August 23, 2007
Stem Cell Therapy Improves Sheep Knee Arthritis

An adult stem cell therapy by an Australian company appears to help improve osteoarthritic knees in sheep.

Melbourne, Australia; 20 August 2007: Australia's adult stem cell company, Mesoblast Limited (ASX:MSB;USOTC:MBLTY), today announced that preclinical trials of its patented adult stem cells had shown that the therapy significantly protected knee cartilage against damage in osteoarthritis.

Millions of people have osteoarthritis of the knee.

More than 10 million people in the US currently suffer from osteoarthritis of the knee, making it the most common joint disease. Osteoarthritis results in loss of cartilage which cannot repair itself after injury and for which there is no effective therapy. Current treatments attempt to alleviate painful symptoms but are unable to preserve the cartilage lining the joint. Moreover, many of the currently used pharmaceutical therapies are associated with severe side-effects and can even cause death. Joint replacement is often the only option for restoring function.

You may have knee osteoarthritis some day even if you don't now. Or you'll have it in your back or hands or shoulders or hips or some combination thereof. Your parts are wearing out. You need replacement parts.

People and dogs really suffer from decaying joints. We need stem cell therapies for joint rejuvenation and repair.

With the support of the Australian Government's Commercial Ready Grant award, Mesoblast's cartilage trials evaluated the effectiveness and safety of the company's allogeneic (donor unrelated) adult stem cells to treat osteoarthritis of the knee in 48 sheep arthritic joints. The results showed that joint cartilage in osteoarthritic knees of animals receiving Mesoblast's stem cells had significantly greater thickness, reduced breakdown, and greater biomechanical strength three months after injection into the knee than did control joints receiving injections of hyaluronic acid.

The trial's principal investigator, Professor Rick Read at the Murdoch University in Western Australia, said: "We are delighted with the significant cartilage protective effects of Mesoblast's allogeneic cells in our large animal model of knee osteoarthritis, without any adverse events of the cells at all".

We need this technology to work in humans. The benefits will be enormous. We need it faster.

Share |      Randall Parker, 2007 August 23 11:19 PM  Biotech Stem Cells


Comments
P KUMAR said at September 9, 2007 1:41 AM:

sir i have been advised knee joint replacement under bitleral Osteo arthritis in both knee-joint space is not observed in xray in weight bearing condition(100 kg) kindly guide me whether stem cell treatment is useful to me? when? expense?

P KUMAR said at September 9, 2007 1:41 AM:

sir i have been advised knee joint replacement under bitleral Osteo arthritis in both knee-joint space is not observed in xray in weight bearing condition(100 kg) kindly guide me whether stem cell treatment is useful to me? when? expense?

kunal patel said at December 10, 2007 10:13 PM:

Dear sir,my grand father has ostioarthritis for 10 years.He has age of 70 years today and weight is arround 80 kg.So we are looking for accurate treatment. So please guide me that weather stemcell therapy is useful for him or not?What is the exect procedure and expense of this therapy.Pls reply me on my mial-id.Keen for your reply.

CARL KESSLER said at April 2, 2009 6:09 PM:

I AM LOOK FOR ADUIT STIM CELLS TO FIX MY DOGS KNEE AND ARTHRITIS PROBLEMS
ANY SCIENTES LIKE TO HELP WITH THE TREATMENT.

Rosemary Gaussen said at May 15, 2009 6:14 PM:

I am interested in stem cell technology for my Wiltshire Horn sheep. The most commonly affected area is the elbow, initially on the left hand side. Unfortunately, the condition is not limited to older sheep. I currently have a four and a half year old ram who first showed signs of arthritis about 12 months ago. His condition appears to be seasonally affected, deteriorating with cooler conditions.
I would be grateful for any guidance as to who might be prepared assist. Thank you.

dean said at September 20, 2010 5:57 AM:

Good day

I have a 1 and 1/2 year old pet dorper sheep who is suffering from degenerative arthritis in both her front knees. As she is part of the family we love her very much and desperately want to help her in any possible way. We live in Durban, South Africa. Is it in any way possible to get hold of this therapy to help our sheep? If so, how?

Kind regards

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