November 02, 2010
Black Raspberries Cut Colon Cancer In Mice

Fitting with my general advice to eat berries and cherries (higher in phytonutrients than the bigger fruits) black raspberries cut the incidence of colon cancer in two mouse strains.

The researchers used two strains of mice, Apc1638 and Muc2, which each have a specific gene knocked out, causing the mice to develop either intestinal tumors (in the case of Apc1638) or colitis in the case of Muc2. Colitis is an inflammation of the large intestine that can contribute to the development of colorectal cancer.

Both mouse strains were randomized to be fed either a Western-style, high-risk diet (high in fat and low in calcium and vitamin D) or the same diet supplemented with 10 percent freeze-dried black raspberry powder for 12 weeks.

The researchers found that in both mouse strains the black raspberry-supplemented diet produced a broad range of protective effects in the intestine, colon and rectum and inhibited tumor formation.

In the Apc1638 mice, tumor incidence was reduced by 45 percent and the number of tumors by 60 percent. The researchers found that black raspberries inhibited tumor development by suppressing a protein, known as beta-catenin, which binds to the APC gene.

In the Muc2 mice, tumor incidence and the number of tumors were both reduced by 50 percent, and black raspberries inhibited tumor development by reducing chronic inflammation associated with colitis.

Since colon cancer is the number 2 cancer killer of both men and women the ability to avoid it would substantially cut your risk of dying from cancer.

This report fits with a larger pattern about berries, cherries, and grapes as colon cancer risk reducers. See my previous posts Blueberries Reduce Colon Cancer Risk?, Grapes Might Reduce Colon Cancer Risk, and Purple Corn And Chokeberries Against Colon Cancer.

Share |      Randall Parker, 2010 November 02 10:15 PM  Aging Diet Cancer Studies


Comments
Tuck said at November 3, 2010 1:15 PM:

So in a nutshell, if you head away from the Modern American Diet in any direction you find yourself healthier. That Modern American Diet is quite an accomplishment.

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