dr. Ophir Klein, MD, PhD Approximately $3 million to study teeth regeneration at UCSF. So lets keep are fingers crossed people to health before politics and business in the feild of teeth regeneration.

Tony

juan said at August 17, 2008 12:29 PM:

hi tony,
why they don't cmmunicate ? for hide and keep their progress secret ??? come on it's more important that our pain ????
they can regrow it on a mice since few years now why they don't try on human ????
...

juan said at August 17, 2008 12:35 PM:

or maybe its juts a dream for us ...

David said at August 21, 2008 2:57 AM:

Hi Jaime,

I live in Zaragoza, if you want to contact me my email is davidtrabajo@yahoo.es

I have read your comments and I think we suffer a similar problem. I hope your treatment is going fine, I will start my treatment next year.

Regards,

David.

Nic said at August 23, 2008 11:35 AM:

I just that I would post this article I recently found. Perhaps this device will be available in the not so distant future after all:

http://www.medtechwatch.ca/6-4_2008/company_profile_2_e.html

Company Profile: LIPUS

LIPUS Device

The LIPUS device easily fits into the mouth, where it stimulates regrowth of broken tooth roots. The pulse is controlled remotely through a base unit. -Courtesy Dr. Tarek El-Bialy, University of Alberta

For the last few decades, dental high technology has focused largely on implants; but thanks to Dr. Tarek El-Bialy of the University of Alberta, these might soon be a thing of the past.

Dr. El-Bialy’s LIPUS (low-intensity pulsed ultrasound) system uses a small wireless ultrasound device, inserted in the mouth, to repair teeth. LIPUS stimulates specific cell signalling that can produce tissue matrix proteins, repairing broken tooth roots. This could mean fewer implants, and better overall dental health.

LIPUS has been used since early 1980s, mainly for bone-fracture healing and to heal other tissue, such as tendons and skin ulcers. Dr. El-Bialy first discovered that ultrasound can stimulate dental tissue formation in rabbits in 1999, when he cut the lower jaw to lengthen it and applied LIPUS to help bone formation at the surgical cut site. The rabbit teeth start to grow faster on the treated side than on the non-treated side. He published the results of this experiment in the American Journal of Orthodontics.

Following his research on the animal model, Dr. El-Bialy started working on human teeth that undergo shortening (resorption) in people who wear orthodontic braces. He found LIPUS can prevent this shortening from happening by a daily 20-minute application over four weeks.

The handheld device used in the above research was cumbersome, however. So, over the last few years, his team has been developing a refined prototype that can be used inside the mouth. The miniaturized device is now undergoing electronic and biological testing, and a completed version should be ready to start clinical trials by November 2008.

Dr. El-Bialy cites funding as a challenge, as well as perceptions of the new technology by scientists. His team—which includes University of Alberta electrical/computer engineers Jie Chen and Ying Tsui—received an NSERC Idea to Innovation (I2I) grant and an Alberta Heritage Foundation for Medical Research (AHFMR), which helped considerably.

Dr. El-Bialy is one of the newest faculty members at the university, but brings considerable expertise and perspective, thanks to training in orthodontics, law, and bioengineering from Egypt, the US, and Canada.

For more information, please contact:

Dr. Tarek El-Bialy
University of Alberta,
Faculty of Medicine and Dentistry
4051 Dent/Pharm Bldg.
Graduate Orthodontic Program
Edmonton, AB T6G 2N8
telbialy@ualberta.ca

John said at August 28, 2008 12:21 PM:

People I am specifically interested in what this article has to say about "Tooth Cryopreservation" and the clinics that offer it to their patients. " Procedures of a perserved wisdom tooth that has been extracted from one reciepant and transplanted into another". I am looking for information to cantact one of these clinics and or a tissue bank for teeth. Would anyone be kind as too do any research and post if found. The article is by Dental Care Advice. Com. and it has a contact email address that doesn't seem to have emails go through. If anyone can find a contact email address for Dental Care Advice. Com that would also help. This is the address to the article.


www.dentalcareadvice.com/dental-surgery-procedures/tooth-transplants.php

John said at September 13, 2008 12:40 PM:

http://www.dentalcareadvice.com/dental-surgery-procedures/tooth-transplants.php

Here is the address again click on it and it should take you to the page.


Johny

Mohanty said at September 16, 2008 7:23 AM:

please can anyone give any realistic timeline of when tooth re-generation can be possible?
although the reports that i have read gives pretty optimistic news.
why cant the scientists periodically publish their advancements to the general public?

yna said at October 12, 2008 12:55 PM:

hi! i also sufffer similar problems with a lot of you here. i thought i was alone in the world feeling like this because of my teeth and what the dentist did to me. can we sue those dentists?

shuun said at October 13, 2008 11:03 AM:

Hi Randall,

I want to know how to create and host a webpage such as this one. I am thinking of creating one for another issue that I like people to share ideas and post articles they have written about the subject. How large of a space is needed? I am thinking of something that is permanent and can accomodate many articles and comments.

Thanks in advance for your help.

Shuun

Jaime said at October 14, 2008 1:49 PM:

Hi Shuun, I'd like to help you. I have a friend who may provide us hosting. I am learning html, php, javascript, mysql and some ajax. I hope we can collect more people to enhance a project and give it more relevance, with more issues to speak about of this matter.

加油!

Boob said at November 12, 2008 2:35 PM:

Any news in teeth regeneration???

JA said at November 21, 2008 3:14 PM:

I wrote Dr. El-Bialy recently regarding ultrasound tooth regeneration and he said we should have a working device on the market sometime in 2011. It still remains unclear to me whether it will work on root canal teeth. I have one treated with calcium oxide.

justin said at February 2, 2009 8:50 PM:

haha,jaime is also from china?

it's now beginning of year 2009.several centuries passed,we still have the same old teeth treatment as what president George washington received.we can fly to outerspace and deep sea,we can colone animals,but we just can not make our teeth regenerate!!!

i suffered periodontitis problems in year 2005,i went to dentist clinic(or hospital),but the dentists told me there was no way to cure,periodontitis is hard to cure worldwide,they know only drill and fill.they asked me to remove my two loosened teeth first,how could i accept this---taking two of my healthy looking teeth away!!!i got the same result from different dentists.God,now it seems i would lost all of my teeth!!(i have lost 2 already because of without any treatment).in China,more than 90% people have periodontitis disease,but the government did nothing.we don't even have similar research institutes like those in Japan,US,UK.

4 years passed,i searched high and low about the latest technology about teeth regenation,but till now,so frustrating.i guess we wont be able to re-generate our teeth in the next 20 years.because it's nearly 10 years since the breaking news(teeth regeneration in pig's mouth) released.

I don't know why the united nations can not set up a teeth regeneation project,with scientists from all countries working together and big funding backing?this would make our dreams come true much earlier.

Good luck everyone,let's smile even we lost of our teeth!

Simon said at February 5, 2009 2:31 PM:

"XENON
Xenon is most useful for regeneration. Of course this is very controversial. We don't have the ability in traditional science to produce regeneration in human beings very easily. We usually mix Xenon with various other gases to focus on particular parts of the body. We have a Xenon-based combination for regrowing teeth. I have worked with several people who have regrown missing teeth. The combination includes Neon and Helium with the Xenon. Next, we have some cases of people who have regenerated hips and improved their backs. Here we generally use Krypton mixed with the Xenon, as it seems to help bone and skin."

http://hilarion.com/igd.html

Simon said at February 5, 2009 2:41 PM:

"I don't know why the united nations can not set up a teeth regeneation project,with scientists from all countries working together and big funding backing?this would make our dreams come true much earlier."

That's because the United Nations aren't interested in your having healthy teeth, neither are dentist. Most of them are businessman and very comfortable with the way things are. The sicker people are the more money they make.

Monica said at March 3, 2009 1:59 PM:

Does any one know when President Barack Obama is going to lift the restrictions on Stem-Cell Research? And the ban on federal funding for Stem Cell Research?

Simon said at March 14, 2009 1:56 AM:

Well, the restrictions were removed. See here,

http://www.youtube.com/watch?v=2Gs39k0IxZ0&feature=dir

Obama Supporter said at March 28, 2009 4:19 PM:

Barack Obama will find can cure economy, cancer, regrow teeth and etc

Edward said at April 21, 2009 9:09 PM:

Thanks to everyone who continues to provide updates to this page: there is so much info on dental healing it's great to have just the important stuff aggregated into one place!

I need teeth NOW!! said at May 8, 2009 8:59 AM:

Pres. Obama lifted the restrictions on Stem Cell research and I needed this service for my teeth 20 years ago..What do I do to get it...

johnny said at May 8, 2009 3:24 PM:

"I don't know why the united nations can not set up a teeth regeneration project,with scientists from all countries working together and big funding backing?this would make our dreams come true much earlier." -That's because the United Nations aren't interested in your having healthy teeth, neither are dentist. Most of them are businessman and very comfortable with the way things are. The sicker people are the more money they make.

I completely agree with that! I also think that growing new teeth is already possible but now they are searching for ways on how to make this technology as much as profitable (e.g. instead of growing permanent teeth, you'll get temporary teeth that would last for about six months and then you'll have to grow new ones, and so on...).

Jaime said at May 20, 2009 7:19 PM:

I received this from google alerts.

http://www.sciencealert.com.au/news/20092105-19174.html

Sad but positive said at May 27, 2009 1:46 AM:

Hi folks,
I'm new to this forum and have been tracking this forum since last few months. I too have lost one tooth due to an accident but had the root was intact. I went to a dentist who, without informing me about the pros and cons of a bridge, reduced my the tooth structure of my adjoining teeth and put up a bulky bridge which I hated from day one.
Now I am going to another dentist who suggested to have a post and core on the middle and crowns on the adjoining ones. Suddenly for no apparent reason he is suggesting me to have a Root canal on one of the adjoining tooth. I feel utterly devastated and am angry on all the dentists that I had been to. I have decided not to do RC on the adjoining tooth whatever may be the case and put crowns on the side ones . I always look up to this forum for latest news on tooth and enamel re-generation. I'm pretty sure if we keep this discussion forum alive we can come upto something concrete in a few years. Folks dont lose heart and be positive. If scietists can really grow new teeth in pigs ands rats , it wouldnt be really be too farfetched an idea to grow on humans too. And besides when so much funding and research is going on(all the research that we have read going in on regeneration in Australia, US, UK and Japan ), I think its just a matter of time before we can really have a new set of teeth. So folks be positive and pray that we can have this miracle as soon as possible.

Thrina said at June 18, 2009 6:13 AM:

I e-mailed Dr. El-Bialy and he replied that LIPUS cannot regrow lost tooth. Is this true or what?

Jaime said at June 19, 2009 1:35 PM:

I think ultrasound is only for enamel regeneration and maybe cement. This device cannot create teeth. It is just a device and irradiate some kind of ultrasound that stimulate the enamel wall and maybe his adjacent. I definetly think we will need stem cells to make new teeth from the scratch. Be patient and talk about with your dentist. Ask him if it's possible to replace an implant by an stem cell teeth in the future. There's no more alternative than have an implant right now.

?? anyone know if it will be possible to make the teeth root regrow by ultrasound? I did read something about this but I am not sure right now.

creativedick said at June 28, 2009 6:44 PM:

Guys,
Lipus devices are in use in the |US, for horse teeth regeneration.
I made myself one Lipus device emitting at 1.5mhz, pulsed at 200ms - just what is needed for my teeth to grow, and i mu7st say it works.
You just need to go a little deeper, and purchase/or make yourself one cool LIPUS device, and use it as you find proper, not some government or some dentists that will dissapear the moment people begin regrowing their own teeth by themselves.

Sad but positive said at June 29, 2009 12:58 AM:

Dear creativedick,
Do you have any idea as to whether this LIPUS device can be used to regenerate enamel on a crowned tooth(I have crowns on 2 live tooth)?
Is it possible to make the this device yourself??
It would be kind of you if you can you give some more information and links on the same..

Alex said at July 7, 2009 11:57 PM:

you can find LIPUS device on eBay
it does not work on humans.
but you can entertain yourself

Alex said at July 8, 2009 12:02 AM:

Dr. El-Bialy - fraud
Dr. Sharpe - fraud
implants its only solution.

goat said at July 8, 2009 3:23 AM:

you can buy this thing on ebay, it's called the exogen 2000 bone healing system, its exactly the same but not miniture, you'd have to do one tooth at a time

Alex said at July 8, 2009 10:33 AM:

Exactly if its working why it should be miniature? Who cares if it size of the brick?

Kevin said at July 10, 2009 10:57 AM:

I have been waiting for this day my whole life. Ever since i was a kid my teeth grew in damaged from fluoride in the drinking water here in United states. And on top of that i chipped my tooth while rollerblading when i was 13. I knew this day would come. Thank god.

Robert said at July 26, 2009 12:49 PM:

People,

Type in Ophir Klein in the google search engine and you will find a scientist from UC San Franciso who has been working on regrowing teeth. Also type in CIRM and then CIRM/Home and you will find another great source for developmental biology. These are two very good recources.

Sad but positive said at July 27, 2009 7:03 AM:

Great resource Robert!!!
Cheers...

Mrs M Bolton said at July 28, 2009 4:15 AM:

There was an ultra-sound toothbrush, but the company has gone bankrupt. I'm sure another company will produce one eventually. Do you think this type of brush could stimulate bone growth?

Mrs M Bolton said at July 28, 2009 4:20 AM:

There was an ultra-sound toothbrush but the company has gone bankrupt. I'm sure another company will produce one eventually. Could such a toothbrush stimulate bone growth?

Hope said at August 9, 2009 2:19 AM:

I hope it is true and become a common dentistry tool. It will perhaps brings less pressure for dentists and oral surgeons. But I do worry that it will also stimulate wisdom teeth accidentally.

Sad but positive said at August 10, 2009 9:56 AM:

Folks, we have something solid to cheer about!!!
http://www.pnas.org/content/early/2009/07/31/0902944106.full.pdf+html

James said at August 12, 2009 3:29 AM:

Tbh, it really isn't something to cheer about!

In 2007, Takashi Tsuji from the Tokyo University of Sciencet (the exact same place as in your link). Made a report in Nature Methods that they had successfully regrown a tooth from cells extracted from mouse embryos. The researchers were able to transplant the tooth into an adult mouse, and the tooth bud continued to grow to full size.

Before that, a group of researchers from the University of Southern California (USC) recently regrew tooth roots in pigs using adult stem cells from wisdom teeth. The team, led by Songtao Shi, assistant professor of USC's School of Dentistry, isolated stem cells from the extracted wisdom teeth of 18-to-20-year-old humans. From these cells, the researchers successfully recreated a tooth's root and periodontal ligament, which, when transplanted into the oral cavity of a pig, could support a synthetic crown.

In the 1940's, Dr. Shapiro was transplanting tooth buds from 10 week old kittens into older cats who had teeth surgically extracted. Said tooth grew fully!

I personally would give anything to have shiny brand spanking new teeth which I'd cherish a lot more than unfortunately I did with this set. However it will still be many years in future before anybody will be getting it done in their local dentists. First they'll need to get licenses & all that stuff. Then human trials, which will take years to monitor the new teeth to make sure they stay fully functional & don't erode etc, etc. No point in getting a new teeth, or even getting old ones with fillings pulled to find out that the new one fails a little over a year in. Meaning you'll end up worse than you started off with. In that case you had a natural teeth with filling, when the new ones fails, you'll have nothing & need a dental implant that gets screwed into your jawbone.

So regardless, it'll be years before human trials are even done anywhere. Years more to observe the results. Assuming no setbacks anywhere, then maybe 10 years, but I'd be willing to bet it'll be closer to 20 before you nip into your local dentist & get yourself a new tooth.

That story in your link would only be something to cheer about is if it was re-grown in a human mouth!

Robert said at August 12, 2009 10:46 AM:

James! Progress is progress and I cheer to that!!!! People also, remember to support CIRM....California Institute for Regeneratvie Medicine, the leader in research and funds in developmental and bio-engineering. Look at the CIRM homepage and then click ANNOUNCEMENTS and there you will find the latest progress and developments.


Cheers everyone!!!

bamboo said at August 23, 2009 7:42 AM:

re, James said at August 12, 2009 3:29 AM:
James, how negative can you get?
Bio teeth have a great future, how about all those that are not suited to titanium implants?
There must be dozens of people with one or two cavities that would be more than happy to become guinea pigs for the first generation of products such as those under development by Odontis. Logic dictates that those volunteers have little to lose.
The lack of news fron Odontis since 2004 could well be due to commercial considerations. Progress in Japan [aug 2009]indicates the possibility that medical trials may commence sooner rather than later

bamboo said at August 23, 2009 7:43 AM:

re, James said at August 12, 2009 3:29 AM:
James, how negative can you get?
Bio teeth have a great future, how about all those that are not suited to titanium implants?
There must be dozens of people with one or two cavities that would be more than happy to become guinea pigs for the first generation of products such as those under development by Odontis. Logic dictates that those volunteers have little to lose.
The lack of news fron Odontis since 2004 could well be due to commercial considerations. Progress in Japan [aug 2009]indicates the possibility that medical trials may commence sooner rather than later

Anonymous said at August 28, 2009 3:52 PM:

This was lame! Another whacky scientist claiming he can raise the dead or understands the origins of life and can't even cure a cold. BOGUS!!!

Alan said at September 1, 2009 11:02 AM:

Just a thought: WHEN this new-teeth technology becomes available, it will be available first outside the U.S. and the U.K. The U.S. and U.K. are too mired in bureaucracy, hyperregulation, legal obstacles, etc.; everything is much too expensive and slow. China, and other Asian countries, will be where the action is -- particularly the real accessible and affordable TREATMENT action. Both research and practice are flying ahead over there, while we're bringing up the rear. Be prepared to fly to Beijing for your new tooth bud implantations. My SWAG (Scientific Wild-Ass Guess) is 6-10 years.

Alan said at September 1, 2009 11:16 AM:


the latest... september 2009:

http://www.informahealthcare.com/doi/abs/10.1517/14712590903103795

Expert Opinion on Biological Therapy

September 2009, Vol. 9, No. 9, Pages 1143-1154

Dental stem cells for tooth regeneration and repair

Andrea Mantesso‌1,2 DDS PhD & Paul Sharpe‌†1,3,4
1Professor, Guy's Hospital, Dental Institute, Kings College London, Department of Craniofacial Development, Tower Wing, 27th floor, London, SE1 9RT, UK +44 2071881795; +44 2071881674; paul.sharpe@kcl.ac.uk
2University of Sao Paulo, Dental Institute, Department of Oral Pathology, Av. Lineu Prestes, 2227, CEP 05508-900, Brazil
3Guy's and St Thomas NHS Foundation Trust Hospital, Biomedical Research Centre, London, SE1 9RT, UK
4MRC Centre for Transplantation, Kings College London, UK
†Author for correspondence

Mesenchymal stem cells (MSCs) resident in bone marrow are one of the most studied and clinically important populations of adult stem cells. Cells with, similar properties to these MSCs have been described in several different tooth tissues and the potential ease with which these dental MSCs could be obtained from patients has prompted great interest in these cells as a source of MSCs for cell-based therapeutics. In this review we address the current state of knowledge regarding these cells, their properties, origins, locations, functions and potential uses in tooth tissue engineering and repair. We discuss some of the key controversies and outstanding issues, not least of which whether dental stem cells actually exist.


Alan said at September 1, 2009 11:21 AM:

from China... 5'll get you 10 that they will solve the problems before the West does...

http://www.liebertonline.com/doi/abs/10.1089/ten.teb.2008.0165

Current Approaches and Challenges in Making a Bio-Tooth

To cite this article:
Jinhua Yu, Junnan Shi, Yan Jin. Tissue Engineering Part B: Reviews. September 2008, 14(3): 307-319. doi:10.1089/ten.teb.2008.0165.

Published in Volume: 14 Issue 3: February 4, 2009
Online Ahead of Print: July 29, 2008
Full Text: • PDF for printing (302.9 KB) • PDF w/ links (292.4 KB)

Jinhua Yu, D.D.S., Ph.D.
Institute of Stomatology, Nanjing Medical University, Nanjing, Jiangsu, P.R. China.
Department of Endodontics, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Junnan Shi, D.D.S.
Department of Endodontics, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Yan Jin, D.D.S., Ph.D.
Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.
Department of Oral Histology & Pathology, School of Stomatology, Fourth Military Medical University, Xi'an, Shaanxi, P.R. China.

Tooth loss adversely affects not only mouth functions but also the esthetics of one's face. To repair these defects, current treatment methods mainly depend on nonbiological materials or artificial implants that also can, sometimes, reduce the quality of life because of their limited physiological function, or elicit an immunological rejection. Theoretically, a biological tooth (bio-tooth) that is made from the patient's own cells and grows in its intended location should be the best choice for treating tooth loss, although such bioengineered teeth have been nothing more than a dream for many centuries. Recently, significant advances in the fields of tissue engineering, stem cell biology, developmental biology, molecular genetics, and bionics have brought us close to the realization of a bio-tooth. However, issues involving in the reconstruction of a bio-tooth regarding the shape determination, size control, availability of dental epithelium, directional growth and eruption, and graft rejection in the jaws remain to be resolved. Here, this review outlines the current approaches toward the tooth regeneration, and focuses on several key challenges that must be met in the making of a bio-tooth.

Alan said at September 1, 2009 11:26 AM:

Japan also:

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B8JJW-4SK59NG-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=4fb77b6bc4bc8900f6405c3f4d145c77

Japanese Dental Science Review

Volume 44, Issue 1, July 2008, Pages 70-75

doi:10.1016/j.jdsr.2007.11.001

Copyright © 2008 Japanese Association for Dental Science Published by Elsevier Ltd.

Mini review

Dental regenerative therapy: Stem cell transplantation and bioengineered tooth replacement

Kazuhisa Nakaoa, b and Takashi Tsujia, b, Corresponding Author Contact Information, E-mail The Corresponding Author, E-mail The Corresponding Author

aDepartment of Biological Science and Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Noda, Japan

bTissue Engineering Research Center, Tokyo University of Science, Noda, Japan

Received 1 November 2007;
revised 6 November 2007;
accepted 6 November 2007.
Available online 23 May 2008.

Summary

For clinical treatment of tooth defects and tooth loss, nonbiotechnological approaches, such as the use of prostheses and implants, have generally been employed. Dental regenerative therapies which restore or replace defective teeth using autologous explants are being investigated using current understandings of developmental biology, stem cell biology, and regenerative medicine. Recently, dental tissue stem/progenitor cells, which can differentiate into dental cell lineages, have been identified in both impacted and erupted human teeth, and these cells can be used to regenerate some dental tissues. Tissue engineering using scaffold and cell aggregate methods may also be used to produce bioengineered teeth from dissociated cells for therapeutic applications of whole tooth replacement. Recent breakthroughs in single cell manipulation methods for the reconstitution of bioengineered tooth germ and the investigation of in vivo development of artificial tooth germ in the adult oral environment have been reported. These researches and developments will ultimately lead to the realization of dental regenerative therapies for partial repair by stem cell transplantation and for whole tooth replacement using bioengineered tooth germ.

Keywords: Dental regenerative therapy; Stem cells; Bioengineered tooth; Cell aggregate method; Tooth germ
Article Outline

1. Introduction
2. Tooth development
3. Dental tissue stem/progenitor cells
4. Whole tooth regeneration by in vitro cell manipulation
5. Regeneration of teeth in adult oral environment
6. Future perspectives on dental regenerative medicine
Acknowledgements
References

Corresponding Author Contact: Department of Biological Technology, Faculty of Industrial Science and Technology, Tokyo University of Science, Yamazaki 2641, Noda, Chiba 278-8510, Japan. Tel.: +81 4 7122 9711; fax: +81 4 7125 1841.

Alan said at September 1, 2009 11:36 AM:

Too conservative and pessimistic, IMO, but good background info... FULL TEXT is free at the link...

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2651620&tool=pmcentrez

Int J Biol Sci. 2009; 5(3): 226–243.
Published online 2009 February 24.

PMCID: 2651620

Copyright © Ivyspring International Publisher. This is an open-access article distributed under the terms of the
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A Curriculum Vitae of Teeth: Evolution, Generation, Regeneration

Despina S. Koussoulakou, Lukas H. Margaritis, and Stauros L. Koussoulakos[env]
University of Athens, Faculty of Biology, Department of Cell Biology and Biophysics, Athens, Greece
Conflict of Interest: The authors have declared that no conflict of interest exists.
Received November 19, 2008; Accepted February 21, 2009.

Abstract
1. Introduction
2. Origin and Evolution of Teeth
3. Teeth Development, Genetics and Diseases
4. Is Human Teeth Regeneration a Prospective Clinical Reality or a Fantasy?
5. Conclusions
References

Abstract

The ancestor of recent vertebrate teeth was a tooth-like structure on the outer body surface of jawless fishes. Over the course of 500,000,000 years of evolution, many of those structures migrated into the mouth cavity. In addition, the total number of teeth per dentition generally decreased and teeth morphological complexity increased. Teeth form mainly on the jaws within the mouth cavity through mutual, delicate interactions between dental epithelium and oral ectomesenchyme. These interactions involve spatially restricted expression of several, teeth-related genes and the secretion of various transcription and signaling factors. Congenital disturbances in tooth formation, acquired dental diseases and odontogenic tumors affect millions of people and rank human oral pathology as the second most frequent clinical problem. On the basis of substantial experimental evidence and advances in bioengineering, many scientists strongly believe that a deep knowledge of the evolutionary relationships and the cellular and molecular mechanisms regulating the morphogenesis of a given tooth in its natural position, in vivo, will be useful in the near future to prevent and treat teeth pathologies and malformations and for in vitro and in vivo teeth tissue regeneration.

Keywords: epithelial-mesenchymal interactions, teeth evolution, development and regeneration

1. Introduction

A huge amount of literature is devoted to the origin, evolution, organogenesis, pathology and therapy of teeth. There have been tremendous advances in recent years towards a better understanding of the regulation of teeth development 1, 2. The immense interest in this subject is quite justified since, apart from the intrinsic scientific merit, teeth congenital abnormalities account for 20% of all inherited disorders, whereas, oral pathology occupies a leading position in the list of human diseases 3, 4.

[.....BIG SNIP.... go to the URL for full text....]

5. Conclusions

This review provides insight into how teeth are made in nature and how we might make them using our accumulating knowledge and technology. There are many teeth types, such as cutting incisors, tearing canines, grinding premolars and molars. Continuously growing teeth are common in many animals (e.g., mouse incisors, vole molars), and some organisms (e.g., sharks) can replace lost teeth throughout life. There are also species variations in the extent of enamel coverage on teeth (e.g., man, mouse, horse, elephant). Despite such differences, most recent teeth, including those of humans, originate from a common precursor and develop under similar molecular instruction. Tooth defects or missing dentition compromises human health physically and psychiatrically. Evolutionary and developmental biologists, as well as tissue engineers, are working together to investigate and compare the tissue origin, patterning and growth of various teeth parts in an effort to restore healthy and/or repair defective tissue. Our understanding of these biological processes may serve as a foundation for the future design and fabrication of regenerated teeth. Research continues with the goal of being able exploit natural processes to generate new therapies. To that end, we have extended our knowledge of the cellular and molecular biology and the genetic circuits involved in the epithelial-ectomesenchymal interactions. We have acquired numerous somatic stem cell lines with higher plasticity than what was previously thought possible, and we have learned that missing components of a morphogenetic field can be replaced by similar components from other tissues. Future work will continue to explore the possibility of tooth tissue restoration in vivo and the regeneration of whole teeth, both in vivo and in vitro. It seems now that the recent convergence of the human genome project and other projects in different scientific and technological fields has significantly enriched our arsenal of tools that can be applied towards our goal, i.e., teeth tissue regeneration.

There is no doubt that it will take a long time before even partial restoration of dental tissues, let alone complete tooth regeneration, will be achieved both in vivo and in vitro and applied in clinical practice. Nonetheless, there are reasons to be optimistic. It is hoped that by continuing to improve our understanding in these areas, we will be able to improve the way we diagnose and treat pathologies affecting teeth, whether they arise from genetic or environmental factors, injury or disease.

Alex said at September 30, 2009 9:33 PM:

Clock Turned Back on Aging Muscles, Researchers Claim

http://news.yahoo.com/s/livescience/clockturnedbackonagingmusclesresearchersclaim

Check this for a change

Alex said at September 30, 2009 9:34 PM:

Clock Turned Back on Aging Muscles, Researchers Claim

http://news.yahoo.com/s/livescience/clockturnedbackonagingmusclesresearchersclaim

Check this for a change

dws said at February 9, 2010 11:25 AM:

Has this forum moved?

dws said at February 9, 2010 11:31 AM:

There was a lot of activity here which seems to have faded away. This was very interesting. Are there other forums/topics on this subject that are as active as theis one once was?

bamboo said at February 12, 2010 2:01 PM:

has odontis shut up shop?
something about wellcome foundation funding being withdrawn because of a lack of saleable product at the end of the third year?
any news about this company?

http://www.publications.parliament.uk/pa/cm200910/cmselect/cmsctech/memo/bioengineer/ucm2302.htm

""Case Study 2

33. A second case study reached EESCN directly after a Board meeting of the otherwise promising spin out company, Odontis. Professor Paul Sharpe writes:

34. "I am founder and scientific director of a university stem cell spin-out company Odontis, and I have just returned from Odontis had been funded by a 3 year Wellcome Trust strategic Translation award that had been running for 2 years. However because it was clear that we would not have a "product" ready for translation by the end of the third year, Wellcome decided not to continue funding for the final year." """

Bob Badour said at February 12, 2010 3:18 PM:

It looks like odontis has indeed gone tits up. Prof. Paul Sharpe is still around, though.

bamboo said at February 13, 2010 1:53 AM:

Bob, thanks for the reply.
please post here any further updates on this kind of research.
worldwide, there are at least two other groups working on this technology as far as i know. japan and US.
perhaps prof paul sharpe will collaborate with another group.


things are beginning to happen in other areas, for example, news from US company, Organogenesis. a new treatment for receeding gums. testing complete and approval for use sought.

Company Applies Regenerative Medicine Expertise for New Therapeutic Class in Dentistry, Periodontology and Oral Surgery

Clinicians currently have limited options to correct gingival recession. Most commonly they perform a free gingival graft, in which tissue is taken from the roof of the mouth (palate) and is transplanted to the gum in order to prevent further recession. This procedure is performed approximately 500,000 times per year in the U.S. Drawbacks to free gingival graft procedures include pain and morbidity (at the site of the palate graft), insufficient tissue to treat all sites requiring treatment and often unappealing aesthetics due to poor color and texture match of the graft to the adjacent gums.

"We designed CelTx to address these shortcomings. Once approved, CelTx will allow a clinician to fully treat all compromised gums, will reduce patient pain and complications by eliminating the need for a graft, and provide a highly aesthetic clinical outcome,” continued Eklund. “We are looking forward to introducing what we believe will be a new therapeutic class in dentistry."


http://www.organogenesis.com/news/press_releases/press_release_ogn_files-21122009.html

ily said at February 24, 2010 12:07 PM:

I want it to happen RIGHT NOW,

I don't know about you but i can't live without my teeth it's really difficult, it's not what we can name a life it's a "waiting life", maybe iam crazy but i personally think that they are now able to regrow human teeth but something "prevent" them to start (dentists lobbying, money,lack of curiosity???...) i really think this because like someone said it "they are able to clone human or animals, and no teeth?" it sounds a little bit strange to me, and also how can we explain the fact that Paul Sharpe, i think since 2004, was saying "we will be able to regrow teeth in 5 years" and later "we will start human trials in 5 years" why did he said that if it was not the case or not sure? Now he say "within 7 to 10 years". Why should i believe in this masquerade and HOW can he specifies a date "7 years or ten years" if the procedure is "only at its early stage" if it was the case he couldn't even know if it will be possible or available one day with human cells in humans mouth!? this is one of the reason why i came in this conclusion that there is a lot of incoherences.

Plus, i learn that they have in the past re-grew teeth in pigs with human 18-20 years old stem cells and that it was a success, this means that they know which human cells are involved in the processus, so why they now say that they are searching for human stem cells which can do the same in human? (this is what the japanese said on Plosone)

So i hope someone will be as sceptic as me or maybe this is my despair which is making me crazy...


ily said at February 24, 2010 12:13 PM:

Is this normal that i can't find the Paul Sharpe wabsite (odontis.co.uk) ??

Bob Badour said at February 24, 2010 12:26 PM:

See above at: It looks like odontis has indeed gone tits up. Prof. Paul Sharpe is still around, though.

For clarification, "tits up" means the same as "gone under" as in "This parrot is no more!"

ily said at February 24, 2010 2:36 PM:

But where is the initial website? (odontis.co.uk)

Bob Badour said at February 24, 2010 2:50 PM:

It's gone. Kaput. No longer registered. The company closed up shop and the website for good.

Websites are not free. Just like the phone and the lights, when you stop paying for them, they get turned off.

ily said at February 24, 2010 3:49 PM:

OMG if they dont' have enough money for this...

Bob Badour said at February 24, 2010 4:18 PM:

It was a time to market issue:

Odontis had been funded by a 3 year Wellcome Trust strategic Translation award that had been running for 2 years. However because it was clear that we would not have a "product" ready for translation by the end of the third year, Wellcome decided not to continue funding for the final year.

Basically, they hit a snag and the principal financier backed out:

no provision in the system for flexibility. A project like ours is making progress but we reached a stage where we needed to spend some time going back to basics in order to progress further. This is not acceptable in translational funding.

In other words, they had a single investor who was willing to put up money to translate the basic science into a business. However, basic science doesn't always progress in a linear fashion. When it hit a setback, the investor pulled the funds to invest in something else instead.

The same scientist continues to do the same science so all is not lost.

ily said at February 25, 2010 3:18 AM:

If they don't have enough money i think every people who lost one or more tooth will have what they need... and also i would give them my mouth...

ily said at February 27, 2010 10:23 AM:

Pleaase say something folkssss!!

shuun said at February 27, 2010 7:03 PM:

Ily, just hang on. I fully believe that it is not too long before we see explosion of regenerative medicine including teeth. Many biological and biomedical research fields are in their mid to late stages, so it is logical to think that they will all explode and commercialize around the same time. Another thing is that once one application is commercialized, others quicken the pace of development. Never give up hope. Not now, not ever.

ily said at March 6, 2010 2:40 AM:

desperate

Hopeful said at March 8, 2010 12:48 AM:

Hi I had weak enamel but nice teeth. I went to dentist and he advised me to cap them all with 360 degree veneers to protect them from further erosion and prevent need for root canal treatment & further gum recession. I am only 33 years old a mother and have always had a healthy mouth with no cavities. All my teeth are alive. I had 20 of my frent teeth (10 upper & 10 lower) capped and I haven't been the same. I should've researched more but the Dr was famous & I trusted him. I have been very depressed and refused to take medications for depression. I have evrything to live for but just am so upset about making a hasty uninformed decision. Drilling down of Tooth enamel is irreversible & I regret it so much I can't enjoy anything. The ceramic feel so unnatural in my mouth and its like I have glass teeth. Please everyone or anyone ever considering veneers or lumineers please DO NOT DO IT. No matter how bad your teeth are hold on to them to th every end.

Here's a link I added to my favourites because it gives me hope that maybe I will one day smile again and be the person I used to be.

http://165.193.122.153/science/science_news/articles/something_to_chew.html

Investigators have made several attempts to grow enamel from the cells that make it within the gums, but "nobody has really demonstrated true enamel," says Pamela Robey of the National Institute of Dental and Craniofacial Research in Bethesda, Md.

Excerpts from May 2005 article above:

Researchers have isolated several of the other cell types involved in tooth development. They have used these cells to regenerate dentin; cementum, which is the hard tissue on root surfaces; and the periodontal ligament that attaches each tooth to the jaw. "The one thing that's missing now is enamel," says Robey.

With several recent discoveries, researchers have gotten the best glimpse yet of enamel in formation. Thanks to advances in materials science as well, they're closer than ever to making synthetic enamel that can compete with nature's version. With that, they hope to reach an even more audacious goal: growing an entire tooth from scratch.

With a biomaterial that mimics the properties of natural enamel, researchers could bypass the need for enamel-producing cells. For instance, scientists might create a crown out of synthetic enamel and use it as a mold, says Robey. Inside the mold, researchers would then place all the necessary cells for regrowing the rest of the tooth, she says.

That 's the vision. It may take more than a decade before researchers realize such a goal. However, if successful, it would represent a major feat in bioengineering—not to mention a major boon for patients, who won't have to run back to the dentist so often for repairs on false teeth.

Good luck to all of you and may we all soon have our natural teeth again. I read somewhere that it might be very expensive, with a whole tooth regrowth costing something like $4000. God help us.

I pray researchers have this ready asa & we get to benefit from it.

Hopeful said at March 8, 2010 4:50 AM:

This could be the dream come true alternative to having to withstand porcelain ceramic glass-feeling like materials in crowns placed on our mouths.

Using synthetic enamel instead:

http://www.nanotech-now.com/news.cgi?story_id=16626

Please post if you have any updates on these scientific break-throughs.

Hopeful said at March 8, 2010 9:26 PM:

Based on all research, conservatively speaking, it will take another 10 to 15 years before regrowing teeth is tested on human beings. Scientists all over the world are working hard on this as I write this.

We just have to fight to stay alive till then:)

ghbm said at March 12, 2010 1:22 PM:

A french laboratory situated in Marseille said they will try to start human trials in 5 years...

http://www.laprovence.com/article/region/a-marseille-on-fait-pousser-les-dents (in french)

Hopeful said at March 15, 2010 12:51 AM:

Thanks for posting. This is the only English version I could find since I do not speak French.

http://www.daylife.com/photo/0aih5gjfFDfSI

Let's pray they succeed. Please keep this page going and let's keep updating for any new info./news/latest developments out there.

Hopeful said at March 15, 2010 11:53 PM:

Thanks ghbm. What's your story? Did you loose or ruin your teeth? I am so unhappy and suffer from acute depression. I have so far refused to take medication. Every second is a battle to stay alive. I could use some encouraging words. How have you all managed to live with the feeling of crowns or implants in your mouth? For me I just cant have fun anymore and I'm terrified to live the rest of my life like this. Its worse than death:(

ghbm said at March 16, 2010 12:29 PM:

I lost "only" 4 of my back teeth but i want them back RIGHT NOW, i think the loss of these teeth change a little bit my face i mean aesthetically,but i do not have any implant and i refuse to have any implant...
I want to say "Oh my god" to what you said because i feel exactly the same "For me I just cant have fun anymore and I'm terrified to live the rest of my life like this" Sometimes iam really hopeful but some other time iam totally depressed...but i think we do not have choice we have to be hopeful the problem is that our thoughts are every single day and every single second focused on this problem. What make me feel hopeful is to imagine a tooth regrowing in my mouth, i imagine myself going to a laboratory for tests clinics it would make me so HAPPY!

I send a email to the team of Marseille iam waiting for an answer...

Take care of you!

ghbm said at March 16, 2010 2:07 PM:

i can translate what it is said on the video :

The journalist : « Photography session for a performance which is going to revolutionize the world of the dental surgery. Professor Imad About is not in his try, his laboratory in Marseille was already the first one to the world to maintain in vitro alive teeth. For 5 years with his team he works on stem cells and the results are promising. To grow a tooth in the mouth of a patient or to regenerate damaged parts from stem cells is not science fiction anymore.”

Prof. About : “What is the idea of our work ? While knowing that there are stem cells in the dental pulp which have the potential to make many things, regenerate several tissues, we are to attach to demonstrate their capacity to regenerate the missing tissue which was damaged, the dentin, and biomaterials is going to replace the enamel it means stimulating sleeper cells to regenerate essential tissues for the vitality of the tooth and of the dental pulp”.

The journalist : “The potential of the stem cells of teeth is very important,it could revolutionize the other medical discipline.”

Prof. About : “What we know today it is that the "stem cells" which are in the dental pulp are capable of regenerating the bone, the nerve cells and the ?? cells.

The journalist : “The appointment for the first clinical trials on human is planned in five years”

Hopeful said at March 16, 2010 10:41 PM:

Thanks ghbm for posting. I know a lot of people who have had smile-makeovers and full mouth construction implants & crowns and that are living normally and happily. Perhaps we suffer from OCD? An anxiety disorder where we are obssessed with just this one thought. I just pray we stay alive and make it. Its very difficult. I have read that enamel is the hardest thing to replace and will be the biggest challenge. Does Dr. About's research promise enamel regrowth as well? I pray so. How old are you ghbm? Are you a parent?

ghbm said at March 17, 2010 5:59 AM:

Yes iam agree with the "anxiety disorder" unfortunately for myself the only thing which could stop this anxiety is growing back TRUE teeth in my mouth.

What I understood about Prof, About's research is that he can repare damage teeth and grow new teeth with bone marrow cells,about growing enamel he just say : " To obtain a tooth bud, we need two types of cells proparents, mesenchymal cells , who are going to create the pulp, and the epithelial cells , which form the enamel ". Problem: if stem cells remain present in the grown-up tooth, cells capable of producing the enamel die in its eruption [...] so we turn to stem cells resulting from bone marrow, which are capable to produce enamel", pursues Pr About."

About my age iam young, young enough to hope i will be alive when growing new tooth will be available, and not iam not parent...

Hopeful said at March 17, 2010 11:00 PM:

Thanks ghbm. So you see there is always hopw and hopefully soon by the grace of God, they will be able to replace crowns with natural enamel regeneration. Nothing in this life is impossible. Don't you want to stick around and be one of the first people to regrow natural teeth? ok i have been able to reach top scientists involved in this research and they guess it would not be available before 3 years and will be available in a maximum of 15 years. Even if it never happens, so what? many people have lived with worse things in life. Think of generations before us. Life is worth so much more than throwing it on something as silly as this. Some people are seriously debilitated and living and laughing bc life is a gift. So my advise to you is to be strong and realize you're making a big deal out of n/in. A 38 year old I know is currently undegoing full mouth construction to have 12 back teeth implanted and all front teeth crowned and he's a young father and very happy to be able to do this. He laughs and jokes and is grateful he can afford to save the rest of his teeth. I know a lot of 22 year olds who have capped their whole teeth for cosmetic reasons and are happy. So what you need to realize is that you are blowing this way out of proportion. The cure is coming so hang in there but in the mean time don't waste your life sad and unhappy. That would truely be a sin. Scientists are working very hard on this and it will happen; infact they want it to happen sooner that we do. So you never know it might even happen before that. In the mean time, my advise is that if your eating ability is affected try implants else if you wait too long you might need bone grafting & eventually might not even be an implant candidate. Only reason I know is bc I have been reading a lot. Its up to you. We all have our weak moments but we must fight our fears and never succumb to misery or fear. I am a mother and a lot of people depend on me financially so I must live and fight and go on for the sake of others not just me. You see its not always just about us. Some people in the world dont have food or shelter and no teeth. Reflect.

ghbm said at March 18, 2010 3:20 AM:

Thanks for answering.

Fortunetaly, my eating ability is not affected and even if it was the case iam totally "against" implants i think if i had implants i would be more depressive than i am...

Iam totally conscious of the fact there are people who are in worse situations than mine (no teeth, no food...), we always can find people who are in worse situations but our problem is real, it is there we cannot deny it and we have to live with it. Yesterday i watched a television programm in which there was women who suffer from...their beauty! The title was "iam beauty and i suffer from this".

Personnaly,really,the only thing i want is teeth i don't want love i don't want money i don't want anything just my teeth back, and yes iam obsessed, all my thoughts are focused on this.What i don't understand is why scientists don't begin clinical trial now, what are they waiting? Is there something they do not know? If it's the case how could they know this thing will be resolved in 3 years or more? Also i wondered if they could grow tooth in vitro in order to use it as an implant is it possible?

Iam agree with the fact we have to be aware of the others (family, friends...) but most of the time these "others" are not informed of our problem and this makes the problem more difficult, we have to pretend we are happy or not unhappy etc...

We have to pray God He's the only one who can really help us!


Hopeful said at March 18, 2010 6:46 AM:

ghbm you only lost 4 back teeth have no implants and dont suffer from any feeling in your mouth. Its not like you have ceramic glass in your mouth that you cant get used to. What would I say? You can even live your whole life andyour back teeth will not affect your eating ability and you may never really need to have them implanted. So I do not understand what you are stressing about. With me, I have a feeling of glass in my mouth that I have to live with possibly for the rest of my life if the work of Scientists does not come to fruition. So please be reasonable and do not put people like me and who have even worse teeth problems down.

Shuun said at March 18, 2010 8:10 AM:

Check the following site out. There is a small article that talked about how scientists bred mice without the gene that blocks replacement teeth. The mice without this gene grow replacement teeth just like sharks do. Sharks are able to replace a lost tooth with a new one, and they can do this over and over again. They are studying this gene to understand the mechanism of creating a whole tooth. They will also probably alter these genes in future generation of people. The idea is that genes can be turned on and off, since this mechanism is already inherent in our cells. So, they can turn it off when a person is still in embryo. On, off, on, off. They will be able to do this with many genetic diseases as well as with other aspects of human development. Darned it, I should have been born right about now or 5 to 10 years from now. I don't think these gene switching stuff will work for adults or children that are already partially grown.

Here is the site:
http://www.nydailynews.com/news/national/2009/02/26/2009-02-26_new_genetic_discovery_may_help_people_to.html

Shuun said at March 18, 2010 8:51 AM:

Here is another recent article about another success story. Hopefully all of these separate and fragmented research will converge to create applications real soon.

http://www.bu.edu/today/2010/01/27/broke-tooth-grow-it-back

Shuun said at March 18, 2010 9:26 AM:

http://nextbigfuture.com/2010/03/helsinki-researchers-have-mathematical.html

I also thought the above article is worth looking at. A team of researchers developed a mathematical model of a whole tooth development. They used computers to generate the correct size and the tooth's entire structure. Does anyone on this site get the journal called Nature? It seems that all reports of this sort are published by this journal. something is got to give from all of the work that is being done. It is just a matter of time before research turns to application. Just the other day, I saw on TV the first person who had both of his arms implanted successfully. This man lost both of his arms at the war and had donor arms implanted. He is going through therapy, and he was using both of his arms during the news filming. The arms were severely swollen, but everything else looked normal. The swollen will go away after some time, and the exercise helps him heal it. Watching this was really amazing. Hang in there everyone, it will happen soon.

ghbm said at March 18, 2010 4:30 PM:

Hope, the fact i don't have implant doesn't mean i don't need to have some, it's just that i don't already have them but my dentist said to me that i should have...you have a feeling of glass in your mouth and i have a feeling of gaps in mine...Plus, aesthetically iam not like when i had my teeth i mean my face has changed because of the tooth loss, there is less bone where teeth are normally. So, of course, i can live like that but my face is not like it used to be. You can consider it is not really a problem but for me it is, and, the fact iam here is a proof that i feel this like a problem.

Hopeful said at March 20, 2010 11:28 PM:

Thanks Shunn for posting these & giving us hope. ghbm I understand how you feel but all I'm saying is that you might benefit by implanting rather than waiting so you dont get worse problems like bone & changing aesthetics and then hopefully one day sooner than later you can replace with natural teeth asa the technology becomes available. Let's keep praying it happens sooner than later. I'm sure it will there's just such a HUGE market need for it and HUGE money to be made. It also means all dentists will have to go back to school:) God bless science and all researchers!

Shuun said at March 25, 2010 5:40 PM:

Guys, check out this site:
http://www.nidcr.nih.gov/Research/facingthefuture/toothDevelopment.htm

I found the information in here very helpful. They really go into details of the research these people are doing, and how much they understand. Fascinating!

Hopeful said at March 27, 2010 11:51 PM:

thanks for posting; its all old news; we are still waiting for new news that says ready for human testing and it looks like we have to wait for another 10 to 15 years. In the meantime, how do we live? I suffer from anxiety and depression that totally debilitate me and my ability to enjoy life. Please help. This all surfaced after I capped my teeth. Has anyone been in similar situation? I am irritated, impatient all the time. All I want to do is cry all the time. I am anxious and become withdrawn and fear losing it all. I am so scared. I want to just be my old normal self again. I don't feel okay and fear this will not pass. I don't want to live rest of my life like this. If its just teeth issue then its not worth ruining my whole life for it. I want to be normal so I can raise my child. I want to laugh again. I want to feel happy & relaxed again. I have refused to take medications so far. Has anyone been through something like this? How did you get out of it?

ghbm said at March 31, 2010 7:16 PM:

Does anyone know one or more researchers involved in teeth regrowth studies? I really need to know reasons why they promise things like "it will be available in five years (or more)" how can they know when? Maybe things will go faster than expected no? Or maybe it will never be possible? What i fear is that they claim they suceed in regrowing tooth or part of it in order to attract investors.

I NEED real teeth!

Hopeful said at April 1, 2010 3:30 AM:

ghbm I think we have to work our best to psychologically accept the realities of our teeth and accept living with them and try to laugh again. I do NOT think its wise to spend our time dreaming of a new cure that might or might never be created. I know its hard esp. when the articles and studies give promising hope. I know how you feel b/c I feel the same. I am seeing a psychiatrist and taking anti-depressants. Usually I was always a strong person now I feel broken, struggle with inner doubt constant fear and anxiety even to the point of social phobia for I fear people will laugh at me not only if they realize how stupid I was to let a dentist crown all my teeth without getting second opinion or researching but more so at how weak I am in letting something as trivial as teeth ruin my entire life and ability to enjoy anything. Not before 15 years will any clinical trials surface. I am so down and wish I can just forget about my teeth and the obsession with how glass feels in my mouth. I know many people who have had similar procedures but it has not affected them like this. Please anyone advise if you think you can help or have had a similar experience.

THANKS

ghbm said at April 1, 2010 6:37 AM:

Actually iam not waiting for clinical trials that can allow growing teeth directly in my mouth, what i hope is growing teeth in vitro in order to implant them even if i think a tooth implanted does not stay as long as a tooth which grow directly in it but it would be a temporary solution.

Every day iam searching on the internet for new news about regrowing tooth, be sure that if i came across something i will post it.

Sorry if my english is not perfect.

shuun said at April 14, 2010 2:31 PM:

The informatin in that last article was written 8 yrs ago. So let's hope that they are going to be really close to a success by the end of the 10 yr mark.

One thing we can do is to get our imagition to work. Instead of being sad, angry, or frustrated, we can start to feel how we would feel when our teeth are fixed. I am learning that feelign good about a particular thing can cause that thing to come true. This good feeling is a form of prayer.

In quantum physics, they are finding that thoughts create things. They say thoughts travel through space and time, and they are fast. The good thoughts are much faster than the bad thoughts. So when they measure the physical changes that the body goes through when a person is agnry or depressed and they compare that to a measuring of someone in a calm or meditative state, they found stounding differences. They also found physical changes in the body of a person who is receiving or is the subject of a lot of prayers. This happened even when the person does not know that he or she is being prayed for. May be miracles do happen.

Let's get our collective thoughts together and pray calmly for fast solution. Let's try to create that great feeling and start to feel that now instead of waiting for it to happen later.

shuun said at April 15, 2010 7:54 AM:

I found out that the ultrasound device is being developed by a company called SmileSonica. I visited their website and it does not say when the device will be available.

Hopeful said at April 18, 2010 1:41 AM:

as far as i know this device does not regrenerate tooth enamel does it? Can it replace crowns in teeth with real teeth? What does this device do?

Shuun said at April 18, 2010 11:43 AM:

From what I understand, it grows new root. So it would help people who have lost the bone that supports the teeth, and those who have root issues. So, instead of a crown, you would grow your own root. We'll have to wait to see what else it does when it becomes available for commercial use.

Hopeful said at April 19, 2010 4:56 AM:

Sadly it doesnt look like I will be able to replace my crowns with natural teeth anytime soon nor with any other mouth-friendlier synthetic material:(

ghbm said at April 19, 2010 2:14 PM:

Hope, the french laboratory of Marseille said that a more successful material to replace enamel would be commercialised by the end of the year ;)

Hopeful said at April 19, 2010 11:38 PM:

did they really? It was in French so I couldnt understand. I pray it actualizes.

ghbm said at April 20, 2010 4:17 AM:

You can translate with google translate : "En ce qui concerne l'émail, un matériau extérieur est actuellement apporté à la dent. A ce sujet, le Pr Imad About, joint par téléphone par LEXPRESS.fr, explique avoir mis au point un matériau plus performant qui devrait être commercialisé d'ici la fin de l'année."

Hopeful said at April 20, 2010 5:31 AM:

thanks I pray it actualizes very soon as promised. I pray we all get our natural teeth back much sooner than expected.

ghbm said at April 24, 2010 11:02 AM:

No news?

shuun said at April 27, 2010 10:29 AM:

I wonder if teeth could be cloned. To find a partial solution, what if they cloned teeth. Say somone has broken parts of their tooth, but most of it is intact. Instead of filling the broken part with artificial mateirals that does not last long, the whole tooth is cloned. Of course, those who lost the whole tooth would still need other methods of regrowing it. Or May be they can clone the twin tooth and put it in the open space. I wonder if anyone has thought about that.

ghbm said at April 27, 2010 12:58 PM:

I also wondered about that, if they can clone a whole ewe, can they clone just a tooth? Maybe it's a stupid question...

ghbm said at April 28, 2010 3:32 PM:

Don't you have the feeling that it's is already possible to regrow teeth but that, because of commercial reasons they prefer to wait in order to let implant industry reconvert itself? I mean, why don't they start human trial? It's been several years they succeed in regrowing teeth : on chiken, on pigs, on mice...what will be the next step? Waiting for 5 years but waiting what?
I really feel that it's because of commercial reasons that they do not start human trials, imagine if ovenight we can regrow teeth, what would become all those who produce dental implants?
I would like to go to King's college in London to meet Paul Sharpe and convince him to begin right now! What would happen if tommorow a team of researchers decide to begin trials? Others will do the same?

Hilary said at May 2, 2010 9:45 AM:

ghbm...I encourage you to meet Paul Sharpe and ask him to start regrowing human teeth right now.

ghbm said at May 4, 2010 5:07 AM:

I would go if i lived in London

shuun said at May 6, 2010 12:57 PM:

I wonder if anyone on this block lives in Florida. The TERMIS-NA 2010 Annual Conference is going to be held at the Walt Disney Resort in Orlando in
December 5-8, 2010. They going are to discuss the latest discoveries in regenerative and tissue re-engineering, which of course, Craniofacial and Dental Tissue Engineering is part of.

If you happen to live in or near Orlando, FL, try to attend this meeting.

ghbm said at May 8, 2010 10:48 AM:

I came across somebody on the internet who said that in his University they was about to start clinical trials for tooth regeneration, but i don't think it's about regrowing a whole tooth http://answers.yahoo.com/question/index?qid=20100427195932AADuNZn ...

Shuun said at May 9, 2010 3:59 PM:

Interesting. I tried sending this person email to ask what kind of trials it was,but I could not get through. The person did not specify if it was for a whole tooth generation or just enamel generation. Either way, it is encouraging that at least someone is thinking of human trials. I think trying to regenerate teeth would not impose much of a danger to a person, especially if they are missing teeth. I would think the only danger would be growing teeth that are not correct size at first, but they can always be extracted and retried again. Luckily, teeth are the only organ that does not pose a lot of danger to a person. I have a feeling that there are more people who are either starting trials or have already began trails on humans but they are keeping it quiet until they are successful. Whoever commercializes it first will make a fortune.

ghbm said at May 9, 2010 6:05 PM:

if only i could die while sleeping

shuun said at May 10, 2010 11:52 AM:

This abstract details what dentistry research could achieve with nanotechnology. It was written back in 2000 and it was estimating at the time that it would take 10-20. Perhaps we are a lot closer to something by now.

http://jada.ada.org/cgi/content/full/131/11/1559

ghbm, there is nothing worth dying for. Hang in there and you will see that all and any problem can be fixed. May I suggest a book to read. It is titled "Excuse Me Your Life is Waiting." Let me know what you think of it.

ghbm said at May 17, 2010 4:24 PM:

Shuun, i read the synopsis of your book i agree with this phylosophy but sometimes it's difficult...i came across this : http://www.longevitymeme.org/ but i don't understand what it is about, is there someone who can translate/explain it? You can read here :

"Another Step Forward For Tooth Regeneration
May 17 2010 | Permanent Link
Researchers have regrown teeth in rats by manipulating existing stem cells: "a new technique [can] orchestrate the body's stem cells to migrate to three-dimensional scaffold that is infused with growth factor. This can yield an anatomically correct tooth in as soon as nine weeks once implanted in the mouth. ... These findings represent the first report of regeneration of anatomically shaped tooth-like structures in vivo, and by cell homing without cell delivery. ... By homing stem cells to a scaffold made of natural materials and integrated in surrounding tissue, there is no need to use harvested stem cell lines, or create a an environment outside of the body (e.g., a Petri dish) where the tooth is grown and then implanted once it has matured. The tooth instead can be grown 'orthotopically,' or in the socket where the tooth will integrate with surrounding tissue in ways that are impossible with hard metals or other materials. ... A key consideration in tooth regeneration is finding a cost-effective approach that can translate into therapies for patients who cannot afford or who aren't good candidates for dental implants. Cell-homing-based tooth regeneration may provide a tangible pathway toward clinical translation."

Hopeful said at May 19, 2010 2:42 AM:

I went to dentist and he advised me that I should remove the only wisdon tooth I have left as it is half grown and can be a home for infection. I don't want to pull it out because I had read somewhere that wisdom teeth can be an important source of stem cells that can be used to regrow teeth sometime in the future if and when this technology materializes. He advised that regrowing teeth or enamel is a far off dream that may not happen in our life-time. I so wish to believe this is indeed something that will happen in the near future but even scientists have cited not before 10 to 15 years. In the meantime, for those of us who have lost their natural teeth or have veneers or crowns and cannot live with them or accept them, the suffering just seems to go on. I think its psychological more than physical. I suffer from severe anxiety and fight feeling debilitated all the time. Anyone been there please help:(

ghbm said at May 19, 2010 2:36 PM:

"He advised that regrowing teeth or enamel is a far off dream that may not happen in our life-time" I think we don't have to listen to what our dentists say, even if they are competent they are not necessarly aware of research about regrowing teeth, i already ask a dentist about this and he was suprised while his secretary knew more about the subject...

About the article i have cited, what do you understand? I don't understand if they are talking about regrowing teeth or bone...they are too evasive and my english is not perfect.

Hopeful said at May 20, 2010 1:02 AM:

ghbm - they are basically saying that they have found a way to regrow teeth in the mouth instead of having to grow it outside the mouth and then implant it when its fully grown. That this will help give people who cannot implant teeth other options for regrowing teeth. That the tooth will grown in onoly 9 weeks. That this might be more affordable for patients and can be clinically used. Lets pray all this research comes implemented in clinics and works on humans very soon. Post any new articles you come across. I haven't found anything new yet.

ghbm said at May 20, 2010 8:23 PM:

Thanks :)

shuun said at May 21, 2010 11:47 AM:

Hopeful,

I also suffered from anxiety, in fact, I was diagnosed with an anxiety disorder few years ago. While some elements of anxiety are physical, a lot of it is psychological. The physical elements of anxiety can be overcome or greatly reduced with psychological methods. I found much help in self help books. In my experience, I found that once a person gets used in the existence of anxious states, it becomes normal. In other words, your mind becomes addicted to it, and so it runs the same anxious messages minute after minute and day after day. Once I became aware of this, I started breaking it. What was so interesting and still is interesting is feeling myself in two different states. Once I free myself of worries, I become relaxed, happy, I see things in techno color, my taste intensifies, I feel light and energetic, and I start to feel and experience host of other things I cannot even begin to explain. All kinds of positive things start to happen. Then, I crash and loose the good feeling as my anxious mind takes over and start to run old messages of negativity, I feel my body tensing up, I loose energy and feel weak, food losses taste, and things look dull. Everything looks, feels, and tastes dull. Dullness is everywhere. Then I compare the two states. The first one feels much like heaven. Heaven is really on earth. If you can feel emotionally amazing despite of anything and everything that is going on around you, you will be in heaven right here on earth.

What is interesting is that when I am feeling good, elated, happy and all the amazing sensations that result from this emotional state, I remember that I used feel this way all the time. Then I try to pinpoint when I started loosing it and why. Funny, because my anxiety was not a result of anything bad happening to me. Instead, most negative things happened as a result of it.

I encourage those of you who are dealing with negative emotions to question it. Think of it this way, anything bad that is about to happen will not be prevented by negativity. Research has shown that positive thinking and feelings produce much better results than negative feelings. We are all familiar with the term "Self-fullfiling prophecy."

I encourage you to look into the works of Byron Katie, and others. Also quantum physics is an emerging field that scientifically measures the power and energy of thoughts and emotions. There is a book called The Secret. I haven't read the book, but I have seen the film with the same name and it blew me away after the third time I watched it. Bottom line is think about how you think, and if you don't like it, change it. I guarantee few of you if not many of you will see the power of your own will.

Hopeful said at May 23, 2010 2:50 AM:

Thanks Shunn I have read the Secret. It basically says you attract what you think/beleive. That if you say for e.g. Health is on its way; its coming, it will. I try to fight negative thoughts and tell myself everybody has to eventually fox their teeth and mine needed work so I didnt do anything wrong but the relief is only temporary and anxiety persists as I'm intensely aware of feeling of foreign ceramic in my mouth. I have no reason to be depressed thats what beats me but somehow I dread socializing for fear I won't be able to act it up anymore and my condition is exposed. I don't want to embarass my family and people will mistake this for weakness versus a medical condition. I never imagined I would ever suffer from such a condition, I am tense and my arms and legs ache all the time. I used to be so bubbly I just never imagined fixing my teeth would affect me so negatively. I keep praying scientists find a cure. For me, I just want to go back to my old self and do not want my daughter to grow up with a sick mummy. I keep praying for a miracle.

Nom said at May 24, 2010 5:45 AM:

ghbm and others, I had nearly all my teeth dug out and ruined when I was a teenager and I was never the same again, my health deteriorated and I never at the time connected it with the damage to my teeth and the mercury. Decades later I have nonending problems with my teeth, and chronic health problems and up until last year severe anxiety attacks and depression. Months ago I discovered craniosacral therapy (and meditation) and with weekly treatments many of my problems have been greatly alleviated. I still have many problems including with my teeth, but I don't allow any problem to take over my mind or puts me in depression or fear. I see it as a challenge I work on every day. I too am waiting for the breakthrough in growing new teeth, and I will pray for that.

shuun said at May 24, 2010 8:50 PM:

Hopeful, I am glad you read the Secret. If we constantly work on changing our thoughts it can be done. I found out that the pattern of negative thinking persists and the mind always finds reasons to think negatively once it gets stuck in a pattern. I found that once I overcome one thinking, my mind quickly finds another negative reason to think about. It is like a tape recorder, it plays and rewinds bad news whether it is yesterday's news or today's. Fearing what others think about us is not a worth while reason to feel bad about oneself. It is difficult to do, but people that are most happy have managed to not worry about what others think of them. Once you start living for you and only you, you start seeing how your life changes completely.

I truly believe that thoughts are more powerful than we know. Thoughts do attract physical manifestations of the things we are thinking about. When I learned this, I started looking back at my life. I started tracking the different things that has happened in my life and how I have been thinking at those times. What I found was just plain scary. I also started paying attention to my current thoughts, though I am not always successful in keeping full awareness. Most times than not,what I am thinking manifests. You can try this for yourself. You can start with simple things like you thinking about long lost friend. If you think about talking to that friend, you will somehow hear from or about that friend. If you think about going to the movies with a specific person, and that person performing specific actions, like say, bringing something to munch on for both of you at the movies, boom it will happen. Even if that person is not the kind of person who does that sort of thing. And you don't even have to ask him/her to do that, you just think of him her doing it. I also noticed things I think of when I am relaxed manifest faster than other things.

Not long ago, I was watching 60 minutes. They were talking to a guy who was working on computer chips that can read people's minds. It was to help people with spinal cord and other injuries who have lost the ability to speak and move their muscles. They can think but they cannot move their body with their thoughts because the connection have been lost. I watched these people move their wheel chairs, open doors, type words on screens, and they were doing that all through just thinking. The chip was picking up their thoughts. All they did was think about opening the door, or saying something like I want to call Jim.

These examples may not sound earth shattering, but it is a good way to test the power of your thoughts. Big things work in similar way. I started noticing these things, and I am shocked how often they occur. My thinking is shifting in such a way that I now just declare my intentions and believe that it will manifest instead of thinking "That will never happen." I am amazed at how negative I have been. I wish I have figured this out long ago. Don't get me wrong, I still have doubts that certain things will happen, and I have to fight that. If you do some research, you will find out that people who have done amazing things believed fully that they could do what they did even though it looked impossible to others.

May be there is something to the statement in the bible " Ask and you shall receive."

Hopeful said at May 30, 2010 12:58 AM:

http://www.japanjournal.jp/tjje/show_art.php?INDyear=05&INDmon=08&artid=04318aa7a110d74f9046cba5ca671d0e

This was published in 2005 but here we are in 2010 and still no clinical application.

I try to think positive but somehow I know I might never be my old same self again.

Hopeful said at May 30, 2010 1:01 AM:

shunn,did you take medication and did they help?

Hopeful said at May 30, 2010 1:02 AM:

Shunn, did you take any medication and did they help? Did youwean off easily? Anyone?

shuun said at May 30, 2010 7:57 PM:

NO, I did not take any medications simply because my body is extremely sensitive and I figured it will probably react to any medication. The only medications they offer are for depression. I was told by my doctor that anxiety medications are extremely addictive, so they usually do not recommend them for long-term use.

shuun said at June 4, 2010 6:59 PM:

Wow! This is the best news I have heard in a long time! Thanks for the great post, Martyn.

Hopeful said at June 6, 2010 4:07 AM:

when do u think this will become available to clinics? Also does it cause cancer?

Hopeful said at July 3, 2010 2:56 AM:

I have seen may dentists they all say this will not be available before 50 years if ever & that our problem is obsessisive phobic OCD anxiety etc so my advise for all of us is to stope dreaming of impossible & start living our lives & make best out of what we got.

Mthson said at July 3, 2010 10:41 PM:

Hopeful,

50 years or more doesn't seem too likely. Stem cell research has only been around for ~15 years, and it was only ~10 years ago that we sequenced the first humon genome. It's not going to happen overnight, but medicine is advancing faster than it ever has in the past.

ghbm said at July 5, 2010 12:57 PM:

Please don't say what you don't know.

martyn said at July 11, 2010 1:57 AM:

I received an email from Prof. Sharpe, about 3 months ago. He said simply "There is nothing new I can report. " I am grateful, however, for the illumination that other users have managed to shine on this topic. It seems that, perhaps, that the folks at Odontis were a little too interested in the product's commercial value and chose to overhype their work before the research was able to yield any meaningful results.

The work continues elsewhere, however, as Dr. Mao's discovery proves. It's important to point out, though, that according to the article published by Dr. Mao in March, "no attempt was made to regenerate dentin or enamel." As such, the "tooth" was simply a root and corresponding periodontal ligament that allowed for implementation of a ceramic crown. We can likely think of it, therefore, as a biological replacement for a tooth implant, rather than a completely regenerated tooth. Still, if the trials are successful, it would represent a vastly improved way to replace missing teeth, as the procedure would preserve natural function and allow for movement and growth, unlike modern implants.

This all makes sense, however, as tooth enamel seems to be the hardest substance - both literally and figurative - to reproduce. In February 2009, two discoveries seem to have been made, amazingly, within the same month. First scientists at Oregon State University were able to map the gene responsible for enamel production (Ctip2). Then, another team of geneticists at the University of Rochester found the gene that prevents mammal teeth from regrowing naturally (Osr2). In August of that year (less than a year ago), researchers at Peking University in China were able to regenerate enamel by dipping a tooth in a solution that was, unfortunately for us, toxic to humans. It is, however, the first instance I know of of tooth enamel being successfully regenerated.

If you stop and think about it, the research in this area is still incredibly young. I think it was unfortunate of Odontis to jump out of the gate so early when there was clearly still a lot of road in front of them. I mean, basically everything we know about tooth enamel was just discovered in the last 18 months. But that means that scientists will be able to hone their research even further and that practical human applications are now within viewing distance - albiet a blurry one. I suspect that first we shall see Dr. Mao's work yield a replacement tooth root in humans, maybe within 5 years. Then, perhaps a way to regenerate dentin and enamel on existing teeth, in 5 to 10 years. Then, once these technologies are being used and researched on a large human population, we'll have a better idea of where we stand and see people start to regenerate a whole teeth from scratch. For that, however, I wouldn't guess anything less than 20 years before we're actually seeing these walking around in people. There's lots and lots to hope for, though


http://www.dimensionsofdentalhygiene.com/ddhright.aspx?id=5620

ghbm said at July 16, 2010 7:50 AM:

Martyn, where did you read that Jeremy mao technique allow only to regrow tooth root (and not enamel)? Anyways, i think regrow tooth root is a great step.

Nick said at July 30, 2010 11:19 PM:

Hello I think this is Great I have now teeth and I am 29 years old I had every one out because they were killing me If you are looking for people to working on your cell for new teeth I will come from the us and do it. I don't like the way I am, I fill like I am a 80 year old man with no teeth Please help.

shuun said at August 19, 2010 2:06 PM:

We have been wondering what happened to Paul Sharp. This article mentions that he is working on ways to grow human teeth from adult stem cells. Article says he has been successful in growing teeth from bone marrow stem cells but he believes the extraction process is too painful for humans, so he is looking for alternative methods. The article was posted in 2007, and it says he hopes to come up with something within 3 years.

https://www.technologyreview.com/biomedicine/18216/

Anna said at September 15, 2010 10:32 AM:

When will it be available? Or, indeed, WILL it be possible one day? I`ve lost the hope...Was to the dentist today, he found caries in the fist phasis and took it away, but I`m afraid of getting more and more cavitites..I want new teeth! I would look after them a lot more, ..I just want a second chance!

bamboo said at October 25, 2010 11:46 AM:

Printing Teeth

Jeremy Mao, a dentist and researcher at the Columbia University Medical Center in Manhattan, New York, took the high-tech route, as he and his colleagues reported in the August Journal of Dental Research (Kim et al., 2010: PMID20448245). Mao is looking to re-grow lost teeth from stem cells. Mechanical implants, he noted, do not integrate with the jawbone and can come loose. Stem cells, he hopes, can form teeth that hook up with the jaw.

Researchers have attempted to form dental tissue in hydrogels, Mao said, and made components such as dentin and enamel. But those ingredients fail to coalesce in an organized fashion. “You have multiple pieces, and you don’t have the anatomic shape,” Mao said.

Mao used a 3-D bioprinter to craft precise, tooth-shaped chemical scaffolds, including plenty of channels for cells and vascular structures to fill. The machine works much like a regular printer, he said, but instead of red, cyan and yellow inks, the cartridges hold biomaterials.

The researchers extracted teeth from rats and implanted the scaffolds. Endogenous stem cells migrated to the site. They formed tooth-like structures that connected to the jawbone and filled up with blood vessels.

Mao is planning to try the same technique with PEOPLE in a small safety study.

http://www.ncbi.nlm.nih.gov/pubmed/20448245

martyn said at January 3, 2011 3:17 AM:

The First International Conference on Dental and Craniofacial Stem Cells
Location: New York Academy of Sciences
When: 26 april till 29

shuun said at January 3, 2011 6:43 PM:

Happy New Year everyone! Here is to hoping that the new year brings about amazing successess.

J77 said at February 27, 2011 4:35 PM:

is salvia a counterpart of comfrey? it has same properties? does someone tried eggshells and comfrey to regrow enamel?

eryn said at March 24, 2011 4:39 PM:

Is this serious? : http://growingtooth.com/

HOPE? said at March 25, 2011 11:35 AM:

Are there still people out there waiting for this?
Do you think holding out hope is too folish? It's the oly thing that enables me to carry on, this hope that someday I will be able to gro a new set of teeth and smile again!
I am so afraid, 'cause everyday it is worse and worse. How much will it take? Will it ever goign to happen? And if, is there a hope that not only celebrities will get new teeth? Gettin' descouraged...and my dentist doesn't know what to do...I think he will pull all my teeth evetnually...I have got 5years, with some luck 8-10 till I am left with NO teeth at all. So..should I hope? Or just try to accept the fact I am going to be without? I could cry when I think of it.

dude said at March 27, 2011 8:25 AM:

@HOPE

well personally i am also waiting for something to happen myself i have become housebound over the last 6 years due to my dental problems hope is the only thing i have left

shuun said at March 28, 2011 1:52 PM:

Dear Hope:

Please don't give up or give in. There are so many people that are working on this, and remarkable progress has already been made. The only obstacle now is making it safe and affordable for mass procedures. Companies don't take up the risk of selling something that the public cannot afford, so it must be affordable in order for it to be marketable. Mostly likely, celebrities will be able to afford it before others can, which will make it possible for others to afford eventually. If those who have money take the risk first and it works, then it will become available for mass usage.

Write down exactly what you want, believe wholeheartedly that it will come true, and wait for it.

Make sure that you get to a place where there is no doubt in your mind and body that in the near future you will get what you asked for. If you can do this, I assure you that your wish will come true.

To speed things up, you can add a little action. Contact research universities in your area and see if they are willing to use you as a guinea pig or if they need volunteer for ongoing dental research. Don't give up in trying this. If there are no such research available at current time locally, get connections to the people in this area. Most research universities with medical schools have dental and medical research departments. Contact the nearest ones to you and get to know people in these area. If can't help you at this time they may be able to help you later or refer you to others they know of now or in the future.

Don't ever give up or get frustrated while doing this. If you become frustrated, don't dwell on it too long. This will only delay your outcome. Just bounce back to your good place of knowing you will get what you are looking for. This knowing must fill your entire being--no room for doubt. You will know when you get to this place, because you will be calm and at peace. You will see yourself smiling already.

HOPE? said at April 1, 2011 6:32 AM:

Yeah, well, but it is not available at the moment. And I want to know HOW long it'll be until it is. My doctor said, he doesn't think it will ever become possible because it would be too expensive, dentures are cheaper. In my country no research is done. I hope for the USA to develop this!

Jaime said at June 8, 2011 3:47 PM:

China seems to be implementing stem cells therapy on cerebral palsy with some success. are they going to do the same with teeth?


here is the link
http://cerebralpalsystemcells.com/

aafom said at June 14, 2011 12:01 PM:

Why aren't we hearing anything of this research? I read 2 interviews: With Dr. Sharp AND Dr. Mao, and they both sounded (cautiously) optimistic that in the future we are jsut going to the dentist to get our teeth regrown. They say it will be expesnive, but in the end it will pay out in comparison with implants. They wouldn't be saying that if they had no reason to believe this will become ture, right? I mean, they are the leading researchers in this field! I really really hope for it...I cannot stand implants and live without teeth is hard.

Nina said at June 19, 2011 1:39 AM:

I had a broken tooth. Upper, next to the back tooth. The Dentist wanted to extract it. He took an X-ray and said there wasn't enough bone to have an implant. I had read about ultrasound growing teeth back if you had the root. I refused treatment and didn't go back. It took 7 years for the last of the tooth to fall out. There was absolutely nothing there - and it was difficult to chew properly. In April this year, bone began to appear in the space - just in one place, at the front of the mouth, right up against the back tooth; and then it spread along the gap. I have no idea if it will grow into a proper tooth. I am in my 60's and am amazed by this. Has anyone had a similar experience?

bamboo said at July 22, 2011 3:13 PM:

hi randall, this comment thread is becomming unwieldy like the original odontis thread. here's news of developments from japan that could become part of an update. i think same team members that gave us the 'glowing' tooth a year and a half ago. an american team [columbia?] plan to start safety tests in humans this year [2011].
read the excerpt below. the reporter gets confused. rats/mice?

http://uk.reuters.com/article/2011/07/12/us-japan-stemcells-tooth-idUKTRE76B4EI20110712

(Reuters) - Scientists in Japan said on Wednesday they have created teeth -- complete with connective fibers and bones -- by using mouse stem cells and successfully transplanted them into mice, a step they hope will lead to progress in stem cell research.

The entire tooth units, which were inserted into lower jaws of mice, attached successfully with jaw bones and the rats were able to chew normally, the researchers wrote in a paper in PLoS One (Public Library of Science)...

...Tsuji's team removed two types of stem cells from the molar teeth of mice and grew them in the laboratory. To control the length and shape of the teeth, the cells were placed in a mold, where they grew into entire tooth units.

The entire tooth units were then transplanted into the lower jaws of one-month-old mice. They fused with the tissues and jaw bones around them after about 40 days, Tsuji said. Nerve fibers too could be detected in the new teeth.

Tsuji stressed the importance of finding the right "seed cells" for reparative therapy. In this case, entire tooth units could be grown because the stem cells were taken from molar teeth of mice -- where they later grew into enamel, dental bones and other parts that comprised a regular tooth unit.

======================================================

so the difference between this japanese research report and the previous one, is that here the teeth are grown in the lab, then transplanted into the jaw, whereas previously, the jaw was seeded with a tooth bud and allowed to develop within.

original research article here, free access,

http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0021531

Randall Parker said at July 24, 2011 12:01 PM:

bamboo,

I hadn't noticed just how gigantic this page had become. Yes, you are right, the page is too long. Time for a new post and we should shift the discussion over to it. I will write a post as you suggest and then come back here and add a link to it and direct future commenting to that new post.

lillyroz said at July 28, 2011 2:18 AM:

Bamboo, you wrote: "an american team [columbia?] plan to start safety tests in humans this year [2011]"

Please tell me where did you read this?

shuun said at August 5, 2011 2:22 PM:

This may be what Bamboo is referring to. At the bottom of the article, it talks about what Columbia university is trying to achieve.

http://www.mayanz.com/2011/06/stem-cell-dental-implants-%E2%80%93-tooth-regeneration-may-be-on-the-horizon/

bamboo said at August 8, 2011 6:48 AM:

hi lillyroz, this comment thread is too large, so i have replied in the comments of randalls latest post on the subject here,
http://www.futurepundit.com/archives/008201.html#precomments

[Randall says: And I strongly encourage everyone to shift their future comments to the new URL. This page has gotten far too long and takes too long to load. The new page should last us for a few more years. Hope to see you there.]

Randall Parker said at August 9, 2011 5:57 PM:

Hi everyone,

Please make all future dental technology posts at this new page which I put up for this. This page has become far too long and has posts for over 5 years. The new page will load much faster and many new reports on dental biotechnology can be made there.

joshua davis said at December 6, 2011 12:25 PM:

I recently contacted Dr. El-Bialy about his LIPUS product and he responded rather quickly directing me to the company which is supposed to be handling production and distribution. smilesonica.com advertises that the product is in production and should be available commercially "soon." I'm not sure what soon means. I sent them an email and they have not yet responded. Their last news posting was March of 2010... The product is listed as "patent pending," so perhaps they are waiting for approval to release it to the public. All speculation at this point. I encourage everyone to try to contact smilesonica.com and try to get a good solid date of sale.

Shely Russell said at August 21, 2012 2:47 PM:

That is really cool technology. If it gets developed soon or not, I don't care. It just seems like a cool technology to look into. After my brother got braces, we found out he had a rare condition where when his teeth move, the roots decay and disappear. It would have been really cool if the orthodontist had been able to use something like this so my brother could have continued his term with braces. He ended up having to get them removed much sooner than we anticipated and he isn't pleased with his smile.

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