February 19, 2008
Immune System Gene Therapy Cures Rat Brain Cancer

Aliens from outer space might marvel at how hard humans try to cure diseases in other species.

A new gene therapy approach that attracts and “trains” immune system cells to destroy deadly brain cancer cells also provides long-term immunity, produces no significant adverse effects and -- in the process of destroying the tumor -- promotes the return of normal brain function and behavioral skills, according to a study conducted by researchers at Cedars-Sinai Medical Center’s Board of Governors Gene Therapeutics Research Institute.

The study was conducted in a recently developed laboratory rat model of glioblastoma multiforme (GBM) that closely simulates outcomes in humans and supports the translation of this procedure to human clinical trials later this year. Results of the study are described in the Feb. 19 issue of Molecular Therapy, the journal of the American Society for Gene Therapy.

Gene therapy to train immune systems to attack cancers seems one of the most promising approaches against cancer.

Share |      Randall Parker, 2008 February 19 09:42 PM  Biotech Cancer

cathy said at February 20, 2008 5:11 AM:

I wonder if it would 'promote the return of normal brain function' if the loss of function was caused by something other than a tumor? That would be really exciting.

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