A very large number of very useful genetic discoveries are awaiting sequencing technology cheap enough to enable a huge increase in the amount of DNA sequencing that scientists can do. Well, the $1000 genome has finally arrived.
SAN DIEGO--(BUSINESS WIRE)--Jan. 14, 2014-- Illumina, Inc.(NASDAQ:ILMN) today broke the ‘sound barrier’ of human genomics by enabling the $1,000genome. This achievement is made possible by the new HiSeq X Ten Sequencing System. This platform includes dramatic technology breakthroughs that enable researchers to undertake studies of unprecedented scale by providing the throughput to sequence tens of thousands of human whole genomes in a single year in a single lab. Initial customers for the transformative HiSeq X Ten System include Macrogen, a global next-generation sequencing service organization based in Seoul, South Koreaand its CLIA laboratory in Rockville, Maryland, the Broad Institutein Cambridge, Massachusetts, the world’s leading research institute in genomic medicine, and the Garvan Institute of Medical Research in Sydney, Australia, a world leader in biomedical research.
Sign me up. I want to get my full genome sequenced.
I like the sound of this: "we have an opportunity to learn as much about the genetics of human disease as we have learned in the history of medicine."
“For the first time, it looks like it will be possible to deliver the $1,000 genome, which is tremendously exciting,” said Eric Lander, founding director of the Broad Institute and a professor of biology at MIT. “The HiSeq X Ten should give us the ability to analyze complete genomic information from huge sample populations. Over the next few years, we have an opportunity to learn as much about the genetics of human disease as we have learned in the history of medicine.”
What I'm hoping for: these genetic engineering machines will get installed in some countries without of the US FDA attitude about direct-to-consumer genetic testing. Preferred: a country that has good vacation spots. Go on vacation, come back with a full genome sequence.
The US FDA has shut down 23andme's ability to sell services that give you digested genetic variant interpretation, at least in the US. If 23andme or another company could sell you genetic interpretation services while are in, say Bermuda or Mexico or Australia (or Taiwan, Hong Kong, Singapore, or Ukraine) we could go on vacation trips and find out useful information about our genomes.
If any readers ever come across genetic full genome testing services outside of the United States for affordable countries please let us all know. I'd like to be able to pay while abroad to get a stream of years of genetic interpretation updates by email.
We will know about impacts of hundreds and possibly thousands of more genetic variants in the next few years.
Another big benefit: identification of many mutations that help cancers grow. Anyone getting diagnosed with cancer will likely get tested for dozens or hundreds of mutations to see which ones are in that cancer. Since cancers are genetically very heterogeneous (different cancer cells have different mutations) many different cells extracted from different parts of a tumor will get tested. This will allow targeting of treatments at the specific mutations one has.
Starting in late 2007 the cost of genome sequencing started falling much more rapidly than the previous historical trend. Check out this trend line:
|Share |||Randall Parker, 2014 January 18 08:37 PM|