October 24, 2015
Enzyme Inhibitors Might Reverse Male Pattern Baldness
So far the drugs have only been tested on a different cause of baldness.
NEW YORK, NY (October 23, 2015) --Inhibiting a family of enzymes inside hair follicles that are suspended in a resting state restores hair growth, a new study from researchers at Columbia University Medical Center has found. The research was published today in the online edition of Science Advances.
In experiments with mouse and human hair follicles, Angela M. Christiano, PhD, and colleagues found that drugs that inhibit the Janus kinase (JAK) family of enzymes promote rapid and robust hair growth when directly applied to the skin.
These drugs, tofacitinib and tofacitinib, are already FDA approved for other purposes.
The study raises the possibility that drugs known as JAK inhibitors could be used to restore hair growth in multiple forms of hair loss such as that induced by male pattern baldness, and additional types that occur when hair follicles are trapped in a resting state. Two JAK inhibitors have been approved by the U.S. Food and Drug Administration. One is approved for treatment of blood diseases (ruxolitinib) and the other for rheumatoid arthritis (tofacitinib). Both are being tested in clinical trials for the treatment of plaque psoriasis and alopecia areata, an autoimmune disease that causes hair loss.
A medical doctor or pharmacist could try one of these drugs on their own scalp.
Randall Parker, 2015 October 24 05:58 PM
I doubt these drugs could even work for male pattern baldness. Alopecia areata is an autoimmune disease, like Rheumatoid Arthritis and Psoriasis and that's why these drugs can help regrow hair in these cases. I have alopecia universalis, the most severe form of alopecia areata. I don't have any hair on my body, including eyelashes. It also affects my nails. My mom sent me information about the case study that led to these clinical trials a while back. I'm not really that encouraged by it. These drugs, besides being very expensive as another poster mentioned, are immunosuppressants. This is not an unintended side effect, but how they work. If I had Rheumatoid Arthritis, I would consider the benefits worth the risks, but for alopecia I don't.
Don't your eyes itch a lot? When I lost all my body hair during chemo, that was an annoying consequence of not having eyebrows or lashes. Stuff kept getting in my eyes.
Personally, I've got male pattern baldness, which certainly isn't an auto-immune disease. But the only way I'd take anything for it is if it was amazingly cheap, or had positive side effects. It's just a cosmetic thing, after all.
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