November 14, 2015
Anti-Alzheimer's Drug Slows General Mouse Aging

Anti-plaque drugs did not work to block Alzheimer's disease development. So Salk Institute researchers decided to screen for drugs that reduce aging. They found a drug that seems slow the aging process in mice.

LA JOLLA--Salk Institute researchers have found that an experimental drug candidate aimed at combating Alzheimer's disease has a host of unexpected anti-aging effects in animals.

...

When these mice were treated with J147, they had better memory and cognition, healthier blood vessels in the brain and other improved physiological features, as detailed November 12, 2015 in the journal Aging.

The process of aging causes many degenerative diseases. So it makes sense to try to slow aging as a way to prevent the diseases of old age.

Several years ago, Schubert and his colleagues began to approach the treatment of the disease from a new angle. Rather than target amyloid, the lab decided to zero in on the major risk factor for the disease--old age. Using cell-based screens against old age-associated brain toxicities, they synthesized J147.

What's amazing: they found a drug that works. The researchers used a breed of mice that ages more rapidly. This breed aged more slowly while fed the experimental drug J147.

The team wanted to explore the effects of the drug candidate on a breed of mice that age rapidly and experience a version of dementia that more closely resembles the age-related human disorder.

In this latest work, the researchers used a comprehensive set of assays to measure the expression of all genes in the brain, as well as over 500 small molecules involved with metabolism in the brains and blood of three groups of the rapidly aging mice. The three groups of rapidly aging mice included one set that was young, one set that was old and one set that was old but fed J147 as they aged.

The old mice that received J147 performed better on memory and other tests for cognition and also displayed more robust motor movements. The mice treated with J147 also had fewer pathological signs of Alzheimer's in their brains. Importantly, because of the large amount of data collected on the three groups of mice, it was possible to demonstrate that many aspects of gene expression and metabolism in the old mice fed J147 were very similar to those of the young animals. These included markers for increased energy metabolism, reduced brain inflammation and reduced levels of oxidized fatty acids in the brain.

Another notable effect was that J147 prevented the leakage of blood from the microvessels in the brains of old mice. "Damaged blood vessels are a common feature of aging in general, and in Alzheimer's, it is frequently much worse," says Currais.

Can a drug developed with this approach help humans? I'd take it if it did.

Share |      Randall Parker, 2015 November 14 07:22 PM 


Comments
Wolf-Dog said at November 14, 2015 10:43 PM:

The articles say that the J147 drug is derived from curcumin, which is entirely natural and without side effects. Curcumin is already known to be helpful for Alzheimer's Disease and other cognitive problems, but apparently it was not as helpful as they originally hoped. Curcumin only clears the amyloid plaque, but more recently the so-called "tau" and other things are also shown to be part of Alzeheimer's Disease, and so the curcumin tablets are not as effective as the researchers thought. However, curcumin is a VERY effective anti-inflammatory compound, and it has many other health benefits, including mental clarity.

Curcumin is basically an Indian spice, and it is harmless, but because 99 % of curcumin does not get absorbed by the intestines, expensive mixtures are prepared to make it absorbed properly.

Two of the most successful (well absorbed) curcumin preparations are:

1) Longvida (a nano fat-soluble version of curcumin that gets absorbed well):
http://longvida.com/
Purchase from here:
http://www.phytosensia.com/Longvida-Capsules-and-Powder.html
or from here:
http://www.amazon.com/Curcumin-LongvidaTM-Nutrivene-500-capsules/dp/B003D0A8Q0/

2) Theracurmin (this is the Japanese formulation of curcumin that is water soluble and well absorbed):
http://www.amazon.com/Natural-Factors-Curcuminrich-Turmeric-Extract/dp/B00GHC2FL2/

Both 1) and 2) versions above are used in clinical trials, but for some reason the Theracurmin was favored more in some clinical trials because this version is said to be more stable in blood. However, the fat soluble Longvida might be better to cross the blood-brain barrier. I feel that in my case, taking simultaneously both 1) Longvida and 2) Theracurmin is best.

But tablets above (Longvida or Theracurmin) are best taken on an empty stomach, for good absorption, twice a day.

Separately,the articles about the J147 drug say that it is also very save an non-toxic, just like the parent compound Curcumin it is derived from. And the articles also say that J147 has many anti-aging benefits outside cognition. Probably anything curcumin is good, and as soon as it becomes available as a prescription drug, most likely over the counter versions might also be sold separately.

Wolf-Dog said at November 14, 2015 10:53 PM:

The articles say that the J147 drug is derived from curcumin, which is entirely natural and without side effects. Curcumin is already known to be helpful for Alzheimer's Disease and other cognitive problems, but apparently it was not as helpful as they originally hoped. Curcumin only clears the amyloid plaque, but more recently the so-called "tau" and other things are also shown to be part of Alzeheimer's Disease, and so the curcumin tablets are not as effective as the researchers thought. However, curcumin is a VERY effective anti-inflammatory compound, and it has many other health benefits, including mental clarity.

Curcumin is basically an Indian spice, and it is harmless, but because 99 % of curcumin does not get absorbed by the intestines, expensive mixtures are prepared to make it absorbed properly.

Two of the most successful (well absorbed) curcumin preparations are:

1) Longvida (a nano fat-soluble version of curcumin that gets absorbed well):
http://longvida.com/
Purchase from here:
http://www.phytosensia.com/Longvida-Capsules-and-Powder.html
or from here:
http://www.amazon.com/Curcumin-LongvidaTM-Nutrivene-500-capsules/dp/B003D0A8Q0/

2) Theracurmin (this is the Japanese formulation of curcumin that is water soluble and well absorbed):
http://www.amazon.com/Natural-Factors-Curcuminrich-Turmeric-Extract/dp/B00GHC2FL2/

Both 1) and 2) versions above are used in clinical trials, but for some reason the Theracurmin was favored more in some clinical trials because this version is said to be more stable in blood. However, the fat soluble Longvida might be better to cross the blood-brain barrier. I feel that in my case, taking simultaneously both 1) Longvida and 2) Theracurmin is best.

But tablets above (Longvida or Theracurmin) are best taken on an empty stomach, for good absorption, twice a day.

Separately,the articles about the J147 drug say that it is also very save an non-toxic, just like the parent compound Curcumin it is derived from. And the articles also say that J147 has many anti-aging benefits outside cognition. Probably anything curcumin is good, and as soon as it becomes available as a prescription drug, most likely over the counter versions might also be sold separately.

MIke said at November 15, 2015 9:49 AM:

Would be interesting to find out what the equivalent human doing would be.

Wolf-Dog said at November 15, 2015 10:32 AM:

The articles say that the J147 drug is derived from curcumin, which is entirely natural and without side effects. Curcumin is already known to be helpful for Alzheimer's Disease and other cognitive problems, but apparently it was not as helpful as they originally hoped. Curcumin only clears the amyloid plaque, but more recently the so-called "tau" and other things are also shown to be part of Alzeheimer's Disease, and so the curcumin tablets are not as effective as the researchers thought. However, curcumin is a VERY effective anti-inflammatory compound, and it has many other health benefits, including mental clarity.
Curcumin is basically an Indian spice, and it is harmless, but because 99 % of curcumin does not get absorbed by the intestines, expensive mixtures are prepared to make it absorbed properly.
Two of the most successful (well absorbed) curcumin preparations are:

1) Longvida (a nano fat-soluble version of curcumin that gets absorbed well). You can purchase these capsules from the website of Longvida where the retailers are listed, or from Amazon. There has been some clinical trials for Longvida, and it is a good anti-inflammatory formulation that also increases cognition, even though it may not be enough for Alzheimer's disease since it only removes the amyloid plaque without dealing with tau and other things that also go wrong.

2) Theracurmin (this is the Japanese formulation of curcumin that is water soluble and well absorbed). You can purchase these capsules from Amazon(double strength version of Natural Factors brand might be cheaper than rivals, gram per gram). It seems that 6 capsules from the double strength version of Natural Factors brand, might be approximately the amount that some clinical trials have been using, 3 tablets in the morning and 3 tablets in the afternoon, as far as the trials for Theracurmin are concerned.

Both 1) and 2) versions above are used in clinical trials. But in one of these trials the Theracurmin was favored more because this version is said to be more stable in blood. However, the fat soluble Longvida might be better to cross the blood-brain barrier. I feel that in my case, taking simultaneously both 1) Longvida and 2) Theracurmin is best, although both formulations significantly improve my cognition.

But the tablets above (Longvida or Theracurmin) are best taken on an empty stomach, for good absorption, twice a day.

Separately, the articles about the J147 drug say that it is also very safe an non-toxic, just like the parent natural compound Curcumin that it is derived from. And the articles also say that J147 has many anti-aging benefits outside cognition. Apparently anything curcumin is good, and as soon as the J147 formualtion becomes available as a prescription drug, most likely over the counter versions might also be sold separately.

alan2102 said at November 16, 2015 10:06 AM:

Hello, Randal.
How come there is no "older posts" link on your main page?
In order to get to older posts, one must find, and then go to,
the archive page. It would be nice to have a direct link off the
main page.
Thanks!
Alan

gejala stroke said at August 29, 2016 8:56 PM:

gejala stroke ringan dan cara menanganinya secara alami harus diperhatikan selalu secara serius , karena saat ini kasus penyakit stroke banyak terjadi dikalangan masyarakat dari mulai stroke ringan hingga stroke berat.
Meski yang dialami masih gejala stroke ringan tapi penanganannya harus secara tepat karena bisa berakibat fatal jika tidak diatasi dengan obat stroke yang ampuh. Sebelum kita membahas lebih lanjut mengenai pengobatan stroke, maka kita harus mempelajari dulu tentang apa itu penyakit stroke, penyebab penyakit stroke, gejala stroke,
serta bahaya apa yang bisa muncul? Setelah itu baru kita bisa memilih obat stroke yang tepat yang akan kita gunakan.

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