September 26, 2009
Vitamin D Lack, Fructose Excess Linked To High Blood Pressure

Among women enrolled in the Michigan Bone Health and Metabolism Study high blood pressure developed at 3 times the rate in women who were vitamin D deficient before menopause. Do not wait until you get older before starting to take nutrition seriously. If you wait the damage will already be done before you act.

Women who have vitamin D deficiency in the premenopausal years are at three times increased risk of developing high blood pressure in mid-life.

Hypertension rose from 6 percent to 25 percent over 15 years in this study population of women average age 38.

The age range was 24 to 44 at the start of the study in 1992. So the oldest at the end of the study were 59. A 25% overall high blood pressure rate seems pretty high.

You can get a blood test on your vitamin D to see where you stand. A blood test in winter will be especially telling due to shorter days and less sunshine.

Vitamin D deficiency was defined as less than 80 nanomoles per liter (nmol/L), while normal levels were considered more than 80 nmol/L. Experts in the medical community generally agree that vitamin D deficiency among women is widespread. Some researchers report many women don’t get enough sunlight exposure to help keep vitamin D levels near to normal, nor do they have diets or practice supplementation that support normal levels of vitamin D, Griffin said. Vitamin D is either synthesized in the skin through exposure to ultraviolet B rays in sunlight or ingested as dietary vitamin D.

Another cause of higher blood pressure: large amounts of fructose.

CHICAGO, Sept. 23, 2009 — A high-fructose diet raises blood pressure in men, while a drug used to treat gout seems to protect against the blood pressure increase, according to research reported at the American Heart Association’s 63rd High Blood Pressure Research Conference.

“This is the first evidence of a role of fructose in raising blood pressure and a role for lowering uric acid to protect against that blood pressure increase in people,” said Richard Johnson, M.D., co-author of the study and professor and head of the division of Renal Diseases and Hypertension at the University of Colorado–Denver medical campus in Aurora, Colo.

They used 200 grams of fructose per day. Since grapes appear to be about 8% fructose by weight You'd have to eat about 5 lbs of grapes per day to get 200 grams of fructose from grapes.

Johnson and co-author Santos Perez-Pozo, M.D., a nephrologist at Mateo Orfila Hospital in Minorca, Spain who led the study, evaluated 74 adult men, average age 51, who consumed a diet that included 200 grams (g) of fructose per day in addition to their regular diet. The amount is much higher than the estimated U.S. daily intake of 50 g to 70 g of fructose consumed by most U.S. adults. Half of the men were randomly assigned to get the gout drug allopurinol and the other half acted as controls.

After only two weeks on the diet, the high-fructose plus placebo group experienced significant average blood pressure increases of about 6 millimeters of mercury (mm Hg) in systolic blood pressure (the pressure when the heart beats) and about a 3 mm Hg rise in diastolic blood pressure (the pressure between heartbeats). They were measured with strap-on monitors that record blood pressure periodically around the clock.

Gout drug allopurinol blocked this effect. The main threat comes from high fructose corn syrup used in soda and processed foods.

Fruits contain good stuff that isn't present in high fructose corn syrup.

Fruit, which has just 4 g to 10 g of fructose per serving, also contains many beneficial substances including antioxidants, vitamin C, potassium and fiber that are believed to counter the effects of fructose alone. The main risk for excessive fructose consumption in the Western diet comes from sweetened drinks and foods rich in sugar or high fructose corn syrup, he said.

I'd really like to know if there's a fructose health threat from eating lots of fruits. I happen to eat at least 1 apple a day and lots of grapes daily as well. I've come across a number of scientific reports showing a positive correlation between fruit consumption and health. So I'm still eating lots of fruits. Curiously, the ratio of fructose to total sugar varies greatly between fruits. Note in table 1 how apricot and peach have especially low ratios of fructose to total sugar.

Share |      Randall Parker, 2009 September 26 02:50 PM  Aging Diet Heart Studies

David Govett said at September 27, 2009 9:23 AM:

Anyone have a more-complete list containing fruit such as strawberries, oranges, watermelon, etc.

Fly said at September 27, 2009 2:26 PM:

Amylase released into the gastrointestinal tract breaks sucrose down into glucose and fructose. The glucose is readily absorbed and enters the blood stream. The fructose is absorbed in the small intestines and carried via the portal vein to the liver where it is metabolized. According to some experts excessive fructose can cause problems associated with liver metabolism...but it doesn't matter whether the fructose comes from sucrose or from free fructose.

High fructose corn syrup is about 55% fructose which differs little from the 50% fructose bound up in sucrose. The problem with high fructose corn syrup is that it is cheap. When food manufacturers removed fat from their products, they often replaced it with cheap sugar. Also Americans are drinking far more sugar drinks. The modern US diet has far more sugar than it did in the 1950's. More sugar means more fructose which must be metabolized by the liver.

If you already have too much fructose in the liver, the sugars in fruit may make the problem worse. If you avoid sugar drinks (including fruit juices) and packaged foods with added sugar then you can eat fruit without worrying about the fructose it contains.

matthew said at September 27, 2009 5:55 PM:

there is a competition at 3bananas for the most comments to fund non profits with sens near the front.

It's a real nail biter. Maybe if you had a post on it they would win 5k.

DADvocate said at September 30, 2009 1:31 PM:

I take Lisinopril for my blood presure. I recently quit taking multi-vitamins and my blood pressure dropped 10 point on average within days. I get plenty of sunlight daily. I wonder not taking the multi-vitamin with the extra Vitamin D had something to do with my high blood pressure.

bc said at September 30, 2009 4:27 PM:

There are two (natural) ways to become deficient in vitamin D.
1. You can receive grossly insufficient UV B radiation to the skin.
2. You can over run the conversion reaction for D3 (the vitamin) to the secosteroid form Dihydroxy D3, which is the active form. Running this reaction too far to the right, converting your stores of D3 to the hormone depletes D3.

This conversion reaction is under tight feedback control in both the liver and kidneys. If D3 is depleted, you should check blood levels of secosteroid D before gobbling supplements. Our systems are designed for reasonable seasonal D3 variation. You have about 1000 times more D3 levels than you need to convert to hormone, plus or minus. The tight control is imposed at the conversion step. If D3 is low, check dihydroxy D levels.

tom scott said at September 30, 2009 6:51 PM:

Coincidentally I just happened to view this video this afternoon regarding sugar, HFCS (Hight Fructose Corn Syrup) and others. Very interesting video. It's and hour and a half long tho so have some time available if you want to watch it.

Enrique said at January 16, 2010 2:01 AM:

Dear guys:

I am sending you the abstracts of the fructose study.

Best regards.


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