January 16, 2012
Ultra Short Telomeres With Osteoarthritis

Every time most cells divide their telomere chromosome caps get shorter. When the telomere caps get very short cellular division is inhibited. Cells that can't divide can not repair damaged tissue. It is not a coincidence that cells around damaged arthritic joints have short telomeres.

Telomeres, the very ends of chromosomes, become shorter as we age. When a cell divides it first duplicates its DNA and, because the DNA replication machinery fails to get all the way to the end, with each successive cell division a little bit more is missed. New research published in BioMed Central's open access journal Arthritis Research & Therapy shows that cells from osteoarthritic knees have abnormally shortened telomeres and that the percentage of cells with ultra short telomeres increases the closer to the damaged region within the joint.

While the shortening of telomeres is an unavoidable side effect of getting older, telomeres can also shorten as a result of sudden cell damage, including oxidative damage. Abnormally short telomeres have been found in some types of cancer, possibly because of the rapid cell division the cells are forced to undergo.

The question: are the short telomeres a result of osteoarthritis? Or are the short telomeres a cause of osteoarthritis? Does the inflammation associated with osteoarthritis accelerate cell division and thereby cause short telomeres? Or do joints wear down and become osteoarthritic once few cells remain that can do repairs on them?

A Danish team developed a better assay to measure telomere length. Better assays speed up scientific discovery.

There has been some evidence from preliminary work done on cultured cells that the average telomere length is also reduced in osteoarthritis (OA). A team of researchers from Denmark used newly developed technology (Universal single telomere length assay) to look in detail at the telomeres of cells taken from the knees of people who had undergone joint replacement surgery. Their results showed that average telomere length was, as expected, shortened in OA, but that also 'ultra short' telomeres, thought to be due to oxidative stress, were even more strongly associated with OA.

Maria Harbo who led this research explained, "We see both a reduced mean telomere length and an increase in the number of cells with ultra short telomeres associated with increased severity of OA, proximity to the most damaged section of the joint, and with senescence. Senescence can be most simply explained as biological aging and senescent cartilage within joints is unable to repair itself properly."

Cartilage damage and telomere shortening are both contributing to the development of osteoarthritis.

She continued, "The telomere story shows us that there are, in theory, two processes going on in OA. Age-related shortening of telomeres, which leads to the inability of cells to continue dividing and so to cell senescence, and ultra short telomeres, probably caused by compression stress during use, which lead to senescence and failure of the joint to repair itself. We believe the second situation to be the most important in OA. The damaged cartilage could add to the mechanical stress within the joint and so cause a feedback cycle driving the progression of the disease."

Lots of researchers investigate a large assortment of diseases of old age. But many of these diseases have a common cause: loss of ability of the body to do repairs. So while the diseases manifest in different ways with different symptoms they could be reversed with a common strategy: restore the body's ability to do repairs on itself. Cell therapies to deliver youthful cells are a key part of a larger strategy to reverse the aging process and repair aged tissues.

Share |      Randall Parker, 2012 January 16 10:07 PM  Aging Mechanisms

Mark said at January 17, 2012 3:57 PM:

There's a theory of aging that preventing telomeres from shortening will slow aging and improve health. There have been several things that have been found to keep telomeres from shortening: fish oil, carnosine, vitamin D, curcumin, antioxidant vitamins like C and E, green tea and exercise. Much more research needs to be done in this area but it would probably be very helpful to incorporate these into your health regimen and to keep track of further research in this area.

Pam said at February 23, 2012 3:42 PM:

If you're looking for a product that supports healthy telomeres go to www.pamreich.isagenix.com and look at Product B Antioxidants Plus Telomere Support.

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