Researchers at Karolinska Institutet have shown that they may be able to monitor the aging process in the brain, by using MRI technique to measure the brain lactic acid levels. Their findings suggest that the lactate levels increase in advance of other aging symptoms, and therefore could be used as an indicator of aging and age-related diseases of the CNS.
My initial reaction to the first paragraph: Geez, I hope this is an indicator of poor brain circulation and therefore low brain oxygen. That's something we could hope to delay. But no. The researchers believe the rising lactic acid is an indicator of accumulated mitochondrial gene damage. A much harder problem to avoid or fix.
In the current study, which is published in the Proceedings of the National Academy of Sciences, the researchers show that the damage to the mitochondria slowly increases with age in brains of mice and causes altered expression in certain genes that are responsible for the formation of lactate. They also show that brain lactate levels may increase in advance of other indices of aging, and can be detected using non-invasive magnetic resonance imaging techniques.
The researchers suspect MRI measurements of lactic acid will also predict brain deterioration in humans.
We need gene therapy that will deliver replacement mitochondrial genes to all the cells in the body, especially to brain cells.
Brain rejuvenation is going to be the most difficult challenge for reversing general human aging. The cells must be repaired in place rather than replaced with new organs or stem cell therapy. So brain rejuvenation requires the most advanced techniques for cell repair.
|Share |||Randall Parker, 2010 November 04 10:28 PM Aging Brain Studies|