May 17, 2012
DHA Cancels Harmful Sugar Effects On Rat Brains

Smarter rats eat fish.

Attention, college students cramming between midterms and finals: Binging on soda and sweets for as little as six weeks may make you stupid.

A new UCLA rat study is the first to show how a diet steadily high in fructose slows the brain, hampering memory and learning and how omega-3 fatty acids can counteract the disruption. The peer-reviewed Journal of Physiology publishes the findings in its May 15 edition.

"Our findings illustrate that what you eat affects how you think," said Fernando Gomez-Pinilla, a professor of neurosurgery at the David Geffen School of Medicine at UCLA and a professor of integrative biology and physiology in the UCLA College of Letters and Science. "Eating a high-fructose diet over the long term alters your brain's ability to learn and remember information. But adding omega-3 fatty acids to your meals can help minimize the damage."

While earlier research has revealed how fructose harms the body through its role in diabetes, obesity and fatty liver, this study is the first to uncover how the sweetener influences the brain.

High-fructose corn syrup makes rats dumber.

The UCLA team zeroed in on high-fructose corn syrup, an inexpensive liquid six times sweeter than cane sugar, that is commonly added to processed foods, including soft drinks, condiments, applesauce and baby food. The average American consumes more than 40 pounds of high-fructose corn syrup per year, according to the U.S. Department of Agriculture.

"We're not talking about naturally occurring fructose in fruits, which also contain important antioxidants," explained Gomez-Pinilla, who is also a member of UCLA's Brain Research Institute and Brain Injury Research Center. "We're concerned about high-fructose corn syrup that is added to manufactured food products as a sweetener and preservative."

I eat a lot of berries,cherries, and dark grapes. They've got lots of antioxidants along with the fructose.

Gomez-Pinilla and study co-author Rahul Agrawal, a UCLA visiting postdoctoral fellow from India, studied two groups of rats that each consumed a fructose solution as drinking water for six weeks. The second group also received omega-3 fatty acids in the form of flaxseed oil and docosahexaenoic acid (DHA), which protects against damage to the synapses the chemical connections between brain cells that enable memory and learning.

"DHA is essential for synaptic function brain cells' ability to transmit signals to one another," Gomez-Pinilla said. "This is the mechanism that makes learning and memory possible. Our bodies can't produce enough DHA, so it must be supplemented through our diet."

One gram of DHA per day.

Still planning to throw caution to the wind and indulge in a hot-fudge sundae? Then also eat foods rich in omega-3 fatty acids, like salmon, walnuts and flaxseeds, or take a daily DHA capsule. Gomez-Pinilla recommends one gram of DHA per day.

This is a useful reminder to get on daily DHA.

Share |      Randall Parker, 2012 May 17 10:02 PM  Aging Diet Brain Studies

Empiricist said at May 18, 2012 6:44 AM:

This isn't cause for concern in terms of eating fruit, even though it's got fructose. researchers use fructose as an easy way to load up with sugar. The fructose in fruits is not high enough to be of concern but the fructose in, say, soda, is certainly high enough to be a problem.

It's really interesting that it makes you dumber. maybe that's because it encourages sugar dependence?

Brett Bellmore said at May 19, 2012 5:26 AM:

Hm, how long until "energy drinks" start incorporating DHA?

Peter McCluskey said at May 19, 2012 9:48 PM:

Walnuts have a lousy ratio of omega-6 to omega-3, so it's risky to treat them as if they resembled flax or salmon.

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