Correlation is not causation. But people who eat foods high in omega 3 fatty acids appear to get less aggressive prostate cancer.
March 24, 2009 -- Men who eat salmon and other fish high in omega-3 fatty acids on a regular basis have a decreased risk for developing advanced prostate cancer, new research suggests.
The association was most pronounced among men believed to have a genetic predisposition for developing aggressive prostate cancer.
Men in the study who ate one or more servings of fatty fish a week were found to have a 63% lower risk for developing aggressive prostate cancer than men who reported never eating fish, study co-researcher John S. Witte, PhD, tells WebMD.
A similar trend was seen for different levels of shellfish intake. Shellfish also contains omega-3 fatty acids. Omega-3 intake also had a major impact on the effect of a hazardous variant of the COX-2 gene, which promotes inflammation and is known to be linked to prostate cancer.
Men with the variant have a more than five-fold increased risk of aggressive prostate cancer. But a high consumption of oily fish effectively wiped out this risk factor.
A half gram of omega 3 looks like enough to do the trick for people who have a high risk genetic variant of COX-2. So maybe the 3 fish oil capsules I take per day might be sufficient.
The researchers then assessed the effect of omega-3 fatty acid among men with the variant rs4647310 in COX-2, a known inflammatory gene. Men with low long chain omega-3 fatty acid intake and this variant had a more than five-fold increased risk of advanced prostate cancer. But men with high intake of omega-3 fatty acids had a substantially reduced risk, even if they carried the COX-2 variant.
"The COX-2 increased risk of disease was essentially reversed by increasing omega-3 fatty acid intake by a half a gram per day," said Witte. "If you want to think of the overall inverse association in terms of fish, where omega-3 fatty acids are commonly derived, the strongest effect was seen from eating dark fish such as salmon one or more times per week."
For an additional potential prostate cancer risk reduction eat fish with mushrooms.
|Share |||Randall Parker, 2009 March 25 10:34 PM Aging Diet Cancer Studies|