June 20, 2015
Periodic Partial Fasting Cuts Biomarkers For Aging

First the researchers tried calorie reduction in old mice with promising results

In a new study, Longo and his colleagues show that cycles of a four-day low-calorie diet that mimics fasting (FMD) cut visceral belly fat and elevated the number of progenitor and stem cells in several organs of old mice -- including the brain, where it boosted neural regeneration and improved learning and memory.

Then the researchers did a similar low calorie regime for 5 days a month for 3 months with good effects on biomarkers for aging.

In a pilot human trial, three cycles of a similar diet given to 19 subjects once a month for five days decreased risk factors and biomarkers for aging, diabetes, cardiovascular disease and cancer with no major adverse side effects, according to Longo. 'Strict fasting is hard for people to stick to, and it can also be dangerous, so we developed a complex diet that triggers the same effects in the body,' said Longo, Edna M. Jones professor of biogerontology at the USC Davis School of Gerontology and director of the USC Longevity Institute. Longo has a joint appointment at the USC Dornsife College of Letters, Arts and Sciences. 'I've personally tried both, and the fasting mimicking diet is a lot easier and also a lot safer.'

This beats long term calorie restriction. Could you cut your calories by a third or a half for 5 days a month?

The diet slashed the individual's caloric intake down to 34 to 54 percent of normal, with a specific composition of proteins, carbohydrates, fats and micronutrients. It decreased amounts of the hormone IGF-I, which is required during development to grow, but it is a promoter of aging and has been linked to cancer susceptibility. It also increased the amount of the hormone IGFBP-, and reduced biomarkers/risk factors linked to diabetes and cardiovascular disease, including glucose, trunk fat and C-reactive protein without negatively affecting muscle and bone mass.

Seems like it could help.

Share |      Randall Parker, 2015 June 20 04:35 PM 

Brett Bellmore said at June 20, 2015 6:56 PM:

Ok, THAT I could do. If they'd just say what the diet was.

shiva1008 said at June 21, 2015 1:31 AM:

I do something like this. If you restrict all the time then your metabolism just slows down. So bodybuilders alternate between low caloric and high caloric periods every few days.

OT: http://www.infowars.com/robot-grocery-store-gives-high-tech-upgrade-to-food-shopping/

This seems like a pretty major innovation.

Randall Parker said at June 21, 2015 8:46 PM:


I just did a post with that link about robot stores. Thanks. As I say in the post, I think this is a lot easier to do if you chooe to stock foods that are easy to dispense. Use container shapes that are easy to scan, pick up, send down a chute, put in a bag.

Would many people use such a store? Granted, it is useful for when other stores are closed. But how to make it sufficiently appealing the rest of the time? I think speed is the need. Make it so people can order before they get there, roll up with their phone, click to announce their presence, and quickly get (already prepared) bags pushed out to them with their food or other goods.

The same approach could be followed with automated fast food places. Roll up after you've previously placed your order and get immediate food.

shiva1008 said at July 5, 2015 5:48 AM:

Honestly, I know I'm not the be all and the end all but, most likely these would appear in more low-class "food desert" type of places. And personally, I wouldn't want to partake of such food. Whether one has means or not, it's always better to partake of fresh macrobiotic foods rather than petro-"products". And I'm pretty sure the elites will want to stick to their macrobiotic food sources. But, I do see it as an innovation in the sense that, in 20 years people will look at back and say "omg, they didn't used to have those back then?"

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