January 31, 2011
Red Wine Polyphenols Slow Rat Blood Vessel Aging

Tell all your rat friends.

The endothelium is the inner lining of our blood vessels and normal functions of endothelial cells include enabling coagulation, platelet adhesion and immune function. Endothelial dysfunction is associated with reduced anticoagulant properties and the inability of arteries and arterioles to dilate fully.

The gradual decrease in endothelial function over time is a key factor in the development of diseases associated with ageing, especially cardiovascular disease (CVD). Many epidemiologic studies suggest protection against CVD from moderate intake of alcoholic beverages, especially those rich in antioxidants, such as red wine, which is high in polyphenols (RWPs).

This study examined whether intake of red wine polyphenols (RWPs), a rich source of natural antioxidants, prevents ageing-related impairment of vascular function and physical exercise capacity. Vascular reactivity from 12, 20 and 40 week-old rats was assessed in organ chambers. Rats received from week 16 to 40 either solvent, RWPs or the antioxidant and NADPH oxidase inhibitor, apocynin. RWPs and apocynin improved the endothelial dysfunction, normalized oxidative stress and the expression of the different proteins. RWPs also improved ageing-related decline in physical exercise. Thus, intake of RWPs protects against ageing-induced endothelial dysfunction and decline in physical performance. These effects likely involve the ability of RWPs to normalize oxidative stress and the expression of proteins involved in the formation of NO and the angiotensin II pathway.

At the risk of stating the obvious: you can get the so-called red wine polyphenols (RWPs) from dark raisins and grapes. You can get many of them from blueberries and cranberries as well as from other berries and cherries. Regular eating of berries and cherries is a good habit to add to your routine if you aren't doing it already.

If you eat candy then try replacing the candy consumption with berries instead. More reasons to do the berries: Anti-Cancer Effect Of Black Raspberries At Genetic Level, Rats On Grapes Have Better Blood Chemistry, Black Raspberries Cut Colon Cancer In Mice, and Blueberries Reduce Colon Cancer Risk?.

Share |      Randall Parker, 2011 January 31 08:04 PM  Aging Diet Heart Studies

PacRim Jim said at February 1, 2011 10:55 AM:

Humans are hell-bent on immortality.
What if there is a heaven where we are reunited with our dead parents, friends, and others?
What if we succeed in living for millions of centuries, never to rejoin them?
Just wondering (though not expecting).

Nick G said at February 1, 2011 11:59 AM:

I don't know - what if you're widowed, and you remarry? You all three get to heaven, and how do you choose between them??

What I want to know - what age are we in heaven? Are we 21? Or do we get to choose the middle-aged patriarch look we've cultivated in our 60's?

And what about dogs? Surely all dogs go to heaven. But, do other animals? Insects and mollusks have been living and dying for 100's of millions of years - will they all be in heaven??

cameron said at February 1, 2011 1:44 PM:

The number of human range brain volume neurons and possible functionally different wiring is finite. Thus the number of states is finite, and a sufficiently advanced race should given sufficient computational resources be able to instantiate all.

Further the evidence of a potential heaven, is pretty much nonexistent. If I told you my religion says if you take a bullet to the head you get 74 virgins and paradise in some lala land, would you? Of course not, it is ridiculous, the same level of evidence backs most any religion, heaven is a primitive small mind's construct a false hope often portrayed more primitive than what earth will be like a mere few decades from now.

Survive as long as possible, that's the rational path, besides true immortality is nigh impossible.

Nick G said at February 1, 2011 2:24 PM:


Sometimes humor doesn't work well on the Internet.



As far as immortality is concerned: the human genetic code is immortal. It is hundreds of millions of years old, and changes only very, very slightly from generation to generation.

My old Corolla would have been immortal with the right maintenance and part replacement - it was still running at 23 years of age, when I decided a newer car was a better value overall. There's a homeless guy who's now making a living with it delivering restaurant food. It may yet outlast most of us, though I'm going to give it a run for it's money.

PacRim Jim said at February 1, 2011 11:19 PM:

The human genetic code is not immortal. Each atom is replaced multiple time during a single lifetime. So exactly what endures?

lothario said at February 4, 2011 11:37 AM:

I have got 2 issues to deal with:

First - Wine raises my blood pressure. So if I drink more will I need to take anti-hypertensive?
Second - We have a bigger problem in Hinduism. According to the clerics, I am coming back again. I know I am coming back as an artichoke because I have been very bad in this life. Good deeds minus bad deeds = after life determinant. Its an accounting problem for us not an alcohol problem. I can drink all the freaking booze I want and come back as manatee. So prolonging my life means zip to me.

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