April 28, 2009
Drugs And Vitamins Against Prostate Cancer

GlaxoSmithKline PLC's Avodart (dual 5-alpha-reductase inhibitor dutasteride which inhibits the conversion of testosterone into dihydrotesterone) cuts the risk of prostate cancer (and the same drug is also used to slow hair loss btw).

In the study, which involved 8,231 patients with increased risk of prostate cancer, 22.5% of men taking Avodart were diagnosed with prostate cancer after four years, compared with 29% who were taking a placebo.

But it did not cut the incidence of high grade tumors. Maybe those cancers were already present when Avodart dosing was started. Dutasteride might be better than finasteride (Proscar) for this purpose.

But wait, there's more. A big Mayo Clinic study found that statins seem to reduce the incidence of prostate cancer, erectile dysfunction and prostate enlargement.

Vitamin D might slow the development of existing prostate cancer.

Out of 26 men with recurrent prostate cancer, who took a daily dose of vitamin D2 bought from the chemist, five responded to the treatment.

In two the PSA level, fell by more than half, in two by 25-50% and in one man it fell by less than 25%.

Another small study found that pomegranate juice slows prostate cancer growth.

The two-stage clinical trial followed a total of 48 participants over six years. Eligible participants had a rising PSA after surgery or radiotherapy, a PSA greater than 0.2 ng/ml and less than 5 ng/ml and a Gleason score of 7 or less. These patients were treated by drinking eight ounces of pomegranate juice daily. Currently, in the sixth year of treatment, active patients who remain on the study have a median total follow-up of 56 months. These participants continue to experience a significant increase in PSA doubling time following treatment, from a mean of 15.4 months at baseline to 60 months post-treatment, with a median PSA slope decrease of 60 percent, 0.06 to 0.024.

One problem: I've yet to see pomegranate juice in a store.

So guys you've got drugs, a vitamin, and a juice to cut your risks of dying from prostate cancer.

Share |      Randall Parker, 2009 April 28 12:47 AM  Aging Diet Cancer Studies

David Govett said at April 28, 2009 1:00 AM:

Costco sells big bottles of pomegranate juice, but they're pricey.

Brett Bellmore said at April 28, 2009 4:01 AM:

Yeah, its expensive, and if you do see it, check the find print, it's usually apple juice with a little pom mixed in.

Dr. Bob said at April 28, 2009 8:53 AM:

Just get the supplement equivalent at lef.org

David Govett said at April 28, 2009 9:16 AM:

I checked the fine print. It's 100% Pomegranate.

Eric Blair said at April 28, 2009 10:33 AM:

There's a brand called POM that I've seen in various supermarkets on the east coast.

Nick G said at April 28, 2009 3:06 PM:


Have you seen the dosage of Vitamin D used in that study? I googled madly, and couldn't find it.

The Undiscovered Jew said at April 28, 2009 3:28 PM:

Yeah, its expensive, and if you do see it, check the find print, it's usually apple juice with a little pom mixed in.

Nothing is too good for my prostate.

Randall Parker said at April 28, 2009 6:34 PM:

Dr. Bob, Concentrated pomegranate in a pill is a good idea. Thanks for the suggestion.

Any idea what in the pomegranate does this? Is pomegranate natural Lupron? Are there harmful side effects?

JCee said at April 30, 2009 7:44 AM:

Why they used vitamin D2 instead vitamin D3 is a mystery to me. They are not the same thing. D3is a lot more biologically active than D2 and is the form your body naturally makes . The only thing I can think of is D2 is available in prescription form whereas D3 is only available over the counter (no prescription form available).

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