August 26, 2011
Peptide Paint Reverses Tooth Decay

Got a cavity on a tooth? No problem. Just paint on a special peptide solution and the tooth will repair itself. (a peptide is chain of amino acids)

It's a vicious cycle, but one that can be broken, according to researchers at the University of Leeds who have developed a revolutionary new way to treat the first signs of tooth decay. Their solution is to arm dentists with a peptide-based fluid that is literally painted onto the tooth's surface. The peptide technology is based on knowledge of how the tooth forms in the first place and stimulates regeneration of the tooth defect.

It is amazing that the solution to tooth decay can be this simple.

"This may sound too good to be true, but we are essentially helping acid-damaged teeth to regenerate themselves. It is a totally natural non-surgical repair process and is entirely pain-free too," said Professor Jennifer Kirkham, from the University of Leeds Dental Institute, who has led development of the new technique.

The 'magic' fluid was designed by researchers in the University of Leeds' School of Chemistry, led by Dr Amalia Aggeli. It contains a peptide known as P 11-4 that - under certain conditions - will assemble together into fibres. In practice, this means that when applied to the tooth, the fluid seeps into the micro-pores caused by acid attack and then spontaneously forms a gel. This gel then provides a 'scaffold' or framework that attracts calcium and regenerates the tooth's mineral from within, providing a natural and pain-free repair.

On a small group of people the peptide reversed decay from dental caries.

The technique was recently taken out of the laboratory and tested on a small group of adults whose dentist had spotted the initial signs of tooth decay. The results from this small trial have shown that P 11-4 can indeed reverse the damage and regenerate the tooth tissue.

"The results of our tests so far are extremely promising," said Professor Paul Brunton, who is overseeing the patient testing at the University of Leeds Dental Institute. "If these results can be repeated on a larger patient group, then I have no doubt whatsoever that in two to three years time this technique will be available for dentists to use in their daily practice."

Can this peptide be used for tooth rejuvenation? Will it improve worn teeth that have grooves and other signs of wear? It might make sense as a periodic treatment to slow or possibly reverse tooth aging.

Share |      Randall Parker, 2011 August 26 10:58 AM  Biotech Teeth And Gums

Mthson said at August 26, 2011 2:26 PM:

How about creating mouth bacteria strains that don't eat teeth and that outcompete the strains that do eat teeth?

Brushing and flossing is a time drain, particularly if you do at after most meals.

Abelard Lindsey said at August 26, 2011 7:24 PM:

When will this peptide be available from the Chinese suppliers on

I found Resveratrol for the first time on

Lono said at August 27, 2011 7:44 AM:


This is excellent news - I grind my teeth unfortunately while sleeping and I would imagine this would restore some of their strength.

We are getting closer and closer to real sustainable body rejuvination - glad I'm not a smoker - I may just live to see this play out.

PacRim Jim said at August 27, 2011 12:10 PM:


I recommend caution with Chinese-made products purchased over the Web, unless you particularly like benzene, lead, and other contaminants in your supplements.

Kukui23 said at August 27, 2011 12:12 PM:

@Mthson - Bacteria don't eat teeth, their waste products, acids, do.

Mthson said at August 27, 2011 2:37 PM:

Kukui23, thanks for the correction. Still, it seems doable with current technology to change the bacteria strains in our mouths into a less damaging form.

Dave said at August 27, 2011 10:52 PM:

where can you get this "peptide"?

Abelard Lindsey said at August 27, 2011 10:53 PM:

Perhaps there is a recipe to make this peptide.

roy said at August 29, 2011 9:33 AM:

@Mthson - this may interest you:

Bacteria Enlisted for New Trials on Dental Health

Jim said at August 29, 2011 1:26 PM:

Mthson, I remember this story from several years back. Note the promise: :)

"Mr. Soponis of Oragenics said that if all goes well with this safety trial and future trials on effectiveness, the treatment could reach the market by 2009 or 2010.?

cghj said at September 11, 2011 7:00 AM:

According to Froogle "P11-4" is a 'bamboo pot' or a Porsche Carburetor. Which do I stick in my mouth first?

Randall Parker said at September 11, 2011 6:16 PM:


Great investigation. If the bamboo pot is made out of bamboo then I'd chew that. Otherwise, you could get the Porsche Carburetor ground up into fine metal dust and eat a portion of it every day. Perhaps it will coat your teeth and make them iron-coated. You'd gain a wicked bite if nothing else.

Dave said at April 10, 2012 5:19 PM:

Does peptide 11-4 occur naturally in foods or other substances?

housemaid said at September 28, 2016 9:09 PM:

I remember reading about how they would have a tooth decay preventing vaccine soon back when I was a child 60 years ago! When you read these articles, it's always "soon, 2 or 3 years". Well, here it is 2016 and I'm not seeing this peptide paint at my dentist's office. No, it's still the old drill and fill. I don't expect to ever see this peptide paint because it would put dentists out of business. No more fillings, root canals, crowns, implants? No, they won't let that happen.

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