March 07, 2010
Genetic Test Indicates Best Weight Loss Diet

Stanford and Interleukin Genetics researchers find that the best way to lose weight depends on your genes. Low carbo or low fat? It depends on your genes.

Key Stanford findings from the study include:

  • Individuals on genotype-appropriate diets lost 5.3 percent of body weight compared to individuals on diets not matched to their genotype, who experienced only 2.3 percent weight loss (p=0.005);
  • The weight loss differences were even stronger when considering the individuals who were trying to follow the lowest carbohydrate (Atkins) and the lowest fat (Ornish) diets: 6.8% weight loss for those whose genotype matched the diet they were following vs. 1.4% for those not matched to their genotype (p=0.03);
  • The statistical significance of the findings increased when taking into account the actual diet habits reported by study participants (rather than just the specific diet they were asked to follow);
  • Improvements in clinical measures related to weight loss (e.g., blood triglyceride levels) paralleled the weight loss differences.

“The differentiation in weight loss observed for individuals who followed a diet matched to their genotype versus one that was not matched to their genotype is highly significant in numerous categories and represents an approach to weight loss that has not been previously reported in the literature,” said Christopher Gardner, Ph.D., Director of Nutrition Studies at the Stanford Prevention Research Center and an Associate Professor of Medicine at Stanford University. “The potential of using genetic information to achieve this magnitude of weight loss without pharmaceutical intervention would be important in helping to solve the pervasive problem of excessive weight in our society. We are eager to follow-up on this study and to determine the magnitude of health benefits that may result from following a diet that is matched to one’s genotype.”

Once more genes are discovered that influence how you metabolize food we can find out what we ought to eat. What I'm wondering: Does anyone have a metabolism that functions best on chocolate ice cream? Or cheese burgers? "Oh sorry, my genetic profile says I shouldn't eat vegetables".

If a genetically appropriate diet doesn't help then blame it on stomach bacteria.

Increased appetite and insulin resistance can be transferred from one mouse to another via intestinal bacteria, according to research being published online this week by Science magazine.

The finding strengthens the case that intestinal bacteria can contribute to human obesity and metabolic disease, since previous research has shown that intestinal bacterial populations differ between obese and lean humans.

So eat special yogurt to give yourself weight loss bacteria?

Share |      Randall Parker, 2010 March 07 03:06 PM  Aging Diet Metabolism

Rina Andersen said at March 7, 2010 8:26 PM:

I had an impulsive moment in October and bought this test.
The results took 3 weeks to come back which was annoying.
By that time it was Thanksgiving and I decided to not read my results until after the Holidays.
U then lost track of the results until early January.
It turns out my favorite diet plan Low carb wasn't the right one.
Low calorie all the way.
Its been hell sticking to low calorie but it worked way better than low carb diet ever did.
I have lost 27 lbs in 8 weeks.

Fat Man said at March 7, 2010 9:17 PM:

That's the ticket. I blame the bacteria.

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