June 29, 2010
Broccoli Compound Blocks Breast Cancer Cell Growth

A compound in broccoli and brussel sprouts blocks the growth of breast cancer cells. Frequent consumption of these vegetables might lower breast cancer risk.

COLUMBUS, Ohio Researchers at the Ohio State University Comprehensive Cancer Center-Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James) have discovered how a substance that is produced when eating broccoli and Brussels sprouts can block the proliferation of cancer cells.

Compelling evidence indicates that the substance, indole-3-carbinol (I3C), may have anticancer effects and other health benefits, the researchers say. These findings show how I3C affects cancer cells and normal cells.

The laboratory and animal study discovered a connection between I3C and a molecule called Cdc25A, which is essential for cell division and proliferation. The research showed that I3C causes the destruction of that molecule and thereby blocks the growth of breast cancer cells.

The molecule Cdc25A probably also serves useful purposes in people who not happen to have early stage cancer. So an obvious question arises: Will higher daily doses of indole-3-carbinol (I3C) cause undesired side effects due to, for example, inhibition of cell growth to do repairs on aging body parts?

There's a real tension between blocking undesired cellular growth and allowing or even stimulating desired and needed cell growth.

Share |      Randall Parker, 2010 June 29 11:27 PM  Aging Diet Cancer Studies


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