Along with scientists Nanjoo Suh, also of Rutgers, and Agnes Rimando of the USDA’s Agricultural Research Service (ARS), Reddy and his associates conducted a small pilot study to determine the effect of pterostilbene on colon cancer. The study included 18 rats that were given a compound (azoxymethane) to induce colon cancer in a manner similar to human colon cancer development. Nine of the animals were then placed on a balanced daily diet, while the other nine were given the same diet supplemented with pterostilbene (at a level of 40 parts per million).
At the end of an eight-week study period, the rats that were fed pterostilbene showed 57 percent fewer pre-cancerous lesions in their colon in comparison to the control group, Reddy and his associates say. Pterostilbene also reduced colonic cell proliferation and inhibited certain genes involved in inflammation, both of which are considered colon cancer risk factors, the researchers say.
You can read the full paper online: Pterostilbene, an Active Constituent of Blueberries, Suppresses Aberrant Crypt Foci Formation in the Azoxymethane-Induced Colon Carcinogenesis Model in Rats. The full paper reports that pterostilbene has been found in blueberries, cranberries, sparkleberries, lingonberries, and grapes.
Pterostilbene lowers blood lipids and cancer. Some labs report that pterostilbene lowers blood glucose sugar levels as well.
Glucose levels in rats with hyperglycemia induced by streptozotocin were determined after i.p. administration of marsupsin (1), pterosupin (2), and pterostilbene (3), three important phenolic constituents of the heartwood of Pterocarpus marsupium. Marsupsin and pterostilbene significantly lowered the blood glucose level of hyperglycemic rats, and the effect was comparable to that of 1,1-dimethylbiguanide (metformin).
For reasons that are unclear, pterostilbene is not normally found in wine, Rimando says. This may be because it is unstable in light and air, which makes it less likely to survive the wine-making process, she says.
Pterostilbene and resveratrol are both antifungal compounds and they deliver some of same health benefits as each other.
This research provides yet more argument for eating more berries, grapes, and cherries. Eat the full fruit for maximal benefit rather than drinking juice.
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