June 29, 2010
Ovary Transplants Rejuvenate Old Mice

Another reason for guys to become a transvestite?

Rome, Italy: Scientists have discovered that when they transplant ovaries from young mice into aging female mice, not only does the procedure make the mice fertile again, but also it rejuvenates their behaviour and increases their lifespan. The question now is: could ovarian transplants in women have the same effect?

Dr Noriko Kagawa will tell the 26th annual meeting of the European Society of Human Reproduction and Embryology in Rome today (Tuesday) that successful ovarian transplants increased the lifespan of the mice by more than 40%. "At present ovarian transplants are performed with the aim of preserving a woman's fertility after cancer treatment for instance, or of extending her reproductive lifespan. However, the completely unexpected extra benefit of fertility-preserving procedures in our mouse studies indicates that there is a possibility that carrying out similar procedures in women could lengthen their lifespans in general," she said.

Imagine transplanted ovaries that didn't pop out eggs but which did pump out hormones. A way to slow aging?

40% longer life thru ovary transplants.

Dr Kagawa said: "All the mice in both experiments that had received transplants resumed the normal reproductive behaviour of young mice. They showed interest in male mice, mated and some had pups. Normally, old mice stay in the corner of the cage and don't move much, but the activity of mice that had had ovarian transplants was transformed into that of younger mice and they resumed quick movements. Furthermore, the lifespan of the mice who received young ovaries was much longer than that of the control mice: the mice that had received two ovaries lived for an average of 915 days, and the mice that had received one ovary, for an average of 877 days. The newest of our data show the life span of mice that received transplants of young ovaries was increased by more than 40%.

With humans the ovary transplants might help. But resulting hormone surge might boost the risk of breast and cervical cancer. The net effect on human lifespans is hard to estimate at this point. Though the eventual development of cures for cancer would eliminate some of the downsides of ovary transplants and of other means to restore youthful hormone levels.

Share |      Randall Parker, 2010 June 29 11:34 PM  Aging Treatment Studies


Comments
Lee said at June 30, 2010 12:14 AM:

This is awesome. I wonder if it somehow relates to telomeres though.

Lou Pagnucco said at June 30, 2010 10:40 AM:

There have already been human ovary transplants.
Maybe only young ovaries to old subjects will extend longevity. Likewise with immunological matching.

This also works in dogs.

"Rottweiler study links ovaries with exceptional longevity"
http://www.avma.org/onlnews/javma/mar10/100301g.asp

"Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805875/

It might be worth reading the recent press release:

Eat fish twice a week to delay menopause
- lifelong sun exposure increased the risk of it starting early.
- history of heavy physical activity also doubled the risk, as did high blood pressure
http://www.dailymail.co.uk/health/article-1290391

Too bad so little of our national budget is spent on increasing human longevity.


Gyorgy Magyary said at June 30, 2010 4:50 PM:

Wow wow ...

With the technology of stem cells and cloning of organs, which begin to function reliably, women will have a great advantage over men for a long time ...

Of course, if it is able to produce cloned testicles, men also have promising rejuvenation.


Propehecy said at July 1, 2010 1:12 PM:

Wow indeed. I wonder if the impact would still be felt by freezing sections of my ovaries now while I'm still young to implant later in my 40s.

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