March 15, 2010
Scopolamine Lifts Depression In A Few Days

Most anti-depressants show beneficial effects only after a few weeks. By contrast, scopolamine joins ketamine as a rapid depression lifter.

Philadelphia, PA, 1 March 2010 - Conventional antidepressant treatments generally require three to four weeks to become effective, thus the discovery of treatments with a more rapid onset is a major goal of biological psychiatry. The first drug found to produce rapid improvement in mood was the NMDA glutamate receptor antagonist, ketamine.

In a new issue of Biological Psychiatry, published by Elsevier, researchers from the National Institutes of Health report that another medication, scopolamine, also appears to produce replicable rapid improvement in mood. Scopolamine temporarily blocks the muscarinic cholinergic receptor, thought to be overactive in people suffering from depression.

For people with severe depression just getting it lifted in a few days could provide hope that a life of depression need not be a permanent state of affairs.

Drs. Wayne Drevets and Maura Furey recruited outpatients with major depressive disorder who were randomly assigned to receive placebo and then scopolamine treatment, or vice versa, in a double-blinded design so that neither the researchers nor the patients knew which treatment they were receiving.

"Scopolamine was found to reduce symptoms of depression within three days of the first administration. In fact, participants reported that they experienced relief from their symptoms by the morning after the first administration of drug," explained Dr. Furey. "Moreover, one-half of participants experienced full symptom remission by the end of the treatment period. Finally, participants remained well during a subsequent placebo period, indicating that the antidepressant effects persist for at least two weeks in the absence of further treatment."

Among the side effects: blurry eyes, dry mouth, and allergic reaction. Those side effects seem to compare favorably with ketamine side effects.

Share |      Randall Parker, 2010 March 15 10:37 PM  Brain Depression

Fat Man said at March 16, 2010 5:46 AM:

Don't forget the hallucinations.

Ric said at March 19, 2010 4:03 PM:

At least it'll make an honest man of you

faruq said at March 20, 2010 4:49 AM:

This is off-topic: but if a person has a very boring job,and needs the time to pass quicker,then what's the best drug/pharmaceutical for that? (bearing in mind,it must be something which has low risk of neurotoxic brain damage). I was thkingin something along the lines of aderall or ritalin. but these are hard to obtain in the UK. Anyone have any ideas? Thanks.

dino said at May 19, 2010 6:00 AM:

if a person where to have such a boring job, then likewise a good legit remedy would be 480mg of dxm, combined with 100mg of benadryl. good for a 5 hour, or if you want 8 hours make sure dxm is polistirex, instead of hydrobromide. this is an an official chill pill that will not put you out and will make things seem a bit more interesting.

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