April 19, 2010
Vitamin K Cuts Non-Hodgkin Lymphoma Risk?

A reason to eat green leafies.

WASHINGTON In the first study of vitamin K and Non-Hodgkin lymphoma risk, researchers at the Mayo Clinic campus in Minnesota have found that people who have higher intakes of vitamin K from their diet have a lower risk of developing Non-Hodgkin lymphoma. Non-Hodgkin Lymphoma is a cancer of the immune system and is the most common hematologic malignancy in the United States.

At the 101st Annual Meeting of the American Association for Cancer Research (AACR), the researchers report that the risk of developing Non-Hodgkin lymphoma was approximately 45 percent lower for participants who had vitamin K intakes in the top quartile of intake in the study (>108 ug/day), compared to participants who had intakes in the bottom quartile (<39 ug/day). This association remained after accounting for other factors such as age, sex, education, obesity, smoking, alcohol use and intake of foods with high amounts of antioxidants.

I happen to take a 2400 ug vitamin K pill (a mix of K1 and K2 forms) about once every 2 weeks. The study finds that supplemental vitamin K delivers some protective benefit as well but tops out. The press release doesn't report what level of supplementation maxes out the benefit.

Here's a good list of high vitamin K foods. Eat your kale or collard greens.

Share |      Randall Parker, 2010 April 19 11:38 PM  Aging Diet Cancer Studies

FreeKnight said at April 20, 2010 12:50 AM:

Warning: Vitamin K affects the blood clotting factors and makes you more susceptible to clotting. If you are on blood thinners (e.g. coumadin or warfarin) you have to consistently eat the same amount and make sure to get tested if you increase your amount of Vit. K foods.

FreeKnight said at April 20, 2010 12:55 AM:

Good list...didn't realize spinach was so high. Guess why Popeye could take all of that abuse and keep coming back for more!

Lono said at April 20, 2010 8:45 AM:


You only take it once every two weeks?

I had been supplementing K2 much more often than that so as to offset potential calcification of the arteries that can be caused by long term D3 supplementation - and advising my followers to do the same.

Are you on such a protracted schedule because you are concerned about increasing clotting factors as well?

Randall Parker said at April 20, 2010 5:48 PM:


No, simpler than that: 2400 ug per 2 weeks is 171 mcg per day which is well above the adult daily recommended 120 mcg. Since it is oil soluble I figure it sticks around. Plus, I must be getting some from foods.

Lono said at April 21, 2010 8:14 AM:

Ahh - thanks for the explanation...

I had been under the impression that the daily recommended amounts on K2 were based on severly antiquainted data - and thus - perhaps unfairly - ignored it completely.

I'll have to re-check my dosage - but I feel confident - that I should probably reduce my consumption based on the potential clotting dangers.

I wonder if taking asprin would offset any clotting issues through an independent mechanism - or if it would just nullify the benfeits of the K2 supplementation.

Randall Parker said at April 21, 2010 6:15 PM:


Note that the top quartile in this study got 108 mcg per day. Well, that mens that over three quarters of the study participants did not get the recommended daily allowance. The daily allowance appears to deliver a big benefit. Would a bigger dose deliver a bigger benefit? Don't know.

Morgan said at March 4, 2011 1:26 PM:

I have been increasing my vitamin K intake (naturally) for osteoporosis issues...Kale Salad with avocados yum!

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