February 18, 2007
Coffee Drinking Slows Cognitive Decline

Big coffee drinkers experience less cognitive decline as they age.

Six hundred and seventy six healthy men born between 1900 and 1920 from Finland, Italy and the Netherlands participated in a 10-year prospective cohort study.

...

Results:Men who consumed coffee had a 10-year cognitive decline of 1.2 points (4%). Non-consumers had an additional decline of 1.4 points (P<0.001). An inverse and J-shaped association was observed between the number of cups of coffee consumed and cognitive decline, with the least cognitive decline for three cups of coffee per day (0.6 points). This decline was 4.3 times smaller than the decline of non-consumers (P<0.001).Conclusions:Findings suggest that consuming coffee reduces cognitive decline in elderly men.

This makes sense. Recall my recent post High Caffeine Diets Reduce Heart Risk In Over 65s. Also recall my other related recent post Reduced Blood Flow And Inflammation Precede Alzheimers Put those two together. If something reduces the risk of heart disease it probably improves circulation overall. Well, circulatory problems might well be the root cause of Alzheimer's Disease. If coffee slows the aging of the vascular system then it will reduce both heart disease and Alzheimer's.

Coffee isn't the only candidate for delivering that benefit. Tea and dark chocolate (even more so cocoa powder) have many of the same compounds.

Mars, the makers of Dove chocolates, has just put out a press release describing recent research on the health effects of cocoa. Flavanols in chocolate boost circulation in the brain.

A special cocoa made to retain naturally occurring compounds called flavanols may have the potential to help maintain healthy brain function and chart the course for future research that could lead to new solutions for preventing cognitive decline and dementia, according to a panel of scientists who presented new data at the annual meeting of the American Association for the Advancement of Science (AAAS).

The enhanced brain blood flow from cocoa mentioned below might reduce the odds of developing Alzheimer's disease and other forms of dementia associated with old age.

During the session entitled "The Neurobiology of Chocolate: A Mind- Altering Experience?," a panel of scientists presented evidence from several recent studies that demonstrated the enhanced brain blood flow after study participants consumed a specially formulated flavanol-rich cocoa beverage that was supplied by Mars, Incorporated. One study, conducted by Ian A. Macdonald, PhD, from the University of Nottingham Medical School in the United Kingdom, found that the consumption of this cocoa resulted in regional changes in blood flow in study participants, suggesting that cocoa flavanols may have therapeutic potential for the treatment of vascular impairments within the brain itself.

"Our study showed that acute consumption of this particular flavanol-rich cocoa beverage was associated with increased blood flow to grey matter for 2 to 3 hours," Macdonald said. "This raises the possibility that certain food components like cocoa flavanols may be beneficial in increasing brain blood flow and enhancing brain function among older adults or for others in situations where they may be cognitively impaired, such as fatigue or sleep deprivation."

Mars has their own method of processing cocoa called CocoaPro that retains more of the bioflavonoids found in cocoa. While choosing one brand of chocolate over another might help it is more important to eat cocoa in a form that is least diluted. For example, milk chocolate is most diluted. Dark chocolate is less diluted. Semisweet chocolate is even less diluted. The less sugar and the more cocoa the stronger the dose.

By Randall Parker at 2007 February 18 09:58 PM  Aging Diet Brain Studies | TrackBack

Comments
Purenoiz said at February 19, 2007 07:18 AM:

"If something reduces the risk of heart disease it probably improves circulation overall."

http://en.wikipedia.org/wiki/Caffeine#Mechanism_of_action

I am betting that the method has more to do with the actions on glucose and cellular health with increased blood flow to the muscles and away from the inner organs.

Typically in these studies 1 cup = 5oz. It's the size of a British tea cup. thats equivalent to 2 cups US. Europeans don't typically drink drip coffee either like us Americans, I actually never once saw any drip pots in the 3 months I traveled around Europe and Scandinavia. They also tend to sit back and enjoy the drink, a weird concept for everybody but art student bohemians on this side of the pond.

Coffee also has some strong antioxidant properties, which also would result in protection of cells in thy body.

Kelly Parks said at February 19, 2007 10:03 AM:

How certain is it that caffiene is the cause? I know it's the likely suspect but there's more to coffee than just caffiene. Has a similar effect ever been observed in people who don't drink coffee but do drink caffinated sodas?

Jim said at February 19, 2007 02:01 PM:

i remember reading (on fp) about the apparently strong correlation between coffee drinking and reduced incidence of liver disease. does coffee possibly have some mechanism of helping the liver pull toxins, undesirables, etc. from the bloodstream which have their own negative effect on blood flow and/or brain function?

Lou Pagnucco said at February 19, 2007 03:28 PM:

Here's one possible explanation.

Coffee, tea and cocoa contain caffeine, theophylline and other xanthines which are non-selective inhibitors of the five families of the phosphodiesterases.

Phosphodiesterase inhibitors are under investigation as therapies for Alzheimers, congestive heart failure, and a variety of inflammatory conditions. For example, see:

"Selective Phosphodiesterase (PDE)-4 Inhibitors: A Novel Approach to Treating Memory Deficit?"
at URL - http://www.ingentaconnect.com/content/adis/rdd/2006/00000007/00000002/art00001

The Wikipedia entry for phosphodiesterase inhibitors may be of interest.
http://en.wikipedia.org/wiki/Phosphodiesterase_inhibitor

John said at February 22, 2007 05:00 AM:

Does this work for people who drink decaf?

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