PHILADELPHIA -- The ability to sort cells or manipulate microscopic particles could soon be in the hands of small laboratories, high schools and amateur scientists, thanks to researchers at the University of Pennsylvania School of Engineering and Applied Science. They have created a device, called "electric tweezers," which can manipulate and move almost any object seen on a simple microscope slide.
The research was led by graduate student Brian Edwards, with the help of his advisor Nader Engheta, professor, and Stephane Evoy, adjunct assistant professor, both of Penn's Electrical and Systems Engineering Department. While devices with similar functionality using lasers exist, they often cost upwards of a quarter-million dollars. Edwards' device performs some of the same tasks as laser tweezers, yet at a price anticipated to be in the same range as a high-end desktop computer.
"The tweezers create an electric field that you can use to manipulate almost any object on a microscopic scale. It has the potential of being a powerful tool for research," said Edwards, a doctoral candidate in Penn's Electrical and Systems Engineering Department. "I would prefer not to put a limit on the type of tasks that can be done with it, but I hope it will find uses in anything from picking an individual cell out of a culture to fabricating circuits."
All it would take to use electric tweezers is a computer and a microscope. The tweezers' action occurs on a common glass microscope slide embedded with five electrodes. These electrodes create an electric field that can be used to push, pull, move and spin a selected object in any direction without actual physical contact. Using software Edwards developed, an operator can select an individual object from a microscope image on a computer screen.
"Different types of particles respond differently to different frequencies in the electric field," Edwards said. "Once you lock onto the object of interest you can move it however you like."
The electric tweezers take advantage of the phenomenon known as dielectrophoresis, where electric fields impart a force upon a neutral particle. In essence, the object that is selected surfs atop the hills and valleys created by subtly changing the electric field. The principle works best on the microscopic scale, which makes it ideal for this application.
Biotechnology is headed down the same path as electronic technology. Computers are accelerating the advance of biotechnology and processes developed to make semiconductors help to push microfluidics technology forward. The general trend is going to be toward smaller, cheaper, and more automated lab instruments.
|Share |||Randall Parker, 2006 August 21 10:21 PM Biotech Manipulations|