November 17, 2012
Need For High Vitamin D Depends On Genetic Variants

Nutrigenomics research is starting to produce useful results.

The researchers found a SNP within the vitamin D receptor (VDR) gene that significantly modified associations of low serum 25-hydroxyvitamin D concentration with major health outcomes of hip fracture, heart attack, cancer, and death over long-term follow-up. "Findings were observed within a large community-based study of older adults in the United States and were consistent in magnitude and direction across individual disease outcomes, and replicated in a meta-analysis of 3 large independent cohorts. An additional vitamin D receptor SNP significantly modified the low 25-hydroxyvitamin D-disease association in a meta-analysis that included results from the discovery and replication cohorts. The discovered SNPs, which are common in European populations, identified subsets of individuals for whom associations between low 25-hydroxyvitamin D concentration and disease outcomes were either strongly positive vs. null. These results suggest that individuals with specific 25-hydroxyvitamin D metabolism genotypes maybe particularly susceptible to, or protected from, the potential adverse health effects of low vitamin D."

One way to think of research into the relationship between nutritional needs, genetics, and health: The results tell us who can be irresponsible about their diets and lifestyles and how.

My guess is the results will likely to also be useful to identify undiagnosed food intolerances as well as information about optimal ratios between nutrients. The optimal ratios between protein, carbohydrates, and fats likely depend on as yet undiscovered genetic variants.

Share |      Randall Parker, 2012 November 17 06:09 PM 

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