August 05, 2008
Injected Vitamin C Kills Cancer

By bypassing regulatory systems that control internal vitamin C levels scientists were able boost vitamin C concentrations so high that it killed cancer cells.

High-dose injections of vitamin C, also known as ascorbate or ascorbic acid, reduced tumor weight and growth rate by about 50 percent in mouse models of brain, ovarian, and pancreatic cancers, researchers from the National Institutes of Health (NIH) report in the August 5, 2008, issue of the Proceedings of the National Academy of Sciences. The researchers traced ascorbate's anti-cancer effect to the formation of hydrogen peroxide in the extracellular fluid surrounding the tumors. Normal cells were unaffected.

Natural physiologic controls precisely regulate the amount of ascorbate absorbed by the body when it is taken orally. "When you eat foods containing more than 200 milligrams of vitamin C a day--for example, 2 oranges and a serving of broccoli--your body prevents blood levels of ascorbate from exceeding a narrow range," says Mark Levine, M.D., the study's lead author and chief of the Molecular and Clinical Nutrition Section of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the NIH. To bypass these normal controls, NIH scientists injected ascorbate into the veins or abdominal cavities of rodents with aggressive brain, ovarian, and pancreatic tumors. By doing so, they were able to deliver high doses of ascorbate, up to 4 grams per kilogram of body weight daily. "At these high injected doses, we hoped to see drug-like activity that might be useful in cancer treatment," said Levine.

Keep in mind that cutting tumor size by 50% does not cure cancer. The remaining cells can bounce back and still kill you. But maybe combined with other treatments vitamin C can help fight cancer.

Share |      Randall Parker, 2008 August 05 12:13 AM  Aging Diet Cancer Studies


Comments
JP Straley said at August 5, 2008 7:22 AM:

Also of interest, dichloroacetate. (DCA) Googlit for anecdotal experience.
JP Straley

David Govett said at August 5, 2008 4:51 PM:

The cells that "bounce back" will be especially nasty. Seems like this treatment would kill one faster.

Randall Parker said at August 5, 2008 6:10 PM:

David Govett,

By itself a 50% shrinkage doesn't buy much. But vitamin C might boost the effectiveness of existing chemo agents.

beowulf said at August 5, 2008 7:39 PM:

I'm glad to see Uncle Sam paying for clinical trials on off patent compounds (no drug company is going to pay for Vitamin C trials). This is the part that caught my eye, "The researchers traced ascorbate's anti-cancer effect to the formation of hydrogen peroxide in the extracellular fluid surrounding the tumors. Normal cells were unaffected."

Hydrogen peroxide (like Vitamin C itself) is touted by alternative health advocates as a miracle cure.
Here's a typical example, http://www.tolifehealth.com/HydrogenPeroxideTherapy.html

HellKaiserRyo said at August 5, 2008 8:37 PM:

I really do not expect ascorbic acid to make a significant difference in chemotherapy unless it would be injected. Maybe nanoparticles might guide them to their correct target.

asdf said at August 7, 2008 1:43 PM:

What are you talking about , 50% size reduction is -huge-

With no metastasis in any of the treated rats? This is a breakthrough.

Brian H said at May 4, 2009 5:12 PM:

The original studies that hyped C as cold preventative also were using injected C. The subsequent studies that debunked the claims used oral C. Hmmm...

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