CHAPEL HILL, N.C. – Researchers at the University of North Carolina at Chapel Hill School of Medicine have shown in an animal study that transplantation of adult stem cells enriched with a bone-regenerating hormone can help mend bone fractures that are not healing properly.
The UNC study team led by Anna Spagnoli, MD, associate professor of pediatrics and biomedical engineering, demonstrated that stem cells manufactured with the regenerative hormone insulin-like growth factor (IGF-I) become bone cells and also help the cells within broken bones repair the fracture, thereby speeding the healing. The new findings are presented Sunday, June 5, 2011 at The Endocrine Society's 93rd Annual Meeting in Boston, Massachusetts.
Peak bone mass is reached most often in one's 20s. Well, why wait for broken bones before delivering stem cell therapies? Once youthful bone stem cell therapy becomes available it will make sense to get it ones 40s or 50s to reverse the bone loss long before breaks become a risk.
Lots of people have problems healing from fractures, including some with genetic defects of bone formation.
A deficiency of fracture healing is a common problem affecting an estimated 600,000 people annually in North America. "This problem is even more serious in children with osteogenesis imperfecta, or brittle bone disease, and in elderly adults with osteoporosis, because their fragile bones can easily and repeatedly break, and bone graft surgical treatment is often not successful or feasible," Spagnoli said.
Approximately 7.9 million bone fractures occur every year in the United States alone, with an estimated cost of $70 billion. Of these, 10 to 20 percent fail to heal.
Stem cell therapies that get developed to treat assorted medical problems will be usable for general rejuvenation. This report is an example of therapy development that will have uses beyond the initial purpose.
While waiting for stem cell therapies you can slow your bone loss by eating a less acidic diet.
Chevy Chase, MD—Diets that are high in protein and cereal grains produce an excess of acid in the body which may increase calcium excretion and weaken bones, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The study found that increasing the alkali content of the diet, with a pill or through a diet rich in fruits and vegetables has the opposite effect and strengthens skeletal health.
"Heredity, diet, and other lifestyle factors contribute to the problem of bone loss and fractures," said Bess Dawson-Hughes, M.D., of Tufts University in Boston, Mass. and lead author of the study. "When it comes to dietary concerns regarding bone health, calcium and vitamin D have received the most attention, but there is increasing evidence that the acid/base balance of the diet is also important."
For additional bone protection use turmeric as a spice on the veggies.
OAK BROOK, Ill. – Arthroscopic surgical repair of torn anterior cruciate ligaments (ACL) or meniscal cartilage injuries in the knee does not decrease the chances of developing osteoarthritis, according to a new study published in the online edition and August print issue of the journal Radiology.
There's a lesson in this sort of report: Surgery falls way short of full repair of tissue damage. The long term effects of those injuries is to accelerate aging. Surgery is inadequate because surgeons can not instruct cells how to do repairs.
If you've had an ACL tear or cartilage damage then osteoarthritis lies in your future until cell therapies and gene therapies are developed that can do full repair.
A decade after the initial injuries were diagnosed using MRI, localized knee osteoarthritis was evident in patients, regardless of whether or not the injuries had been surgically repaired.
"This study proves that meniscal and cruciate ligament lesions increase the risk of developing specific types of knee osteoarthritis," said Kasper Huétink, M.D., the study's lead author and resident radiologist at Leiden University Medical Center in the Netherlands. "Surgical therapy does not decrease that risk."
Gotten yourself pretty banged up by sports, yard work, or an accidental fall? You need the development of gene therapies and cell therapies to render you fully repaired. Otherwise painful arthritis lies in your future.