April 10, 2011
Soy Isoflavones Block DNA Repair

Soy isoflavones block DNA repair mechanisms and help radiation kill cancer cells. But you might worry about what blocking the DNA repair mechanism does to your cells if you aren't undergoing treatment for cancer.

"To improve radiotherapy for lung cancer cells, we are studying the potential of natural non-toxic components of soybeans, called soy isoflavones, to augment the effect of radiation against the tumor cells and at the same time protect normal lung against radiation injury," said Dr. Gilda Hillman, an associate professor in the Department of Radiation Oncology at Wayne State University's School of Medicine and the Karmanos Cancer Institute in Detroit.

"These natural soy isoflavones can sensitize cancer cells to the effects of radiotherapy, by inhibiting survival mechanisms which cancer cells activate to protect themselves," Hillman said. "At the same time, soy isoflavones can also act as antioxidants in normal tissues, which protect them against unintended damage from the radiotherapy. In a recent study, published in the Journal of Thoracic Oncology, we demonstrated that soy isoflavones increase killing of cancer cells by radiation via blocking DNA repair mechanisms, which are turned on by the cancer cells to survive the damage caused by radiation."

Soy is very un-paleo. Soy is high in lectins (unless fermented) and for men the soy isoflavone genistein is only appropriate if you want to shrink your prostate and don't mind the feminization.

Soy might not be as harmful as poisonous sugar and high fructose corn syrup. We need to turn back the clock on our diets by about a century.

Share |      Randall Parker, 2011 April 10 01:03 PM  Aging Diet Studies

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