February 09, 2010
Soy Isoflavones Not Protective For Bones?

Not looking so good for isoflavone benefits.

AMES, Iowa -- A previous six-month study by Iowa State University researchers had indicated that consuming modest amounts of soy protein, rich in isoflavones, lessened lumbar spine bone loss in midlife, perimenopausal women. But now an expanded three-year study by some of those same researchers does not show a bone-sparing effect in postmenopausal women who ingested soy isoflavone tablets, except for a modest effect at the femoral (hip) neck among those who took the highest dosage.

The multi-center clinical trial of 224 postmenopausal women -- led by D. Lee Alekel, professor of nutrition and interim associate director of the Nutrition and Wellness Research Center (NWRC) at Iowa State, and supported by the National Institute of Arthritis, Musculoskeletal and Skin Diseases, one of the research institutes of the National Institutes of Health (NIH) -- was the longest ever conducted on the effects of soy isoflavones on bone mineral density (BMD). It compared the effects of either ingesting daily 80-mg daily or 120-mg soy isoflavone tablets, compared to placebo tablets on BMD and other health outcomes.

The hope was that the isoflavones would act like hormone substitutes and therefore help reduce bone loss. There might have been a small benefit on neck bone.

While the 120-mg dose soy isoflavones did reveal a small protective effect on femoral neck bone BMD, researchers found no significant effect of treatment on lumbar spine, total hip, or whole-body BMD.

There's still exercise, vitamin D, vitamin K, and of course beer for the silicon.

Share |      Randall Parker, 2010 February 09 09:08 PM  Aging Diet Bone Studies

Bob Badour said at February 10, 2010 7:21 AM:

"Femoral neck bone" is different from "neck bone". Neck bones are part of the spine and femoral neck bone is part of the leg.

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