March 03, 2008
Low Testosterone Boosts Depression Risk?

Would testosterone replacement with age lower the risk of depression?

Older men with lower free testosterone levels in their blood appear to have higher prevalence of depression, according to a report in the March issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Depression affects between 2 percent and 5 percent of the population at any given time, according to background information in the article. Women are more likely to be depressed than men until age 65, when sex differences almost disappear. Several studies have suggested that sex hormones might be responsible for this phenomenon.

Osvaldo P. Almeida, M.D., Ph.D., F.R.A.N.Z.C.P., of the University of Western Australia, Perth, and colleagues studied 3,987 men age 71 to 89 years. Between 2001 and 2004, the men completed a questionnaire reporting information about demographics and health history. They underwent testing for depression and cognitive (thinking, learning and memory) difficulties, and information about physical health conditions was obtained from a short survey and an Australian health database. The researchers collected blood samples from the participants and recorded levels of total testosterone and free testosterone, which is not bound to proteins.

A total of 203 of the participants (5.1 percent) met criteria for depression; these men had significantly lower total and free testosterone levels then men who were not depressed. After controlling for other factors—such as education level, body mass index and cognitive scores—men in the lowest quintile (20 percent) of free testosterone concentration had three times the odds of having depression compared to men in the highest quintile.

I really want testosterone replacement to yield a net benefit in physical and mental health because I really want ways to slow up and delay the various deleterious effects of aging. We need prospective studies of its effects to know for sure.

Share |      Randall Parker, 2008 March 03 10:24 PM  Brain Depression

polymathprimate said at March 4, 2008 1:37 AM:

Here's an older article from the Harvard Gazette discussing the link between testosterone and depression, also mentions a little about the the feared risk of prostate cancer.

I believe there is also some research that testosterone supplements improves memory in men.

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