May 20, 2010
Aging Blood Vessels Cause Muscle Loss

Those shriveled muscles are the result of blood vessels that no longer dilate after a meal.

GALVESTON, Texas Why do people become physically weaker as they age? And is there any way to slow, stop, or even reverse this process, breaking the link between increasing age and frailty?

In a paper published online this Wednesday in the Journal of Clinical Endocrinology & Metabolism, University of Texas Medical Branch at Galveston researchers present evidence that answers to both those questions can be found in the way the network of blood vessels that threads through muscles responds to the hormone insulin.

Normally, these tiny tubes are closed, but when a young person eats a meal and insulin is released into the bloodstream, they open wide to allow nutrients to reach muscle cells. In elderly people, however, insulin has no such "vasodilating" effect.

The researchers administered insulin to young people with and without a drug that blocks vasodilation. When administered with a drug that blocks vasodilation then a boost in muscle protein synthesis was blocked. This suggests that muscle wasting with old age is due to increasing rigidity of blood vessels.

We obviously need rejuvenation therapies that will make our blood vessels supple again. Youthful blood vessel stem cells are an obvious candidate therapy. But we also need therapies that will clean out accumulated plaque and other therapies that can reverse protein cross-linkages that reduce flexibility. I also wonder whether receptors for insulin binding decline with age.

Bottom line: Aging of subsystems of the body cause other subsystems to age as well. The ability to rejuvenate key subsystems (e.g. the cardiovascular system) will improve the performance of many other subsystems.

Share |      Randall Parker, 2010 May 20 11:22 PM  Aging Mechanisms

evidence said at May 21, 2010 6:59 PM:

and more broadly speaking, it causes sarcopenia

David Gobel said at May 24, 2010 12:13 PM:

If one restricted their intake of fast carbs (sugar, white bread, beer) and depended primarily on the ketonic metabolic cycle, rather than the insulin pathway then chronic insulin "dosing" levels drop significantly preserving vessel elasticity. I think reduction of carb induced insulin damage is part of the reason the calorie restriction diet extends mammalian life.

Jim M said at May 24, 2010 12:21 PM:

We already have rejuvenation therapies. They are called cardio and weight training. There's a great book out called "Younger Next Year". Read it. The comments above apply to those who spend their days looking for a place to sit. Go to the gym!

colin elliott,MD said at May 24, 2010 4:09 PM:

I've been very interested in the use of Bystolic, a beta blocker that releases NO .My diabetic patients tend to have a rapid and meaningful (about 40 points) drop in fbs. In addition , my PAD patients have a notable increase in their dorsalis ,and in the foot warmth . From personal experience-(I still sprint to keep in shape ),my 200 is a cpl seconds faster than last year.As most of you know, NO is the agent released by sildenafil,et al.The other commentI'm getting at home,"Honey,you're young again," is quite gratifying.
If patients don't have ins, consider dosing 1/2 of 20 mg qod. the half life is such , the patients should do well.
A couple of other points.Don't own any stock,don't speak for them,not having sex with any rep,male/female/animal vegetable or mineral connected with the company (Forest)

jfarreast said at May 24, 2010 4:57 PM:

Jim M - To infer that anyone who does not go to the gym are lazy shows how young you are. For some people, it is just not possible financially. For others, all this new wonderful awareness comes when they are 70 years old and already barely able to get around.

Kent said at May 24, 2010 5:14 PM:

As we age the necessity for ownership of a .357 mag. revolver will make up for the loss of muscle mass..Your Friend In Jesus..Kent

Capn Rusty said at May 24, 2010 5:24 PM:

You don't have to go to the gym to work out. Walk. Do sit-ups. Do push-ups. Lift things. Use the stairs. One of the reasons (there are many) I hate Obamacare is that I'm going to have to pay for people who won't don anything to keep themselves healthy.

Randall Parker said at May 24, 2010 6:58 PM:

David Gobel,

Very interesting about insulin damage. I tend to eat a low glycemic index diet. I'm also eating more meat, mostly turkey. I now eat my way thru about 1 turkey per month.

Got any views on the net health effects of non-fat yogurt?

Jimmy J. said at May 24, 2010 8:48 PM:

Exercise ala "Younger Next Year," a low glycemic carb and reasonable protein intake diet, and supplementing with 6000mg of L-Arginine and L-Citrulline daily (2000mg three times a day - releases NO) has been my regimen. My vessels are open and relaxed. In fact, when I do resistance training I look as vascular as 20 years ago. (I'm 77.)

As Capn Rusty says, you don't need to go to a gym. Get up and start walking. Walk a little further each day until you can walk for 45 minutes to an hour a day. Weather's bad? Go walk in the mall. Get some hand weights and do some resistance exercises with them. Buy an exercise cord and use it for resistance exercises. Do sit ups and push ups. As "YNY" tells you, we are made to move. When we quit, we go downhill faster than need be.

Fred Hahn said at May 25, 2010 3:24 AM:

Agreed - resistance exercise in combination with a low sugar/carb diet is the best therapy available. So few medical professionals understand this. But the medical field is full of hacks. Heck, you have the ADA and the ADtA recommending that diabetics eat a minimum of 130 grams of carbs a day. How more nuts can you get? They claim that the brain needs 130 grams of glucose a day. But when you tell them that there is a process called gluconeogenesis they then state that ketosis is dangerous. When you explain to them that ketoacidosis is dangerous not ketosis they then no longer correspond with you. Sorry for the rant.

In said at May 25, 2010 7:55 PM:

I recall reading that turkey is high in omega 6 (and AA). Sorry can't find where I heard that, but IMO high omega 6 is an easy pitfall if one is avoiding carbs. I suppose that isn't a problem if it is lean turkey.

I also think the glycemic index is not necessarily helpful

It seems also that the quality and preparation of carbs is more important than quantity as evidenced from numerous healthy cultures eating a high carb diet, e.g. the kitavans.

Paleo Garden said at May 27, 2010 6:55 AM:

Fred!, awesome summary. Cool that you read this blog, too. I've been reading Randall's site now for about a year. And "In" awesome post of Stephan's essay.

I enjoy Randall's site for the variety of information and commentators. From a longevity/maintenance standpoint, I think there's a lot to share with some of the people interested in rejuvenation therapies, etc., in the sense that a lot of this rejuvenation possibilities are present already via high intensity strength training (Fred Hahn is an institution in that regard), lowcarb/evolutionary diet practitioners/writers like Stephen from Whole Health Source, etc. There's so much that may be done for one's metabolic health (insulin sensitivity) via these strength training methods and a diet devoid or extremely low in sugar, HFCS, and no grains of any kinds.

Made my day to see Fred comment here and a link for Stephan's site. Randall, thanks as always for the great forum you provide. Have a great weekend.
Best Regards,
Zach said at June 30, 2010 10:52 AM:

The cause of aging.
Vlasov theory.

There are several versions about the cause of aging. Cell division is a limited number of times the gene aging, programming cell death, and so on. Now you have put forward another version of aging. But they do not answer the question about the cause of aging. Can all these versions is easy to refute. But it is a waste of time. Every aspiring scientist will stubbornly stand on his or her opinion, and invent a pill from age. All others interested in the topic, tend to any version made by "credible scientific community." A delve deeply, in general, no one wants.
But it is much easier. Of course, to believe in the pill with age - is naive. Throughout human history there is not one of the most affluent and powerful rejuvenated the oldest old.

The cause of aging lies in the physics of the organism as a whole. A living organism is aging, because increasing. The process of growth is complex, but we consider it fundamentally, in simplified form. Every living thing comes from the seed and grows, increasing in volume, in the tens of thousands of times. It proved easy. What happens when growth in terms of physics? The main reason why there is growth - is the energy process is organized so that the organism grew. The density of the energy produced per unit of body volume, the growth process, amounts that creates the necessary physical parameters (temperature, pressure, density, etc) for the formation of cells with special properties. Simply put, full cage, has a certain amount, elastic, can be compared with the inflated ball. Known physical effect: when heated body expands. Can the energy density for the formation of young cells to the unit. While the organism as a whole produces energy for the entire volume of the body is equal, for example, 100 watts per hour (this is a comparative figure), there are physical conditions for the production of young cells. Lastly, the body reaches a volume of the body, when the energy density per unit volume starts to decline gradually, (0,99, 0,98 and so on, for a long time).
Physical parameters for the production of cells begin to deteriorate (temperature, pressure, density), reduced the rate of production of cells. Produce cells with the deteriorating physical parameters. Aging cell has the parameters are not "inflated ball, and run-flat". A gradual accumulation of old cells, which can not support the physical conditions for the production of energy, which further worsens the production of cells. This process begins slowly, gradually, with age, the rate of increase. That is, with the decrease of the energy density per unit volume of body slows production of young cells, and new cells will have a loss of physical parameters.
Since 1990, advocating this theory. Many thousands of people, including doctors, who are acquainted with the theory, saying that the version is interesting, but they want to trust scientific authority. The latter can not prove the truth of his theoretical predispositions. It turns out that no one is wrong. This version of the Vlasov appeared on the basis of physical theory of energy is the logic and easily confirmed in practice. This power device is easy to recreate and test. What have other versions do not.

Is it possible to rejuvenate?
Rejuvenation - not a scientific term, but it is not essential. Theoretically, restoration of the energy density per unit volume and the recovery rate of metabolic processes can restore the production of young cells. For a real rejuvenation, and, in consequence, a significant slowing of aging. Of course, we need research. The main thing is the correct scientific version, and has a plan to achieve a positive effect, it allows you to get a quick result.
All known versions of the cause of aging - it is the implications of changing energy of the body. Proved difficult.
If you really want to find a way to rejuvenate, you will understand that I am right.

Author: Vlasov, VF

625051, Tyumen, ul. Republic 212-317, Vlasov VF

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