June 24, 2012
Testosterone Replacement Causes Big Weight Loss

Big weight loss from testosterone replacement in testosterone-deficient men.

In testosterone-deficient men, major weight loss was an added benefit of testosterone replacement therapy for most of the patients who participated in a new study. The results will be presented Saturday at The Endocrine Society's 94th Annual Meeting in Houston.

"The substantial weight loss found in our study—an average of 36 pounds—was a surprise," said the study's lead author, Farid Saad, PhD, of Berlin-headquartered Bayer Pharma.

Although prior studies using testosterone therapy in testosterone-deficient men consistently show changes in body composition, such as increased lean mass and decreased fat mass, Saad said the net effect on weight seemed unchanged in those studies. However, Saad said their study, which took place in Germany, had a longer follow-up by at least two years and used long-acting injections of testosterone.

Also, testosterone decline is very often due to obesity and depression. So then weight gain and testosterone decline seem like a vicious cycle.

A new study finds that a drop in testosterone levels over time is more likely to result from a man's behavioral and health changes than by aging. The study results will be presented Monday at The Endocrine Society's 94th Annual Meeting in Houston.

"Declining testosterone levels are not an inevitable part of the aging process, as many people think," said study co-author Gary Wittert, MD, professor of medicine at the University of Adelaide in Adelaide, Australia. "Testosterone changes are largely explained by smoking behavior and changes in health status, particularly obesity and depression."

More sex will boost male testosterone levels. Sated lust is good for health.

Share |      Randall Parker, 2012 June 24 09:07 PM  Aging Treatment Studies

Brett Bellmore said at June 26, 2012 4:05 AM:

OTOH, per my experience, it doesn't work very well if your doctor's goal is to just get you up to the lower end of the "normal" range for your age. While the difference between essentially no testosterone, and just barely high enough to not be considered shockingly low, makes some difference, it certainly hasn't made 36 pounds of difference.

Got to find a better doctor, I guess.

_gms_ said at June 26, 2012 12:32 PM:

Testosterone replacement is at best a short term measure b/c the body uses a negative feedback loop.

Increased testosterone serum levels (what one gets from 'replacement' or supplementation) signal the hypothalamus and pituitary glands to essentially clamp down on the body's production of testosterone precursors. This in turn may trigger atrophy of the testes, since the the number of testosterone producing cells decreases over time. See https://en.wikipedia.org/wiki/Testosterone#Regulation for a high level explanation of the process.

Increasing the supplementation amount of would make things worse. It's tricky, since supplementation works great initially, but over time most people that are supplementing find out it's not working as good.

Brett Bellmore said at June 26, 2012 2:34 PM:

When you're running to 40ng/ml of free testosterone, negative feedback loops are not any great concern. But if you're suggesting that a way of up-regulating the body's own production would be preferable to supplementation, I would heartily agree. Got one?

_gms_ said at June 26, 2012 3:40 PM:

IANAD, but perhaps an approach similar to what's described at http://chriskresser.com/episode-14-andropause-a-k-a-manopause-male-menopause may be useful.

It seems logical to 1) try to quantify the source of the problem, as opposed to symptoms, and 2) see if the root cause can be addressed. My personal take is that #1 may make more sense before attempting to up-regulate the body's own production.

Hope this helps.

Darren said at June 27, 2012 10:33 AM:

What Brett said.

The day I started TRT 7 years ago, I was already negative feedbacked by my own health problems to almost no Test. The replacement therapy makes all the difference in the world to my quality of life.

Richard said at June 28, 2012 10:10 PM:

Same here. 20 years ago I was diagnosed with very low testosterone, the primary symptom in my case was osteopenia, low bone density, but not yet to the point of oteoporosis but close. My endocrinologist place me on a daily regimen of testosterone gel, but while the standard dose wasn't adequate for increasing bone density over a two year period, and my weight was still going up, and ki was not improving my clinical depression (I though I was just a serious person). We doubled the dose and six months later I lost 70 lbs., my BMI had gone from 38 to to 17, and I had as much energy as most men 10 years younger. My work focus improved dramatically, started earning
raises and promotions, and my sexual desire was much stronger (eventually leading to a divorce from a woman who just has little to no desire, for me anyway. I'm happy, outgoing, and have a great lady friend who loves me and keeps me satisfied as if we were in our 20s. My cardiologist was freaked out my by numbers, but he felt that the dramatic improvement in my quality of life was well worth the risk. I can't thank the doctor who first discovered my deficiency and took the initiative to do something about it. Previous doctors just said it was a normal part of aging, but I knew something was wrong. Now wall know!

Praetorian said at June 29, 2012 9:37 AM:

" But if you're suggesting that a way of up-regulating the body's own production would be preferable to supplementation, I would heartily agree. Got one?"

Dead lifts and squats.

Phelps said at June 29, 2012 11:53 AM:

Praetorian is party right. Muscle building is part of the positive feedback loop. Don't worry about cardio. Exercise bikes aren't for men. Weights are. You will get enough cardio from a real lifting program. (I recommend Stronglifts. It's fast, simple, and it works.) Another part is diet. Stop eating like a woman. Saturated fats and cholesterol promote testosterone production. The last part is psychological. Your moods effect your hormone production, and testosterone is a hormone. Nothing boosts testosterone like winning. Find a competition -- some sort of competitive hobby -- and work at it until you start winning at it. Winning boosts testosterone and losing dampens it.

On top of it all, it feeds on each other. The diet helps you build muscle. Building muscle builds confidence, which makes winning easier. When you are winning, you start building muscle faster, you are hungrier... on and on.

Brett Bellmore said at June 30, 2012 5:42 AM:

"Dead lifts and squats."

Ho, ho, ho. Want to know how I found out I had low testosterone? After following the Tony Horton 10 minute workout for three months, I went to my doctor with chest pains: Turned out I'd strained my pectoral muscle doing a pushup. Thought I was ready to do them from the foot instead of the knees, and was wrong. After three months of intensive exercise, I still couldn't do normal pushups without injury. I wasn't one bit stronger than when I started, I'd just finally gained enough determination to push it to the point of injury. (Though I did lose a bit of weight.)

Your advice is probably good for men with marginal testosterone levels; Lose weight, work out, have hot sex, and you'll get back up to normal levels. For those of us with vanishingly low testosterone, heavy exercise just wears the muscle down, because there's not enough tet in the system to get any anabolic effect from exercise. For us it's supplementation, or nothing.

Mthson said at June 30, 2012 6:59 AM:

Our biologies certainly fall along a bell curve, but even biological females can increase their aggressiveness if that's a cause they believe in.

Our minds get nudged by signals in our environment, and our biology responds. Surround yourself with the right kind of images. You should identify with one of these animals more than the other.

The animals who parasite society and make it unsafe for women to ride public transit have no qualms with that, so neither should we. You're doing the world a favor.

andew symon said at July 25, 2012 8:55 AM:

Leading testosterone and men’s health portal manupabouthealth.com was launched in the summer 2012 to help educate men and fill the gaps by the lack of information relating to men’s health issues.

Steve said at September 14, 2013 12:26 PM:

I do not take to the belief of doctors out there that age alone makes testosterone levels drop. The majority of men gain weight as they get older, therefore testosterone levels drop. MDs look at that and somehow make a connection between age and testosterone,but there is really a connection between age and weight ( a connection that is preventable for most men) You can actually lose weight as you get older, and be healthier and live longer as a result. You can raise your testosterone levels, lessen the effects of diabetes or prevent it altogether, lower your BP, lower your Triglycerides and LDL, make every organ in your body healthier, including skin and even in the brain (because you will prevent strokes.)

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