May 27, 2009
Cut Carbos For Longer Prostate Cancer Survival?

Got prostate cancer? A change of diet might help.

DURHAM, N.C. -- Restricting carbohydrates, regardless of weight loss, appears to slow the growth of prostate tumors, according to an animal study being published this week by researchers in the Duke Prostate Center.

"Previous work here and elsewhere has shown that a diet light in carbohydrates could slow tumor growth, but the animals in those studies also lost weight, and because we know that weight loss can restrict the amount of energy feeding tumors, we weren't able to tell just how big an impact the pure carbohydrate restriction was having, until now," said Stephen Freedland, M.D., a urologist in the Duke Prostate Center and lead investigator on this study.

The researchers believe that insulin and insulin-like growth factor contribute to the growth and proliferation of prostate cancer, and that a diet devoid of carbohydrates lowers serum insulin levels in the bodies of the mice, thereby slowing tumor growth, Freedland said.

In miche the no-carbo diet made a big difference in survival times.

"The mice that were fed a no-carbohydrate diet experienced a 40 to 50 percent prolonged survival over the other mice," Freedland said.

This brings up an obvious question: Will a low-carbo diet cut the risks of developing prostate cancer in the first place? Also, will such a diet lower the risks of developing other types of cancer?

Share |      Randall Parker, 2009 May 27 12:29 AM  Aging Diet Cancer Studies


Comments
Thras said at May 27, 2009 6:13 AM:

Randall -- Taubes' book has a section on tumor growth in the presence of insulin.

Lou Pagnucco said at May 27, 2009 8:53 AM:

Interesting study.

If reduced insulin-like growth factor-I is responsible, then perhaps other dietary modifications would also work.

Reducing any single one of the essential amino acids, leucine, lysine, methionine or threonine, greatly decreased IGF-I levels in one experiment.
"Dietary Restriction of Single Essential Amino Acids Reduces Plasma Insulin-Like Growth Factor-I (IGF-I) but Does Not Affect Plasma IGF-BindingProtein-1 in Rats"
http://jn.nutrition.org/cgi/reprint/130/12/2910

Restriction of dietary tyrosine, phenylalanine and methionine is being researched to treat metastic prostate cancer.
"Targets of Amino Acid Restriction in Prostate Cancer"
http://prevention.cancer.gov/funding/recently-funded/ca04004/1R01CA101035-01A1

I wonder how synergystic these various anti-cancer therapies are.
It seems like most of the studies are monotherapies.

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